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Öğe The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury(J Surg Res, 2008) Karabeyoğlu, Melih; Ünal, Bülent; Bozkurt, Betül; Dolapçı, İştar; Bilgihan, Ayşe; Karabeyoğlu, Işıl; Cengiz, ÖmerBackground. Thermal injury causes a breakdown in the intestinal mucosal barrier due to ischemia reperfusion injury, which can induce bacterial translocation (BT), sepsis, and multiple organ failure in burn patients. The aim of this study was to investigate the effect of ethyl pyruvate (EP) on intestinal oxidant damage and BT in burn injury. Materials and methods. Thirty-two rats were randomly divided into four groups. The sham group was exposed to 21°C water and injected intraperitoneal with saline (1 mL/100 g). The sham EP group received EP (40 mg/kg) intraperitoneally 6 h after the sham procedure. The burn group was exposed to thermal injury and given intraperitoneal saline injection (1 mL/100 g). The burn EP group received EP (40 mg/kg) intraperitoneally 6 h after thermal injury. Twenty-four hours later, tissue samples were obtained from mesenteric lymph nodes, spleen, and liver for microbiological analysis and ileum samples were harvested for biochemical analysis. Results. Thermal injury caused severe BT in burn group. EP supplementation decreased BT in mesenteric lymph nodes and spleen in the burn EP group compared with the burn group (P < 0.05). Also, burn caused BT in liver, but this finding was not statistically signifi- cant among all groups. Thermal injury caused a statistically significant increase in malondialdehyde and myeloperoxidase levels, and EP prevented this effects in the burn EP group compared with the burn group (P < 0.05). Conclusion. Our data suggested that EP can inhibit the BT and myeloperoxidase and malondialdehyde production in intestine following thermal injury, suggesting anti-inflammatory and anti-oxidant properties of EP.Öğe The relationship between prognostic factors of breast cancer and thyroid disorders in Turkish women(Journal of Surgical Oncology, 2004) Cengiz, Ömer; Bozkurt, Betül; Ünal, Bülent; Yıldırım, Osman; Karabeyoğlu, Melih; Eroğlu, Abdullah; Koçer, Havva Belma; Ulaş, MuratBackground: Breast carcinoma is a frequent disease that affects the female population. As for other malignant diseases, several studies have been carried out in an attempt to identify its etiology, yet the etiological agent has not been clearly defined. The etiological relationship between thyroid disease and breast cancer is still being investigated. However, most of the studies in this field are conflicting and discussions on this relationship still continue. Patients and Method: Our prospective open study was conducted on 136 consecutive patients operated for breast carcinoma. As a control group, 68 individuals with normal breast examination, who did not have any known malignancy and/or thyroid disease, living in the same geographical region and with matching socio-cultural and economical status, were included in the study. We aimed to identify the occurrence and frequency of thyroid pathologies in both groups to compare the clinical and the laboratory features of thyroid disease and breast carcinoma in an attempt to contribute to the studies investigating the relationship between these two entities. Results: We found thyroid pathology in 77.9% of breast cancer patients while this was 47.1% in the control group. Breast cancer patients had higher levels of free-T3 and more frequent diffuse and nodular enlargement of thyroid gland in ultrasonography when compared to the control group. Furthermore, in the presence of thyroid disease, breast cancer patients had statistically significant increases in the number of metastatic lymph nodes, vascular invasion, and tumor size. Conclusion: In conclusion, the frequency of thyroid pathology is higher in breast cancer patients compared to controls indicating a relationship between breast carcinoma and thyroid pathology. Our study shows that the presence of thyroid pathology in breast cancer patients can be influential on the spread of cancer and adversely affect its prognosis. We thought further studies are needed to confirm these findings and to explain the reason for co-occurrence of breast cancer and thyroid disease and furthermore to investigate the prognosis and survival of breast cancer patients in the presence of thyroid pathology.Öğe Tiroid hastalıklarında sık kullanılan preoperatif testlerin patolojik inceleme ile korelasyonu(Endokrinolojide Diyalog Dergisi, 2009) Ünal, Bülent; Işık, Burak; Bozkurt, Betül; Dirican, Abuzer; Karabeyoğlu, Melih; Kahraman, Latif; Aydın, Cemalettin; Cengiz, Ömer[Abstract Not Acailable]
