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Öğe Acute and chronic effects of electroconvulsive treatment on oxidative parameters in schizophrenia patients(Pergamon-Elsevier Science Ltd, 2011) Kartalci, Sukru; Karabulut, Aysun Bay; Ozcan, Abdul Cemal; Porgali, Esra; Unal, SuheylaElectroconvulsive therapy (ECT) is an effective treatment alternative for schizophrenia. Previous studies have already indicated the possible effects of oxidative stress in this disorder. However, there have been no previous studies evaluating the effects of ECT on the oxidative stress in these patients. We therefore aimed to investigate the acute and chronic effects of ECT on serum levels of oxidant and antioxidant molecules in schizophrenia patients (n = 28). The serum MDA and CAT levels of the patients with schizophrenia were higher than that of the controls before ECT (n = 20) but there was no significant difference in the serum NO and GSH levels of the patient groups compared to the controls. We found that the NO levels of the patients were higher than the controls in the group experiencing their first episode but not in the chronic group. There was a significant clinical improvement in the patients in terms of BPRS. SANS and SAPS reduction after the 9th ECT, but not the 1st ECT. Serum MDA levels were significantly reduced compared to the baseline after the 9th ECT session although there was no significant difference after the 1st session. Separate evaluation of the patient groups revealed that the significant MDA decrease following ECT was in the patients experiencing their first episode and not in the chronic group. No significant difference was noted in the serum levels of other oxidant and antioxidant molecules after either the 1st or 9th ECT session. These results suggest that ECT does not produce any negative effect on oxidative stress in patients with schizophrenia. (C) 2011 Elsevier Inc. All rights reserved.Öğe Association between latent toxoplasmosis and clinical course of schizophrenia - continuous course of the disease is characteristic for Toxoplasma gondii-infected patients(Folia Parasitologica, 2015) Celik, Tuncay; Kartalci, Sukru; Aytas, Ozgur; Akarsu, Gulay Aral; Gozukara, Harika; Unal, SuheylaThe aim of the present study was to investigate the association between various clinical aspects of schizophrenia and seropositivity against Toxoplasma gondii (Nicolle et Manceaux, 1908). We selected 94 patients with schizophrenia and investigated the seropositivity rate for anti-T. gondii IgG antibodies by ELISA. Clinical parameters of schizophrenic patients such as illness type and status, clinical course, awareness of the illness and need for electroconvulsive therapy (ECT) were compared with their serological status. Anti-T. gondii IgG antibodies were detected in 43 (46%) of schizophrenic patients. Chronic patients had a rate of 34 (72%) seropositivity, whereas 9 (22%) of the patients with partial remission showed evidence of latent toxoplasmosis. Of continuous patients, 35 (81%) were found to be seropositive and this rate was significantly more than in the other groups. The rate of latent toxoplasmosis was detected significantly higher in patients who lack awareness of schizophrenia (36, i.e. 72%) than the patients who were aware of their illnesses (7, i.e. 16%). Anti-T. gondii IgG antibodies were detected in 38 (70%) of ECT performed patients while this percentage was 13% in the ones who had never been treated with ECT. This difference was also statistically significant. We showed that Toxoplasma-infected subjects had 15x higher probability of having continuous course of disease than Toxoplasma-free subjects. Our results put forth the possibility of latent toxoplasmosis to have a negative impact on the course of schizophrenia and treatment response of schizophrenic patients.Öğe Association of a haplotype in the NRG1 gene with schizophrenia: a case-control study(Walter De Gruyter Gmbh, 2023) Sozen, Mustafa Mert; Kartalci, SukruObjectives: Schizophrenia (SZ) is a severe multifactorial disease. NRG1 is a gene acting in the development of SZ. A number of NRG1 single nucleotide polymorphisms (SNPs) and their haplotypes are associated with SZ. In the present study, we investigated the association of a NRG1 haplotype (G-C in rs6988339-rs3757930 frame) which was reported to be associated with SZ, and two other SNPs in the same gene (rs74942016, rs80127039) whose rare missense alleles were found in SZ patients. Also, we analyzed disease associations of potential new haplotypes constructed by the variants of these SNPs.Methods: We genotyped 4 SNPs in a sample consisting of 302 SZ patients and 333 controls from a local Turkish population. We tested the disease associations of these variants at single SNP, haplotype and diplotype levels in case-control design.Results: At single SNP level, the CC genotype of rs3757930 was associated with SZ (p=0.038). The previously reported association of G-C haplotype in rs6988339-rs3757930 frame was absent (p=0.416), but we found another haplotype (C-G in rs3757930-rs74942016, p=0.018) and three diplotypes (A-C/G-C diplotype of rs6988339-rs3757930 frame, C-G/C-G diplotype of rs3757930-rs74942016 frame, and A-C-G/G-C-G diplotype of rs6988339-rs3757930-rs74942016 frame) associated with schizophrenia in our sample.Conclusions: Our study indicated the associations of a SNP, a haplotype, and a diplotype of NRG1 with schizophrenia and supported the involvement of NRG1 gene in the development of the disease. Since our sample was collected from a limited geographic area, the associations we have reported need to be supported by further studies in different populations.Öğe An association study of D-amino acid oxidase and D-amino acid oxidase activator polymorphisms and schizophrenia in patients from Turkey(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2016) Kartalci, Sukru; Acar, CerenObjective: Schizophrenia is a highly heritable complex disease. The genetic interactions underlying this heritability is still needs to be understood. Linkage studies pointed out the D-amino acid oxidase (DAO) and D-amino acid oxidase activator (DAOA-G72) genes as candidate genes in susceptibility to schizophrenia. The association studies of interaction partners D-amino acid oxidase and D-amino acid oxidase activator gene polymorphisms and schizophrenia has been performed in different studies with different ethnic origins. However these studies showed conflicting results. In this study, it is aimed to examine the effects of several DAO and DAOA polymorphisms in Turkish schizophrenia patients. Methods: In the present study two single nucleotide polymorphisms (SNPs) within DAO gene (rs2111902 and rs3741775) and one in DAOA gene (rs2391191) were genotyped in individuals with Turkish origin from Malatya region on eastern part of Turkey. 96 schizophrenia patients and 100 mentally healthy individuals are the subjects of this study. Results: No significant difference was found in between the controls and schizophrenia sample for the SNPs rs2111902 and rs3741775 of DAO gene but a significant association was found on the allelic level of rs2391191 of DAOA gene. The relationship between aggressive behaviour, suicide attempts and genotypes were also evaluated in the patient group. Discussion: A significant association for the G allele of rs2391191 at the allelic level (p=0.036) was found, on the other hand no association could be shown between the examined rs2111902 and rs3741775 polymorphisms and the pathology of the disorder in the group of Turkish schizophrenia patients included in this study.Öğe Attachment styles in women with vaginismus(Cumhurıyet unıv tıp fak psıkıyatrı anabılım dalı, cumhurıyet unıv tıp fak psıkıyatrı abd, sıvas, 58140, turkey, 2015) Ozcan, Ozlem; Elbozan Cumurcu, Birgul; Karlidag, Rifat; Unal, Suheyla; Aktan Mutlu, Elif; Kartalci, SukruObjective: Attachment styles reflect individual differences in beliefs about oneself and others, interpersonal functioning and close relationships. This study intended to investigate attachment styles of vaginismus patients. Methods: Our sample was included 56 patients with vaginismus and 51 healthy women. Golombok Rust Inventory of Sexual Satisfaction Scale (GRISS) and Relationship Scales Questionnaire (RSQ) were administered to the patients and healthy control group. Results: The scores of the vaginismus group for secure attachment scores were statistically significantly lower than the healthy control group while there was no difference between the groups for the fearful, preoccupied and dismissive attachment subscale scores. GRISS total and subscale scores were statistically higher in women with an insecure attachment style when the total sample as divided into two groups as secure and insecure attached individuals. Conclusions: These findings taken together support the notion that insecure attachment may be an important factor in the pathogenesis of vaginismus.Öğe The Effect of Agoraphobia on Oxidative Stress in Panic Disorder(Korean Neuropsychiatric Assoc, 2013) Gul, Lsil Gogcegoz; Karlidag, Rifat; Cumurcu, Birgul Elbozan; Turkoz, Yusuf; Kartalci, Sukru; Ozcan, A. Cemal; Erdemli, M. ErmanWe aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAG), paraoxonase (PUN), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAG, PUN, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAG, PUN, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAG, PUN, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.Öğe Effects of Electroconvulsive Therapy on Some Inflammatory Factors in Patients With Treatment-Resistant Schizophrenia(Lippincott Williams & Wilkins, 2016) Kartalci, Sukru; Karabulut, Aysun Bay; Erbay, Lale Gonenir; Acar, CerenObjectives Electroconvulsive therapy (ECT) is the most effective option for several psychiatric conditions, including treatment-resistant schizophrenia. However, little is known about the molecular mechanism of action of ECT. The link between inflammatory system and schizophrenia is the focus of recent studies. However, the impact of ECT on inflammatory functioning in this disorder remains elusive. Whether ECT could modulate inflammatory factors in patients with schizophrenia was examined. Methods Plasma levels of interleukin-4 (IL-4), transforming growth factor- (TGF-), myeloperoxidase (MPO), and nuclear factor-B (NF-B) activation were analyzed in 20 schizophrenic patients, mainly with resistant to antipsychotic medication disorders, and in 20 sex- and age-matched healthy controls. Disease severity was evaluated using the Brief Psychiatric Rating Scale. All patients were followed with measurement of the inflammatory factors before and after ECT treatment and compared with the controls. Results Patients with schizophrenia had markedly raised NF-B and but decreased TGF- levels compared with healthy controls. On the other hand, no significant differences were found for the levels of IL-4 and MPO levels. The clinical improvement during repeated ECT was accompanied by a gradual and significant increase in IL-4 and TGF- level, but MPO and NF-B activation were left unaffected. Increases in TGF- were negatively correlated with the change in Brief Psychiatric Rating Scale scores after ECT. Conclusions It is shown that ECT, while increasing the anti-inflammatory response such as the levels of IL-4 and TGF-, it did not affect the levels of MPO and NF-B activation in this study.Öğe EVALUATION OF BLOOD ZONULIN LEVELS, INFLAMMATORY PROCESSES AND NEURONAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDER(Medicinska Naklada, 2022) Kartalci, Gulsen; Demir, Arzu Caliskan; Kartalci, Sukru; Uremis, Nuray; Turkoz, YusufBackground: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by symptoms such as limited, and repetitive behavior patterns and disordered social interaction and communication. The etiology of Autism Spectrum Disorder (ASD) is not clearly known, it has been emphasized that the immune-inflammatory system may also play a role in this disease. This study aimed to evaluate in intestinal permeability, food antigen-antibody levels, inflammatory processes, and neuron damage in patients with ASD. Subjects and methods: Thirty-five children between the ages of 3-12 with ASD and 35 controls were included in the study. Both participants' height and weight were measured, and the parents filled the Socio-demographic Data and the Gastrointestinal Systems (GIS) Symptoms Form. Venous blood samples were collected, and serum zonulin, anti-gliadin Ig A and Ig G, IL6, TNF-alpha, TGFJ3, S100B, and NSE levels were measured by ELISA. Results: Serum zonulin levels in the ASD group were found to be significantly lower. IL-6 and TGF-beta were found to be significantly higher in the ASD group. There was no difference between the two groups in terms of serum anti-gliadin Ig A and Ig G and TNF-alpha values. Also, GIS symptoms, NSE and SlOOB levels were found similar between two groups. Conclusions: Although findings showing low zonulin levels and increased inflammatory processes in ASD were found in this study, no difference was found in the parameters of brain damage. The findings show that intestinal permeability does not decrease in ASD and that inflammatory processes may play a role in ASD.Öğe Evaluation of CSF flow dynamics in patients with schizophrenia using phase-contrast cine MRI(Elsevier Ireland Ltd, 2021) Kartalci, Sukru; Erbay, Mehmet Fatih; Kahraman, Aysegul; candir, Fatih; Erbay, Lale GonenirPatients with schizophrenia show progressive clinical deterioration. Brain abnormalities have been suggested in these patients, including enlargement of the lateral ventricles, increased cerebrospinal fluid (CSF) volume and reductions in the frontal and temporal lobes. CSF flow pathology is a central factor in the development of many neurological disorders, but much less is known about the role of CSF flow dynamics in schizophrenia. In this study, parameters of CSF flow dynamics at the aqueduct level of 50 schizophrenic patients were compared to those of 50 controls using phase-contrast cine magnetic resonance imaging. Patients had lower peak velocity, lower net forward volume, and lower average flow over the range studied than controls. The average velocity was significantly lower in patients exhibiting violent behavior compared to non-violent patients. The aqueduct tendedto be larger in schizophrenic patients with earlier age of onset of the disorder. Furthermore, as the number of hospitalizations increased, the average velocity and flow over the range studied decreased commensurately. This study demonstrated that CSF flow dynamics are altered in patients with schizophrenia. The results indicated that additional studies of CSF flow dynamics in schizophrenia are needed, along with volumetric examinations of the brain, to elucidate the pathophysiology of the disease.Öğe Evaluation of dynamic thiol/disulfide balance and oxidative metabolism in obsessive compulsive disorder patients(Klinik Psikiyatri Dergisi, 2023) Yilmaz, Omer Furkan; Kartal, Fatma; Kartalci, SukruObjective: We aimed to compare Total Oxidant Level (TOL), Total Antioxidant Level (TAL), Oxidative Stress Index (OSI), Thiol/Disulfide levels, Plasma Malondialdehyde (MDA) levels in both plasma and erythrocyte patients with OCD and healthy controls. Method: Our study included 47 patients with OCD and 49 healthy controls. Sociodemographic data form was applied to all participants, CGI and Y-BOCS were applied to the patient group. TAL and TOL measurements were made in both plasma and erythrocytes, and Malondialdehyde (MDA) and Thiol/Disulfide measurements were made only in plasma. Results: TAL, TOL, OSI and MDA values in the plasma of the patient and control groups were compared, no statistically significant difference was found. However, erythrocyte TAS level was lower in the patient group (p<0.05) and OSI level was higher (p<0.05) in the patient group. While no difference was observed in plasma total thiol level in the patient group compared to the cont-rols, plasma native thiol levels were significantly higher (p<0.001) and plasma disulfide levels were significantly lower (p<0.05). Conclusion: The high level of native thiol, an antioxidant molecule in plasma, in OCD patients can be interpreted as an effort to compensate for the decreased antioxidant capacity in erythrocytes. According to these results, we think that when evaluating oxidative stress parameters in psychiatric diseases such as OCD, it is important to study the thiol/disulfide ratio as well as the total oxidant capacity of the plasma, and it would be appropriate to measure these parameters not only in the plasma but also in the erythrocyte.Öğe The Evaluation of Premenstrual Dysphoric Disorder Incidence and it's Relationship with Antiepileptic Drugs in Epilepsy Patients(Kare Publ, 2013) Kamisli, Ozden; Kamisli, Suat; Kartalci, Sukru; Bakir, Meryem; Kaplan, Yuksel; Ozcan, CemalObjectives: Premenstrual dysphoric disorder (PMDD) is a condition characterized by psychiatric and somatic symptoms commonly seen in women of childbearing age. There are few studies investigating the prevalence of PMDD in patients with epilepsy. In this study we investigate the frequency of PMDD in epilepsy patients and evaluate the relationship between antiepileptic drugs and PMDD. Methods: The subjects were 93 women with epilepsy and 30 controls. Patients were divided into five subgroups according to their medications as carbamazepine, oxcarbazepine, valproic acide, lamotrigine, and levetiracetam. Each group were examined for the frequency of PMDD. In addition, the incidence of PMDD was compared according to antiepileptic drugs in subgroups. Results: The frequency of PMDD was similar in patients with and without epilepsy. Focal epilepsy group, especially temporal lobe epilepsy, has a higher incidence of PMDD, but similar results were also found in women without epilepsy. Looking at the relationship between antiepileptic treatments and PMDD, patients treated with lamotrigine had the lowest frequency. Conclusion: The frequency of PMDD was similar in patients with and without epilepsy. Focal epilepsy patients, especially temporal lobe epilepsy patients, had a higher incidence of PMDD. The LTG group had the lowest rate of PMDD. In terms of PMDD, LTG may be beneficial for young women with epilepsy.Öğe EVALUATION OF PSYCHIATRIST'S COMMUNICATION WITH PSYCHOSIS PATIENTS(Univ Chile, Centro Interdisciplinario Estudios Bioetica, 2022) Karatas, Mehmet; Kartalci, Sukru; Selcuk, Engin Burak; Yetis, Hakan; Karatas, Turgay; Gozukara, HarikaEvaluation of the physician-patient relationship is very important in determining priorities in medical practice and medicine. For this purpose, in this study the psychiatrist's communication with psychotic patients as a sensitive group was evaluated. A questionnaire was administered to 210 patients in a psychiatric clinic of Inonu University Hospital in Turkey to determine how the examination is performed in the facility for outpatients in the psychosis unit. According to the study conducted, it was observed that the evaluation score of the psychiatrist's communication with psychotic patients increased positively with increasing consultation duration. Our work is particularly noteworthy because it deals with a sensitive area, such as a group of psychiatric patients. The scores were obtained based on data from the evaluation of the questionnaires, which showed that the communication between the psychiatrist and the psychotic patient was conducted in a sensitive and careful manner, and without ethical problems.Öğe Forensic aspect of the frontal lobe syndrome: a case report(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2011) Kartalci, Sukru; Unal, Suheyla; Ozdemir, SerdalIn this case report, it is discussed a patient with frontal lobe syndrome (FLS) who was subjected to forensic and psychiatric observation. A 39 year-old woman have presented severe disabilities in daily life activities after traumatic brain injury. She showed slowness, reduction of emotion and apathy at her clinical evaluation. Despite the notably impairment in social behavior, she was unaware of this situation. Computerized tomography of head was conducted atrophy of frontal lobe. It was diagnosed as a FLS. FLS consists of two distinct clinical syndromes. The orbitofrontal syndrome is the most well known and consists of major antisocial behavior. Apathetic states lie at the other end of the syndrome. Psychiatry generally focuses to orbitofrontal syndrome in criminal behaviour. However in this case, it is discussed a patient with apathetic FLS in terms of forensic psychiatry. (Anatolian Journal of Psychiatry 2011;12:160-162)Öğe IL-4, TGF-?, NF-?B and MPO levels in Patients with Treatment Resistant Schizophrenia(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2016) Kartalci, Sukru; Erbay, Lale Gonenir; Zayman, Esra Porgali; Otlu, Onder; Karabulut, Aysun Bay; Kartalci, GulsenObjective: Schizophrenia is a chronic psychotic disorder in which genetics and environmental factors such as infection and the corresponding immune response play a role in the etiopathogenesis. The aim of this study was to compare some immune factors such as nuclear factor-kappa B (NF-kappa B) activation, myeloperoxidase (MPO), the anti-inflammatory cytokine interleukin-4 (IL-4), and regulatory cytokine transforming growth factor-beta (TGF-beta) in schizophrenia patients and an age- and gender-matched control group. Method: Plasma levels of IL-4, TGF-beta, MPO, and NF-kappa B activation in 20 subjects with treatment-resistant schizophrenia and 20 age- and gender-matched healthy controls were analyzed. Disease severity was evaluated using the Brief Psychiatric Rating Scale (BPRS). Results: Plasma TGF-beta levels were found to be significantly lower and NF-kappa B to be significantly higher in antipsychotic treatment-resistant schizophrenia patients than in controls in this study. No significant differences were found between the patient and control groups for serum IL-4 and MPO levels. Conclusion: The low TGF-beta level in treatment-resistant schizophrenia patients in the symptom exacerbation period indicates that there is inadequate Th1/Th2 balance. Large-scale studies are required to investigate whether this is responsible for resistance in schizophrenia. The fact that the increase in NF-kappa B that we found in treatment resistant schizophrenia patients in this study has also been reported in the first attack in untreated schizophrenia patients in previous studies indicates that NF-kappa B plays a role in the disorder's physiopathology from the beginning.Öğe Insular volume reduction in young male schizophrenia patients(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2020) Erbay, Mehmet Fatih; Kartalci, SukruObjective: Recent developments in neuroimaging have advanced the understanding of biological mechanisms underlying schizophrenia. Structural and functional abnormalities of the insular cortex have been reported in schizophrenia patients. Many studies have demonstrated that insula volume is lower in schizophrenia patients than healthy individuals. The present study aimed to compare insula volumes of young male schizophrenia patients with that of age-matched young healthy male subjects to eliminate age and gender bias. Methods: Twenty-three male schizophrenia patients meeting DSM-5 diagnostic criteria, who were at the age of 18-40 years, and age-matched 25 healthy male subjects were included into the study. All patients magnetic resonance imaging (MRI) procedure was completed. Insula volume of schizophrenia patients and healthy male volunteers was calculated using MRICloud method. Disease severity was assessed using Positive and Negative Symptom Scale (PANSS). Results: Volumes of both the left and the right insula were significantly lower in the patient group vs. the control group. Moreover, a positive correlation was determined between the right insula volume and the scores of positive symptom severity scale. Conclusion: Decreased insular volume is not a specific marker, but it may be a general marker regarding psychopathology. However, investigating whether the diagnostic specificity of insular cortex abnormalities in psychopathologies will be the focus of future studies.Öğe Matrix metalloproteinase 9 gene-MMP9-DNA methylation status in Turkish schizophrenia patients(Walter De Gruyter Gmbh, 2023) Karaaslan, Ezgi; Kartalci, Sukru; Bag, Harika Gozde Gozukara; Acar, CerenObjectives: Schizophrenia is a neuropsychiatric disease caused by disorders in brain development due to genetic and environmental factors. The interactions and mechanisms of the two main etiological factors are not fully understood despite neurobiological, clinical and genetic research and more research is needed. In this study, we aimed to investigate the DNA methylation differences in the matrix metalloproteinase 9 gene (MMP9) between schizophrenia and healthy control groups.Methods: Our study investigates DNA methylation patterns in the MMP9 gene in peripheral blood cells of schizophrenia patients. For this purpose, pyrosequencing method was used to analyze DNA methylation status of C-phosphate-G (CpG) regions in the 7th exon of MMP9 in 40 schizophrenia patients and 32 healthy individuals who admitted to our university hospital's psychiatry clinic.Results: In our results, it has been shown that there is a difference between MMP9 gene DNA methylations between healthy individuals and schizophrenia patients. Significant differences were found in the MMP9 gene exon 7 region in CpG 7-3, CpG 7-4, CpG 7-5 positions and mean methylation patterns between these two groups. Conclusions: This study provided evidence that DNA methylation differences may exist between schizophrenia patients and healthy individuals, and emphasized the epigenetic aspect of the disorder.Öğe Neurosteroid Levels in Patients with Obsessive-Compulsive Disorder(Korean Neuropsychiatric Assoc, 2015) Erbay, Lale Gonenir; Kartalci, SukruObjective Changes in serum neurosteroid levels have been reported in stress-related disorders such as anxiety and depression, but not in patients with obsessive-compulsive disorder (OCD). We thus investigated such changes in patients with OCD. Methods We compared the serum levels of progesterone, pregnanolone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEA-S), cortisol and testosterone in 30 patients with OCD and 30 healthy controls. Results When male and female patients were evaluated together, DHEA and cortisol levels were significantly higher in patients with OCD than the control group. When the genders were evaluated separately, DHEA and cortisol levels were higher in female patients than the female controls. The increase in DHEA levels in female patients is likely an effect of the hypothalamic-pituitary-adrenal (HPA) axis. In contrast, cortisol levels in male patients were higher than the control group, while testosterone levels were lower. The increased cortisol and decreased testosterone levels in male patients likely involves the hypothalamic-pituitary-gonadal (HPG) axis. Conclusion These findings suggest that neurosteroid levels in patients with OCD should be investigated together with the HPA and HPG axes in future studies.Öğe No evidence of androgenic neurosteroid involvement in pediatric OCD(Elsevier Science Bv, 2015) Erbay, Lale Gonenir; Ozcan, Ozlem Ozel; Kartalci, Sukru; Yuksel, Tugba; Kutuk, Meryem OzlemCertain androgenic neurosteroids have been shown to have a relationship with anxiety disorders in adults. Demonstrating these changes in pediatric patients as well is important in terms of elucidating the etiology of these disorders. The aim of this study was to investigate the testosterone, DHEA-S and cortisol levels in pediatric obsessive-compulsive disorder (OCD) patients. A total of 39 pediatric OCD patients aged 7-16 years and 34 healthy children of similar age and gender were included in this study. Serum total testosterone, DHEA-S and cortisol levels were measured by using the ELISA method and their relationship with clinical data was investigated. No statistically significant difference was found between the patient and control groups in terms of testosterone, DHEA-A and cortisol levels in the analyses performed (p=0.175, p=0.642. p=0.842. respectively). The results of this first study have revealed that testosterone, DHEA-S and cortisol levels in pediatric OCD patients are not different than in the controls. However, the fact that these neurosteroid levels have been found to differ between adult patients and controls previously indicates that neurosteroid changes may be a finding that appears during the course of anxiety disorders. (C) 2015 Elsevier Inc. All rights reserved.Öğe Oxytocin and Vasopressin Blood Levels in People with Post-Traumatic Stress Disorder(Aves, 2023) Zayman, Esra Porgali; Karabulut, Aysun Bay; Ozdemir, Serdal; Kartalci, SukruBackground: The neuroendocrine system and the hypothalamic-pituitary-adrenal axis are among the possible neurobiological factors that may be involved in the emergence and persistence of post-traumatic stress disorder. Here, we determined the levels of vaso-pressin and oxytocin in the peripheral blood of people with post-traumatic stress disorder, investigating their correlation with post-traumatic stress disorder symptoms. Methods: The study included patients with post-traumatic stress disorder according to the Diagnostic and Statistical Manual of Mental Disorders Version 4 and healthy controls. People who accepted to participate in the study, who did not have any additional diseases, who had the ability to understand the questionnaires, and who did not use medications during the 3 months preceding the study onset were enrolled. The levels of vasopressin and oxytocin were measured using the enzyme-linked immunosorbent assay. Results:Twenty-eight subjects with post-traumatic stress disorder and 19 healthy controls were included. The 2 groups were not significantly different in terms of oxytocin blood levels (P = .481). However, subjects with post-traumatic stress disorder had a significantly lower vasopressin level than controls (P < .001). We found no significant correlations of trauma duration and scale scores with oxytocin or vasopressin levels. Conclusion: The findings of this study show that blood vasopressin may play a role in post-traumatic stress disorder. Prospective studies based on a larger number of partici-pants are warranted to clarify how neuromodulators may affect the pathogenesis of post -traumatic stress disorder.Öğe Pituitary volume in patients with panic disorder(Pergamon-Elsevier Science Ltd, 2011) Kartalci, Sukru; Dogan, Metin; Unal, Suheyla; Ozcan, A. Cemal; Ozdemir, Serdal; Atmaca, MuradPanic patients have many functional deficiencies in the hypothalamic-pituitary-adrenal (HPA) axis. Previous studies have shown changed pituitary gland volume in some psychiatric disorders that have functional deficiencies in the HPA axis: However, to date no study has evaluated the pituitary gland volume in patients with panic disorder (PD). We investigated the pituitary gland volume in patients with PD (n = 27) and age- and sex-matched healthy controls (n = 27), using 1.5-T magnetic resonance imaging in this study. Analysis showed that patients with PD had significantly smaller pituitary volume compared to healthy subjects. Patients with agoraphobia especially had a significantly smaller pituitary volume than patients without agoraphobia. There was a significant relationship between the pituitary volume and both the severity of symptoms and the illness duration in the patient group. The results show that patients with PD have reduced pituitary volume, which may reflect the functional abnormalities seen in this disorder. These findings may help us better understand the pathology of PD. (C) 2010 Elsevier Inc. All rights reserved.
