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Öğe Congenital partial pericardial defect and herniated right atrial appendage a rare anomaly(Echocardiography, 2006) Karakurt, Cemşit; Oğuz, Deniz; Karademir, Selmin; Sungur, Metin; Öcal, BurhanA congenital partial defect of the right-sided pericardium is a rare cardiac anomaly and it represents defective formation of the pleuropericardial membrane. Patients can be asymptomatic, but they may experience chest pain, myocardial ischemia, emboli, arrhythmia, and sudden death. In this report, we present an 8-month-old boy with pericardial defect and right atrial appendage herniation. It was diagnosed by echocardiography and cardiac magnetic resonance imaging.Öğe Cutis laxa with growth and developmental delay(Clinical Pediatrics, 2001) Karakurt, Cemşit; Sipahi, T.; Ceylaner, S.; Şenocak, Filiz; Karademir, Selmin; Becer, M.Congenital cutis laxa is a rare inherited disorder of connective tissue manifested by loose, hanging skin. Cutis laxa may be inherited (autosomal dominant, autosomal recessive) or acquired. As opposed to the recessive form of cutis laxa, the dominant form has been reported to be free of pulmonary and other internal manifestation.' Skin fibroblast cultures from cutis laxa patients exhibit reduced elastin. The genetic map locus of autosomal dominant form is 7q11.2. Tassabehji et a12 have described patients with autosomal dominant cutis laxa and mutations in elastin gene.Öğe Cutis laxa with growth and developmental delay(Clinical Pediatrics, 2001) Karakurt, Cemşit; Sipahi, T.; Ceylaner, S.; Şenocak, Filiz; Karademir, Selmin; Becer, M.Cardiac examination revealed apical midsystolic click and 2/6 systolic murmur. Radiographic examination of the chest and gastrointestinal system and abdominal ultrasonography appeared normal. Echocardiography revealed mitral valve prolapse. A skin biopsy was obtained and processed for light microscopy. It revealed a decrease in the number of the elastic fibers. Chromosomal analysis yielded normal findings.Öğe Onüç Aylık Bir Çocukta Tam Olarak Kopmuş Port Kateterin, Transvenöz Olarak Snare Kateter ile Çıkartılması(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2011) Şenocak, Filiz; Örün, Utku Arman; Ceylan, Özben; Doğan, Vehbi; Keskin, Mahmut; Karademir, SelminÇocuk hastalarda uzun süreli intravenöz tedavi gerektiren durumlarda santral venöz kateter ve port uygulanmaktadır. Yerleştirilmiş olan santral kateter ve parçalarının dolaşım sistemine embolizasyonu nadir, ancak ciddi bir komplikasyondur. Bu gibi durumlarda da kateter ve ilgili parçaların dolaşım sisteminden çıkartılması şarttır. Perkutan transvenöz yol ile, embolize parçaların çıkartılması güvenilir bir tekniktir. Akut myeloblastik lösemi tanısı ile izlenen 13 aylık bir hastada, pulmoner arter içine embolize olmuş kateter parçasının, başarılı bir şekilde transvenöz yol ile geri çıkartılmasını sunduk.Öğe Percutaneous transvenous removal of an entire detached port catheter by using a snare-loop catheter in a 13-month-old child(2011) Şenocak, Filiz; Örün Arman, Utku; Ceylan, Özben; Doğan, Vehbi; Keskin, Mahmut; Karademir, SelminAbstract:Çocuk hastalarda uzun süreli intravenöz tedavi gerektiren durumlarda santral venöz kateter ve port uygulanmaktadır. Yerleştirilmiş olan santral kateter ve parçalarının dolaşım sistemine embolizasyonu nadir, ancak ciddi bir komplikasyondur. Bu gibi durumlarda da kateter ve ilgili parçaların dolaşım sisteminden çıkartılması şarttır. Perkutan transvenöz yol ile, embolize parçaların çıkartılması güvenilir bir tekniktir. Akut myeloblastik lösemi tanısı ile izlenen 13 aylık bir hastada, pulmoner arter içine embolize olmuş kateter parçasının, başarılı bir şekilde transvenöz yol ile geri çıkartılmasını sunduk.Öğe Plasma endothelin 1 and nitrate levels in Down s syndrome with complete atrioventricular septal defect associated pulmonary hypertension a comparison with non Down s syndrome children(European Journal of Pediatrics, 2009) Sungur, Metin; Öcal, Burhan; Oğuz, Deniz; Karademir, Selmin; Karakurt, Cemşit; Şenocak, FilizAbstract Children with Down’s syndrome (DS)-associated complete atrioventricular septal defect (AVSD) have rapid and aggressive development of pulmonary vascular disease when compared with non-Down’s syndrome (ND) children. We aimed to evaluate the role of plasma endothelin-1 (ET-1) and nitrate levels in DS children with complete AVSD-associated pulmonary hypertension (PH) and compare this to ND patients. The study included 20 patients (11 males, nine females) who had complete AVSD associated with PH. Comparisons were made between DS patients (n=12) aged 4 to 8 months (median 5 months) and ND patients (n=8) aged 4 to 12 months (median 7 months). Blood samples were drawn from the inferior vena cava, pulmonary artery, pulmonary vein, and aorta. The plasma ET-1 concentrations of the two groups were compared to the peripheral venous and arterial ET-1 levels, and pulmonary vein nitrate was compared to the peripheral arterial nitrate levels of ten healthy infants. The mean pulmonary artery (PA) pressure and pulmonary vascular resistance (Rp) were significantly higher in the DS group than ND patients, and the pulmonary blood flow (Qp) in ND patients was higher than DS patients. There were no differences between the two study groups in regard to plasma ET-1 and nitrate levels obtained from matched sampling sites. The plasma ET-1 and nitrate levels were significantly higher in both study groups compared to the control subjects. The plasma ET-1 and nitrate levels in DS patients with PH were not different when compared to those of ND patients.Öğe Plasma endothelin 1 and nitrate levels in Down s syndrome with complete atrioventricular septal defect associated pulmonary hypertension a comparison with non Down s syndrome children(Eur J Pediatr (2009) 168:593–597., 2009) Sungur, Metin; Öcal, Burhan; Oğuz, Deniz; Karademir, Selmin; Karakurt, Cemşit; Şenocak, FilizChildren with Down’s syndrome (DS)-associated complete atrioventricular septal defect (AVSD) have rapid and aggressive development of pulmonary vascular disease when compared with non-Down’s syndrome (ND) children. We aimed to evaluate the role of plasma endothelin-1 (ET-1) and nitrate levels in DS children with complete AVSD-associated pulmonary hypertension (PH) and compare this to ND patients. The study included 20 patients (11 males, nine females) who had complete AVSD associated with PH. Comparisons were made between DS patients (n=12) aged 4 to 8 months (median 5 months) and ND patients (n=8) aged 4 to 12 months (median 7 months). Blood samples were drawn from the inferior vena cava, pulmonary artery, pulmonary vein, and aorta. The plasma ET-1 concentrations of the two groups were compared to the peripheral venous and arterial ET-1 levels, and pulmonary vein nitrate was compared to the peripheral arterial nitrate levels of ten healthy infants. The mean pulmonary artery (PA) pressure and pulmonary vascular resistance (Rp) were significantly higher in the DS group than ND patients, and the pulmonary blood flow (Qp) in ND patients was higher than DS patients. There were no differences between the two study groups in regard to plasma ET-1 and nitrate levels obtained from matched sampling sites. The plasma ET-1 and nitrate levels were significantly higher in both study groups compared to the control subjects. The plasma ET-1 and nitrate levels in DS patients with PH were not different when compared to those of ND patients.Öğe Prognostic value of hart rate turbulence and heart rate variability in children with dilated cardiomyopathy(Acta Cardiologica, 2007) Karakurt, Cemşit; Aytemir, Kudret; Karademir, Selmin; Sungur, Metin; Oğuz, Deniz; Öcal, Burhan; Şenocak, FilizThe aim of our study is to evaluate the prognostic value of heart rate turbulence and heart rate variability in children with dilated cardiomyopathy (DCM). Twenty-five children with DCM and 24 age- and sex-matched healthy children who were admitted between January 2002 and September 2004, enrolled in this prospective study at our hospital. After the echocardiographic examination, three-channel 24-ambulatory ECG recordings were obtained in all patients with DCM and in the control group. Time domain heart rate variability parameters were obtained in both groups. Heart rate turbulence was measured in DCM patients, but we could not calculate heart rate turbulence in the control group since no ventricular ventricular premature complexes (PVC) were found in the 24-hour ECG monitoring in the control group. The mean follow-up period of the DCM group was 13.4months (3-26months). Five patients died (20%) during the follow-up period.Triangle index, turbulence slope (TS), age and availability of nonsustained ventricular tachycardia (VT) on 24-hour ECG monitoring were prognostic factors according to the correlation analyses. Only triangle index was detected as an independent risk factor among the prognostic factors according to the logistic regression analyses. This study assessed the prognostic value of heart rate turbulence and heart rate variability in children with dilated cardiomyopathy. Further studies are needed to investigate the prognostic value of heart rate turbulence.Öğe Pseudoachondroplasia in a child with prolapse of the mitral valve(Cardiology in the Young, 2001) Karakurt, Cemşit; Karademir, Selmin; Üner, ÇiğdemPseudoachondroplasia is an autosomal dominant variant of osteochondroplasia that results in mild to severe short-limb dwarfism and early-onset of osteoarthrosis. It has been linked to results from mutations in the gene for cartilage oligomeric matrix protein. We describe a 4-year-old boy with pseudoachondroplasia who also had prolapse of the mitral valve. To the best of our knowledge, this association has not previously been reported.Öğe Pseudoachondroplasia in a child with prolapse of the mitral valve(Cardiol Young 2001; 11: 559–56., 2001) Karakurt, Cemşit; Karademir, Selmin; Üner, Çiğdemt Pseudoachondroplasia is an autosomal dominant variant of osteochondroplasia that results in mild to severe short-limb dwarfism and early-onset of osteoarthrosis. It has been linked to results from mutations in the gene for cartilage oligomeric matrix protein. We describe a 4-year-old boy with pseudoachondroplasia who also had prolapse of the mitral valve. To the best of our knowledge, this association has not previously been reported.Öğe Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects(Pediatrics International, 2003) Karademir, Selmin; Oğuz, Deniz; Şenocak, Filiz; Öcal, Burhan; Karakurt, Cemşit; Çabuk, FeryalBackground : The arthritis of rheumatic fever is very responsive to treatment with salicylates, but there aremany adverse reactions, especially hepatotoxicity, due to aspirin (acetylsalicylic acid) therapy. These side-effects change the course and duration of rheumatic fever. Other non-steroidal anti-inflammatory drugs maybe equally effective, although no reports are available. Methods : We studied 72 patients with rheumatic fever who were admitted to Dr Sami Ulus Children’s Hospitalbetween 1995 and 1999. Twenty patients with arthritis were treated with tolmetin (25 mg/kg per day; group I)and 52 patients with arthritis and/or mild carditis were put on aspirin therapy (75–100 mg/kg per day) for 4–6weeks (group II). Arthritis had disappeared at the same time in both the aspirin and tolmetin groups (P = 0.675). Results : The erythrocyte sedimentation rates of patients upon admission, at the first week and at the end oftherapy were not different in the two groups (P > 0.05). No adverse effect of tolmetin therapy was observed,whereas side-effects of salicylate were observed in 19 patients (36.5%) in the aspirin group. Hepatotoxicity,gastric irritation and salicylism were found in 16, four and three patients, respectively. Renal toxicity andReye syndrome were not demonstrated. Because of these side-effects of aspirin, therapy had to be stopped for10–20 days and the duration of hospitalization in this group was lengthened unnecessarily. Conclusion : Tolmetin was safe and effective treatment for arthritic rheumatic fever patients without carditis.Tolmetin can be used particularly in patients who cannot tolerate aspirin.Öğe Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects(Pediatrics International, 2003) Karademir, Selmin; Oğuz, Deniz; Şenocak, Filiz; Öcal, Burhan; Karakurt, Cemşit; Çabuk, FeryalBackground: The arthritis of rheumatic fever is very responsive to treatment with salicylates, but there are many adverse reactions, especially hepatotoxicity, due to aspirin (acetylsalicylic acid) therapy. These sideeffects change the course and duration of rheumatic fever. Other non-steroidal anti-inflammatory drugs may be equally effective, although no reports are available. Methods: We studied 72 patients with rheumatic fever who were admitted to Dr Sami Ulus Children’s Hospital between 1995 and 1999. Twenty patients with arthritis were treated with tolmetin (25 mg/kg per day; group I) and 52 patients with arthritis and/or mild carditis were put on aspirin therapy (75–100 mg/kg per day) for 4–6 weeks (group II). Arthritis had disappeared at the same time in both the aspirin and tolmetin groups (P = 0.675). Results: The erythrocyte sedimentation rates of patients upon admission, at the first week and at the end of therapy were not different in the two groups (P > 0.05). No adverse effect of tolmetin therapy was observed, whereas side-effects of salicylate were observed in 19 patients (36.5%) in the aspirin group. Hepatotoxicity, gastric irritation and salicylism were found in 16, four and three patients, respectively. Renal toxicity and Reye syndrome were not demonstrated. Because of these side-effects of aspirin, therapy had to be stopped for 10–20 days and the duration of hospitalization in this group was lengthened unnecessarily. Conclusion: Tolmetin was safe and effective treatment for arthritic rheumatic fever patients without carditis. Tolmetin can be used particularly in patients who cannot tolerate aspirin.
