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    Decreased serum lipoprotein levels as a guide for clinical severity in patients with idiopathic dilated cardiomyopathy
    (Tohoku Univ Medical Press, 2005) Sezgin, N; Sezgin, AT; Gullu, H; Karabulut, A; Barutcu, I; Topal, E; Yalcintas, D
    Hyperlipidemia is a cardiovascular risk factor. In patients with idiopathic dilated cardiomyopathy (IDC), prognostic roles of endogenous lipoproteins are not fully clarified. It has been known that there is a direct relationship between the levels of cytokines (tumor necrosis factor-alpha [TNF-alpha] and interleukin-6 [IL-6]) and deteriorating functional classes of heart failure and mortality. The present study compared the levels of circulating TNF-alpha, IL-6, lipoproteins, and apolipoproteins in patients with stable IDC (n = 28) with those of patients with unstable IDC (n = 26) and controls (n = 24). Mean serum total. cholesterol (TC) was significantly lower in stable IDC patients than controls (p < 0.05). In unstable IDC patients, mean serum TC was also lower than controls but not statistically significant. The IDC patients had significantly higher concentrations of IL-6 and TNF-alpha than the controls (p < 0.01). Serum IL-6 and Apo AI levels were significantly different between stable and unstable IDC patients (p = 0.021 and p = 0.012, respectively). Increased levels of IL-6 were associated with decreased levels of TC (r = -0.266, p = 0.019), LDL-C (r = -0.376, p = 0.001) and apolipoprotein AI (apo AI) (r = -0.495, p < 0.001) in all IDC patients. TNF-a was also inversely related to apo AI (r = -0.455, p < 0.001) and LDL-C (r = -0.364, p = 0.001) in all patients. Thus, elevated serum levels of cytokines in patients with IDC are associated with decreased lipoprotein concentrations, which may indicate impaired prognosis. (c) 2005 Tohoku University Medical Press.
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    What should be done with patients who have abnormal GCT but normal GTT?
    (Medimond Publishing Co, 2004) Kafkasli, A; Karabulut, A; Kazezoglu, G; Kulak, N; Koçak, M; Yologlu, S
    The aim of this study is to evaluate the carbonhydrate metabolism in pregnants with abnormal glucose challenge, but normal 100g-3-hour oral glucose tolerance test. Pregnants who were delivered at Ynonu University School of Medicine Department of Obstetrics and Gynecology and meet the criteria included the study. Group 1(n:6) gestational diabetes mellitus, Group 2(n: 8) Type 2 diabetes mellitus, Group 3(n: 10) plasma glucose levels were 140mg/dl f after glucose challenge test, but normal 100g-oral glucose tolerance test, Group 4(n:8) pregnants with normal glucose challenge test and have appropriate-for-gestational-age neonate as control group,Group 5(n:8) pregnants with normal glucose challenge test and have macrosomic neonate were included the study. Maternal blood was collected to evaluate the carbonhydrate metabolism by comparing the IGF-I,II and IGFBP-1,2,3 levels. IGF I-II and IGFBP1,2,3 measurements were done by RIA and IRMA technics respectively. Maternal plasma levels of IGF-II and IGFBP-1, -3 were found to be significantly higher than control group in gestational diabetics, type-2 diabetic pregnants, pregnants with abnormal glucose challenge test but normal 100g-oral tolerance test and pregnants with macrosomic infant (p<0.000, p<0.000, p<0.05, p<0.05).