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Öğe Arthroscopic limited intercarpal fusion without bone graft in patients with Kienbock's disease(Turkish Joint Diseases Foundation, 2016) Ertem, Kadir; Gormeli, Gokay; Karakaplan, Mustafa; Aslanturk, Okan; Karakoc, YunusObjectives: This study aims to present our clinical results obtained in arthroscopic limited intercarpal fusion performed without using bone graft in patients with Kienbock's disease. Patients and methods: The study included 11 patients with Kienbock's disease (6 males, 5 females; mean age 28.9 years; range 14 to 51 years) who were performed arthroscopic lunate excision and scaphocapitate fusion between November 2012 and December 2013. Bain and Begg Arthroscopic Classification was used for the staging of Kienbock's disease. Quick Disabilities of Arm, Shoulder and Hand and Mayo Wrist scorings were used for clinical evaluation. Results: Intercarpal fusion was achieved in approximately 7.2 weeks. There was a statistically significant difference in Mayo Wrist scores of postoperative third and sixth months and pre- and postoperative Quick Disabilities of Arm, Shoulder and Hand scores. There was no postoperative complication. Conclusion: According to our study findings, arthroscopic limited intercarpal fusion without using bone graft may be performed in patients with Kienbock's disease. Satisfactory clinical and functional results were obtained as a result of treatment with this method in stage 3 and 4 Kienbock's disease.Öğe The changes in bone mineral density of the forearm and distal radius-ulna subcortical bone due to ulnar variance(Springer, 2009) Ertem, Kadir; Kekilli, Ersoy; Karakoc, Yunus; Yologlu, SaimThe aim of this study was to evaluate the changes in subcortical bone mineralization of the distal radius and ulna in the presence of negative ulnar variance. A total of 77 healthy right hand-dominant volunteers [34 women and 43 men of mean age 38 +/- A 14.8 years (range 14-71)] were enrolled in this study. Bilateral bone mineral density (BMD) and bone mineral density ratio (BMDR) measurements of the distal radius and ulna were performed by using dual energy X-ray absorptiometry. We found a significant decrease of ulnar subcortical BMD and BMDR subcortical in the dominant forearms of the subjects with negative ulnar variance when compared to that of subjects with neutral ulnar variance (P < 0.02). But this difference was not seen on the non-dominant side. There was no significant difference in BMDRs between the dominant and non-dominant forearms for all subjects. Radial and ulnar subcortical BMD values were significantly different between dominant and non-dominant forearms in subjects with bilateral neutral ulnar variance, whereas not significantly different in subjects with bilateral negative ulnar variance. The increase found in the BMD value of radial subcortical bone in subjects with negative ulnar variance may be due to the indirect shift of axial forces through the ulna to radius.Öğe Comparison of the effects of first and second generation silicone hydrogel contact lens wear on tear film osmolarity(Ijo Press, 2013) Iskeleli, Guzin; Karakoc, Yunus; Ozkok, Ahmet; Arici, Ceyhun; Ozcan, Omer; Ipcioglu, OsmanAIM: To compare the effects of first and second generation silicone hydrogel (SiH) contact lens wear on tear film osmolarity. METHODS: The healthy subjects who have never used contact lenses before were enrolled in the study. Tear film osmolarity values of 16 eyes (group 1) who wore first generation SiH contact lenses were compared with those of 18 eyes (group 2) who wore second generation SiH contact lenses after three months follow-up. RESULTS: Before contact lens wear, tear film osmolarity of groups 1 and 2 were 305.02 +/- 49.08 milliosmole (mOsm) and 284.66 +/- 30.18mOsm, respectively. After three months of contact lens wear, osmolarity values were found 317.74 +/- 60.23mOsm in group 1 and 298.40 +/- 37.77mOsm in group 2. Although osmolarity values for both groups of SiH contact lens wear after three months periods were slightly higher than before the contact lens wear, the difference was not statistically significant. CONCLUSION: Contact lens wear may cause evaporation from the tear film and can increase tear film osmolarity leading to symptoms of dry eye disease. In the current study, there is a tendency to increase tear film osmolarity for both groups of SiH contact lens wear, but the difference is not statistically significant.Öğe Effects of 85 dB Noise Exposure on Macro and Trace Element Levels in Plasma and Brain Areas of Rats(Humana Press Inc, 2013) Karakoc, Yunus; Orum, Mehmet Hamdi; Kilic, Muhammed; Dursun, Mehmet Fatih; Erdogan, SelimIn this study, our hypothesis was that workplace noise can alter brain element levels like immobilization and light-dark cycle shift, and we aimed to investigate the effects of workplace noise on element levels of brain areas as well as changes in blood of chronically noise-exposed rats. Twenty-four rats were randomly divided into three groups. The first group was the control. The second group (noise exposed) was subjected to daily 8 h 85 dB workplace noise for 15 days, and the third group (noise exposed plus normal condition) was also subjected to the same noise exposure and then returned to normal condition for 15 days. In noise-exposed group, Na, K, Ca, Mg , Fe, Cu, and Zn levels in plasma significantly increased when compared with controls (p = 0.03 for Na; p = 0.005 for K and Mg; p = 0.002 for Ca and Fe; p = 0.01 for Cu and Zn). In this group, Fe level of temporal lobe significantly increased (p = 0.021) while Mg level significantly increased in frontal (p = 0.021) and temporal (p = 0.001) lobes when compared with controls. In the noise-exposed plus normal condition group, plasma Na, K, Fe, Cu, and Zn levels were greatly similar to controls. But, plasma Ca and Mg levels significantly decreased when compared with controls (p = 0.002 and p = 0.007) and noise-exposed group (p = 0.002 and p = 0.001). Fe level of temporal lobe significantly increased when compared with controls (p = 0.001) and noise exposed group (p = 0.001). These alterations may be attributed to impaired intake of water and micronutrients or their excretions, emerging by acoustic stress.Öğe Effects of acute moderate and strenuous exercise bouts on IL-17 production and inflammatory response in trained rats(Journal Sports Science & Medicine, 2009) Duzova, Halil; Karakoc, Yunus; Emre, Memet Hanifi; Dogan, Zumrut Yilmaz; Kilinc, EvrenIn this study, we aimed to compare the effects of a single bout of acute moderate and strenuous running exercise on the production of interleukin-17 (IL-17), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and inflammatory response of skeletal muscles in regularly trained rats. Eight week old rats were trained by treadmill running 5 days per week for 13 weeks at the durations of 30 min (moderate) and 60 min (strenuous). Two days after the last training session, the animals were subjected to a single bout of moderate or strenuous exercise and serum samples were analyzed for IL-17, IL-6, IL-1ra levels and myeloperoxidase (MPO) activity of gastrocnemius muscle were determined. IL-17 level significantly increased in strenuous exercise group when compared to that of sedentary controls (p < 0.01), On the other hand, only in the moderate exercise group, there was a negative correlation between IL-6 and IL-17 levels (r = 0.857 and p = 0.014). In conclusion, acute single bout of strenuous exercise increased IL-17 production in trained rats and, this cytokine may be involved in inflammatory process of skeletal muscles.Öğe Effects of Chronic Light/Dark Cycle on Iron Zinc and Copper Levels in Different Brain Regions of Rats(Humana Press Inc, 2011) Karakoc, Yunus; Buruk, Mehmet Seyfi; Aktan, Burak; Kirvar, Ramazan; Erdogan, Songul; Sahbaz, Mehmet Akif; Aksoy, SevketIn this study, we aimed to investigate whether chronic shift in light/dark cycle alters brain trace element concentrations. For this purpose, 20 male Wistar albino adult rats were weighed and randomly divided into three groups. The first group (n = 6) was the control and had been subjected to 12/12-h light/dark cycle for 30 days. The second group (n = 7) was subjected to 6/18-h light/dark cycle for 15 days, and the third group (n = 7) was also subjected to 6/18-h light/dark cycle for 15 days and then returned to normal 12/12-h light/dark cycle for 15 days. When light/dark cycle protocols were completed, tissue specimens of the frontal lobe, temporal lobe, and brain stem were collected. Iron (Fe), zinc (Zn), and copper (Cu) concentrations of the frontal lobe, temporal lobe, and brain stem were determined by an atomic absorption spectrophotometer. When compared with controls, Fe levels of the temporal lobe significantly increased in 6/18-h light/dark cycle group (p < 0.05), whereas it was statistically unchanged in rats which were exposed to 6/18-h light/dark cycle then returned to the normal 12/12-h light/dark cycle period. Our results show that chronic shift in light/dark cycle affects trace element concentrations of the brain, especially Fe level in the temporal lobe, and these changes are reversible.Öğe Effects of Direct Current Administration on Hyperhidrosis Disease Severity Scale in Patients with Axillary Hyperhidrosis(Hindawi Ltd, 2019) Sener, Serpil; Karakoc, YunusBackground. Focal hyperhidrosis mostly affects the axillae, hands, feet, and face. For the management, several techniques are used. The aim of this study was to investigate the effects of direct current administration on the hyperhidrosis disease severity scale (HDSS) in patients with axillary hyperhidrosis that have various HDSS scores. Design and Setting. Original article, University Hospital. Methods. Sixty patients with primary axillary hyperhidrosis were inquired about the HDSS scores and the scores were noted at the onset and at the end of the 10th application. One month after the last session, HDSS scores were also inquired. At the end of 1-month follow-up, the patients whose HDSS scores rose after the 10th session were accepted as nonresponder. For the current delivery, a new iontophoresis application module (Sweat CureR) designed by Dr. Karakoc was used. Results. Direct current application decreased axillary sweat intensity by 70% at both sides, and lowered the HDSS by about 1.5 degree. Major reduction in sweat intensity was in the patients with low HDSS scores (75%). Negative correlation was found between initial HDSS scores and median values of decreased sweat intensity (r=-0.317, p=0.022). Minimal temporary side effects including skin irritation and one or more vesicle formation were inspected in 29 patients and, the permanent punctual pigmentation was observed only in one patient. Conclusions. Decrease in axillary hyperhidrosis is satisfactory for these patients. Since iontophoresis application has beneficial effect and minimal side effects, it should be recommended to the patients before advanced management or surgical techniques.Öğe The effects of irradiation on the blood dynamics(Ios Press, 2009) Erkal, Haldun Suekrue; Karakoc, Yunus; Serin, MeltemAim: The present study evaluates the effects of irradiation on the blood dynamics. Materials and methods: Thirty-six volunteers providing written consent participated. A blood sample was transferred into three tubes containing CPDA-1 solution while another blood sample was transferred into three tubes containing heparin. Each tube containing CPDA-1 solution was paired with another tube containing heparin. The first pair was not irradiated, not stored and analyzed immediately (Group 1). The second pair was not irradiated, stored and analyzed at seven days (Group 2). The third pair was irradiated, stored and analyzed at seven days (Group 3). The blood count was performed and the blood viscosity was determined. Results: The mean hemoglobin contents were 126 g/l for Group 1, 128 g/l for Group 2 and 129 g/l for Group 3. For the mean hemoglobin contents, the difference between Group 1 and Group 3 (P < 0.001) and Group 2 and Group 3 (P = 0.01) were significant. The mean red blood cell volumes were 81.8 fl for Group 1, 82.1 fl for Group 2 and 82.3 fl for Group 3. For the mean red blood cell volumes, the difference between Group 1 and Group 2 (P = 0.003) and Group 1 and Group 3 (P = 0.006) were significant. The mean blood viscosities were 2.2 mPa s for Group 1, 2.8 mPa s for Group 2 and 3.2 mPa s for Group 3. For the mean blood viscosities, the difference between Group 1 and Group 2 (P < 0.001), Group 1 and Group 3 (P < 0.001) and Group 2 and Group 3 (P = 0.004) were significant. Conclusion: The present study indicates that the recommended doses of irradiation for the blood products to be used in attempt to prevent the transfusion associated graft versus host disease leads to marked alterations in the blood dynamics and might decrease the viability of the red blood cells following transfusion.Öğe Effects of Tianeptine Pretreatment on Stress-Induced Trace Element Alterations in Rats(Kure Iletisim Grubu A S, 2009) Karakoc, Yunus; Kasar, Muzaffer; Mengi, Murat; Yildirim, Ejder Akgun; Yurdakos, Ertan; Barutcu, U. BoraIntroduction: Although the alterations in trace elements levels were shown in chronically restrainted rats, the association between stress-induced changes in trace element levels and the effects of psychopharmacological agents has not been well documented yet. Tianeptine has been a widely used antidepressant in experimental studies investigating stress related behavioral changes. In this study, we aimed to search the effects of tianeptine pretreatment on stress-induced trace element alterations in rat brain. Methods: The animals were divided into three groups: controls (n=9), chronic restraint stress group (n=7), chronic restraint stress+tianeptine group (n=9). Restraint stress procedure was 6 hours per day for 21 consecutive days and the rats had either intraperitoneal 1 ml saline injection or 10 mg/kg tianeptine twice a day within an interval of 8 hours. The rats were decapitated 30 minutes after the last restraint period. Following digestion procedures, Zn, Cu and Fe levels of the frontal lobe, temporal lobe, brain stem, liver and spleen were determined by flame atomic absorption spectrophotometer. Results: We found that Cu and Fe levels were significantly increased in the frontal lobe, temporal lobe and brain stem whereas Zn levels did not change significantly following chronic restraint stress. With tianeptine pretreatment Zn levels were significantly increased in all tissues investigated, whereas Cu and Fe levels were significantly decreased when compared with those of control and chronic restraint stress groups. Conclusions:We assume that the decreases in Cu and Fe levels might be the result of decreased induction of metallothionein-I due to inhibition of stress-evoked HPA axis by tianeptine. Increased levels of Zn might be associated with possible interaction between Zn and tianeptine through NMDA receptors. Consequently, it may be suggested that the effects of tianeptine pretreatment on trace element levels might account for its preventive effects on stress-induced behavioral disturbances.Öğe Effects of whole-body vibration on plasma sclerostin level in healthy women(Tubitak Scientific & Technological Research Council Turkey, 2014) Cidem, Muharrem; Karakoc, Yunus; Ekmekci, Hakan; Kucuk, Suat Hayri; Uludag, Murat; Gun, Kerem; Karamehmetoglu, Safak SahirBackground/aim: To determine whether plasma sclerostin levels are affected by applying whole-body vibration treatments. Materials and methods: Following a pilot study, the present prospective, randomized, controlled single-blind study was performed on 16 healthy volunteer women (ages 20 to 40 years). Subjects were randomly divided into 2 groups, and whole-body vibration was applied to the treatment group but not to the controls. The plasma sclerostin levels were measured before the treatment and at the 10th minute after whole-body vibration on the 1st, 2nd, and 5th days of application. Results: The plasma sclerostin level measured at 10 min after the whole-body vibration treatment increased 91% (P = 0.024) on the 1st day and decreased 31.5% (P = 0.03) on the 5th day in the whole-body vibration group. In the control group, there was no change in the plasma sclerostin level at any time. A progressive increase in baseline plasma sclerostin levels during the 5 days of vibration sessions was also found. Conclusion: Our study demonstrated that whole-body vibration can change plasma sclerostin levels, and that this change is detectable 10 min after whole-body vibration treatments.Öğe End-to-side repair of thenar motor branch of median nerve to the ulnar nerve after excision of the median nerve neurofibroma(Springer, 2009) Ertem, Kadir; Karakoc, YunusA 13-year-old male patient suffering for the past 5 years with a gradually swelling and occasionally painful volar side of right forearm, presented to our clinic without any trauma. An end-to-side nerve repair performed between the ulnar nerve and thenar motor branch, and second common digital nerve to the digital nerve of the first finger for mend the sensorial, digital, and motor impairments related to the median nerve associated plexiform neurofibroma that occured after the excision of the tumor.Öğe Impairment of Peripheral Nerve Healing After Nerve Repair in Rats Chronically Exposed To Alcohol(Elsevier Science Inc, 2009) Ertem, Kadir; Ceylan, Fethi; Zorludemir, Suzan; Karakoc, Yunus; Yologlu, SaimBackground and Aims. The aim of this study was to determine the effect of chronic alcoholism on the healing of repaired peripheral nerve and muscle. Methods. Group 1 rats (n = 9) were fed with an alcohol-free modified liquid diet (MLD) throughout the experiment and received no nerve transection or repair. Group 2 rats (n = 9) were fed the same isocaloric MLD and underwent nerve transection and repair. Group 3 (n 7) consisted of alcoholic rats without nerve transection and repair and Group 4 (it 8) consisted of alcoholic rats with nerve transection and repair. To assess the effects of chronic alcoholism on nerve healing, surgical procedures were applied to rats in Groups 2 and 4. After 2 months, posterior tibial nerve and gastrocnemius muscle samples were taken for histological analysis. Results. Group 2 rats displayed a group of atrophic fibers, whereas Group 3 rats showed myophagocytosis and endomysial mononuclear infiltration and type 2 fiber atrophy. Group 4 rats displayed a large section of atrophic fibres. Axonal loss, prominent regenerative clusters and endoneural fibrosis Occurred in Group 2 rats. Axonal and myelin degeneration, myelin remnants and thinly myelinated axons were exhibited in Group 3 rats. whereas severe axonal loss, myelin degeneration, regenerative clusters and endoneural fibrosis were discovered in Group 4. There was a significant difference in the number of myelinated axons among the various groups of rats. Conclusions. Our findings show that chronic alcoholism has a negative influence oil peripheral nerve regeneration associated with a significant decrease in axon number and increased axonal degeneration. (C) 2009 IMSS. Published by Elsevier Inc.Öğe Investigation of Lead Mobilization from the Buckshot Residues to the Critical Organs(Humana Press Inc, 2011) Celbis, Osman; Karakoc, Yunus; Ozdemir, Bora; Gulyasar, Tevfik; Cakina, SuatLead exposure causes neurotoxicity, reproductive system dysfunction, renal failure, and blood and endocrine system disorders in human and experimental animals. In this study, we investigated lead mobilization from gunshot fragments to the critical organs (brain, heart, liver, and kidney) and its interaction with essential trace elements on experimental rat model. Thirty-five rats were randomly divided in five groups. The first group was a control and the others were subjected to buckshot implantation in their skeletal muscles (second and third groups) and abdomen (fourth and fifth groups). The control group and the second and fourth groups were sacrificed 1 month after the onset of experiment while the third and fifth groups were followed after 2 months. Blood lead levels were significantly elevated in both 2 month-followed groups and 1 month-followed intraabdominal group. There were significant increases in brain lead levels of both 2 month-followed groups. For the 1 month-followed groups, kidney lead levels were also significantly higher than those of controls. Results show that lead mobilizes from the buckshot residues in distance tissues to the critical organs and interacts with iron, copper, and zinc even though blood lead level sometimes remains unchanged. Our findings are crucial in revealing lead accumulation in critical organs of subjects carrying any gunshot fragments. These subjects and physicians should be in alert for emergence of lead-induced manifestations.Öğe Plasma viscosity and mean platelet volume in patients undergoing coronary angiography(Ios Press, 2010) Senen, Kubilay; Topal, Ergun; Kilinc, Evren; ten Cate, Hugo; Tek, Ibrahim; Karakoc, Yunus; Yetkin, ErtanBackground: Markers of platelet activation and haemorrheological indices have been demonstrated to play a role in the pathophysiology of atherosclerosis and cardiovascular events. In this study, we aimed at investigate the association between plasma viscosity and platelet indices in patients undergoing coronary angiography. Materials and methods: Three hundred and eighty four consecutive patients scheduled to undergo coronary angiography were included in the study. Prior to coronary angiography, blood samples were withdrawn to determine routine biochemical markers, blood cell analyses and viscosity measurements. According to the results of coronary angiography, patients were classified either in a subgroup with coronary artery disease (CAD; 1 or more stenoses > 50%) or normal coronary arteries (NCA; no stenoses or < 50%). Results: There was a statistically significant correlation between plasma viscosity and mean platelet volume levels in all patients undergoing coronary angiography (r = 0.199, p < 0.001). Additionally, when correlation analysis was performed within each group, plasma viscosity significantly correlated with MPV both in patients with CAD (r = 0.18, p = 0.004) and in patients with NCAs (r = 0.272, p = 0.002). Linear regression analysis revealed that plasma viscosity was positively associated with MPV while platelet number was inversely but significantly associated with MPV. Conclusion: We have shown for the first time that MPV correlates with plasma viscosity in patients undergoing coronary angiography, suggesting a relation with plasma proteins and activation of circulating platelets or peripheral consumption of platelets. To evaluate this relation further controlled studies also in patients with acute coronary syndromes are warranted.Öğe Tear film osmolarity in patients with thyroid ophthalmopathy(Springer Tokyo, 2008) Iskeleli, Guzin; Karakoc, Yunus; Abdula, ArzuPurpose: To compare tear film osmolarity between patients with thyroid ophthalmopathy and normal healthy subjects. Methods: The tear film osmolarity in 15 normal subjects (15 eyes) (control group) and 21 patients (21 eyes) with thyroid ophthalmopathy was evaluated. Tear film osmolarity in milliosmole (mOsm) was determined by using an auto-osmometer. The palpebral fissure width, degree of proptosis, and tear break-up time (BUT) were also determined. The results for the two groups were compared statistically. Results: The mean palpebral fissure width was 9.13 +/- 0.74 mm in the healthy subjects and 13.33 +/- 1.55 mm in the thyroid ophthalmopathy patients. This difference was statistically significant (P = 0.0001). The mean proptosis was 15.33 +/- 1.39 Hertel units in the healthy subjects and 20.71 +/- 0.95 Hertel units in the patients. This difference was also statistically significant (P = 0.0001). The mean tear BUT was 6.35 +/- 1.56 s in the patients and 18.27 +/- 1.53 s in the healthy subjects, and this difference was also statistically significant (P = 0.0005). The mean tear film osmolarity was 290.80 +/- 13.58 mOsm in the healthy subjects and 340.38 +/- 18.74 mOsm in the patients. There was a statistically significant difference between the groups (P = 0.0001). Conclusions: The significantly higher tear film osmolarity in patients with thyroid ophthalmopathy was most likely due to the increased proptosis and lid fissure width. These conditions may lead to injury of the ocular surface.
