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Öğe 47,XYY karyotipli infertil bir çiftte ICSI ile gebelik eldesi ve genetik danışmanlık süreci(İnönü Üniversitesi Sağlık Bilimleri, 2012) Kara, Murat; Kumbak Aygün, Hatice Banu; Tekedereli, İbrahim47,XYY sendromu erkeklerde ekstra Y kromozomunun olduğu bir cinsiyet kromozomu anöploidisidir ve bu erkeklerin büyük bir kısmı fenotipik olarak normal özellik gösterirler. Ancak infertilite, kanser, nörolojik hastalıklar riskinde artma bildirilmiştir. Bu olguda intrasitoplazmik sperm enjeksiyonu (ICSI) ile normal genotipte bir çocuğa sahip olan 47,XYY genotipli bir vaka sunularak bu tür genotipe sahip bireyler için genetik danışmanlık sürecinin önemi tartışıldı.Öğe Genotype distribution in Hepatitis C patients admitted to Erzincan Mengücek Gazi Training and Research Hospital(2020) Yilmaz, Aysun; Kara, Murat; Karakecili, Faruk; Dabanlioglu, Bulent; Arslan, Yusuf KemalAim: We aimed to determine the genotype distribution in Hepatitis C patients who Parasitology applied to Erzincan Binali Yildirim University, Mengücek Gazi Training and Research Hospital. Hepatitis C virus, the only member of the genus Hepacivirus of Flaviviridae family, is responsible for 25%-40% of all liver diseases. Hepatitis C virus causes acute hepatitis C and chronic hepatitis C infections. Chronic hepatitis C infection causes cirrhosis, liver failure, hepatocellular cancerand liver diseases in terminal periods. Material and Methods: A total of 77 patients, 41 male and 36 female, who were admitted to Erzincan Binali Yıldırım University, Mengücek Gazi Training and Research Hospital in the period of January 2013-June 2019, were included in our study. RT-PCR and DNA sequencing for the 5’UTR region of the HCV genome for HCV genotyping was performed using the ABI Prism 3130 × 1 DNA Sequencer device.Results: Sex of a total of 77 patients included in the study; 41 of them are men (53.2%) and 36 are women (46.8%). Average age of the patients; It was 59.9 ± 16.6 (minimum 20 and maximum 94). HCV G1b (80.5%) in 62 patients, HCV G1a (7.8%) in 6, HCV G3a (3.9%) in 3, HCV G3 (2.6%) in 2 and HCV G2 (2.6%) was found in 2 patients. HCV G1 (1.3%) was detected in 1, HCV G4 (1.3%) in 1 patient.Conclusion: The dominant genotype in Hepatitis C patients who applied to Mengücek Gazi Training and Research Hospital was determined as “HCV Genotype 1b”.Öğe Genotype distribution in Hepatitis C patients admitted to Erzincan Mengücek Gazi Training and Research Hospital(2020) Yılmaz, Aysun; Kara, Murat; Karakeçili, Faruk; Dabanlıoğlu, Bülent; Arslan, Yusuf KemalAbstract: Aim: We aimed to determine the genotype distribution in Hepatitis C patients who Parasitology applied to Erzincan Binali Yildirim University, Mengücek Gazi Training and Research Hospital. Hepatitis C virus, the only member of the genus Hepacivirus of Flaviviridae family, is responsible for 25%-40% of all liver diseases. Hepatitis C virus causes acute hepatitis C and chronic hepatitis C infections. Chronic hepatitis C infection causes cirrhosis, liver failure, hepatocellular cancerand liver diseases in terminal periods. Material and Methods: A total of 77 patients, 41 male and 36 female, who were admitted to Erzincan Binali Yıldırım University, Mengücek Gazi Training and Research Hospital in the period of January 2013-June 2019, were included in our study. RT-PCR and DNA sequencing for the 5’UTR region of the HCV genome for HCV genotyping was performed using the ABI Prism 3130 × 1 DNA Sequencer device. Results: Sex of a total of 77 patients included in the study; 41 of them are men (53.2%) and 36 are women (46.8%). Average age of the patients; It was 59.9 ± 16.6 (minimum 20 and maximum 94). HCV G1b (80.5%) in 62 patients, HCV G1a (7.8%) in 6, HCV G3a (3.9%) in 3, HCV G3 (2.6%) in 2 and HCV G2 (2.6%) was found in 2 patients. HCV G1 (1.3%) was detected in 1, HCV G4 (1.3%) in 1 patient. Conclusion: The dominant genotype in Hepatitis C patients who applied to Mengücek Gazi Training and Research Hospital was determined as “HCV Genotype 1b”.Öğe Geriatric Nutrition Risk and Creatinine Indexes in Estimating the Nourishment Situation of Elderly Hemodialysis Patients(Mattioli 1885, 2022) Yakaryilmaz, Funda Datli; Pembegul, Irem; Kara, MuratObjective: Malnutrition is a common complication in hemodialysis (HD) patients, although it cannot be evaluated adequately due to the limitations of available malnutrition screening tools. The aim of our study is to evaluate the relationship between Mini nutritional Assesment-Short Form (MNA-SF) and objective malnutrition tool Geriatric Nutritional Risk Index (GNRI) and Creatinine Index (CI) in HD patients. Methods: This is a cross-sectional study of 129 patients aged 65 years and older (female=61 (47.3%) and male=68 (52.7%), 68.88 ?? 7.24 years) receiving maintenance HD therapy. Malnutrition was diagnosed with MNA-SF. GNRI and CI were calculated using existing formulas. Results: Of the participants, 26 (20.15%) were diagnosed with severe malnutrition, 25 patients (19.4%) were at risk of malnutrition and 78 (60.45%) were diagnosed with normal nutritional status. The optimal cut-off value for GNRI <95 was determined in predicting malnutrition with GNRI, sensitivity and specificity 85.4% and 88.6%, respectively. CI (< 20) was not found effective in determining malnutrition patients due to its low sensitivity and specificity (sensitivity and specificity of 35.9% and 45.0%, respectively). GNRI (<95) is a better predictor of malnutrition screening than CI (<20). Conclusions: In the evaluation of undernourished elderly HD patients, GNRI was as effective as MNA-SF, but CI was insufficient in detecting malnutrition individuals.Öğe The Insertion allele of angiotensin converting enzyme increases the risk for coronary artery ectasia(Drunpp-Sarajevo, 2012) Tekedereli, Ibrahim; Kara, Murat; Dagli, Necati; Gurevin, Mehmet Sait; Kobat, Mehmet AliCoronary artery ectasia(CAE) is characterized by dilation of the coronary arteries, exceeding the 1.5-fold of normal adjacent segment in coronary angiography. A common polymorphism in the angiotensin converting enzyme (ACE) gene is insertion/deletion (I/D) polymorphism. The presence of D allele has been shown to be associated with higher blood ACE concentrations. One hundred CAE patients and the 100 healthy controls were enrolled in the study. The frequencies of DD, ID and II genotypes were 42, 48 and 10% for CAE patients, 65, 33 and 2% for healthy controls, respectively (p=0.0014). The allele frequencies for D and I allele were 0.815 and 0.185 for the control group and 0.660 and 0.340 for the patient group (p=0.0004). In conclusion, our data suggest that the I allele which represents lower ACE levels leads to a decrease in vascular tone and increase in the susceptibility to CAE.Öğe Kalite yönetim sistemleri ile iç kontrol sistemi uygulamaları arasındaki etkileşimin değerlendirilmesi ve bir araştırma(İnönü Üniversitesi, 2018) Kara, MuratKalite, günümüz rekabet koşullarında yerel ve uluslararası pazarlarda üstünlük sağlamak isteyen işletmelerin üzerinde durmaları gereken bir konudur. Kalite yönetim sistemi ise işletmelere pazar paylarını büyütmede, işletmenin maliyetlerini azaltmada, riski daha etkili bir biçimde yönetmede veya müşteri memnuniyetini artırmada yardımcı olmaktadır. Kalite yönetim sistemi, seçilen her alanda performansın izlenmesi ve arttırılması için gereken çerçeveyi işletmeye sağlar. Kalite yönetimindeki felsefe hizmetten faydalananların memnun edilmesidir. Kalite yönetiminde müşteri memnuniyeti amaçlanmakla birlikte bir işletmedeki çalışan tepe yönetimden en alt kademedeki çalışanların iş süreçlerine katılımı esastır. Günümüzde artan rekabetten dolayı işletmelerin yeniden yapılanmaları, örgütsel olarak yenilenmeleri, varlıklarını korumaları, sermaye yapılarını güçlendirmeleri ve olası muhtemel hataları ortadan kaldırmak için güvenilir ve doğru finansal bilgilere ihtiyaçları attırmıştır. Etkin bir iç kontrol sayesinde rekabet baskısı ve piyasa koşullarında da işletmeler faaliyetlerine devam etmektedir. Böylece işletmeler güçlü ve zayıf yönlerini tahmin ederek olası risk ve tehditlere önlem almış olacaklardır. Bu çalışma ile kalite yönetim sistemi belgesine sahip olan ve sahip olmayan işletmelerin iç kontrolde ne kadar etkin olduğu araştırılmış ve bu amaçla işletmelere anket çalışması yapılmıştır. Anket çalışması Malatya ve Van ilinde bulunan 275 işletmeye uygulanarak çalışmada kullanılacak veriler elde edilmiştir. Yapılan analizler ile kalite yönetim sistemi belgesine sahip olan ve sahip olmayan işletmeler ile iç kontrolün beş bileşeni arasındaki etkileşim incelenmiştir. Anahtar Kelimeler: İç Kontrol, Kalite, Kalite Yönetim Sistemi, ISO (Uluslararası Standart Organizasyonu), Toplam Kalite Yönetimi.Öğe Kars bölgesinde hidatik kist prevalansı(Türkiye Parazitoloji Dergisi, 2005) Karaman, Ülkü; Miman, Özlem; Kara, Murat; Gıcık, Yunus; Aycan, Özlem Makbule; Atambay, MetinÖz: Hidatik kistin, hayvancılıkla uğraşan toplumlarda daha sık görüldüğü bildirilmiştir. Ülkemizin çeşitli bölgelerinde epidemiyolojik çalışmalar yapılmış olmasına rağmen hayvancılığın oldukça yaygın olduğu Kars ilinde bu konuda insanlarda yapılmış bir araştırmaya rastlanamamıştır. Çalışmada Kars ili merkezi ve köylerinde yaşayanlarda seroprevalans belirlemek amacı ile 511 serum toplanmış ve örnekler İndirekt Hemaglütinasyon Tekniği (IHAT) ve İndirekt İmmunofluoresans Tekniği (IFAT) ile çalışılmıştır. Çalışmada elde edilen %34,6 (177) sero-pozitiflik oranı, hidatik kistin bölgede önemli bir sağlık sorunu olabileceğini göstermiş olup daha kapsamlı çalışmalar yapılmasının uygun olacağı sonucuna varılmıştır.Öğe Multiple Myeloma Emerging After Chemotherapy for Breast Cancer: Case Presentation and a Brief Review(2015) Gürel, Ali; Aygen, Bilge; Kara, Murat; Tamer Elkiran, EminAbstract: Meme kanseri kadınlarda en sık görülen kanser türüdür. Multipl myelom ise tek hücre tipi kökenli plazma hücrelerinin aşırı çoğalması karakterli bir hastalıktır. Literatürde kemoterapiye ikincil bir çok malignite bildirilmiştir. Sunduğumuz olguda kemoterapi ve radyoterapi sonrası remisyon sağlanmıştır. İskelet sistemi ile ilgili yakınmaları nedeniyle değerlendirilen olguya multipl myelom tanısı konup, ve kemik iliği nakli planlanmıştır. Bu olguyu meme kanseri nedeniyle verilen kemoterapi sonrasında multipl myelom tanısı konması ve antineoplastik ilaç uygulaması dışında başka herhangi bir etyolojik faktör saptanmaması nedeniyle sunmaktayız.Öğe Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms(Zhejiang Univ Sch Medicine, 2015) Gurbuz, Sukru; Yildiz, Mustafa; Kara, Murat; Kargun, Kursat; Gurger, Mehtap; Atescelik, Metin; Alatas, Omer DoganBACKGROUND: The effect of increased oxidative stress on the development of chronic obstructive pulmonary disease (COPD) is well known. One of the antioxidative systems against oxidative stress in human body is paraoxonase (PON) enzyme that protects low density lipoproteins (LDL) against oxidation. This study aimed to explore the polymorphisms on PON1, Q192R, L55M genes of patients with COPD. METHODS: DNAs extraction was obtained from blood samples of 50 patients diagnosed with COPD and 50 patients as a control group who were presented to emergency clinic. Genotypes were obtained with polymerase chain reaction (PCR) and AIw I and Hsp92II restriction enzymes were used for Q192R and L55M polymorphisms, respectively. Analysis of data was done with the Chi-square test and Fisher's exact test. RESULTS: A statistically significant difference in Q192R polymorphism was found between the COPD patients and the control group (P=0.05). There was no statistically significant difference in L55M polymorphisms between the patient and control groups (P>0.05). Q192R polymorphism was significantly correlated with the PON1 gene and cigarette smoking; however other risk factors did not show any significant correlation with this polymorphism. Though L55M polymorphism was significantly correlated with family history and tuberculosis, there was no significant correlation with other risk factors. CONCLUSION: We believe that more studies are needed to study the correlation of L55M polymorphism with other factors.Öğe Polydioxanone suture fixation for the repair of pediatric maxillofacial fractures(2020) Cinal, Hakan; Aydin, Osman Enver; Tan, Onder; Algan, Said; Kara, Murat; Yilmaz, Kerem; Karaduman, HarunAim: Unique pattern of the pediatric facial skeleton and its fractures confers a special issue to take into account. Conservative management, occlusal splints and wiring techniques are popular among pediatric facial fractures. As titanium plates require plate removal after the fracture healing, resorbable plates have gained popularity. However, they are expensive and it may not be possible to obtain resorbable plates in some medical facilities. This led us to question the mechanical stability and functional outcome after fracture fixation using polydioxanone (PDS) sutures.Material and Methods: Seven children with maxillofacial fractures were included in this study. After limited sufficient dissection and periosteal striping the fracture lines were reduced and four holes were made with a drill on preoperatively planned sites where no tooth buds were projected. After that a number 2 PDS loop suture was passed through these holes in a figure of eight fashion and tied to stitches after sufficient stability and anatomic reduction.Results: No complication occurred, except for two cases that had tooth extractions.Conclusion: To sum up, PDS suture fixation in a figure of eight fashion is a feasible and cheap alternative to titanium and resorbable plate systems.Öğe Prevalence of cystic echinococcosis in humans in Erzincan Province(2020) Davarci, Ismail; Kara, Murat; Dabanlioglu, BulentAim: A study was carried out in human patients with suspicion of cystic echinococcosis. Echinococcosis granulosus is a zoonotic disease that causes cystic echinococcosis in humans and animals. The disease caused by adult or larval stages of tapeworms of the genus Echinococcus family.Material and Methods: 1,102 blood samples sent to Erzincan Binali Yıldırım University, Mengücek Gazi Training and Research Hospital Medical Microbiology Laboratory between January 2011 and December 2018 with suspicion of cystic echinococcosis were centrifuged at 1500 rpm for 10 minutes. Serum samples were tested immediately by indirect hemagglutination test in order to detect specific antibodies.Results: 248 of 1,102 blood samples of patients were found to be infected with cystic echinococcosis for the 9-year of period (an average annual incidence of 10.48 per 100,000 inhabitants). Conclusion: It is understood that hydatid disease is decreasing in the province, but there is always a risk of increases in cystic echinococcosis for humans.Öğe The rs3768777-G allele of ITGAV gene is associated with rheumatoid arthritis(Springer Heidelberg, 2014) Koca, Suleyman Serdar; Kara, Murat; Ozgen, Metin; Dagli, Mustafa Necati; Gozel, Nevzat; Yolbas, Servet; Gundogdu, BarisIntegrin alpha v beta 3 (vitronectin receptor) plays a prominent role in angiogenesis, a key pathogenic feature of rheumatoid arthritis (RA). Moreover, integrin alpha(V) (ITGAV) subunit gene has been associated with a susceptibility to RA. The aim of the present study was to detect the potential association between ITGAV gene polymorphisms and a susceptibility to RA in a Turkish cohort. DNA samples were harvested from 160 patients with RA and 144 healthy controls (HC). Three single-nucleotide polymorphisms of ITGAV gene (rs3738919, rs3768777, and rs10174098) were genotyped using real-time PCR. Serum vitronectin levels were analyzed in 30 RA patients, 28 Beh double dagger et's disease (BD) patients, and 30 HC subjects. There was no significant difference between the RA and HC groups in terms of the genotypic and allelic distributions of rs3738919 and rs10174098 polymorphisms. However, the prevalence of rs3768777-G allele was higher in the RA group than in the HC group (OR 2.3, 95 % CI 1.6-3.2, p < 0.0001). Moreover, there was a significant association between RA and the genotypic distribution of rs3768777 (GG + AG vs. AA: OR 2.1, 95 % CI 1.3-3.4; GG vs. AG + AA: OR 4.1, 95 % CI 2.1-7.8). Serum vitronectin levels were lower in the RA and BD groups than in the HC group (p (ANOVA) = 0.002). The rs3738919 and rs10174098 polymorphisms of the ITGAV gene seem not to be associated with susceptibility to RA in Turkish patients. However, rs3768777 increases the risk of RA in this group. These results suggest that the ITGAV gene may be a candidate gene for the etiopathogenesis of RA.Öğe Serum IL-33 level and IL-33 gene polymorphisms in Behcet's disease(Springer Heidelberg, 2015) Koca, Suleyman Serdar; Kara, Murat; Deniz, Firat; Ozgen, Metin; Demir, Caner Feyzi; Ilhan, Nevin; Isik, AhmetBeh double dagger et's disease (BD) is a chronic inflammatory disease. Increased productions of cytokines including interleukin (IL)-1 beta and IL-18 are documented, and IL-1 alpha and beta gene polymorphisms are associated with susceptibility to the disease. IL-33 is a recently discovered member of IL-1 cytokine family. The aim of the study was to detect serum IL-33 level and IL-33 gene polymorphisms in a cohort of BD. Unrelated 117 patients with BD and 149 healthy controls (HC) were enrolled. Serum IL-33 levels were analyzed by enzyme-linked immunosorbent assay method. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. Serum IL-33 level was not significantly different in the BD and HC groups (p > 0.05). However, its level was lower in the active BD patients compared to the inactive ones and HC group (p = 0.044 and p = 0.037, respectively). There was no significant difference in terms of the genotypic and allelic distributions of rs1157505 and rs1929992 polymorphisms (p > 0.05 for all). However, the TT variants of rs7044343 and rs11792633 polymorphisms were very rare, and the T allele frequencies of these polymorphisms were lower, in the BD group compared to the HC group (p < 0.0001 for all). The rs7044343 and rs11792633 variants of IL-33 gene are associated with the decreased risk of BD in our cohort. Therefore, it may be concluded that IL-33 acts a protective role on the pathogenesis of BD.Öğe Trisomy 13 with the Absence of Gallbladder(Elsevier Taiwan, 2013) Kara, Murat; Tekedereli, Ibrahim; Durukan, Mehtap; Bozgeyik, Zulkif; Aygun, Denizmen[Abstract Not Available]
