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Öğe Assessment of change in neutrophil-lymphocyte ratio, platelet-lymphocyteratio in patients with acute and chronic urticaria(2018) Sarac, Gulbahar; Mantar, İrem; Sener, Serpil; Cenk, Hülya; Kapicioglu, YeldaAim: Urticaria is a skin disease characterized by erythematous, oedematous, itchy,and spontaneously disappearing urticaria lesions. One of the most common skin diseases, it is the most common reason underlying the presentations to emergency departments. Our objective is to investigate the role of systemic inflammation in urticaria pathogenesis by measuring the indicators of NeutrophilLymphocyte ratio (NLR) and Platelet-Lymphocyte ratio (PLR) in routine hemograms in patients with acute and chronic urticaria. Material and Methods: Of patients visiting the Dermatology Policlinic of İnönü University Medical School Hospital between July 2017 and February 2018, 69 patients diagnosed with acute urticaria and 188 patients diagnosed with chronic urticaria as well as 90 healthy people taken as controls with an age range of 18to 70 were included in our study. Blood values of patients were studied retrospectively. (For the study, a Research Ethics Approval was obtained from Malatya Research Ethics Board.) Results: No significant difference was detected among the study groups in terms of demographic properties. Whereas a significant difference was noted among the three groups with regard to NLR values, no statistically significant difference was detected among the groups with respect to PLR values. No statistically significant difference was observed between the group of patients with urticaria and the control group in terms of erythrocyte distribution(p:0.01). On the other hand, when the patient group with chronic urticaria was divided into two subgroups as patients with a complaint duration of 90 days and less, and those with a complaint duration of more than 90 days and evaluated, no statistically significant difference was detected between these groups in terms of RDW, lymphocytes, neutrophils, platelets, NLR and PLR values Conclusion: In our study, we have determined that systemic inflammation has increased in the group of patients with urticaria as compared to the control group. What’s more interesting in this study is our conclusion that the pathways involved in continued inflammation do not change by time in chronic urticaria.Öğe A case of angioedema-like atypic scleromyxedema responding to treatment with steroid(Deri Zuhrevi Hastaliklar Dernegi, 2016) Polat, Aysegul; Kapicioglu, Yelda; Sahin, Nurhan; Yilmaz, MikailLichen myxedematosus is a chronic, inflammatory, systemic dermatose characterized by dermal musin deposition and increased fibroblasts in the absence of thyroid dysfunction. It is usually seen together with paraproteinemia. It is clinically classified as scleromyxedema (papular mucinosis), localized lichen myxedematosus, and atypical lichen myxedematosus. Etiopathogenesis of the disease which is very difficult to treat is still unknown. Herein, we present a case of atypical scleromyxedema without monoclonal gammopathy mimicking angioedema, rapidly developing and responding to steroid treatment.Öğe Comparison of Antiaging Effects on Rat Skin of Cog Thread and Poly-L-Lactic Acid Thread(Lippincott Williams & Wilkins, 2019) Kapicioglu, Yelda; Gul, Mehmet; Sarac, Gulbahar; Yigitcan, Birgul; Gozukara, HarikaBACKGROUND Polydioxanone Cog thread and poly-L-lactic acid (PLLA) thread have been used clinically for lifting and antiaging purposes. However, the histological changes in tissue and the efficacy of these 2 different types of thread have not been compared. OBJECTIVE This study used hematoxylin and eosin (H&E) staining, Masson's trichrome staining, and electron microscopy (EM) to compare the results associated with the use of Cog thread and PLLA thread in rat skin. METHODS Thirty female rats were divided into 3 groups of 10 rats each: a control group; a Cog group; and a PLLA group. Biopsy specimens obtained at 1, 3, and 6 months were examined using H&E, MT, and EM. RESULTS Although significant increases were observed in dermal thickness and the numbers of fibroblasts in the PLLA group compared with the control group within the first month (p: .019), there were no significant differences between the Cog and control groups during this period (p: .245). Dermal thickness (p: .002) and numbers of fibroblasts (p: .001) were similar in samples obtained from the PLLA and Cog groups at 3 and 6 months, and both groups showed significantly improved outcomes compared with the control group. CONCLUSION Poly-L-lactic acid and Cog sutures were effective in facial rejuvenation; both increased dermis thickness and stimulated collagen production.Öğe Comparison of polycaprolactone and calcium hydroxylapatite dermal fillers in a rat model(Wiley, 2021) Yanatma, Irem; Sarac, Gulbahar; Gul, Mehmet; Gul, Semir; Kapicioglu, YeldaPolycaprolactone (PCL) and calcium hydroxylapatite (CaHA) are semipermanent dermal fillers that are frequently preferred in the last decade. This study aims to compare the effects of these two fillers in the rat skin. A total of 30 female rats were divided into; control, PCL, and CaHA group. Tissue samples taken at the second and fourth month were stained with hematoxylin-eosin, Masson trichrome, collagen type 1, and 3 immunohistochemical antibodies. Collagen density was quantitatively compared using the Image J computer program. At 2 and 4 months, the density of collagen increased in both filler groups compared to the control group. There was no significant difference between collagen density or type 1 and type 3 collagen H scores in the filler groups. The number of fibroblast nuclei was significantly higher in the PCL group at 4 months compared to the other two groups. Dermis thickness was found to be superior in both filler groups compared to the control group at the fourth month, there was no significant difference between the filler groups. We compared the effect of CaHA and PCL filler on collagenization histologically and immunohistochemically. We found that PCL and CaHA fillers are effective in increasing dermal collagen density, type 1 and type 3 collagen amount, and preventing dermis atrophy and showed that they have no advantage over each other in this respect. We have shown that PCL filler provides more fibroblast increase compared to CaHA filler and the effect of stimulating fibroblast proliferation takes longer.Öğe Comparison of the efficacies of polycaprolactone filler and lidocaine-added filler on neocollagenesis in a rat model(Wiley, 2022) Sezer, Suat; Sarac, Gulbahar; Gul, Mehmet; Zayman, Emrah; Kapicioglu, YeldaBackground Polycaprolactone (PCL) is a semi-permanent filler stimulating neocollagenesis. Lidocaine is frequently used to reduce the pain and, however, may have negative effects on collagen. It was aimed to compare the histological changes on rat skin and efficacies of PCL filler and lidocaine addition. Objective In this study, results of PCL and PCL+Lidocaine application on rat skin were compared using hematoxylin-eosin (H&E) staining, Masson's trichrome (MT) staining, and electron microscope (EM). Methods A total of 30 adult female rats were divided into three groups: the control group, the PCL group, and the PCL+Lidocaine group. The tissue samples taken at months 2 and 4 were examined using H&E, MT, and EM. Results At month 2, dermis thickness, fibroblast count, and collagen fiber diameter increased similarly in the PCL and PCL+Lidocaine groups. Collagen fiber diameter was significantly higher in the PCL group than in the PCL+Lidocaine (p:0.016) and control groups (p:0.009). At month 4, no significant difference was detected between the PCL and PCL+Lidocaine groups in terms of fibroblast count, collagen fiber count, and collagen fiber diameter; dermis thickness was lower in the PCL+Lidocaine group at month 4 (p < 0.46). Dermis thickness, fibroblast count, collagen fiber count, and collagen fiber diameter were found to be significantly lower than in the PCL and PCL+Lidocaine groups. Conclusions Our study showed that lidocaine addition to PCL filler does not affect the efficacy of the filler and PCL filler stimulates neocollagenesis.Öğe Dermoscopic findings of psoriatic nail and their relationship with disease severity(Turkish Soc Dermatology Venerology, 2017) Polat, Aysegul; Kapicioglu, YeldaBackground and Aim: The use of dermoscopy in nail diseases is quite recent. Dermoscopy allows a better visualisation of abnormalities of the nail bed and matrix in case of atypical clinical features in psoriatic nail. This study aimed to determine the frequency of findings in psoriatic nail by dermoscopic examination, to compare dermoscopy with clinical examination and to investigate the relationships between the indicators of disease severity. Materials and Methods: This study included 40 patients who presented with psoriatic nail. The severity of skin involvement of the disease was determined by the Psoriasis Area Severity Index (PASI) and the severity of nail involvement was determined by the Nail Psoriasis Severity Index (NAPSI). Patients' nails were evaluated both by clinical examination and dermoscopy. Results: The most common dinical and dermoscopic findings were pitting (92.5%) and leukonychia (92.5%), respectively. No statistically significant difference was observed between the clinical and dermoscopic NAPSI scores (p>0.05). No statistically significant relationship was noted between the PASI and the clinical and dermoscopic NAPSI scores (p>0.05). Dermoscopically, dilated, extended capillary vessels were observed in the nail bed but without the evidence of a relationship with disease severity. A positive correlation was noted between the duration of the disease and the duration of nail involvement (p<0.05). There was a statistically significant positive relationship between the duration of nail involvement and the clinical and dermoscopic NAPSI scores p<0.05. Conclusion: Nail dermoscopy was considered to be a preferable method as a supportive and non-invasive procedure prior to biopsy in cases of isolated nail involvement where clinical diagnosis of nail psoriasis is suspicious.Öğe Determination of sunscreen and cosmetic product use awareness in adolescents(2019) Sarac, Gulbahar; Kayhan Tetik, Burcu; Sener, Serpil; Mantar, İrem; Kapicioglu, YeldaAim: Using an appropriate sunscreen is very important because the role of sun rays in development of skin cancer is well known. Besides, the recent increase in the use of cosmetics among adolescents is noteworthy. In this study, we aimed to determine the frequency of using cosmetics and the level of awareness of harmful effects of the sun, in adolescents. Material and Methods: In this cross-sectional descriptive study, a questionnaire consisted of 25 questions was applied, on voluntary basis, in middle schools. Results: A total of 607 students participated in the study; 434 participants were female students (71.5%), 173 were male students (28.5%) and the average age was 17 years. The question “Do you think it is necessary to protect from the sun?” is answered as “yes” by 361 of the female students (81.1%) and 109 of the male students (62.3%). The question “Do you use sunscreen?” is answered as “Yes” by 33.3% of all participants. Conclusion: In our study, we found that adolescents had a good understanding of the harmful effects of sun, but in contrast to this, we found that the use of sunscreen products was at very low levels. We think that education and methods for building awareness in this regard will be effective.Öğe Effectiveness of topical Nigella sativa for vitiligo treatment(Wiley, 2019) Sarac, Gulbahar; Kapicioglu, Yelda; Sener, Serpil; Mantar, Irem; Yologlu, Saim; Dundar, Cihat; Turkoglu, MuratVitiligo is a pigment disease characterized by the disruption of melanocyte structure and function. Its etiology is unknown; however, genetic predisposition, biochemical factors, and neural mechanisms are thought to be effective. Although many agents are being used for its treatment, generally there is no absolute cure. The aim of the present study is to evaluate the effectiveness of topical Nigella sativa seed oil on vitiligo patients. Thirty-three vitiligo patients were included in the study. Totally 47 areas were evaluated in all patients. Cream containing N sativa seed oil was topically applied to hands, face, and genital region two times a day for 6 months. Statistically significant repigmentation was detected in hands, face, and genital region, the three treatment areas, and the p values are found .005, .001, and .004, respectively. N sativa can be used as an adjuvant therapy that can contribute to the treatment especially in sensitive skin areas like genital region.Öğe Efficacy of 577-nm Pro-Yellow laser in port wine stain treatment(Wiley-Hindawi, 2019) Sarac, Gulbahar; Kapicioglu, YeldaA port-wine stain (PWS) is a congenital capillary malformation that is seen in 0.3-0.5% of newborns. Although many types of lasers have been used to treat PWSs, few studies have investigated the efficacy of 577-nm Pro-Yellow lasers. The aim of this study was to establish the efficacy of Pro-Yellow lasers in PWS treatment. In total, 26 patients, comprising 15 females (57.7%) and 11 males (42.3%) with a mean age of 24.7 +/- 11.8 (range 1-50) years were included in the study. All were treated with a 577-nm Pro-Yellow laser at 4-week intervals, 3-10 times. The sessions initially used scan mode and a fluence dose of 24 J/cm(2) per session, on average. The mean dose was increased by 4 J/cm each session and the maximum dose administered was 44 J/cm(2). A mean regression of 68.8 +/- 13.9% in the size of the lesions over 5.23 +/- 2.7 sessions was observed. There was no statistically significant difference between the female and male patients when they were compared in terms of the number of treatment sessions (p = .789) and treatment success (p = .39). These case series demonstrate that the Pro-Yellow laser is a safe and well-tolerated treatment for PWSs. However, deep-seated lesions required more treatment sessions and it was observed that clinically the lesions did not completely disappear.Öğe Elevated Monocyte to High-Density Lipoprotein Cholesterol Ratio and Endothelial Dysfunction in Behcet Disease(Sage Publications Inc, 2018) Acikgoz, Nusret; Kurtoglu, Ertugrul; Yagmur, Julide; Kapicioglu, Yelda; Cansel, Mehmet; Ermis, NecipBehcet disease (BD) is a multisystemic disorder characterized by endothelial dysfunction and inflammation. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged indicator of inflammation and oxidative stress. Sixty patients with BD and 50 control individuals were included to investigate the relationship between MHR and endothelial dysfunction. Endothelial function was assessed by flow- and nitroglycerin-mediated dilatation technique (FMD and NMD, respectively). Serum high-sensitivity C-reactive protein (hsCRP) levels were measured in all study participants. The MHR and hsCRP levels were significantly higher in patients with active BD than in controls. Brachial artery FMD was significantly lower in patients with active BD than in controls. Brachial artery NMD was similar between groups. There was a strong inverse correlation between MHR and FMD and a strong positive correlation between MHR and serum hsCRP levels. Thus, elevated MHR may be a useful marker reflecting impaired endothelial function and systemic inflammation in patients with BD.Öğe An evaluation of the efficacy of a single-session 577 nm pro-yellow laser treatment in patients with postacne erythema and scarring(Wiley, 2021) Sarac, Gulbahar; Kapicioglu, Yelda; Cenk, HulyaErythema and scarring are among the most common complications of severe inflammatory acne. In this study, we aimed to share our experience with pro-yellow laser and document the efficacy and safety of this treatment in postacne erythema and scarring. The study included 40 patients, 24 (60%) females, and 16 (40%) males with a mean age of 29.5 +/- 8.16 (min. 18 years, max. 57 years). The pro-yellow laser was applied to all patients as a single session with irradiation of 22 J/cm(2). Improvement in postacne erythema and scars were evaluated after the treatment. The study included 40 patients, 24 patients (60%) were females and 16 patients (40%) were males with the mean age of 29.5 +/- 8.16 (ranged between 18 and 57 years old). A total of 21 patients (52.5%) had good improvement (51%-75% regression), 10 patients (25%) had excellent improvement (76%-100% regression), and a moderate improvement (26%-50%) was detected in 9 patients (22.5%). Also, there were mild improvement (1%-25%) in 20 patients (76.9%) and a moderate improvement (26%-50%) in 6 patients (23.1%). We found that pro-yellow laser is highly effective in the treatment of postacne erythema, while its effectiveness was mild to moderate in atrophic acne scars. Also, it has been observed that the pro-yellow laser system can be used safely immediately after cessation of systemic isotretinoin treatment.Öğe Management of complications of vitamin e injections into the face(Wıley, 111 rıver st, hoboken 07030-5774, nj usa, 2018) Sarac, Gulbahar; Kapicioglu, Yelda; Sener, Serpil; Cenk, Hulya; Akatli, AysenurÖğe Management of complications of vitamin E injections into the face(Wiley, 2018) Sarac, Gulbahar; Kapicioglu, Yelda; Sener, Serpil; Cenk, Hulya; Akatli, Aysenur[Abstract Not Available]Öğe A new treatment option for poikiloderma of Civatte: 577 nm pro-yellow laser(Wiley, 2022) Sarac, Gulbahar; Kapicioglu, Yelda; Cenk, HulyaBackground Although many laser systems have been used in the treatment for Poikiloderma of Civatte (POC), there is no standard treatment guideline. Objectives We aimed to present our data on the efficacy and safety of single-session pro-yellow laser treatment for POC. Methods The study included 14 patients treated with pro-yellow laser (QuadroStarPRO YELLOW(R) Asclepion Laser Technologies, Germany) between 2017 and 2019. Treatment had been applied in two passes during the same session; a general pass with 22 j/cm(2) over the whole lesion, then, one more pass only on the telangiectatic lesions with 18 j/cm(2) fluence. They were evaluated based on their pictures taken before and 4 weeks after the treatment and scored by a 4-item scoring in terms of the improvement (0:no change, 1:1%-25% mild, 2:26%-50% moderate, 3:51%-75% well, and 4:76%-100% excellent improvement). Results The mean age of the patients (1 female, 13 males) was 59.64 +/- 8.16 years. Five patients had Fitzpatrick-2 and 9 patients had Fitzpatrick-3 skin types. Six patients had mild, 8 patients had moderate improvement, one of them has been illustrated in Figure 1. Sixty-minute mild erythema was the only adverse effect observed. Conclusions We think that pro-yellow laser is a good treatment option for POC treatment. Repeated sessions are required for the complete healing of the lesions, while one single session has proved to be deficient. We observed that it was a quite safe treatment option, especially for the neck region, which was inclined to scarring and atrophy development.Öğe Psychiatric morbidity in children and adolescents with dermatological disorders(Exeley Inc, 2021) Miniksar, Dilsad Yildiz; Ozcan, Ozlem Ozel; Cenk, Hulya; Kapicioglu, Yelda; Polat, AysegulBackground: Understanding the existence of a cycle, where psychological disturbances cause skin diseases and in turn, skin diseases cause psychological disorders, provides the basis for good dermatological practice. Objective: The aim of this case-control study is to examine the psychiatric morbidity of dermatological disorders in children and adolescents with no history of psychiatric disorders. Method: In this study, 502 participants (251 patients and 251 healthy individuals) were evaluated according to DSM-IV criteria. All participants were interviewed and evaluated using the Turkish version of the Kiddie Schedule for Affective Disorders and Schizophrenia -Present and Lifetime Version (K-SADS-PL) and the State-Trait Anxiety Inventory for Children (STAI-1 and STAI-2), the Childhood Depression Inventory (CDI), adolescent and parent forms of the Strengths and Difficulties Questionnaire (SDQ-A and SDQ-P) and a questionnaire evaluating child's level of school success. Results: Our results indicated that the rates of general psychiatric comorbidity, mood disorders, anxiety disorders, and adjustment disorders were significantly higher in the study group compared to the control group. The CDI, STAI-1, STAI-2, and SDQ (and subscales) scores were significantly higher in the study group. Moreover, psychiatric comorbidity was higher in inflammatory and allergic dermatoses compared to other dermatological subgroups. Having a dermatological disease restricts physical activity thus increasing the risk of psychiatric comorbidity. Conclusions: Investigating the education, attitudes, and awareness of dermatologists about psychocutaneous disorders might contribute to the development of new educational strategies and elicit appropriate biopsychosocial approaches.Öğe Rituximab therapy in pediatric pemphigus patients: A retrospective analysis of five Turkish patients and review of the literature(Wiley, 2019) Bilgic-Temel, Asli; Ozgen, Zueleyha; Harman, Mehmet; Kapicioglu, Yelda; Uzun, SonerBackground/Objectives There is inadequate knowledge regarding rituximab (RTX) administration in autoimmune bullous diseases (AIBDs), disease prevalence, clinical characteristics, and treatment outcomes within pediatric populations due to the rarity of AIBDs affecting the pediatric age group. The aim of this retrospective analysis was to evaluate the effectiveness, safety of RTX, and treatment outcomes in Turkish pediatric patients with pemphigus vulgaris (PV) and to review the literature. Methods Five patients under 18 years of age and diagnosed with PV received RTX treatment and were identified in four dermatology departments of Turkey. Results The mean age of the patients at the time of RTX therapy initiation was 15 years (range: 11-17 years), and the total duration of follow-up after RTX therapy was 42.6 months (range: 19-60 months). All patients showed a clinical response. At the last visit, complete remission off therapy was achieved in three patients. The remaining two patients achieved partial remission off therapy. No adverse events were observed. Conclusions This retrospective case series of five pediatric patients showed that RTX treatment can be effective and safe for the treatment of recalcitrant PV in pediatric patients. With increasing evidence, RTX is a good treatment choice in adults and pediatric patients with pemphigus.Öğe Tinea incognito: Case series(Deri Zuhrevi Hastaliklar Dernegi, 2015) Yilmaz, Mikail; Kapicioglu, Yelda; Sener, Serpil; Cenk, Hulya; Polat, Aysegul; Yasar, DeryaTinea incognito is a dermatophytic infection which has lost its typical clinical appearance because of inappropriate use of topical or systemic corticosteroids. The clinical manifestations of tinea incognito can mimic many dermatoses such as eczema, psoriasis, allergic contact dermatitis, rosacea, seborrheic dermatitis and atopic dermatitis. The diagnosis of tinea incognito is confirmed by direct KOH (potassium hydroxide) examination (native preparation), making the fungal cultures from the lesion and histopathological examination in some cases. Systemic antifungal therapy is recommended in the treatment of tinea incognito. Herein, 10 cases of tinea incognito which mimicking various dermatoses were diagnosed and treated in our clinic in 2014 is presented.Öğe Treatment of erythematotelangiectatic rosacea, facial erythema, and facial telangiectasia with a 577-nm pro-yellow laser: a case series(Springer London Ltd, 2019) Kapicioglu, Yelda; Sarac, Gulbahar; Cenk, HulyaVarious lasers have been used for the treatment of erythematotelangiectatic rosacea (ETR), facial erythema (FE), and facial telangiectasias (FT). The assessment of the treatments of all of these conditions with a 577-nm pro-yellow laser has not been reported yet. The aim of this work was to assess the efficacy and safety of the 577-nm pro-yellow laser in ETR, FE, and FT. Forty patients suffering from ETR, FE, and FT (25 female and 15 male) were enrolled in this study. All of the patients were treated with 577-nm pro-yellow laser (QuadroStarPRO YELLOW (R) Asclepion Laser Technologies, Germany) at 4-week intervals, for one to four sessions. The assessment of the treatment was made based on the digital photographs and the percentage of fading of the erythema and telangiectasias in the lesions. Significant clinical improvement (80-100%) was observed in the first or second sessions of the treatment in FE and ETR patients and in second and fourth sessions of the treatment in FT patients. The treatment was very well tolerated. No side effect was observed except for a few patients who had mild to moderate erythema fading away in 12-24h. This case series has shown that the pro-yellow laser is a very effective, safe, and well-tolerated treatment for ETR, FE, and FT.
