Yazar "Kaplan, Mehmet" seçeneğine göre listele
Listeleniyor 1 - 3 / 3
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Çözüm odaklı yaklaşımın aşı reddinin giderilmesine etkisi(İnönü Üniversitesi, 2022) Kaplan, Mehmet; Ercı?, Behı?ceAmaç: Bu çalışma, çözüm odaklı yaklaşımın aşı reddinin giderilmesine etkisini belirlemek amacıyla yapıldı. Materyal ve Metot: Araştırma ön test- son test kontrol gruplu yarı deneme modeli olarak Kasım 2020 ile Mayıs 2021 tarihleri arasında uygulandı. Araştırmanın evrenini Bingöl ilinde yaşayan, 0-24 ay arasındaki bebeklerine aşı yaptırmak istemeyen 148 kadın ve erkek oluşturdu. Bireyler olasılıklı örnekleme yöntemlerinden basit rastgele örnekleme yöntemi ile örneklem grubuna seçildi, randomize olarak sıralandı. Deney grubunda toplam 43 kişi, kontrol grubunda 23 kişi ile araştırma tamamlandı. Araştırmada tanıtıcı bilgi formu ve Çocukluk Çağı Aşılarına İlişkin Ebeveyn Tutumları Ölçeği kullanıldı. Deney grubu, gruplara ayrıldı ve bir grup 8 kişi diğer gruplar 7 kişi olmak üzere toplamda 6 grup oluşturuldu. Her bir gruba, dört oturum çözüm odaklı yaklaşım danışmanlığı verildi. Her oturum yaklaşık 60-90 dk sürdü. Bulgular: Deney grubundaki ebeveynlerin çocukluk çağı aşıları hakkında ebeveyn tutumları ölçeği ön test puan ortalaması 25.76±3.08, son test puan ortalaması 16.69±3.81 bulunmuştur. Kontrol grubundaki ebeveynlerin ön test puan ortalaması 27.21±2.17, son test puan ortalaması 25.60±2.27 bulunmuştur. Yapılan analizler sonucunda iki ölçüm arasında istatiksel olarak önemli fark bulunmuştur. ÇOY uygulanmasından sonra çocukluk çağı aşıları hakkında ebeveyn tutumları ölçeği davranış alt boyutunda artış bulunurken tutum ve güvenlik alt boyutlarında önemli azalma görüldü (p<0.05). Sonuç: Çözüm Odaklı Yaklaşım Terapisi, ebeveynlerin aşıya yönelik tutum ve davranışlarını olumlu yönde değiştirmiştir. Anahtar Kelimeler: Aşı, Aşı Reddi, Çözüm Odaklı Yaklaşım, Hemşirelik.Öğe Effect of mucosal immunomodulation with fed cholera toxin on healing of experimental colonic anastomosis(Diseases of the Colon & Rectum, 2002) Kaplan, Mehmet; Menteş, Bülent; Tatlıcıoğlu, Ertan; Kayhan, Başak; Aybay, CemalettinThe aim of this study was to investigate in rats whether preoperative orogastric administration of low doses of cholera toxin would influence the mechanical strength of experimental colonic anastomosis on the basis of the gut mucosal immunomodulation effect of this antigen. METHODS: The cholera toxin group (n 14) was fed 10 g of cholera toxin in phosphate-buffered saline three times before surgery at 10-day intervals, whereas the controls (n 14) received phosphate-buffered saline only. Twenty-four hours after the last dose of cholera toxin (or placebo in control group), the animals underwent left colonic transection and anastomosis. Seven days after colonic transection-anastomosis, the bursting pressure of the anastomotic segment was recorded in situ. Perianastomotic and extra-anastomotic tissue samples were obtained for measurements of tissue transforming growth factor-beta, interleukin-6, and interferon-gamma levels with enzyme-linked immunosorbent assay. RESULTS: Cholera toxin administration resulted in a significantly higher bursting pressure than in the control group (165.78 12.37 vs. 138.4 7.87 mmHg; P 0.001). Compared with the control group, the heightened mechanical strength of colonic anastomosis provided by cholera toxin was associated with significant increases in the perianastomotic tissue levels of transforming growth factor-beta (199.34 24.85 vs. 70.66 10.63 pg/ml; P 0.001) and interleukin-6 (439.31 95.14 vs. 289.57 96.59 pg/ml; P 0.001), whereas interferongamma was significantly lower (174.04 44.82 vs. 219.00 31.35 pg/ml; P 0.05). This cytokine pattern induced by cholera toxin in the wound milieu was also found to be similar in the extra-anastomotic colon. CONCLUSION: The mechanical strength of uncomplicated experimental colonic anastomosis increased significantly with gut mucosal immunomodulation with repeated low preoperative doses of cholera toxin. This enhanced healing had significant positive correlation with the colonic tissue level of transforming growth factor-beta and inverse correlation with interferon-gamma. If the relevant dose regimen is identified and its safety is assured in humans, gut mucosal immunomodulation might provide an efficient, safe, and inexpensive tool to improve surgical outcome in colorectal surgery, particularly in high-risk situations.Öğe Turkish Real Life Atrial Fibrillation in Clinical Practice: TRAFFIC Study(Kare Publ, 2024) Karabay, Can Yucel; Tasolar, Hakan; Kunak, Aysegul Ulgen; Cap, Murat; Astarcioglu, Mehmet Ali; Sen, Taner; Kaplan, MehmetBackground: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide and is associated with an increased risk of thromboembolism, ischemic stroke, impaired quality of life, and mortality. The latest research that shows the prevalence and incidence of AF patients in Turkiye was the Turkish Adults' Heart Disease and Risk Factors study, which included 3,450 patients and collected data until 2006/07.The Turkish Real Life Atrial Fibrillation in Clinical Practice (TRAFFIC) study is planned to present current prevalence data, reveal the reflection of new treatment and risk approaches in our country, and develop new prediction models in terms of outcomes. Methods: The TRAFFIC study is a national, prospective, multicenter, observational registry. The study aims to collect data from at least 1900 patients diagnosed with atrial fibrillation, with the participation of 40 centers from Turkiye. The following data will be collected from patients: baseline demographic characteristics, medical history, vital signs, symptoms of AF, ECG and echocardiographic findings, CHADS2VASC2 and HAS -BLED (1 -year risk of major bleeding) risk scores, interventional treatments, antithrombotic and antiarrhythmic medications, or other medications used by the patients. For patients who use warfarin, international normalized ratio levels will be monitored. Follow-up data will be collected at 6, 12, 18, and 24 months. Primary endpoints are defined as systemic embolism or major safety endpoints (major bleeding, clinically relevant nonmajor bleeding, and minor bleeding as defined by the International Society on Thrombosis and Hemostasis). The main secondary endpoints include major adverse cardiovascular events (systemic embolism, myocardial infarction, and cardiovascular death), all -cause mortality, and hospitalizations due to all causes or specific reasons. Results: The results of the 12 -month follow-up of the study are planned to be shared by the end of 2023. Conclusion: The TRAFFIC study will reveal the prevalence and incidence, demographic characteristics, and risk profiles of AF patients in Turkiye. Additionally, it will provide insights into how current treatments are reflected in this population. Furthermore, risk prediction modeling and risk scoring can be conducted for patients with AF.
