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Öğe Effect of hyperbaric oxygen on hyperglycemia-induced cochlear damage: An experimental study(2019) Yiğider, Ayşe Pelin; Gül, Mehmet; Körpınar, Şefika; Kaplan, Mehmet Ali; Server, Ela; Yiğit, Özgür; Daştan, Sevgi; Toklu, Akın SavaşAbstract: Objectives: This study aims to investigate whether hyperglycemiainducedcochlear damage can be treated with hyperbaric oxygentherapy (HBOT) in rats with diabetes mellitus using distortionproduct otoacoustic emission (DPOAE) and histopathological analysis.Materials and Methods: The study included 18 male albinoSprague Dawley rats (weighing ?350 g, at least two months ofage). Animals were divided into three groups as the control group(group 1), streptozocin (STZ)-induced diabetes group (group 2),and STZ-induced diabetes+HBOT group (group 3). Distortionproduct otoacoustic emission was used to demonstrate functionalstatus of cochlea and applied at the beginning and at the end of theeighth week. Group 3 was treated with HBOT for one week at sixthweek. By the end of the eighth week, all animals were decapitated.Histological evaluation was performed under light microscopy.Results: All animals in groups 2 and 3 had fasting blood glucose levels>250 mg/dL. There was no difference in terms of signal-to-noise ratiovalues between groups at the end of the study except for 2 kHz, whichwas lower in groups 2 and 3. Histological evaluation showed thatdegenerations including hydropic degeneration, loss of supportingand hair cells, basilar membrane deformation, and fibrinoid materialin deposition in the scala media were higher in group 2 than group 3.Conclusion: In our study, HBOT ameliorated diabetes-inducedcochlear damage histologically. In light of our findings, we believethat the management of hearing loss in diabetics may evolvedramatically if the proper algorithm is formed.Öğe Multicentric study on malignant pleural mesothelioma in Turkey: clinicopathologic and survival characteristics of 282 patients(Humana Press Inc, 2012) Elkiran, Emin Tamer; Kaplan, Mehmet Ali; Sevinc, Alper; Aksoy, Sercan; Demirci, Umut; Seker, Mesut; Harputluoglu, HakanMalignant pleural mesothelioma (MPM) is a relatively rare, but aggressive tumor that causes high mortality. The major risk factor involved in the etiology is environmental and occupational exposure to asbestos. The optimal modality of therapy is controversial. The present study retrospectively evaluated the data pertinent to 282 patients who were examined and treated in 11 different medical oncology centers in Turkey. There were 161 males (57.1 %) and 121 females (42.9 %), with a mean age of 56.38 +/- A 12.07 years. Surgery was used in 74 patients, 21 patients (28.4 %) received only chemotherapy and 28 patients (37.8 %) received chemoradiotherapy after surgery. The median survival in patients who were administered adjuvant therapy after surgery was 24 months, while the median survival in patients who had only surgery was 6 months (p = 0.029). 106 patients were administered pemetrexed-platinum combination and 35 patients were administered gemcitabine-platinum combination as front-line chemotherapy. Median survival, 1- and 2-year survival rates in patients who received platinum analogues and pemetrexed or gemcitabine combinations were found statistically similar (p = 0.15). The median survival for all patients with MPM in our study was 18 months. The main factors influencing the overall survival were stage of the disease (p = 0.020), performance status (p < 0.001), asbestos exposure (p = 0.030) and mesothelioma histological subtypes (p < 0.001). Results of our study suggest that multi-modality treatment regimens consisting of surgery, radiotherapy and chemotherapy prolong overall survival. Survival rates in patients who received combining platinum analogues with pemetrexed or gemcitabine as front-line chemotherapy were found similar.