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Öğe Concordance of the frequency, typing, and results of high risk human papilloma virus in cervical cytology materials with biopsy: Retrospective analysis of 5604 patients(2019) Akay, Ebru; Tekelioglu, Fatoş; Karaman, HaticeAim: The aim of the study is to evaluate retrospectively the results of human papilloma virüs (HPV) screening test started at our center, to identify the rates of high risk HPV (hrHPV) causing /not causing cellular anomalies and HPV16, 18/45 genotypes, to review the concordance of smear results and biopsy, and to compare our results with the similar studies conducted in different parts of the world and our country. Material and Methods: Five thousand six hundred four cases in Hospital, between 2016 and 2017, with transcription-mediated amplification and hybridization protection method,14 hrHPV types including HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 were investigated with presence of HPV E6/E7 mRNA. HPV(+) cases were reevaluated with the genotyping study for detection of HPV16, 18/45. Results: When the hrHPV results of 5604 patients were evaluated, 421 cases (7.5%) were hrHPV positive and 5183 cases (92.5%) were hrHPV negative. In the genotyping study of hrHPV positive cases, it was found that HPV16 was present in 97 cases (23%), HPV18/45 was present in 40 cases (9.5%) and other hrHPVs were found in 282 cases (67%). HPV16 and HPV 18/45 coexisted in 2 cases (0.5%). Biopsy results of hrHPV positive cases were 56 cases (32.7%), 40 cases (23.4%) and 5 cases (2.9%) for low grade squamous intraepithelial lesion (LGSIL), high grade squamous intraepithelial lesion (HGSIL) and Squamous Cell Carcinoma (SCC), respectively. Conclusion: In our study, prevalence of hrHPV is 1.2% in cases with normal cytology results and 7.5% in general population. In the majority of studies conducted in our country, HPV positivity is very high because HPV is studied in smear and cervical anomaly cases instead of general population. We believe that this study contributes to determine the frequency and genotype distribution in normal/ abnormal cytology of HPV in our countryÖğe Histopathological features of salivary gland tumors: A single-center experience(2020) Senel, Fatma; Karaman, HaticeAim: This study’s goal was to retrospectively evaluate cases who were diagnosed with primary salivary gland tumors in our center, to examine the histopathological features of these tumors, and to reveal difficulties in the differential diagnosis. Material and Methods: Sixty-four patients who applied to our center with complaints of pain and swelling in the salivary gland region between January 2016 and February 2020 and who were diagnosed with salivary gland tumor in our pathology clinic were analyzed retrospectively. The age and sex of the patients, the salivary gland where the tumor was located, and the histopathological examination results were recorded. Results: The age range of the patients was 13-89 years, and 57.8% and 42.2% of 64 patients in total were female and male, respectively. While 86% of the patients had tumors located in the parotid gland, 14% of them had tumors located in the submandibular gland. According to the histopathological examination results, 89% and 11% of the patients had benign and malignant tumors, respectively. While the most common tumor among benign tumors was a pleomorphic adenoma at a rate of 57.8%, the most common tumor among malignant tumors was a mucoepidermoid carcinoma at a rate of 4.7%. Conclusion: In the present study, salivary gland tumors were more common in females. The majority of salivary gland tumors were located in the parotid gland, and the majority of them were benign. The majority of tumors located in the submandibular gland were malignant.Öğe Results of concurrent HER2 (CERB-B2) staining in the primary tumor and lymph node metastasis in advanced stage gastric carcinoma(2020) Akay, Ebru; Tekelioglu, Fatos; Karagoz Eren, Saliha; Donder, Yunus; Karaman, HaticeAim: We hypothesized that tumor cells with metastatic capacity and nodal metastasis would exhibit prominent HER2 overexpression in gastric cancer for which intratumoral heterogeneity is highly variable. This study purposed to investigate the mismatch for HER2 immunohistochemical staining between the primary tumor cells and the metastatic cells in patients with advanced-stage gastric cancer.Material and Methods: A hundred and forty-four patients with advanced staged gastric cancer, and lymph node metastasis who underwent surgical resection were enrolled in this retrospective study. Primary tumor and lymph node metastasis underwent concurrent immunohistochemical staining for addressing the HER2 positivity. The concordance of HER2 positivity between the primary tumor samples and the lymph node metastases was investigated.Results: There was a significant difference in HER2 positivity rate among the well, moderate, and poorly differentiated carcinomas, which was primarily driven by the high HER2 overexpression in well-differentiated subgroup. HER2 positivity was highly frequent in stage 3 tumors, whereas HER2 was negative in the majority of the stage 4 tumors. Tumor size was also significantly larger in subjects without HER2 overexpression compared to those with HER overexpression [6 (IQR=4.88) cm vs. 5.25 (IQR=3.5) cm, p = 0.037]. Concordance of primary tumors and the metastatic lymph nodes regarding HER2 positive IHC staining were 93.7%. Conclusion: HER2 might be positive in lymph node metastasis samples even if the primary tumor is negative for HER2. We suggest that HER2 IHC staining of the lymph node metastasis should be considered if the primary tumor is signet ring cell carcinoma, moderately or poorly differentiated, and negative for HER2 in subjects with gastric carcinoma and lymph node metastasis.Öğe The role of fine-needle aspiration cytology in papillary thyroid carcinoma cases(2020) Senel, Fatma; Karaman, HaticeAim: Thyroid diseases are among the most common diseases in our country and all over the world. Fine-needle aspiration cytology (FNAC) is a useful and simple method for diagnosing papillary thyroid carcinoma (PTC) and can be used as a first step. The aim of this study was to determine the diagnostic value of FNAC in PTC cases by comparing FNAC and histopathological findings and to present our experiences.Material and Methods: This retrospective study evaluates 800 cases who underwent thyroidectomies in our center and had a histopathological examination in the pathology clinic. The age, gender, operation procedure, FNAC findings, and histopathological results of PTC cases were recorded.Results: Of 800 thyroidectomy cases, 119 (14.9%) were diagnosed with PTC; 50 (42%) were classic PTC cases and 69 (58%) were papillary microcarcinoma (PMC) cases. Of the 50 classic PTC cases, 45 had FNAC, which were included in the study. Of these, the positivity rate was 84.5% when atypia of undetermined significance (AUS) cases and suspected malignancies were included with those diagnosed with malignancy. Of 45 PTC cases, 3(6.6 %) were inadequate, 4 (8.9 %) were benign, 7 (15.5 %) were AUS, 4 (8.9 %) were suspected of follicular neoplasm, 18 (40 %) were suspected of malignancy, and 9 (20 %) were diagnosed as malignant. Conclusion: In our study, the false positivity rate was 0.5% and the false negative rate was 8.9%. Carcinomas in the follicular pattern can only be diagnosed by histopathological approach. FNAC is currently the gold standard for diagnosing PTC. However, a benign FNAC diagnosis should be viewed with caution as false-negative results do occur. When a benign FNAC diagnosis is given, surgery is necessary if there is any clinical suspicion of malignancy.
