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    Dry Mouth Caused by Facial Nerve Ischemia due to Subarachnoid Hemorrhage: An Experimental Study
    (Elsevier Science Inc, 2021) Pasahan, Ramazan; Yardim, Ahmet; Karadag, Mehmet Kursat; Alpaslan, Aslihan; Aydin, Mehmet Dumlu
    OBJECTIVE: Parasympathetic network damage results in facial nerve damage, sublingual ganglion degeneration, sublingual gland dysfunction, and dry mouth. In this study, subarachnoid hemorrhage (SAH) was considered to be the cause of dry mouth. METHODS: We assessed 23 hybrid rabbits, including 5 control (group 1, Control). One milliliter of serum saline was injected into the cisterna magna of 5 animals (group 2). SAH was induced by injecting 1 mL of autologous blood into the cisterna magna of 13 animals (group 3). The animals were killed after 3 weeks of induction. The animals' sublingual ganglion and sublingual gland were excised for histopathological examination. The number of degenerated cells in the sublingual ganglion, secretory vesicles, and secretory granules in the sublingual gland that contain salivary components were estimated using Sequential Window Acquisition of All Theoretical Mass Spectra data analysis. The values were compared by the Mann-Whitney U-test. RESULTS: The numbers of secretory vesicles in the sublingual gland were 5.3 +/- 1.1 x 10(3) (group 1), 4.23 +/- 0.45 x 10(3) (group 2), and 1.56 +/- 0.22 x 10(3) (group 3); the numbers of secretory vesicles containing saliva in the sublingual gland were 324 +/- 12.18 (group 1), 263 +/- 36.23 (group 2), and 114 +/- 23.14 (group 3); and the numbers of degenerated cells in the sublingual ganglion were 11 +/- 3/mm(3) (group 1), 98.43 +/- 15.54/mm(3) (group 2), and 346 +/- 12.28/mm(3) (group 3) (P < 0.05). CONCLUSIONS: Clinical findings in infection and diseases such as Sjogren syndrome, aseptic meningitis, and SAH are similar. However, until now, SAH has not been demonstrated experimentally to cause dry mouth. Discovering that SAH might cause dry mouth might prevent unnecessary use of antibiotics and decrease morbidity due to the wrong or late diagnosis.