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Öğe Acquired atopic disease after liver transplantation in children; Similarities to and differences from adults: A preliminary study(Lippincott Williams and Wilkins, 2014) Topal E.; Çatal F.; Selimo?lu M.A.; Karabiber H.; Kilic T.; Başkran A.; Senbaba E.OBJECTIVE: The aim of this study was to determine the similarities and differences in the frequency and follow-ups of newly diagnosed atopic diseases after liver transplantation in pediatric and adult patients. MATERIALS AND METHODS: Patients who underwent liver transplants between 2005 and 2013 and who are still alive were enrolled in the study. Patients who came for checkups filled out a survey evaluating atopic diseases. Those who had an atopic disease before transplantation were excluded from the study. RESULTS: A total of 165 patients were enrolled in this study; 114 (69.1%) were males and 29 (17.6%) were children. The average transplantation age was 40.8 (0.3-67) years, and the most frequent reason for transplantation was chronic viral hepatitis. In 22 patients, atopic diseases [allergic rhinitis in nine patients (5.5%), asthma in six patients (3.9%), atopic eczema in six patients (3.9%), food allergy in six patients (3.9%), and drug allergy in one patient (0.6%)] developed after transplantation. Atopic diseases after transplantation were more common in children (P=0.03). When the atopic diseases were examined on a case-by-case basis, there were no differences between children and adults with respect to asthma (P=0.284), allergic rhinitis (P=1.0), or atopic eczema (P=0.284), but food allergy (P=0.009) and peripheral eosinophilia (P=0.002) were more common in children. The periodicity of allergic diseases after transplantation (P=0.192) and total IgE levels (P=0.086) were similar. CONCLUSION: Atopic diseases developed after liver transplantation and had a greater impact on children than adults. Therefore, after undergoing liver transplantation, patients should be monitored closely for signs of atopic diseases. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.Öğe Acute central nervous system depression after subcutaneous use of prilocaine in an infant(2012) Karabiber H.; Selimoglu M.A.; Cetin M.; Tekin S.; Gurbuz S.[No abstract available]Öğe Bilateral split feet: A new finding in Cornelia de Lange Syndrome(2010) Dogan D.G.; Dogan M.; Aslan M.; Karabiber H.We report on a male infant with Cornelia de Lange syndrome and bilateral split feet. Bilateral split feet do not appear to have ever been a reported feature in any of the published cases of Cornelia de Lange syndrome.Öğe A Collodion baby with hypothyroidism(2010) Dogan D.G.; Aslan M.; Karabiber H.Collodion baby is a rare keratinizing congenital disorder. Although it is milder in degree than harlequin fetus, the infant is at risk for increased water loss, thermal instability, percutaneous toxicity, and infection as a result of an impaired skin barrier function. Here we report on an 11 days-old collodion baby with hypernatremic dehydratation, septicemia and congenital hypothyroidism. To our knowledge congenital hypothyroidism associated with collodion baby is reported in only one case up to date.Öğe Hallermann-Streiff syndrome with hemihypertrophy(2010) Dogan D.G.; Karabiber H.; Erhan M.D.; Garipardic M.; Davutoglu M.; Guler E.We report on a five year old girl with Hallermann-Streiff syndrome and hemihypertrophy. Hemihypertrophy does not appear to have ever been associated with Hallermann-Streiff syndrome.Öğe Serum nitrite and nitrate levels in epileptic children using valproic acid or carbamazepine(Elsevier B.V., 2004) Karabiber H.; Yakinci C.; Durmaz Y.; Temel I.; Mehmet N.In experimental epilepsy studies, nitric oxide was found to act as both proconvulsant and anticonvulsant. The objective of this study was to investigate the effects of valproic acid and carbamazepine on serum levels of nitrite and nitrate, which are the metabolites of nitric oxide. To achieve this goal, serum nitrite and nitrate levels were determined in active epileptic 34 children using valproic acid and 23 children using carbamazepine and in non-active epileptic 38 children (control group) not using any antiepileptic drug. In the valproic acid group serum nitrite and nitrate levels were 2.66±2.11?mol/l and 69.35±23.20?mol/l, 1.89±1. 01?mol/l and 49.39±10.61?mol/l in the carbamazepine group, and 1.22±0.55?mol/l, 29.53±10.05?mol in the control group, respectively. Nitrite and nitrate levels were significantly high in both valproic acid and carbamazepine groups compared to the control group (P<0.01). When valproic acid and carbamazepine groups were compared to each other, level of nitrate was found statistically higher in the valproic acid group in relation to the carbamazepine group (P<0.01), however, there was no statistically significant difference in the levels of nitrite (P>0.05). No relation could be found between serum drug levels and nitrite and nitrate levels. According to these results, it can be suggested that valproic acid and carbamazepine might have antiepileptic effects through nitric oxide. © 2003 Elsevier B.V. All rights reserved.Patients:95 children (52 boys, 43 girls) with an age range of 2 to 17 were included in the study. 23/95 were given Tegretol (13 boys, 10 girls) with a mean age of 9.45 ± 3.73, 34/95 were given valproic acid (17 boys, 17 girls) with a mean age of 7.90 ± 3.93 and 38/95 served as controls (epileptic children who had take antiepileptic drugs previously but were followed up without any medication) (22 boys, 16 girls) with a mean age of 9.01 ± 3.57TypeofStudy:The objective of this comparative, controlled clinical study was to investigate the effects of valproic acid (VPA) and Tegretol on the levels of nitrite and nitrate as an indicator of nitric oxide (NO) level in epileptic children.DosageDuration:Dosage not stated. Duration of treatment at least 6 months.ComparativeDrug:Valproic acid (dose not stated, duration of treatment was for at least 6 months).Results:In the valproic acid group serum nitrite and nitrate levels were 2.66 ± 2.11 mcmol/l and 69.35 ± 23.20 mcmol/l, 1.89 ± 1.01 mcmol/l and 49.39 ± 10.61 mcmol/l in the Tegretol group, and 1.22 ± 0.55 mcmol/l, 29.53 ± 10.05 mcmol in the control group, respectively. Serum nitrite and nitrate levels of both VPA and Tegretol groups were found to be significantly higher than the control group statistically (P < 0.01). When VPA and Tegretol groups were compared to each other, no statistically significant difference could be found in the nitrite levels (P > 0.05), however, nitrate levels of VPA group were found to be statistically significantly higher than the Tegretol group (P < 0.01). Routine biochemical parameters (fasting glucose level, urea, creatinine, AST, ALT, ALP) and complete blood count values were in normal ranges both in antiepileptic users and the control group and no difference could be found between the groups statistically. When NO and drug levels in the blood were compared, there was no statistically significant correlation between them.AdverseEffects:No adverse events were mentioned.AuthorsConclusions:Although carbamazepine and VPA are effective in different ways, nitrite and nitrate levels were found to be higher in both groups in our study when compared to the control group. Since liver, kidney and heart diseases that could elevate nitrite and nitrate levels were excluded previously, the results obtained reflect the data of epileptic patients. With reference to the fact that high levels of nitric oxide have an anticonvulsive effect, the antiepileptic effect of VPA and carbamazepine might be through elevating the level of NO directly or indirectly. When VPA and carbamazepine groups were compared to each other, there were no statistical differences between nitrite levels, however, nitrate levels in the VPA group were found to be significantly higher. VPA may have a stronger effect on NO synthesis than Tegretol and may use NO synthesis pathway more in demonstrating its anticonvulsive effect. Even though the cause of increase in the level of NO cannot be explained clearly, it can be suggested that VPA and carbamazepine might have antiepileptic effects through nitric oxide. Further studies dealing with antiepileptic drugs and NO levels and a more clear demonstration of the relation may lead to new treatment methods in refractory epileptics.FreeText:The children had been diagnosed as having epilepsy according to the clinical and electroencephalographic (EEG) findings and had been followed at least for 6 months. Treatment group included children taking Tegretol or VPA regularly at least for the last 6 months and the control group comprised of children who had taken antiepileptic medication previously and did not get any treatment at least for the last 6 months and had no convulsion as well. All children were evaluated in the aspects of mental-motor retardation, renal or hepatic disorders, heart diseases and hypertension. After getting consent of the families, systemic complaints of the children were inquired prior to the study and physical examinations, complete blood count, hepatic and renal function tests were carried out and Tegretol or VPA levels in the blood were measured as well. Fasting blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea, creatinine, Na, K, Cl , Ca and other routine biochemical analyses were also determined. Following the deproteinization of all samples by adding NaOH/ZnSO4, nitrite and nitrate levels were analyzed together. Nitrite was analyzed directly, however, nitrate was first transformed to nitrite by cadmium reduction and then analyzed by the same method. Results were analyzed using statistical analysis. Serum nitrite and nitrate levels were compared among VPA, Tegretol and control groups by one-way analysis of variance (ANOVA).Indications:23 patients with epilepsy (2/23 tonic, 3/23 atonic, 4/23 complex partial and 14 generalized tonic clonic seizures).Öğe Stroke due to chickenpox: A case report(1998) Yakinci C.; Karabiber H.; Karamahmutyazicioglu K.Stroke due to chickenpox is a very rare clinical condition in children. A four-year-old boy with an acute onset of left hemiplegia, left central facial palsy and aphasia is presented in this case report. The infarction was demonstrated by cranial computed tomography.Öğe Urine xanthine oxidase and myeloperoxidase activity in pediatric urinary tract infections(2013) Davutoglu M.; Karabiber H.; Kurutas E.B.; Olgar S.; Guler E.; Atli Y.Objective: To investigate the relationships between urinary tract infection (UTI), and activity of antioxidant enzymes, xanthine oxidase (XO) and myeloperoxidase (MPO) in urine of children with UTI Design: Prospective observational study Setting: Department of Pediatrics, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Turkey Subjects and Methods: A total of 115 random children admitted to our hospital for urinary symptoms, 61 girls and 54 boys, aged between 2 and 15 years (average 10 years) were included. Study subjects were divided into four groups: Group 1 consisted of 29 pyuria positive and urine culture negative children; Group 2 included 30 children with pyuria and positive urine culture; Group 3 included 26 pyuria negative and urine culture positive children and Group 4 included 30 with pyuria and negative urine culture. Measurement of urine XO and MPO activity were performed spectrophotometrically. Intervension: Urine samples Main Outcome Measures: Antioxidant enzyme activity levels in urine were examined in children with urinary tract infection. Results: Urinary XO activities in Group 2 were significantlyhigher compared with other groups (p < 0.001, p = 0.001 and p < 0.001, respectively). SignificantlydifferentMPOactivitieswere found between Group 1 and Group 2 (p = 0.007). However, no significantdifferencewasfoundbetweenGroup3 and 4. Conclusion: SignificantlyincreasedMPOandXOenzymeactivity was found in children with UTI. Measurement of MPO and XO activity may be useful in children with urinary symptoms to diagnose UTI, before obtaining a positive urine culture.
