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    The effect of demographic characteristics on anxiety and hemodynamic response during intubation in patients undergoing septoplasty
    (2020) Karaca, Onur; Kuzucu, Ihsan
    Aim: To investigate whether the demographic characteristics of patients scheduled for septoplasty had an effect on their trait and preoperative state anxiety and hemodynamic response caused by endotracheal intubation. Material and Methods: In our prospective observational study, after the demographic characteristics of the patients were recorded, the State-Trait Anxiety Inventory (STAI) was administered three times to measure preoperative trait (STAI-1), preoperative state (STAI-2) and postoperative state (STAI-3) anxiety. The preoperative basal hemodynamic parameters were noted. The percentage changes in the hemodynamic responses of the patients during intubation (systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure) were evaluated. The relationship between the severity of anxiety and hemodynamic changes was investigated.Results: Preoperative state anxiety was present in 85% of the patients (STAI-2≥50). The mean STAI-1 score was found to be statistically significantly lower in men (42.81) than in women (45.46) (p=0.005). The mean STAI-2 score, showing preoperative state anxiety, was statistically significantly lower in males (53.89) than in females (57.72) (p=0.001). The mean STAI-2 score was 58.05 in patients aged 45 and over and 54.15 in those under 45 years (p0.001). In addition, the percentage changes in hemodynamic response were significantly higher in the group aged 45 and over (systolic arterial pressure: 16.32 mm-Hg, diastolic arterial pressure: 23.88 mm-Hg, mean arterial pressure: 20.34 mm-Hg) (p0.001).Conclusion: In this study, we observed that preoperative state anxiety was more prevalent in elderly and female patients, and the vital changes during endotracheal intubation were seen at a higher rate in elderly patients.
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    Effects of Pelargonium sidoides (UMCA ®) on pulmonary contusion from blunt thoracic trauma in rats
    (2020) Dogan, Gul; Dogan, Guvenc; Karaca, Onur; Ayaz, Ercan
    Aim: The aim of the present study was to evaluate the effect of Pelargonium sidoides (UMCA ®) which was antibacterial, antiviral, anti-inflammatory and antioxidant, on pulmonary contusion (PC) caused by isolated blunt thoracic trauma (BTT) in an experimental rat model.Material and Methods: A total of 24 rats were divided into three groups: control group (CG), sham group (SG), and Pelargonium sidoidesgroup (PSG). PC was induced by isolated BTT for all the groups except the control group. Pelargonium sidoidestreatment was performed by gavage for 72 hours to the PSG after truma. Blood and tissue samples were collected from the groups. Malondialdehyde (MDA), superoxide dismutase (SOD),glutathione (GSH) and arterial blood gas parameters were measured. Lung tissue samples were collected for histopathology.Results: Histopathologically, alveolar congestion, hemorrhage,edema,disruption and neutrophil infiltrationwere significantly higher in SG when compared with CG(p0.001, p=0.007, p=0.040, p=0.003, p=0.001). Leukocyte infiltration was significantly decreased in PSG when compared with SG (p=0.025). Biochemically, MDA level was significantly higher in SG than in CG (p0.001) and GSH level was significantly lower in SG than in CG (p0.001). MDA level was significantly lower in PSG than in SG (p=0.002). In blood gas parameters PH and PO2 level was significantly higher in PSG than in SG (p=0.013, p0.001) and PCO2 level was significantly lower in PSG than in SG (p0.001).Conclusion: PS prevents further injury by decreasing leukocyte infiltration,MDAand regulating ventilation -perfusion in lung contusions. PS may have a role in the progression of inflammation but not in preventing the pathologic disruption of pulmonary parenchyma exactly.