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Öğe Aplazia Kutis Konjenita Tip VI (Bart Sendromu) Olgusu(2019) Gökçe, İsmail Kürşad; Guliyeva, Lale; Turgut, Hatice; Kaya, Hüseyin; Yılmaz, Ercan; Özdemir, RamazanBart sendromu (aplazia kutis konjenita tip VI olarak ta adlandırılır) aplazia kutis konjenita, epidermolizis bülloza ve distrofik tırnaklarla karakterize genetik bir hastalıktır. Lokalize cilt defektlerine intrauterin dönemde oluşabilen büllöz lezyonların neden olduğu düşünülmektedir. Biz doğumdan hemen sonra her iki ayak bileği ve ayak sırtında cilt defektleri saptanan bir olgu sunduk. Hastamızda postnatal üçüncü günde basıya maruz kalan bölgelerde büllöz lezyonlar gelişti. Aile öyküsü ve tırnaklardaki distrofik değişikliklerle Bart sendromu tanısı aldı. Takip eden günlerde konservatif tedavi (topikal kremler ve ıslak gazlı bez) ile cilt lezyonlarında düzelme izlendi. Hasta postnatal 30. günde taburcu edildi. Klinik kontrollere getiril- meyen hastanın postnatal 57 günlükken öldüğü öğrenildiÖğe Demographic characteristics of cases diagnosed with cleft palate(2020) Kaya, Hüseyin; Guliveya, Lale; Özdemir, Ramazan; Gökçe, İsmail Kürşad; Deveci, Mehmet FatihAbstract: Aim: The aim of this study is to retrospectively evaluate the cleft palate cases in our neonatal clinic and to examine the associated clinical features, predisposing factors, accompanying anomalies, additional fidings, treatment approaches and follow-up results. Material and Methods: The study included babies that were diagnosed with cleft palate in our Neonatal Intensive Care Unit between January 2014 and December 2018. The etiological risk factors, demographic characteristics, clinical features and concomitant malformations of the patients included in the study were retrospectively recorded from the patient fies and the database system of our hospital. Results: A total of 70 cleft palate patients were observed over a fie year period. Of these, 30 (42.9%) were female and 40 (57.1%) were male. The mean gestational age was 38 ± 2.9 weeks and the mean birth weight was 2845 ± 700 grams. 77.1% of the patients were found to additionally have cleft lips. 27 patients (38.5%) had cardiac defects, 18 (25.7%) had central nervous system anomalies and 4 (5.7%) had hypothyroidism. 24 (34.3%) of the parents were consanguineous. The median age at the time of the initial operation was 13 months for cleft palate cases and 5 months for cleft lip cases. Conclusion: As a result, treatment and follow-up of patients with cleft palate defect requires a multidisciplinary approach. These patients should undergo a thorough examination and evaluation. Since many syndromes or malformations may accompany the palate defects, these cases should be investigated with respect to genetic disease and other system anomalies.Öğe The effect of defect size on mortality and morbidity in patients withneural tube defect(2022) Turgut, Hatice; Özdemir, Ramazan; Gökçe, İsmail Kürsad; Kaya, Hüseyin; Önal, Selami ÇagatayAim: Neural tube defects (NTD) occur due to errors in the closing of neural canal in embryo. All over the world, the incidence of all forms of NTD varies between 1.4 and 2 in every 1000 live births. The aim of the present study was to investigate the short term prognosis, accompanying anomalies and complications in patients with NTD and to evaluate the relation between defect sizes. Material and Methods: Patients who applied to Inonu University Neonatology Department between January 2010 and December 2017 with the diagnosis of NTD and were operated on were included in the study. Babies who died within the first 24 hours were excluded from the study. Patients were divided into two groups according to the size of NTD; < 5 cm (Group 1) and ? 5 cm (Group 2). Approval for the study was obtained from local ethics committee. Results: Overall 133 infants were included in the study. Mean birth weight was 3155 ± 531 g and mean duration of pregnancy was on 38.1 ± 1.8 weeks. Of NTD’s 82% was located in lumbosacral region. 90.2% of the patients underwent operation within the first 24 hours. Parameters such as hydrocephalus, need for shunt, need for flap in tissue defects, the rate of postoperative complications, duration of hospitalization, mortality and the use of antibiotics were found to be at a higher rate in cases whose defect size was ?5 cm than in those whose defect size was < 5 cm (p < 0.005). Postoperative complications developed in 48.1% of the patients. The most common complications were observed to be cerebrospinal fluid (CSF) leakage (24.1%) and bladder dysfunction (7.5%). Conclusion: In patients with NTD, as the size of the defect increases, additional interventions, complications, hospitalization rates and mortality increase as well. Therefore, it is recommended that health care personnel should take care against problems in the management of this group of patients and inform familes beforehand on these issues.Öğe Gebelerde ve Yenidoğan Bebeklerde D Vitamini Korelasyonu(2020) Karakuş Sert, Tuba; Kaya, Hüseyin; Yiğit, Özgül; Yavuz, Sinan; Sert, AbdullahGiriş: Gebelikte ve emzirme döneminde güneş ışığına yetersiz maruz kalmak ve yetersiz vitamin D almak, hem anne sütünde hem yenidoğan bebekte yetersiz vitamin D düzeylerine neden olan önemli bir sağlık sorunudur. Biz bu çalışmamızda maternal vitamin D düzeyinin yenidoğan bebeklerin kordon kanı vitamin D düzeylerine ilişkisi ve etkisini saptamayı amaçladık.Gereç ve Yöntem: Gestasyon haftası 37 ve üstünde doğum yapan 108 bebek ve anneleri çalışmaya dahil edildi. Annelerin yaşları, meslekleri, gebelik süresince vitamin desteği alıp almadıkları, günlük süt ve balık tüketimleri, giyinme tarzları ve güneşte kalma süreleri sorularak bir anket formu oluşturuldu. Gebe annelerden doğum öncesi doğum salonunda, bebeklerinden ise doğumdan hemen sonra göbek kordonundan venöz kan alındı.Bulgular: Annelerin D vitamin düzeyi ortalama değeri 4.6 ± 2,7 ng/ml ve bebeklerin D vitamini düzeyi ortalama değeri 5.2 ± 3,5 ng/ml olarak düşük saptandı. Annenin D vitamin değeri ile bebeğin D vitamin değeri arasındaki anlamlı (p ? 0,05) korelasyon mevcuttu.Sonuç: Çalışmamızda anne ve yenidoğan bebeklerinde yüksek oranda vitamin D eksikliği görülürken, anne ile yenidoğan bebeklerin D vitamini düzeylerinin de korele olduğu görüldü. Annelerin D vitamini eksikliğinin zamanında tanı alıp tedavi edilmesinin bebeklerde gelişebilecek D vitamini eksikliğini önleyebileceğini düşünmekteyiz. Anne adaylarının, gebelik ve emzirme dönemindeki annelerin, tüm bebeklerin yeterli miktarda D vitamini alımının sağlanması gerekir.Öğe Mortality related factors on hypoxic ischemic encephalopathic patients treated with therapeutic hypothermia: an 11-year single-center experience.(2022) Deveci, Mehmet Fatih; Turgut, Hatice; Alagöz, Meral; Kaya, Hüseyin; Gökçe, İsmail Kürşad; Özdemir, RamazanBackground/aim: Hypoxic-ischemic encephalopathy (HIE) is a condition that may cause multiple organ dysfunction and has a high rate of mortality and morbidity. Therapeutic hypothermia is the only proven treatment that decreases the sequel and mortality rate of neonates that are born after 36 weeks of pregnancy and have moderate-severe HIE. Material and method: Our study was a single-center, retrospective study that includes newborns (gestational age ? 36 weeks) who underwent therapeutic hypothermia due to hypoxic-ischemic encephalopathy between 2010 and 2020. We evaluated 125 patients who were diagnosed with moderate to severe HIE and received therapeutic hypothermia. Demographic and clinical data were obtained from electronic medical records and patient files. The patients were separated into two groups as exitus group (n = 39) and discharged group (n = 86). We aimed to evaluate factors affecting mortality. Results: We determined that the median resuscitation times were longer in the delivery room [retrospectively, 10th minutes (0–30) vs. 1 min (0–20), p < 0.05], the tenth min APGAR scores were lower [respectively, 4 (0–7) vs. 6 (3–10), p < 0.05], and the median pH value in the first blood gas taken was lower [respectively, 6.87 (6.4–7.14) vs. 6.90 (6.58–7.12), p < 0.05] in the exitus group. We also determined that multiple organ dysfunction is seen more often in the exitus group. Conclusion: This study demonstrated that the depth of acidosis in the blood gas, multiple organ dysfunction, and the existence of earlyonset seizures are the signs of poor prognosis. Therefore, physicians need to be aware of such prognostic factors to follow these patients more closely in terms of possible complications and to inform their parents.