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Öğe ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats(Pergamon-Elsevier Science Ltd, 2017) Cakir, Murat; Duzova, Halil; Tekin, Suat; Taslidere, Elif; Kaya, Gul Busra; Cigremis, Yilmaz; Ozgocer, TubaAim: In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA(2)) inhibitors may have a protective effect on neurons. This study was aimed to investigate the protective effect of TRPM2 and PLA(2) inhibitor N-(p-amylcinnamoyl) Anthranilic Acid (ACA) in a neurodegenerative model induced by Okadaic Acid (OKA). Main methods: OKA (200 ng/10 mu l) was administered bilateral intracerebroventricularly as a single injection. Key findings: OKA-treated rats showed significant impairments of spatial memory in Morris Water Maze Test. OKA-induced memory-impaired rats showed increased numbers of degenerated neurons and Caspase-3, tau phosphorylated ser396, beta-amyloid positive cells in the hippocampus and cerebral cortex. Furthermore, OKA-treated rats exhibited significantly increased MDA, TNF-alpha levels, and decreased SOD, GSH-PX enzyme activates and GSH levels of the tissues. ACA administration ameliorated OKA-induced memory impairment in rats. The ACA treatment also increased SOD and GSH-PX enzyme activation and GSH levels, and conversely decreased the levels of MDA, TNF-alpha. It was found that the numbers of the degenerated neurons and Caspase-3 positive cells of cortex and hippocampus regions were significantly reduced. Significance: ACA administration attenuates the oxidative stress and neuroinflammation of OKA-induced neurodegeneration; and ameliorates the cognitive decline and neurodegeneration. (C) 2017 Elsevier Inc. All rights reserved.Öğe The Effect of Curcumin on Brain TRPM2 Channel Gene mRNA Expression Level in Experimental Alzheimer's Rat Model Induced by Application of Intracerebroventricular Streptozotocin(Karger, 2018) Durhan, Merve; Tunc, Selahattin; Tekin, Suat; Kaya, Gul Busra; Yildiz, Azibe; Cigremis, Yilmaz[Abstract Not Available]Öğe Effects of noopept on cognitive functions and pubertal process in rats with diabetes(Pergamon-Elsevier Science Ltd, 2019) Gurbuz, Perihan; Duzova, Halil; Yildiz, Azibe; Cakan, Pinar; Kaya, Gul Busra; Bag, Harika Gozde Gozukara; Durhan, MerveAim: Type 1 diabetes (T1DM) is a common chronic disease in childhood. Increasing insulin resistance in puberty gives rise to higher doses of insulin usage in treatment. Of this reason new approaches in treatment are needed. Noopept researches suggest it to have anti-diabetic properties. We tried to determine the effects of noopept on pubertal diabetes. Main method: The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats. The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept. T1DM model was induced by streptozotocin on postnatal 28th day. 0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days. Blood glucose and body weight measurements, puberty follow-up and MWM tests were performed. Hippocampus, hypothalamus and testis were evaluated histologically. Hypothalamic GnRH and kisspeptin were studied immunohistochemically. Serum LH, FSH and insulin, hippocampal homogenate NGF and BDNF levels were determined by ELISA. Key findings: Delayed puberty was normalized by noopept (p < 0.05). Blood glucose levels were lower in noopept-administered diabetic groups (p < 0.05). Noopept decreased HOMA-IR in insulin administered diabetic group (p < 0.05). Number of degenerated cells in hippocampus and testis were higher in diabetes control group when compared with other groups (p < 0.05). GnRH immunoreactivity in Diabetes + Noopept group was increased when compared to insulin + noopept group (p = 0.018). There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05). Significance: Noopept may have positive effect in treatment of pubertal diabetes.Öğe Effects of Noopept on Hippocampal NGF and BDNF Levels and Cognitive Functions of Prepubertal Rats with Streptozotocin-Induced Diabetes(Karger, 2018) Gurbuz, Perihan; Duzova, Halil; Kaya, Gul Busra; Cakan, Pinar; Durhan, Merve[Abstract Not Available]Öğe Effects of Noopept on Pubertal Process in Streptozosin-induced Diabetic Prepubertal Rats(Wiley, 2017) Gurbuz, Perihan; Duzova, Halil; Yildiz, Azibe; Kaya, Gul Busra; Bag, Harika Gozukara; Taslidere, Asli Cetin; Gul, Ceren[Abstract Not Available]Öğe Effects of Propolis on Cytokine Levels and Spatial Memory Induced by Lithium Pilocarpine in the Experimental Status Epilepticus Model in the Rats(Wiley-Blackwell, 2015) Kaya, Gul Busra; Emre, Memet Hanifi[Abstract Not Available]Öğe Effects of Propolis on Spatial Memory and Hippocampus of Lithium-Pilocarpine-Induced Status Epilepticus in Rats(Wiley, 2018) Kaya, Gul Busra; Emre, Memet Hanifi; Yildiz, Azibe; Vardi, Nigar[Abstract Not Available]Öğe Investigation of the effects of thalidomide against global cerebral ıschemia-reperfusion ınjury inrats(KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND, 2018) Mete, Ugur Cem; Ozhan, Onural; Parlakpinar, Hakan; Yildiz, Azibe; Vardi, Nigar; Durhan, Merve; Cigremis, Yilmaz; Kaya, Gul Busra; Acet, AhmetÖğe Investigation of the Neuroprotective Effect of N-(p-amylcinnamoyl) Anthranilic Acid on Hippocampal Endoplasmic Reticulum Stress in WAG/Rij Rats with Absence Epilepsy(Wiley, 2022) Kaya, Gul Busra; Duzova, Halil; Kaya, Mehmet; Dundar, Muhammed; Koc, Ahmet[Abstract Not Available]
