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Öğe Determinants of survival in gastric cancer: A single center experience(2019) Dogan, Fadli; Dincer, Mursit; Karabulut, KorayAim: Gastric cancer is the second leading cause of cancer deaths worldwide. The effect of lymph node dissection and the extent of gastric resection on survival remains controversial, while improved survival has been reported with combined chemotherapy and radiotherapy. In this study, we aimed to present a single center experience. Material and Methods: Patients undergoing gastric resection due to gastric cancer were retrospectively assessed in order to examine the determinants of survival in gastric adenocarcinoma. Gastric malignancies other than adenocarcinoma were excluded from the study. Result of preoperative diagnostic work up, operative data, histopathology of the surgical specimen, and postoperative follow up parameters were evaluated and recorded. Results: Among a total of 139 patients operated due to gastric malignancy between January 2008 and January 2014 in our unit, 124 were diagnosed with an adenocarcinoma. The median duration of follow up was 6 months, during which 53 patients (42.7%) were found to have disease recurrence (10 local, and 43 systemic). A higher T stage was associated with shorter survival (p<0.0001), as was the N stage (p<0.0001). Parameters that emerged as having a statistical significance (p<0.05) in the univariate analysis, i.e. gender, tumor size, T stage, N stage, differentiation, and surgical margin status, were subjected to a multivariate analysis, where T stage, N stage, and proximal/distal surgical margin status maintained their significant association with the survival. Conclusion: Several factors such as tumor stage, tumor diameter, histological type, and number of metastases emerged as having significant prognostic importance in patients with gastric cancerÖğe Effect of autotransfusion system on tumor recurrence and survival in hepatocellular carcinoma patients(Baishideng Publ Grp Co Ltd, 2013) Akbulut, Sami; Kayaalp, Cuneyt; Yilmaz, Mehmet; Ince, Volkan; Ozgor, Dincer; Karabulut, Koray; Eris, CengizAIM: To investigate the therapeutic efficacy and safety of continuous autotransfusion system (CATS) during liver transplantation of hepatocellular carcinoma patients. METHODS: Eighty-three hepatocellular carcinoma (HCC) patients who underwent liver transplantation with intraoperative CATS (n = 24, CATS group) and without (n = 59, non-CATS group) between April 2006 and November 2011 at the Liver Transplant Institute of Inonu University were analyzed retrospectively. Postoperative HCC recurrence was monitored by measuring alpha-fetoprotein (AFP) levels at 3-mo intervals and performing imaging analysis by thoracoabdominal multidetector computed tomography at 6-month intervals. Inter-group differences in recurrence and correlations between demographic, clinical, and pathological data were assessed by ANOVA and chi(2) tests. Overall and disease-free survivals were calculated by the univariate Kaplan-Meier method. RESULTS: Of the 83 liver transplanted HCC patients, 89.2% were male and the overall mean age was 51.3 +/- 8.9 years (range: 18-69 years). The CATS and non-CATS groups showed no statistically significant differences in age, sex ratio, body mass index, underlying disease, donor type, graft-to-recipient weight ratio, Child-Pugh and Model for End-Stage Liver Disease scores, number of tumors, tumor size, AFP level, Milan and University of California San Francisco selection criteria, tumor differentiation, macrovascular invasion, median hospital stay, recurrence rate, recurrence site, or mortality rate. The mean follow-up time of the non-CATS group was 17.9 +/- 12.8 mo, during which systemic metastasis and/or locoregional recurrence developed in 25.4% of the patients. The mean follow-up time for the CATS group was 25.8 +/- 15.1 mo, during which systemic metastasis and/or locoregional recurrence was detected in 29.2% of the patients. There was no significant difference between the CATS and non-CATS groups in recurrence rate or site. Additionally, no significant differences existed between the groups in overall or disease-free survival. CONCLUSION: CATS is a safe procedure and may decrease the risk of tumor recurrence in HCC patients. (c) 2013 Baishideng. All rights reserved.Öğe The Effect of Donor Characteristics on the Survival in Patients Undergone Deceased Donor Liver Transplantation(Wiley-Blackwell, 2012) Yilmaz, Mehmet; Akbulut, Sami; Eris, Cengiz; Karabulut, Koray; Yilmaz, Sezai[Abstract Not Available]Öğe The Effect of MELD Score on Survival in Patients with Living Donor Liver Transplantation(Wiley-Blackwell, 2012) Yilmaz, Mehmet; Akbulut, Sami; Karabulut, Koray; Sakcak, Ibrahim; Yilmaz, Sezai[Abstract Not Available]Öğe The Effects of Different Age Categories on Overall Survival in Adults Patients Undergone Liver Transplantation(Wiley-Blackwell, 2012) Akbulut, Sami; Yilmaz, Mehmet; Karabulut, Koray; Ara, Cengiz; Yilmaz, Sezai[Abstract Not Available]Öğe The Effects of Pre-Transplant HDL Cholesterol Levels on Survival in Patients with Liver Transplantation(Wiley-Blackwell, 2012) Akbulut, Sami; Kayaalp, Cuneyt; Yilmaz, Mehmet; Karabulut, Kagan; Karabulut, Koray; Sakcak, Ibrahim; Yilmaz, Sezai[Abstract Not Available]Öğe Is There an Increased Risk of Tumor Recurrence When Intraoperative Blood Salvage Autotransfusion Used for Liver Transplantation in Patients with Hepatocellular Carcinoma?(Wiley-Blackwell, 2012) Akbulut, Sami; Kayaalp, Cuneyt; Yilmaz, Mehmet; Ozgor, Dincer; Karabulut, Koray; Eris, Cengiz; Toprak, Huseyin Ilksen[Abstract Not Available]Öğe Non-operative management of perforated peptic ulcer: A single-center experience(2019) Usta, Sertaç; Liman, Rumeysa Kevser; Dincer, Mürşit; Karabulut, KorayAbstract: BACKGROUND: Perforation is a rare complication of peptic ulcer. Although the most widely accepted treatment for peptic ulcer perforation is surgery, non-operative treatment can be an option in selected patients. In this study, we aimed to present our non-surgical treatment experience in peptic ulcer perforation. METHODS: In this study, the data of the patients who were treated due to peptic ulcer perforation between January 2012 and September 2017 in our clinic were retrospectively reviewed. The diagnosis was reached by physical examination and radiologic findings. After obtaining the informed consent from the patients, non-operative treatment was performed to the selected patients who had normal vital parameters and did not have findings of generalized peritonitis in the abdominal examination. Oral food and fluid intake were stopped and intravenous fluid, antibiotics and pantoprazole were administered to all patients in this study. RESULTS: A total of 41 patients were treated due to the diagnosis of peptic ulcer perforation in our clinic during the study period. Out of 41 patients, while 35 of the patients were operated, six of them were treated non-operatively. There were peritoneal irritation signs and symptoms in the upper quadrants on physical examination in all of the patients. None of them had generalized peritonitis. Abdominal X-ray and computed tomography were obtained from all of the patients. None of the patients in the non-operative group underwent any interventional procedure or surgery during the follow-up period. The median length of hospital stay was four days in this group. All of the patients were discharged uneventfully. CONCLUSION: Standard treatment of peptic ulcer perforation in most of the patients is still surgical repair. Non-surgical treatment should be kept in mind as an option in the selected patients who had normal vital parameters and did not have any findings of generalized peritonitis in the abdominal examination. In this way, it may be possible to avoid unnecessary surgery and reduce the possible morbidity and mortality associated with the operation.Öğe Parameters associated with survival in patients undergoing surgical treatment due to rectal cancer(2019) Gursul, Serdar; Iflazoglu, Nidal; Karabulut, Koray; Sarac, MehmetAim: Colorectal cancer is the third most common type of cancer.Approximately 1/3 of colorectal cancers are rectum cancers. The percentage of local disease stage is 39%, and the 10-year survival rate in such patients is approximately 90%. The aim of our study was to evaluate the relationship between the clinicopathological characteristics and survival of patients with rectal cancer. Material and Methods: Patients who had undergone surgical treatment for rectal cancer in our clinic between January 2008 and December 2013 were evaluated retrospectively. The effects of clinicopathological parameters of these patients on survival were investigated. The preoperative and postoperative variables were evaluated together with survival data. Results: Of the 70 patients, 30 (43%) were females and 40 (57%) were males. The median age was 61 years (min-max = 29-87 years). Eight of the patients (6%) were operated under emergency conditions due to acute abdomen or ileus. 13 (19%) of the patients had undergone laparoscopic surgery and 57 (81%) had undergone open surgical resection. 15 patients (21%) had undergone anterior resection (AR), 51 (73%) had lower anterior resection (LAR) and 4 (6%) had abdomino-perineal resection (APR). According to pTNM staging, 6 patients (8%) were at stage-0, 7 (10%) were at stage-I, 22 (32%) were at stage-II, 26 (37%) were at stage-III, and 9 (13%) were at stage IV. Conclusion: We found that the ASA (American society of Anesthesiologists) score height, final stage of the tumor and vascular (venous) invasion associated with overall survival
