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Öğe Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2013) Cumurcu, Birgul Elbozan; Ozyurt, Huseyin; Ates, Omer; Gul, Isil Gogcegoz; Demir, Suleyman; Karlidag, RifatWe investigated the etiopathogenetic role of manganese superoxide dismutase (MnSOD) (Ala-9Val) and glutathione peroxidase (GSH-Px) (Pro 197 Leu) gene polymorphisms in patients diagnosed with major depressive disorder (MDD) and bipolar I disorder (BD). Eighty patients with MDD, 82 patfents with BD (total 162 patients) and 96 healthy controls were enrolled in this study and genotyped using a Real Time-Quantitative Polymer Chain Reaction (RT-qPCR)-based method. The patients with BD and MDD and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD gene polymorphism. Comparison of the MDD group and control group regarding the Pro 197 Leu GSH-Px gene polymorphism revealed similar genotype distribution but different allele distribution. The BD group and control group were similar both for genotypes and for alleles when compared regarding the Pro 197 Leu GSH-Px gene polymorphism. The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD and Pro 197 Leu GSH-Px gene polymorphism. Although small statistical power of the current study the significant difference between patients with depression and the control group for the Pro 197 Leu GSH-Px polymorphism indicates that the distribution of these alleles may have a contribution in the physiopathogenesis of depression. One of the limitation of the current study is that the sample size is too small. Understanding of the exact role of Pro 197 Leu GSH-Px polymorphism in the development of depression needs to further studies with more sample size and high statistical power. (C) 2013 Association of Basic Medical Sciences of FB&H. All rights reservedÖğe ASSOCIATION OF BDNF / TRKB AND NGF / TRKA LEVELS IN POSTMORTEM BRAIN WITH MAJOR DEPRESSION AND SUICIDE(Medicinska Naklada, 2021) Erbay, Lale Gonenir; Karlidag, Rifat; Oruc, Mficahit; Cigremis, Yilmaz; Celbis, OsmanBackgroundÖğe Attachment styles in women with vaginismus(Cumhurıyet unıv tıp fak psıkıyatrı anabılım dalı, cumhurıyet unıv tıp fak psıkıyatrı abd, sıvas, 58140, turkey, 2015) Ozcan, Ozlem; Elbozan Cumurcu, Birgul; Karlidag, Rifat; Unal, Suheyla; Aktan Mutlu, Elif; Kartalci, SukruObjective: Attachment styles reflect individual differences in beliefs about oneself and others, interpersonal functioning and close relationships. This study intended to investigate attachment styles of vaginismus patients. Methods: Our sample was included 56 patients with vaginismus and 51 healthy women. Golombok Rust Inventory of Sexual Satisfaction Scale (GRISS) and Relationship Scales Questionnaire (RSQ) were administered to the patients and healthy control group. Results: The scores of the vaginismus group for secure attachment scores were statistically significantly lower than the healthy control group while there was no difference between the groups for the fearful, preoccupied and dismissive attachment subscale scores. GRISS total and subscale scores were statistically higher in women with an insecure attachment style when the total sample as divided into two groups as secure and insecure attached individuals. Conclusions: These findings taken together support the notion that insecure attachment may be an important factor in the pathogenesis of vaginismus.Öğe Bipolar Affective Disorders Related to Vitamin B12 and Folic Acid Levels(Karger, 2018) Zayman, Esra Porgali; Karlidag, Rifat; Kurnaz, Ahmet[Abstract Not Available]Öğe Bipolar affective disorders related to vitamin b12 and folic acid levels(Karger, allschwılerstrasse 10, ch-4009 basel, swıtzerland, 2018) Zayman, Esra Porgali; Karlidag, Rifat; Kurnaz, AhmetÖğe Cerebral MR Spectroscopy Evaluation of the Neuroprotective Effects of Lithium and Olanzapine in Bipolar Affective Disorder Patients(Universitatsverlag Ulm Gmbh, 2008) Cumurcu, Birgul Elbozan; Karlidag, Rifat; Sarac, Kaya; Unal, Suheyla; Ozcan, Cemal; Erkorkmaz, UnalAim: We used the NAA measurements obtained by cerebral magnetic resonance spectroscopy to evaluate the neuroprotective effects of lithium and olanzapine in bipolar affective disorder patients in remissions. Methods:Ten bipolar affective disorder patients on lithium treatment for the last six years and who had not experienced a manic or depressive attack for the last three years and were followed up at the psychiatry outpatients department were included in the study. The patients were evaluated while on lithium, 14 days after lithium was stopped and at the end of the 411 week following olanzapine initiation, for a total of three times. Each evaluation consisted of a psychiatric interview, the Hamilton Depression Rating Scale (HDRS) and the Bech-Rafaelson Mania Scale (BRMS) in addition to MR spectroscopy imaging. Results: The cases were compared with a control group consisting of 10 age- and sex-matched healthy subjects. We measured the N-acetyl aspartate (NAA) peak quantitatively in the right dorsolateral prefrontal cortex (DLPF) and left hippocampus areas on MR spectroscopy and checked the ratio to the creatine (Cr) peak. The values from all three imaging studies were compared with each other and with the control subjects. Conclusions: There was no statistically significant difference between the NAA/Cr ratios of the patients receiving lithium, those not on medications or those receiving olanzapine and the healthy subjects. We did not observe any change in cerebral NAA levels following lithium and olanzapine treatment in bipolar affective disorder patients in remission.Öğe The Changes in Tear Film Parameters and Impression Cytology in Heavily Drinking Men(Lippincott Williams & Wilkins, 2013) Cumurcu, Tongabay; Gunduz, Abuzer; Cumurcu, Birgul Elbozan; Gul, Isil Gogcegoz; Akpolat, Nusret; Karlidag, RifatPurpose: To evaluate the tear film function and ocular surface changes in heavily drinking men. Methods: This prospective case-control study involved 35 male subjects with heavy alcohol consumption (group 1) and 35 age-and sex-matched control subjects (group 2). Best-corrected visual acuity measurement, slit-lamp examination, Schirmer I test, tear film break-up time (BUT) measurement, and conjunctival impression cytology were performed in all subjects. The results were compared between the 2 groups. Results: The mean Schirmer I test results in group 1 and group 2 were 8.31 +/- 3.56 mm and 13.17 +/- 5.71 mm, respectively, and the mean BUT values were 9.22 +/- 3.10 seconds and 13.20 +/- 4.04 seconds, respectively. The mean Schirmer I and BUT results were statistically lower in group 1 than in group 2 (P < 0.0001). The mean impression cytology scores in group 1 and group 2 were 2.08 +/- 0.78 and 1.37 +/- 0.94, respectively. A statistically significant difference was noted between the study and control groups for the grading of cytological changes (P = 0.001). Conclusions: Our data showed that heavily drinking men have decreased tear production, tear film instability, and significant degeneration of the ocular surface epithelium when compared with normal subjects.Öğe Does Toxoplasma gondii play a role in obsessive-compulsive disorder? Response(Elsevier Ireland Ltd, 2012) Miman, Ozlem; Mutlu, Elif Aktan; Ozcan, Ozlem; Atambay, Metin; Karlidag, Rifat; Unal, Suheyla[Abstract Not Available]Öğe The Effect of Agoraphobia on Oxidative Stress in Panic Disorder(Korean Neuropsychiatric Assoc, 2013) Gul, Lsil Gogcegoz; Karlidag, Rifat; Cumurcu, Birgul Elbozan; Turkoz, Yusuf; Kartalci, Sukru; Ozcan, A. Cemal; Erdemli, M. ErmanWe aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAG), paraoxonase (PUN), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAG, PUN, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAG, PUN, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAG, PUN, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.Öğe The Effect of Body Mass Index on the Sexual Functions of Morbidly Obese Female Patients(Yerkure tanıtım & yayıncılık hızmetlerı a s, cumhuryet cad 48-3b, harbıye, ıstanb, 34367, turkey, 2017) Erbay, Lale Gonenir; Ozlu, Mustafa; Sahin, Ibrahim; Evren, Bahri; Kayaalp, Cuneyt; Karlidag, RifatObjective: The aim of this study is to investigate whether morbidly obese female patients are suffering sexual dysfunction, in addition to analyzing the effect of body mass index (BMI) on sexual functions. Method: A total of 72 morbidly obese women admitted to the Endocrinology Department, whose BMI scores were 40 or over, and 28 healthy women age-matched with the morbidly obese group, whose BMI scores were under 30 were included in this study. Considering the effects on sexual functioning, the patients and the control group were evaluated by a psychiatric specialist. women with a psychiatric disorder according to DSM-5, taking medicines that could affect sexual functions, and those with a chronic physical or any neurological disease or being pregnant or breastfeeding were excluded from the study. A sociodemographic data form and the Arizona Sexual Experiences Scale (ASEX) were administered to both the treatment and control group. Results: Statistical analyses revealed that morbidly obese female patients more frequently suffered from sexual dysfunction compared to the control group. The Arizona Sexual Experiences Scale (ASEX) and all subscale scores except the sexual satisfaction rate were significantly higher in morbidly obese female patients than in the control group. There was no correlation found between the BMI and sexual function in the analyses conducted. Conclusion: In our study, morbidly obese female patients were found to show more impairments in all areas of sexual functions except sexual satisfaction rate when compared to the control group. Previous studies have suggested that obesity is the cause of sexual dysfunction in men; however, the same relationship could not be demonstrated in women. In a limited study of female patients, conflicting results were attributed to the inability to control variables. The fact that variables such as depression, anxiety, and chronic physical illness, which may affect sexual function, had been assessed in our study is important for accurately interpreting the findings. The data in our study reveals the importance of investigating sexual functions in morbidly obese female patients.Öğe GHRELIN AND LIPID LEVELS IN PANIC DISORDER BEFORE AND AFTER TREATMENT AND THEIR RELATIONSHIP WITH AGORAPHOBIA(Medicinska Naklada, 2015) Gul, Isil Gogcegoz; Cumurcu, Birgul Elbozan; Karlidag, Rifat; Turkoz, YusufBackground: We aimed to evaluate serum ghrelin (GHR) levels and lipid profile in panic disorder (PD), with and without agoraphobia, and to compare these parameters before and after treatment. Subjects and methods: The GHR and lipid profiles were measured in blood samples taken from 31 PD patients with agoraphobia, 22 PD patients without agoraphobia, and 53 control group subjects. 23 of the 53 patients who were prescribed 20 to 40 mg/day paroxetine had continued treatment. The 23 patients who had continued treatment were measured again at the end of twelve weeks. Results: The GHR and triglyceride (TRG), total cholesterol (Total-C), low-density lipoproteins (LDL-C), and very low-density lipoproteins (VLDL-C) levels were higher in the PD with agoraphobia group than the PD without agoraphobia and control groups. The 23 patients that had continued their treatment were re-evaluated, and the serum GHR, Total-C levels, and BMI after treatment were significantly decreased, compared to the values before treatment. Conclusions: There may be a pathophysiological relationship between the GHR and lipid profiles that interact with each other in PD. In fact, this relationship was more marked in PD with agoraphobia than in PD without agoraphobia.Öğe Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?(Elsevier Ireland Ltd, 2010) Miman, Ozlem; Mutlu, Elif Aktan; Ozcan, Ozlem; Atambay, Metin; Karlidag, Rifat; Unal, SuheylaObsessive-compulsive disorder (OCD) is a common psychiatric illness. Although the aetiology of OCD is still unknown, the family-genetic data show that familial forms of OCD may be associated with a specific genetic susceptibility. Recent investigations have associated development of OCD with infectious illness. Toxoplasmic encephalitis (TE) is a common presentation of Toxoplasma gondii infection of the central nervous system (CNS). The most commonly affected CNS region in TE is the cerebral hemisphere, followed by the basal ganglia, cerebellum and brain stem. The basal ganglia has been implicated in the development of OCD. Therefore, in this study, it was aimed to investigate a possible association between Toxoplasma infection and OCD. We selected 42 patients with OCD and 100 healthy volunteers, and investigated the sero-positivity rate for anti-Toxoplasma IgG antibodies by Enzyme Linked Immunosorbent Assay (ELISA). The sero-positivity rate for anti-T. gondii IgG antibodies among OCD patients (47.62%) was found to be significantly higher than the rate in healthy volunteers (19%). This is the first report to examine a potential association between Toxoplasma infection and OCD. The main finding of the present study is an increased level of IgG antibodies to T. gondii in OCD patients when compared with the level in healthy controls. There might be a causal relationship between chronic toxoplasmosis and the aetiology of OCD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.Öğe P50 Sensory Gating in Children and Adolescents with Developmental Stuttering(Kure Iletisim Grubu A S, 2009) Ozcan, Ozlem; Altinayar, Sibel; Ozcan, Cemal; Unal, Suheyla; Karlidag, RifatObjective: Stuttering is a speech disorder, where speech fluency is disturbed by the involuntary repetition and prolongation of words and syllables. Its cause is not fully known. Sensory gating is an essential part of information processing and developing an appropriate behavioral response in the brain. Psychological, social, and learning-related factors together with sensorymotor variables play an important role in ensuring fluent speech. Sensory gating protects the brain from overload by filtering the redundant or potentially irrelevant information from the continuous and intensive stream of information. A lack of sensory gating for auditory stimuli may lead to disturbed auditory signal processing and auditory feedback and result in loss of speech fluency. Our aim in this study was to evaluate the state of sensory gating in children and adolescents with developmental stuttering using P50 suppression to test our hypothesis that sensory gating may be disturbed in stuttering. Method: A total of 20 stuttering children and adolescents in 7-18 age group and 20 age-and sex-matched healthy controls with no speech problems were included in the study. All children underwent psychiatric evaluation by a pediatric psychiatrist. Patients with psychiatric, neurological or chronic disease, those who had a history of using medication that could affect the central nervous system and children with a family history of schizophrenia were excluded from the study. P50 suppression was then recorded with an electroencephalogram (EEG). Statistical analysis was performed using the SPSS package software program. The Mann-Whitney U test was used to compare the P50 values of the two groups and p value <0.05 was considered significant for all analyses. Results: The mean age for the children and adolescents included in the study was 11.8 +/- 2.7 years and the age stuttering started was 4.6 +/- 1.1 years. There were 16 males (80%) and 4 females (20%) in both groups. There was no statistically significant difference between the P50 amplitude, latency and P50 suppression ratios of the two groups. Conclusion: The results of this study have shown no association between P50 and stuttering in children and adolescents. However, this first study evaluating sensory gating in children and adolescents should be repeated with prepulse inhibition, another test used to evaluate sensory gating, on larger samples and in different age groups.Öğe P50 sensory gating in patients with vaginismus(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Gul, Isil Gogcegoz; Karlidag, Rifat; Ozcan, A. CemalObjective: P50 sensory gating was investigated in patients with primary vaginismus (PV) with the hypothesis that interpreting coping capacities as a stress factor during sexual intercourse by perceiving unrelated stimuli and an impairment of the sensory information processing may be associated with fear/anxiety related to a possible pain in vulvovagina. Methods: A total of 35 patients who were diagnosed with PV and 29 healthy volunteers matched for age and gender underwent P50 recording in the neurophysiology laboratory and the results were compared. Results: The PV group's P50 gating ratio and S1 amplitude were statistically significantly lower than in the control group. Conclusion: Sensory gating is required for filtering the stimuli coming to the brain and developing an appropriate behavioral response. The reduced formation of an appropriate behavioral response in the PV group can lead to a perception of excessive and unrelated stimuli coming from internal and external environments and interpreting these as a stress factor exceeding the capacity to cope. Our study is the first to evaluate sensory gating in PV patients and new studies with larger patient groups are required.Öğe Parietal Cortex Volume and Functions in Major Depression and Bipolar Disorder: A Cloud-Based Magnetic Resonans Imaging Study(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2024) Kilic, Fatma; Kartal, Fatma; Erbay, Mehmet Fatih; Karlidag, RifatIntroduction: The present study aimed to compare the Parietal Lobe (PL) volumes and Cancellation Test (CT) performances of euthymic patients with Bipolar Disorder -1 (BD) and Major Depressive Disorder (MDD), and healthy controls. Methods: The present study included 63 participants in three groups; two patient groups in remission involving patients with BD and MDD diagnosed according to DSM-5 and a control group with healthy individuals. Sociodemographic Data Form, CT, and Hand Preference Questionnaire were applied to all participants. Participant PL volumes were measured with the Cloud-Based Brain Magnetic Resonance Image Segmentation - Parcellation System. Results: Both patient groups exhibited lower PL volume when compared to the control group, and there was no difference between the patient groups based on PL volume. It was determined that MDD and BB patients scored less in the CT when compared to the control group. There was a weak correlation between right and left PL volumes and CT performances. Conclusion: The present study findings demonstrated that BD and MDD patients in remission exhibited lower PL volume and CT performance when compared to healthy controls, emphasizing that PL could be structurally and functionally significant in the pathophysiology of mood disorders.Öğe Plasma Iron, Copper, Zinc Levels in Patients Experiencing Delirium Following Coronary Artery Bypass Grafting(Universitatsverlag Ulm Gmbh, 2008) Cumurcu, Birgul Elbozan; Karlidag, Rifat; Unal, Suheyla; Sezer, Ozlem Hesna; Battaloglu, Bektas; Mendil, Durali; But, KadirAim: To investigate the role of plasma iron (Fe), copper (Cu), and zinc (Zn) levels on delirium in patients following coronary artery bypass grafting (CABG). Methods: Twelve of the 50 patients included in the study showed signs of delirium during postoperative follow-up. We diagnosed delirium using DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders) criteria. Delirium Rating Scale (DRS) was used to estimate delirium severity. In both groups pre-and postoperative plasma Fe, Cu, and Zn levels were analyzed with atomic absorption spectrometry (FAAS) method and compared statistically. Results: There was no significant difference between the groups for preoperative plasma Fe and Zn levels, while the Cu level was statistically significantly lower in the delirium group (p<0.05). The postoperative plasma Fe and Zn levels were statistically significantly higher in the delirium group (p=0.0001). The Cu level was statistically significantly higher in the delirium and non-delirium group (p=0.0001, p<0.05, respectively). The comparison of postoperative plasma Fe, Cu and Zn levels between the two groups showed a statistically significantly higher level in the delirium group compared to the non-delirium group (p=0.0001). The postoperative plasma Cu/Zn levels were statistically significantly higher in the delirium group (p<0.05). Conclusion: It may be suggested that the increased postoperative plasma levels of these trace elements may play a role in delirium seen after CABG.Öğe Psychotic Disorder Releated with Graves Disease: A Case Report(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2012) Gul, Isil Gogcegoz; Kartalci, Sukru; Karlidag, Rifat; Cumurcu, Birgul ElbozanAlthough the association between disorders of thyroid function and psychiatric symptomatology is well established, psychoses associated with hyperthyroidism are uncommon. Behavioral abnormalities that may extend to psychosis can be a manifestation of severe hyperthyroidism due to Graves' disease. In this case report, we present a 39-year-old man who developed a psychotic disorder due to Graves' disease. (Archives of Neuropsychiatry 2012; 49: 317-319)Öğe Rabbit syndrome: Developed after increasing the dosage of quetiapine in a patient using quetiapine with duloxetine(Kure Iletisim Grubu A S, 2011) Cumurcu, Birgul Elbozan; Almis, Behice Han; Kartalci, Sukru; Karlidag, RifatRabbit syndrome: Developed after increasing the dosage of quetiapine in a patient using quetiapine with duloxetine Fifty-six years old, female patient who was being followed and treated for resistant depression, had been using duloxetine 60 mg/day and quetiapine 300 mg/day for 3 months. After 2 weeks the quetiapine dose was increased to 600 mg/day because of resistant depression concomitant with insomnia. A movement disorder was observed, appearing as a rhythmic tremor in the perioral muscles which was defined by the patient as involuntary. This involuntary rhythmic perioral tremor was diagnosed as rabbit syndrome and for this reason quetiapine, the only antipsychotic used by the patient, was gradually decrease in dose and eventually stopped. Four weeks after stopping the quetiapine, the patient's involuntary perioral rhythmic movements decreased from four to zero points, according to the lips and perioral subgroup of the Abnormal Involuntary Movements Scale (AIMS).Öğe Recurrent priapism during quetiapine treatment(Kure Iletisim Grubu A S, 2010) Kartalci, Sukru; Gul, Isil Gogcegoz; Karlidag, Rifat; Cumurcu, Birgul ElbozanPriapism is defined as prolonged penile erection without sexual desire or stimulation. Since it is a urological emergency, serious consequences can occur if neglected. Different etiological factors including hemotopoetic disorders, malignancies, various drugs, perineal trauma, etc. can cause priapism. Drug induced priapism can occur during treatment with antispychotic medications. This report discusses a case of priapism, which occurred when the dose of quetiapine was increased.Öğe The review of thyroid hormones levels in lithium therapy patients(Karger, allschwılerstrasse 10, ch-4009 basel, swıtzerland, 2018) Zayman, Esra Porgali; Karlidag, Rifat; Kurnaz, Ahmet
