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    Comparison of Cerb B2 expression and Ki-67 index with modified scarff-bloom-richardson grading system in invasive ductal carcinoma
    (2020) Bostanci, Meric Emre; Karadayi, Kursat
    Emre Bostanci, M., & Karadayi, K. (2021). Comparison of Cerb B2 expression and Ki-67 index with modified scarff-bloom-richardson grading system in invasive ductal carcinoma . Annals of Medical Research
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    The effect of parathyroidectomy on kidney functions in primary hyperparathyroidism
    (2020) Mollaoglu, Murat Can; Bostanci, Meric Emre; Karadayi, Kursat
    Aim: The purpose of this study is to investigate the changes in renal function of the patients having primary hyperparathyroidism with GFR 60 ml/min/1.73 m2 and GFR>60 ml/ min/1.73 m2 before and after PTX. A. Prolonged hypercalcemia leads to impaired renal function and the associated glomerular filtration rate (GFR) decrease. One of the indications of surgery in primary hyperparathyroidism is decreased renal function (GFR 60 ml/min). Discussions about the effect of parathyroidectomy (PTX) on renal function still continue.Materials and Methods: The archive files of 59 patients diagnosed with primary hyperparathyroidism (PHPT), to whom PTX have been performed between January 2008 and October 2019 at Cumhuriyet University Surgical Oncology Clinic, were reviewed retrospectively. GFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Patients were divided into two groups according to their GFR values, as GFR60 ml/min/1.73 m2 and GFR>60 ml/min/1.73 m2. Laboratory outcomes of the patients one week before and after PTX were compared. The data of the study were analyzed in SPSS (ver. 23.0) program.Results: Regarding the patients to whom PTX have been performed, 12 patients (20.3%) were male and 47 (79.7%) were female. The mean age was 54.7 years. In patients with GFR60 ml/min/1.73 m2, pre-op mean Parathormone (PTH) value was 1227.36 pg/ml, Calcium (Ca) 10.60 mg/dl, Creatine (Cr) 5.12 mg/dl: while mean PTH value in post-op period was found to be 131.69 (SS: 2.99), Ca: 8.29, Cr: 3.57. In the patient group with GFR>60 ml/min/1.73 m2, pre-op mean PTH was 309.34, Ca: 11.05, Cr: 0.73 (SD: 0.15); whereas post-op PTH was 48.51, Ca: 8.88, Cr: 0.68. In addition, GFR increased in patients in both groups and statistically significant results were obtained between pre and post PTX values.Conclusion: In this study, an improvement was observed after PTX in the renal function of the patients with impaired renal function, whereas GFR values of the patients with normal renal function were increased.
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    The relationship between Ki-67 index and axillary lymph node metastasis in breast carcinoma
    (2020) Bostanci, Meric Emre; Mollaoglu, Murat Can; Karadayi, Kursat
    Aim: Breast cancer is the most common type of cancer in women. The presence and number of metastatic lymph nodes in the axilla are the most significant prognostic factors in breast cancer. In addition, tumor size, lymphovascular invasion, perineural invasion, histopathological type and grade of the tumor are among the best-known prognostic factors. Ki-67 is expressed in G1, S, G2 and M phases of the cell cycle but not in the G0 phase, which allows it to be used as a marker for proliferating cells. The purpose of this study is to determine the relationship between Ki-67 Index and classical prognostic factors in breast cancer patients and to investigate its effect on axillary lymph node metastasis.Material and Methods: 46 patients, who were diagnosed as breast carcinoma in Sivas Cumhuriyet University Medical Faculty Surgical Oncology Department and who underwent a modified radical mastectomy and axillary lymph node dissection between 2017 and 2019 were included in this study. Histological tumor type, stage, status of axillary lymph nodes and Ki-67 Index were evaluated retrospectively from the pathology reports of the patients. The patients were grouped under three categories according to Ki-67 Index. Results: Regarding the grouping of the patients according to Ki-67 Index, the ones below 15% formed the first group, between 15-29% the second group, and above 30% the third group. The distribution of the patients according to negativity-positivity of axillary lymph node metastasis in the groups was as fallow: First group, 7 (41.2%) negative - 10 (58.8%) positive; Second group 4 (33.3%) negative - 8 (66.7%) positive; Third Group 3 (17.6%) negative - 14 (82.4%) positive. Of the 46 patients included in the study, 14 (30.4%) were negative for axillary lymph node metastasis and 32 (69.9%) were positive. In our study, the relationship between the increase of Ki-67 Index and axillary lymph node positivity was found to be statistically significant.Conclusion: In this study, we investigated the relationship between Ki-67 Index and classical prognostic markers, especially lymph node metastasis. Proliferation is an important indicator used to predict prognosis and treatment response in breast cancer. In our study, Ki-67 Index, one of the cell proliferation markers, was found to be positively correlated with axillary lymph node metastasis and other prognostic factors. Therefore, Ki-67 Index was shown to be a significant prognostic indicator in breast cancer.