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    Retrospective evaluation of sarcoidosis cases: 10 years of experience from Turkey
    (2021) Arguder, Emine; Hezer, Habibe; Kilic, Hatice; Parlak, Ebru; Kus, Serpil; Erguden, Hulya; Er, Mukremin; Hasanoglu, Canan; Karalezli, Aysegul
    Aim: Clinical features in sarcoidosis are very variable and can present with numerous phenotypes depending on organ involvements, clinical onset (acute, subacute, and chronic) and response to therapy. In this study, we aimed to evaluate the clinical findings, diagnostic methods and treatments of patients with sarcoidosis by 10-years data in our hospital in Turkey. Materials and Methods: The study was carried out between January 2018 and January 2019. The patients were screened retrospectively from the hospital information system. Clinical details were collected using a structured data collection form. Results: 172 patients were included in our study. 122 (70.9%) were female and 50 (29.1%) were male. The mean age at diagnosis was 50.18 ± 13.73 years in all patients, while female patients’ mean age was 52.86 ± 13.06, male patients’ was 43.66 ± 13.24 (p <0.001). Arthralgia were more common in men than in women (30% vs 12.3%) (p:0.008). 70.9% of patients were diagnosed by EBUS-TBNA. Most of the patients were at the stage 1 (49.4%) and stage 2 (41.3%). Extra-pulmonary system involvements were detected in 27.3% of the cases. 27.9% (n:48) of the patients (n:172) did not come back for regular follow-ups. Among those who did do regular followups (n:124), 24.2% showed spontaneous remission, 30.6% showed stable disease, and 45.2% showed remission with treatment. Conclusion: The general features of the patients were similar to those reported in the literature. In our cases, arthralgia was more common in males. Most significant finding of our study is that the diagnostic method of sarcoidosis seems to have changed after EBUS-TBNA.
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    The role of thiol/disulfide homeostasis in the differentiation of transudative and exudative pleural effusion
    (2022) Abuzaina, Osama; Hezer, Habibe; Karalezli, Aysegul; Abuzaina, Seray; Neselioglu, Salim; Erel, Ozcan; Hasanoglu, H. Canan
    Aim: The dynamic thiol/disulfide homeostasis performs a major role in keeping up the oxidant-antioxidant equilibrium. We aimed to find the role of dynamic thiol/disulfide balance in pleural effusion transudate-exudate differentiation. This is considered to be the first research investigating the thiol/disulfide homeostasis in pleural fluid. Materials and Methods: This prospective study was conducted in the Clinic of Chest Diseases of Training and Research Hospital. One hundred adult patients with pleural effusion included. 20-100 cc pleural fluid samples were taken through thoracentesis of the patients. These fluids were categorized as exudate and transudate according to Light’s criteria. Automatic spectrophotometric practice which was defined by Erel & Neselioglu was used to gauge thiol/disulfide homeostasis in pleural fluid. Results: Disulfide, total and native thiol levels were significantly higher in the exudative group than the transudative group (p = 0.001). The ratio of disulfide/native thiol and disulfide/total thiol was higher in the transudative group (p = 0.03). In exudates, native thiol/total thiol proportions were higher (p = 0.03). Conclusion: The increased disulfide levels are indicative of increased oxidative stress in exudative pleural fluid. An abnormal thiol/disulfide state may be a major factor in the pathogenesis. These outcomes may conduce to distinguish exudative fluids without requesting synchronous serum thiol/disulfide level measurement.