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    Analysis of the association between anxiety and depression levels and oxidative stress levels
    (2020) Savrun, Atakan; Savrun, Seyda Tuba; Gokcen, Emre; Aygun, Ali; Kasko Arici, Yeliz; Turkarslan, Murat
    Aim: There is a balance between reactive oxygen species (ROS) and antioxidant systems preventing them in the organism. In cases where this balance is impaired, molecular and cellular functions are negatively affected. Thiol-disulfide homeostasis (TDH) is also affected by this imbalance. It has been reported that the balance between oxidative and anti-oxidative systems is disrupted in individuals with psychiatric diseases such as anxiety and depression. Accordingly, it was aimed to determine the level of TDH in the serum of students who took the oral internship exam.Material and Methods: Volunteer fifth grade students of Medical Faculty, 19 male and 21 female, was included in the study. Of the students included in the study, Beck depression and Beck anxiety, albumin, ischemia-modified albumin (IMA), total thiol (SH + SS), native thiol (SH) and SS levels were measured and SS / SH + SS %, SH / SH + SS % and SS / SH % were calculated before and after the oral internship exam. These data were compared with the association between anxiety and depression level changes before and after the oral internship exam.Results: It was observed that the anxiety levels of the participants before the oral exam decreased in the period after the oral exam (p0.001). It was detected that the level of depression of the participants before the oral exam decreased after the oral exam (p0,05). Conclusion: Oral internship exam of Medical Faculty is a factor increasing anxiety and depression levels of the students. However, no association was found between oral internship exam and TDH parameters.
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    Comparison of malondialdehyde, nitric oxide, adenosine deaminase and glutathione levels in patients with Entamoeba coli, Enterobius vermicularis, Giardia intestinalis, Demodex spp. positive, hydatid cyst and Toxoplasma gondii serum positi
    (2019) Kiran, Tugba Raika; Karaman, Ulku; Kasko Arici, Yeliz; Yildiz, Sevgi
    In this study we aimed to compare glutathione (GSH), adenosine deaminase(ADA), nitric oxide (NO) and malondialdehyde (MDA) values between the patients with and without different parasitic infections. Material and Methods: MDA, NO, ADA and GSH levels were studied in the serums of the patients group with T. gondii and cyst hydatid seropositivity and E. vermicularis and E. coli positive and the control group, while ADA levels alone were studied in G. intestinalis and Demodex spp. Results: There was a statistically significant difference between the groups in terms of the amounts of ADA, GSH, MDA, and NO according to results of the variance analysis (p0.001). Conclusion: Given the change in the levels of GSH and ADA activities and MDA and NO levels observed in patients with parasitic infection, over production of active neutrophils, macrophages, reactive oxygen radicals and reactive nitrogen species may be an indicator of accelerated oxidative stress and lipid peroxidation in these patients. Increased serum ADA activity in the group infected by E. coli might be resulted from fight of the immune system with parasites. Low serum ADA activity in the other parasitic infection groups may be explained by suppression of lymphocyte proliferation by macrophages that were activated by sporozoite antigens in the late period of the infection. Accordingly, determination of the levels of MDA, NO, ADA and GSH may be important in treatment follow up and control of parasitic infections.
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    Prevalence of Cyclospora cayetanensis and Cryptosporidium spp. children according to some variables
    (2021) Erturk, Emine Yurdakul; Karaman, Ülkü; Colak, Cemil; Direkel, Sahin; Kasko Arici, Yeliz
    In this study, the prevalence of Cyclospora cayetanensis and Cryptosporidium spp. were researched in children with parasitological investigations requested for a variety of reasons, regardless of immune status. The stool samples of 1057 pediatric patients with parasitological evaluation requested for a variety of reasons within two years were investigated under a microscopy using native-lugol, sedimentation and modified Kinyoun’s acid-fast stain methods. The mean age of the 1057 pediatric patients participating in the research were 8.07±4.32 years, 11.4% were identified to have coccidian parasites (Cyclospora cayetanensis and Cryptosporidium spp.). Evaluation according to age group found the majority of children positive for Cryptosporidium spp. were in the 6-12 year interval. These parasites were observed more frequently in the spring and summer seasons compared to other seasons. There was a significant correlation between parasite positivity and spring and summer seasons (p<0.001). Cryptosporidium spp. was identified to be a significant risk factor in terms of growth retardation (p<0.05). The incidence of Cyclospora cayetanensis and Cryptosporidium spp. is high in children. It was concluded that Cryptosporidium spp. positivity was a significant risk factor for growth retardation.