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Öğe Co-infection of cyclospora cayetanensis and cryptosporidium parvum in an immunocompetent patient with urticaria without diarrhea: case report(Int Scientific Literature, Inc, 2008) Celik, Tuncay; Karincaoglu, Yelda; Karaman, Ulku; Daldal, Nilgun UlfetBackground: Cyclospora cayetanensis and Cryptosporidium parvum, a coccidian parasites and induce a diarrhea illness of the small intestinal, are the causative agents, a transmitted via contaminated water or food. We aimed to examine the stool of a patient being urticaria without diarrhea. Case Report: In 2007 a six-year-old boy living in Elbistan, non-tropical region in Turkey, was transferred by his parents to the Dermatology policlinic of Inonu University from Elbistan state hospital due to only prolonged pruritic swellings on his body. The patient showed no symptoms such as stomachache, fever, nausea and vomiting. His fecal sample was mild with no trace of mucosa or blood. It was reported that The patient didn't have any allergies such as drug. Laboratory studies on admission were notable, with PLT of 434 units/L, EO of 4.4 units/L, ASO of 148 units/L, CRP of 3 units/L, AST of 25 units/L, ALT of 12 units/L, and Total IgE of 75 IU/mL. Otology serum and Prick tests revealed negative results. Moreover the patient was found to have no allergic reactions to any food, tree, grass, mold, and animals. The organisms were identifi ed as C. cayetanensis and C. parvum in the stool sample. After treated with Metronidazole and Azithromycin. Fecal specimen were examined. As a result no sign of the parasites were observed and urticaria complaints disappeared. Conclusions: This report is the first case that have seen co-infection of cyclosporiasis and cryptosporidiasis in an immunocompetent patient who have urticaria complaints and without diarrhea. It is believed that these parasites are likely to cause allergic reactions among patients who have constant urticaria complaints, can not develop immunological reaction to various allergens, and have high total IgE antibodies.Öğe Comparison of malondialdehyde, nitric oxide, adenosine deaminase and glutathione levels in patients with Entamoeba coli, Enterobius vermicularis, Giardia intestinalis, Demodex spp. positive, hydatid cyst and Toxoplasma gondii serum positi(2019) Kiran, Tugba Raika; Karaman, Ulku; Kasko Arici, Yeliz; Yildiz, SevgiIn this study we aimed to compare glutathione (GSH), adenosine deaminase(ADA), nitric oxide (NO) and malondialdehyde (MDA) values between the patients with and without different parasitic infections. Material and Methods: MDA, NO, ADA and GSH levels were studied in the serums of the patients group with T. gondii and cyst hydatid seropositivity and E. vermicularis and E. coli positive and the control group, while ADA levels alone were studied in G. intestinalis and Demodex spp. Results: There was a statistically significant difference between the groups in terms of the amounts of ADA, GSH, MDA, and NO according to results of the variance analysis (p0.001). Conclusion: Given the change in the levels of GSH and ADA activities and MDA and NO levels observed in patients with parasitic infection, over production of active neutrophils, macrophages, reactive oxygen radicals and reactive nitrogen species may be an indicator of accelerated oxidative stress and lipid peroxidation in these patients. Increased serum ADA activity in the group infected by E. coli might be resulted from fight of the immune system with parasites. Low serum ADA activity in the other parasitic infection groups may be explained by suppression of lymphocyte proliferation by macrophages that were activated by sporozoite antigens in the late period of the infection. Accordingly, determination of the levels of MDA, NO, ADA and GSH may be important in treatment follow up and control of parasitic infections.Öğe Dust-mites: Effect on lipid peroxidation(All India Inst Medical Sciences, 2006) Atambay, Metin; Karabulut, Aysun Bay; Aycan, Ozlem Makbule; Kilic, Eser; Yazar, Suleyman; Saraymen, Recep; Karaman, UlkuBackground. Dust-mites are present in our homes, feed on dead exfoliated skin and other organic material. It is also known that oxidative stress may lead to cellular damage that can be confirmed by markers of cellular disruption. Oxidative stress in various infective processes has been documented. We investigated whether house dust-mites cause oxidative stress in patients. Methods. Products of lipid peroxidation in erythrocytes and lymphocytes were assessed by measuring malondialdehyde concentration. Results, Our results showed that patients who had a positive skin test for dust-mite antigens and had dust-mites present in their houses (dust-mite positive) had increased erythrocyte malondialdehyde levels (62.39 [18.56]. nmol/g-Hb) compared with those who were skin test positive, dust-mite negative (45.45 [10.82]) or skin test negative, dust-mite negative (42.20 [5.68]). They also had significantly higher levels of lymphocyte malondialdehyde (4.22 [0.55] nmol/g-protein), compared with those who were skin test positive, dust-mite negative (3.46 [0.29]) or skin test negative, dust-mite negative (1.25 [0.31]; p < 0.05). However, there was no statistically significant difference between the malondialdehyde levels of dust-mite negative/skin test positive and dust-mite negative/skin test negative patients. Conclusion. Increased malondialdehyde activity in lymphocytes and erythrocytes in the dust-mite positive/skin test positive group shows the presence of the oxidative stress in patients with dust-mite infestation.Öğe Epidemiology of Cyclospora Species in Humans in Malatya Province in Turkey(Kowsar Publ, 2015) Karaman, Ulku; Daldal, Nilgun; Ozer, Ali; Enginyurt, Ozgur; Erturk, OmerBackground: Cyclospora species are rare among other Coccidia parasites and can cause recurrent gastroenteritis. Cyclospora spp. can infect reptiles, insects, rodents, and mammals. Objectives: The present study aimed to determine the epidemiology of Cyclospora spp. in Malatya province and its neighboring provinces. Patients and Methods: Totally, 2281 stool samples taken from patients with digestive system complaints who referred to the polyclinics affiliated with Inonu University, Faculty of Medicine in Malatya Province and its neighboring provinces, in 2006, and whose stool specimens were submitted to the parasitology department were examined. A questionnaire was developed to determine the epidemiology of Cyclospora spp. in the patients as the dependent variable of the study. All the participants signed an informed written consent. The samples were coated with Entellan T after staining via acid-fast staining and were examined on an immersion microscope objective. The data are presented as mean, standard deviation, or number/percentage. The chi-square test was used for the statistical analyses. Statistically, a P value < 0.05 was accepted as meaningful. Results: The stool samples were examined via direct microscopic examination and acid-fast staining. Positivity was determined in 129 (5.7%) cases. In the overall assessment of the patients with respect to general body itching, rectal itching, allergy, immunosuppression plus cancer, shortness of breath, ulcerative colitis, diarrhea, abdominal pain, salivation, constipation, nausea, vomiting, growth retardation, and anemia, there was no significant relationship. However, in the statistical evaluations among the positive cases, the difference was found to be significant. Conclusions: The study was conducted in Malatya Province, but patients from the neighboring provinces were also included in the evaluation during the study. Of all the positive cases, 5.6% were those from Malatya Province and its surrounding areas. Additionally, Cyclospora spp. were observed among the patients referring to the polyclinics with digestive system complaints in 8.1% of those from the Adiyaman province and in 6.9% of those from the Kahramanmaras region. The incidence of Cyclospora cayetanensis may be higher in these regions if an epidemiological study is performed. Consequently, we suggest that Cyclospora spp. be investigated in digestive system disorders, especially in immunosuppressed patients.Öğe Evaluation of Patients with Cutaneous Leishmaniasis Who Admitted to Dermatology Clinic in Kahramanmaras Sutcu Imam University Medical Faculty(Duzce Univ, 2017) Sener, Serpil; Karaman, Ulku; Hakverdi, Gulden; Sarac, Gulbahar; Tetik, Burcu KayhanObjective: Leishmaniasis is a group of diseases, in different clinical forms, caused by the intracellular protozoan parasites, Leishmania species. The disease is transmitted by a female sand fly infected with the parasite sucking blood from people. Leishmania species causes three main clinical forms: cutaneous, mucocutaneous, and visceral disease. The clinical forms may vary by species and/or region of acquisition. Two forms are observed in Turkey; visceral leishmaniasis and cutaneous leishmaniasis. The aim of this study is to examine the status of Cutaneous Leismaniasis(CL) in the Kahramanmaras province and contribute to the prevention of the disease in this region. Methods: 20 CL cases were reported officially in 2009. CL was diagnosed by skin biopsy or smear. Intralesional meglumine antimoniate was applied for patients treatment. Results: Out of 20 cases, 12 and 8 were female and male. According to smear and biopsy, was found positive in 13 cases, and negative in 7 cases and the results of biyopsy was assessment as CL. Conclusion: By defining the status of CL in the region, the study can be considered to contribute to the planning of methods of intervention, public health education and personal preventative precautions.Öğe Glutathione and malondialdehyde levels in patients with hydatid cyst(Saudi Med J, 2008) Atambay, Metin; Karaman, Ulku; Kiran, Tugba P.; Colak, Cemil; Karabulut, Aysun B.; Celik, Tuncay; Daldal, NilgunObjective: To investigate the levels of glutathione (GSH), and malondialdehide (MDA) in the sera of patients diagnosed with cyst hydatid. Methods: Forty-six hydatid cyst patients who were indirect hemaglutination (IHA) and indirect fluorescence antibody (IFA) test positive constituted our study group in 2007. Patients diagnosed with hydatid cyst in the Inonu University School of Medicine, Department of Parasitology were re-called for the study. Forty healthy subjects who were negative for hydatid cyst by IRA and IFA methods, and who did not have any parasites on stool inspection formed the control group. The MDA level was analyzed in the sera by Uchiyama and Mihara method. The GSH activity was measured by the Ellman method. Results: The GSH level was 11.31 +/- 3.80 mu mol/L and the MDA level was 67.94 +/- 106.70 mu mol/L in the study group, while they were 24.95 +/- 6.55 mu mol/L and 26.52 +/- 19.42 mu mol/L in the control group. Conclusion: An increase in MDA levels and a decrease in GSH activity in patients with hydatid cyst was observed.Öğe Hydatid cyst of the ovary(Int Scientific Literature, Inc, 2010) Karaman, Ulku; Turkmen, Emine Samdanci; Birol, Fatih; Ak, Sibel; Kalayci, Ozlem Tugce; Beytur, LeylaBackground: Echinococcus granulosus is a cestode that causes hydatid cyst disease with its larval form. The disease is often located in the liver; however, it may also be seen in the lungs, kidneys, spleen, brain, bone and heart. Case Report: A 38-year-old woman who had been operated on 4 years ago due to hydatid cyst disease located in the liver, presented at our clinic with pain in the epigastric and inguinal areas. The sonographic, serological and pathological evaluation of the patient leaded us to an uncommon presentation of hydatid cyst lodged in the ovarium. Conclusions: This case is reported to draw attention to unusual localizations of the hydatic cyst.Öğe INCIDENCE OF CRYPTOSPORIDIUM SPP. IN THE HUMAN POPULATION OF MALATYA IN TURKEY(Carbone Editore, 2015) Karaman, Ulku; Daldal, Nilgun; Ozer, Ali; Engiyurt, Ozgur; Erturk, OmerAims: Cryptosporidium Species, settled in the microvilli of digestive and respiratory systems of vertebrates, infect mammals, poultry, fish and reptiles. Cryptosporidium species are common worldwide. Symptoms vary depending on species of infected host, condition of the immune system and age. In healthy patients with strong immune system it is characterized by self-limiting diarrhea. in approximately 2 weeks, whereas in people with suppressed immune systems it can cause diarrhea such as cholera and could create a life-threatening clinical condition The aim of this study is to,determine the epidemiology of Cryptosporidium species in the human population of Malatya province and around. Materials and methods: In Malatya province in 2006, 2.281 stool samples were taken from patients admitted to the Inonu University Faculty of Medicine Parasitology Department with the gastrointestinal complaints and analyzed. On the other hand a questionnaire has been prepared to determine the epidemiology of Cryptosporidium species in the human population of Malatya province. Each patient included in the study filled out and signed a patient information form. Results: In the studies, it has been reported that the Cryptosporidium injection rate is 6.1% in the developing countries and it is 2.1% in the developed countries. In different studies carried out in Turkey, it has been reported that the prevalence Of infection is between 0-35.5%. Stool samples were examined by direct microscopy and acid-fast staining method and 161 (7.1%) of them were positive. In this study, a significant relationship hasn't been found in patients with loss of appetite, general body itching, allergies, immunosuppressive and cancer, dyspnea, ulcerative. colitis, diarrhea, abdominal pain, salivation, constipation, nausea, vomiting, growth retardation, the rectal itching and anemia, but in the statistical analysis, the difference is statistically Significant. Conclusion: Consequently, molecular studies are needed to determine the common Cryptosporidium species and their sources in Malatya province and around. This will guide in determining strategies of public health education.Öğe The incidence of Demodex species in skin biopsy specimens diagnosed as actinic keratosis and nonmelanoma skin cancer(Walter De Gruyter Gmbh, 2010) Karaman, Ulku; Sener, Serpil; Samdanci, Emine; Colak, Cemil; Sasmaz, SezaiBackground: The most common types of skin cancers include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), which are grouped as non-melanoma skin cancers. Actinic keratosis (AK) is a precancerous lesion that may develop into SCC. The pilosebaceous follicle mites, Demodex folliculorum and Demodex brevis, inhabit most commonly and densely certain facial skin areas where BCC and SCC also develops most frequently. Objective: Determine the prevalence of Demodex species in skin biopsy specimens diagnosed as SCC, BCC, and AK. Method: Specimens of the patients whose reports were available were studied in terms of Demodex. The specimens were stained using Hematoxylin and Eosin, and evaluated for Demodex species positivity. Results: There were Demodex species in seven (38.9%) out of 18 AK cases, 12 (31.6%) out of 38 SCC cases, and 26 (44.8%) out of 58 BCC cases of this study. The rate of Demodex species in patients diagnosed SCC, BCC, and AK was found to be rather high. Conclusion: Demodex species should also be evaluated in the follow-up of the treatment of patients in SCC, BCC, and AK group.Öğe Investigation of Demodex SPP. On the perinea in women visiting urology and gynecology policlinics(Drunpp-Sarajevo, 2012) Beytur, Leyla; Karaman, Ulku; Beytur, Ali; Altindag, Murat; Gecit, Ilhan; Ozer, Ali; Colak, CemilAim: It is reported that species of Demodex can be found in various locations on human body and transmitted via close contact. Types of Demodex are reported to be located in various places of human body. The aim of this study is to investigate the relationship between age and incidence of Demodex spp. among female patients complaining of pruritus in the perinea area. Method: Samples taken from perinea areas of the women using standardized surface skin biopsy (SSSB). Accordingly, samples were obtained using SSSB method from the faces and perinea areas of 431 women aged 18-55, which were then covered with entellan and sent to the parasitological laboratory. Specimens were covered with entellan and evaluated in Parasitology Laboratory. Results: Among the 431 specimens, 21.1% revealed Demodex spp., 1.6% revealed mite, 3.05% revealed Enterobius vermicularis eggs, 0.2% revealed Taenia spp. eggs, and 0.2% revealed Phthirus pubis. Conclusion: It was concluded that it should be taken into consideration that species of Demodex can be found in the women perinea region, thus specimens should be taken from patients consulting with pruritus or allergic reactions in order to diagnose the parasite, and treatment protocol should be planned in this direction. In addition, experimental studies may be planned to investigate the relationship between the parasite intensity in perinea region and pathogenity.Öğe Investigation of Demodex Spp. prevalence among managers and workers of health hazard bearing and sanitary establishment(Elsevier Taiwan, 2012) Ozer, Ali; Karaman, Ulku; Degerli, Serpil; Colak, Cemil; Karadan, Mesut; Karci, ErdalBackground/Purpose: Two Demodex species are known to live on people. Demodex folliculorum lives in the openings of hair follicles alone or in groups. D brevis lives in the depths of the sebaceous glands alone. There are different related on the epidemiology of Demodex species have been published. Method: In this study, taking into account that the parasite is transmitted through close contact from person to person, we aimed to evaluate the relation between the presence of Demodex spp with gender and age among the Health hazard bearing and sanitary establishment operators and workers who came for porter examination. Results: For this purpose, 862 male and 215 female patients with a total of 1077 volunteers from the face area of the standard superficial skin biopsy (SSSB) method and studied samples were taken. More than five mites in 1 cm(2) density was defined as positive. In investigated samples 37.3% Demodex spp. positivity was detected. Only two were found to be D brevis and the others were D folliculorum. The study revealed statistically significant relationships between the positivity of parasites with the occupational group, age and sex. Conclusion: Since the prevalence of Demodex among healthy individuals without any complaint was found to be 37%, we believe Demodex spp should be investigated in porter examinations of people who have dermatological complaints. Copyright (C) 2012, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.Öğe Investigation of Microsporidia in Patients with Acute and Chronic Urticaria(Ankara Microbiology Soc, 2011) Karaman, Ulku; Sener, Serpil; Calik, Sinan; Sasmaz, SezaiMicrosporidia species are one of the major causes of severe diarrhea especially in immunocompromised patients, however they also cause infections in immunocompetent subjects. Urticaria, which is a common dermatologic disease may be triggered by drugs, infections, foods or food additives, psychogenic factors and autoimmune, metabolic and malignant diseases. While the etiologic grounds of acute urticaria are generally identified, the etiology remains unknown in most of the chronic urticaria cases. The studies on the roles of parasitic infections in the etiology of urticaria have indicated that the most responsible protozoa are Giardia intestinalis and Blastocystis hominis. However, no data have been found in the literature concerning the relationship between Microsporidia and urticaria. The aim of this study was to investigate the presence of Microsporidia spores in the stool samples of patients diagnosed as acute or chronic urticaria in dermatology clinics and to determine the rates of positivity. All of the samples stained with modified trichrome and calcofluor staining methods were examined microscopically. The samples were accepted as positive when the spores of Microsporidia were detected by both of the staining methods. Microsporidia were detected in 26 (19.7%) of the patients and in 1 (2.8%) of the control subjects. Thus the total rate of positivity was 16% (27/168). In cases with acute/chronic urticaria, microsporidia positivity rate was found significantly higher than the control group (p= 0.028; p< 0.05). No statistically significant difference was detected between Microsporidia positivity and age or gender (p= 0.27 and p= 0.99, respectively; p> 0.05). In conclusion, Microsporidia should be taken into consideration in patients with unknown origin of urticaria. However, advanced studies are needed for supporting the relation between Microsporidia and acute/chronic urticaria.Öğe The level of adenosine deaminase in the serum of patients who have positive Entamoeba coli(Drunpp-Sarajevo, 2012) Kiran, Tugba Raika; Karaman, Ulku; Colak, Cemil; Ozer, AliAim: The entomoeba coli which is an intestinal parasite is known as apatojen. However in some studies it has also been reported that it may be pathogenic. The Adenosine deaminase (ADA) is the key enzyme of purine metabolizm and controls the levels of adenosine and deoxy adenosine in the cell. The researchers have found that ADA is a marker of cellular immunity and the increased ADA serum in different diseases. In the study the comparison of ADA levels between the serums of the patients with detected Entamoeba coli (E. coli) and the control group is purposed. Methods: In this study the levels of ADA in the serums of 40 control groups and 35 patients who have E. coli are measured. When comparing the averages of the patients and control groups, the independent sample T test was also used. The mean age of the group is 37.97 +/- 5.06, 31 (89%) male and 4 (11%) of them are women. The mean age of healthy 40 people is 40.23 +/- 7.01, 31 (77%) males and 9 (23%) of them are women. Results: In the study according to the controls a significant increase is observed in ADA activity of the patient group. Conclusions: The findings seem to support the parasite's pathojen. In the studies which will be planned to determine whether the parasite is pathogenic or not, the detection of ADA values of Entemoeba coli diagnosed patients' before and after treatment will be guiding. In addition, the determination of ADA levels can give information about the immune mechanisms and we also can reach a conclusion that it can support the criterias for diagnosis and treatment of patients with positive Entemoeba coli.Öğe Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients(Korean Soc Parasitology, Seoul Natl Univ Coll Medi, 2008) Karaman, Ulku; Celik, Tuncay; Kiran, Tugba Raika; Colak, Cemil; Daldal, Nilgun UlfetThe aim of this study was to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels between normal and T. gondii-infected patients. To this end, MDA, GSH, and NO levels in the sera of 37 seropositive patients and 40 participants in the control group were evaluated. In Toxoplasma ELISA, IgG results of the patient group were 1,013.0 +/- 543.8 in optical density (mean +/- SD). A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and NO levels. A decrease in GSH activity was detected, while MDA and NO levels increased significantly. Consequently, it is suggested that the use of antioxidant vitamins in addition to a parasite treatment shall prove useful. The high infection vs control ratio of MDA and NO levels probably suggests the occurrence as a mechanism of tissue damage in cases of chronic toxoplasmosis. Moreover, it is recommended that the patient levels of MDA, GSH, and NO should be evaluated in toxoplasmosis.Öğe Positivity of Demodex spp. in biopsy specimens of nevi(Malaysian Soc Parasitology Tropical Medicine, 2009) Sener, Serpil; Karaman, Ulku; Colak, Cemil; Aydin, Nasuhi Engin; Sasmaz, Sezai; Iraz, MeryemMelanocytic skin tumors are caused by nevus cells, epidermal melanocytes and dermal melanocytes. The aim of the study was to detect the positivity of Demodex spp. in biopsy specimens of skin diagnosed as nevus. In this retrospective study, the specimens obtained from 110 patients diagnosed with nevus and stained by hematoxylin & eosin (H&E) method were assessed for Demodex. Statistical analysis was done using independent sample t test, Pearson Chi-square and Yates' adjusted Chi-square test. For statistics, p<0.05 was considered significant. Consequently, 43 (39.1%) out of 110 specimens were detected to have Demodex spp. Demodex colonization augmented in nevi can be explained by the possible affinity of the parasite to the melanin pigment.Öğe PREVALENCE OF DEMODEX ECTOPARASITES AMONG HUMANS IN ORDU PROVINCE IN TURKEY(Southeast Asian Ministers Educ Organization, 2016) Karaman, Ulku; Koloren, Zeynep; Enginyurt, Ozgur; Colak, CemilDemodex folliculorum and Demodex brevis are common ectoparasites in humans. Demodex parasite infestations have not been determined in the province of Ordu. We determined the prevalence of Demodex species among humans in Ordu Provience, Turkey. Seven hundred ninety-nine subjects (438 males and 361 females) aged >= 18 years living in the central districts of Ordu Province, Turkey, were selected using the World Health Organization cluster sampling method. A superficial skin biopsy of the face was obtained from each subject. Six hundred sixty-nine subjects (83.7%) had a Demodex parasite. Factors significantly associated with the presence of Demodex infestation were: female gender, employment in the private sector, people who only occasionally wash their face and district of residence. Since Demodex ectoparasites were common in Ordu Province, it is suggested that the diagnosis and treatment of this ectoparasite should be carried out in the hospitals of this region.Öğe The Prevalence of Demodex Species and Its Relationship With the Metabolic Syndrome in Women of Malatya Province, Turkey(Ahvaz Jundishapur Univ Med Sci, 2015) Enginyurt, Ozgur; Karaman, Ulku; Cetin, Feray; Ozer, AliBackground: Demodex species are ectoparasites living in the hair follicles and sebaceous glands in human. Only two species, Demodex folliculorum and D. brevis were identified in human. While the D. folliculorum is settling in infundibular part of the hair follicles mostly, D. brevis settles into the sebaceous glands and ducts, which are deeper. These parasites live preferentially in hair follicles on the face and in the sebaceous glands, although they have also been reported to reside in seborrheic parts of the human body. The Demodex species have the highest rate on the face which has thesignificant number of sebaceous glands and sebum production in the skin. However, the rate of infestation increases with age in healthy skin. Objectives: The aim of this study was to determine the prevalence of Demodex species in healthy women and the relationship between the incidence of Demodex and metabolic syndrome (MetS). Patients and Methods: This study consisted of 151,498 women aged >= 20 years who reside in the central district of Malatya province, Turkey. In 5% confidence interval of sample size, while the design effect was 1.5 it was calculated as 552 individuals and while the design effect was 2 it was calculated as 736 individuals. The World Health Organization 30 cluster sampling method was used to select the samples. Women aged = 20 years who were not pregnant or lactating were included in the study. From a total of 669 subjects included in this study, 90.89% of the largest sample was accessed. Results: Parasites were detected in 263 (39.3%) of 669 subjects and 3 of them were D. brevis. In chi-square analysis, nosignificant relationship was found between the incidence of the parasite, age, education level, occupation, marital status, family type, and MetS. However, a significant relationship was found between the diastolic pressure and those who fed with fatty foods and the incidence of parasite's occurrence. Conclusions: According to the results of this study, MetS has no effect on the frequency of occurrence of the parasite; however, weight, fatty foods, and high diastolic pressure are effective in the frequency of occurrence of the parasite. The effects of these factors on the incidence of parasites should be supported by further study designs.Öğe Prevalence of Microsporidium and Other Intestinal Parasites in Children from Malatya, Turkey(Springer, 2011) Calik, Sinan; Karaman, Ulku; Colak, CemilParasite infections are common during the critical developmental period in children. The occurrences of intestinal parasites are also common in orphanage, nurseries and schools in Turkey. The study was carried out to determine the percentage of microsporidium and intestinal parasites in children from Malatya, Turkey. This study was carried out at the Department of Parasitology of Inonu University, Turgut Ozal Medical Center, during January-December 2006. Totally, 1,181 stool samples were examined using the native-Lugol, sedimentation-techniques, modified trichrome (MTS), acid-fast-trichrome stain and calcofluor staining methods. In addition, perianal region material was taken from the children to examine with cellophane tape method. Power analyses were performed for statistical analyses used. Microsporidia were found in 92 (7.8%) of the samples, and also intestinal parasites were detected in 329 (27.8%). The numbers of infections according to the species were as follows: 69 (5.8%) Entamoeba coli, 7 (0.6%) Blastocystis hominis, 114 (9.7%) Giardia intestinalis, 15 (1.3%) Iodomoeba butchlii, 8 (0.7%) Dientamoeba fragilis, 7 (0.6%) Taenia spp. 70 (5.9%) Enterobius vermicularis, 11 (0.9%) Hymenolepis nana, 25 (2.1%) Trichomonas intestinalis, 1 (0.1%) Ascaris lumbricoides and 2 (0.2%) Chilomastix mesnilii. Also, greater than 90% power values were achieved for statistical analyses. Whereas the detection rates of microsporidium and intestinal parasites were found to be low, it was concluded that in addition to intestinal parasites, microsporidium should be also searched for in children with complaints of intestinal system.Öğe The Rates of Seropositivity and Seroconversion of Toxoplasma Infection in Pregnant Women(Ankara Microbiology Soc, 2012) Dogan, Keziban; Kafkasli, Ayse; Karaman, Ulku; Atambay, Metin; Karaoglu, Leyla; Colak, CemilInfections caused by Toxoplasma gondii are frequently asymptomatic in healthy adults, however they may be serious in pregnant women and immunocompromised patients. The aims of this study were to investigate the rates of seropositivity and seroconversion in pregnant women and newborn cord blood samples, and to evaluate those data in the view of relation to lifestyle and nutrition. A total of 312 pregnant women (mean age: 28.1 +/- 5.2 years) who were admitted to and followed by gynecology clinics of Inonu University Medical School Hospital, Malatya, Turkey were included in this observational and cross-sectional study. Anti-toxoplasma IgG and IgM antibodies in pregnants and newborn cord sera were screened by commercial ELISA and immunofluorescence antibody (BioTek; USA) methods. A total of 312 sera from pregnant women and 312 cord blood samples during delivery were collected. IgG seropositivity rate in pregnants was found as 37.5% (117/312), seroconversion was not determined in restrained pregnants and T.gondii IgM was found negative in all pregnants. Also in all newborns IgM was negative and IgG seropositivity was determined as 33.3% (104/312) in cord blood. There was a statistically significant relationship between IgG seropositivity and raw meat consumption (p<0.001) and being engaged in agriculture (p<0.005). It was concluded that toxoplasma antibodies should routinely be searched on the first visit of the pregnants and the seronegative cases should be trained about the preventive measures related to toxoplasmosis. The follow-up of toxoplasma seronegative cases during pregnancy can be achieved by only detecting the IgM class antibodies and this will also reduce the cost of screen test.Öğe Role of Adenosine Deaminase in Patients with Erythematotelan-giectatic Rosacea and Demodex folliculorum Positivity(Iranian Scientific Society Medical Entomology, 2020) Sener, Serpil; Karaman, Ulku; Kiran, Tugba Raika; Colak, Cemil; Aslan, Ali; Direkel, SahinBackground: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in D. foaculorum positive patients with the healthy control individuals. Methods: Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose D. foliculorum. A significant decrease was found in the ADA levels of Demodex-positive rosacea patients when compared to the control group. Results: ADA levels were decreased in the Demodex-positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (P<0.001). There was no significant difference between the patient and control groups in terms of age and gender. Conclusion: During and after treatment of Demodex-positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms.
