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Öğe CHANGE IN MRNA EXPRESSION OF SIRTUIN-2 AND SIRTUIN-3 IN RHEUMATOID ARTHRITIS(Bmj Publishing Group, 2014) Kara, M.; Yolbas, S.; Yildirim, A.; Gundogdu, B.; Ozgen, M.; Sahin, C.; Koca, S. S.[Abstract Not Available]Öğe Comparative evaluation of mda levels during aerobic exercise in young trainedand sedentary male subjects(Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Algul, S.; Ugras, S.; Kara, M.The impacts of acute aerobic exercise on oxidative stress as determined altered MDA levels have been examined in young trained and sedentary male subjects. Total of 20 (10 trained and 10 sedentary) male subjects performed an aerobic cycling exercise at the anaerobic threshold for about 30 min. The venous blood samples (pre and post exercise) and analysed for MDA using HPLC methods. Wilcoxon and Mann Whitney U-tests were included in the statistical methods for data analysis. Acute exercise caused a systematic increase in MDA levels in trained (36.2%) and sedentary (55.4%) subjects during exercise (p<0.001). The increase in MDA levels were higher in sedentary subjects (0.79±0.08 µmol/L vs 1.02±0.05 µmol/L) compared to trained subjects (0.73±0.05 µmol/L vs 0.97±0.07 µmol/L) (p<0.001). Acute exercise may cause higher levels of increase in oxidative stress as determined alteration of MDA levels in sedentary subjects. Thus the sedentary subjects should pay more attention to the physical activities. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe MITOCHONDRIAL DNA 4977 bp DELETION IN CHRONIC CERVICITIS AND CERVIX CANCERS(Macedonian Acad Sciences Arts, 2012) Kara, M.; Tatar, A.; Borekci, B.; Dagli, F.; Oztas, S.Mitochondrial DNA (mtDNA) mutations have been implied in many diseases including cancer and inflammatory diseases. The aim of this study is to investigate the relationship between the 4977 bp deletion of the mtDNA and chronic cervicitis or cervix cancer in patients. The study included a group of patients with chronic cervicitis or cervix cancer, and a control group consisting of individuals without any cervical tissue disease. A total of 72 subjects in an East Turkish population were included in the study. Of these, 35 had chronic cervicitis, 21 had cervix cancer and 16 served as the control group. Isolation of mtDNA was performed from the tissues of these patients and then mtDNA deletions were studied using polymerase chain reaction (PCR). In the cancer groups, there were 9.5% heteroplasmic and homoplasmic deletions. There were no homoplasmic deletions in the cervicitis and control groups, but the frequencies of heteroplasmic deletions were 80.0 and 31.2%, respectively. Chronic inflammation leading to increased reactive oxygen species (ROS) may be the cause of the high mtDNA 4977 bp deletion frequencies in cancer and cervicitis. The older age of the cancer patient may suggest that ageing in addition to long time exposure to ROS may lead to deletions and subsequently cancer. This is the first study to investigate the relationship of the mtDNA 4977 bp deletion to chronic cervicitis and cervix cancer.Öğe Oral findings in children with celiac disease(Blackwell Publishing, 2008) Ertekin, V.; Sumbullu, M. A.; Selimoglu, M. A.; Kara, M.; Kilic, N.[Abstract Not Available]Öğe THE RS11792633-T ALLELE OF IL-33 GENE IS ASSOCIATED WITH SYSTEMIC SCLEROSIS(Bmj Publishing Group, 2013) Koca, S. S.; Pehlivan, Y.; Kara, M.; Oner, F. A.; Yilmaz, N.; Cetin, G. Y.; Kisacik, B.[Abstract Not Available]
