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    The effect of valproate on bone mineral density in adult epileptic patients
    (Academic Press Ltd Elsevier Science Ltd, 2004) Boluk, A; Guzelipek, M; Savli, H; Temel, I; Ozisik, HI; Kaygusuz, A
    The effect of long-term valproate (VPA) treatment on bone mineral density (BMD) in adult epileptic patients is not clearly known, although several studies have been done in children. In adult epileptic patients (it = 50; 24 men, 26 women) treated with VPA, the bone mineral density at lumbar level (L I -L4) and neck, trochanter, and intertrochanter regions of left femur was studied by dual energy X-ray absorptiometry (DXA) at the beginning of the study and after 6 months, with the specific aim to evaluate the effect of long-term valproate monoteraphy on bone mineral density. Routine biochemical parameters were also evaluated. Sixty healthy control subjects were evaluated. Control subjects were similar to patient group with respect to age, race (all White), geographic area, and socioeconomic status. Lumbar and femural BMD values were significantly lower in patient group than control group (0.814 +/- 0.157 g/cm(2) versus 0.894 +/- 0.102 g/cm(2), P = 0.003) and (0.824 +/- 0.144 g/cm(2) versus 0.906 +/- 0.104 g/cm(2), p = 0.001), respectively. Osteopenia were detected in 13 of 60 control subjects (22%) and the others had no osteoporosis. In epileptic group, osteoporosis and osteopenia were detected in 8 subjects (16%), and in 26 subjects (52%), respectively. In epileptic group 16 subjects were normal (32%) at the lumbar regions, and 7 had osteoporosis (14%), 28 had osteopenia (56%), and 15 were normal (30%) at the femoral region. In the second measurements of the patients on valproate treatment, after 6 months, all of the DXA BMD values had worsened compared with the first measurements (P = 0.001 for lumbar BMD values and P = 0.004 for femural BMD values). In the patient group, a significant inverse cot-relation was observed between duration of valproate therapy and all DXA BMD values in the first and second measurements. Parathyroid hormone, alkaline phosphatase, and phosphor levels of patients were significantly higher than those of control group (52 +/- 11 pg/ml versus 46 +/- 13 pg/ml, P = 0.013), (113 +/- 32 U/l versus 95 +/- 36 U/l, P = 0.006), and (4.50 +/- 0.5 mg/dl versus 4.0 +/- 0.7 mg/dl, P = 0.0001), respectively. However, all of the parameters were within the normal reference ranges. It has been concluded that long-term (more than one year) valproate treatment induces a decrease in bone mineral density in epileptic adults. However, the multivariate analysis did show no association between BNID changes and parathyroid hormone, alkaline phosphatase or phosphorus levels. (C) 2003 Elsevier Ltd. All rights reserved.
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    The effects of different skill training on neuromuscular electric activity of the limbs in amateur sportsmen
    (Ios Press, 2005) Kaygusuz, A; Meric, F; Ertem, K; Duzova, H; Karakoc, Y; Ozcan, C
    In this study, we investigated the effects of different skills of sport on electromyography (EMG) of limb muscles in sportsmen. Two different skill groups of sport consisted of 10 soccer players who use extensively lower limb, and 10 handball, basketball and volleyball players with selectively high usage of the upper limb. Surface EMG (sEMG) were recorded from the abductor pollicis brevis and gastrocnemius muscles of subjects. In addition, Hoffmann reflex (H-reflex) were recorded from the lower limb of participants. EMG findings of two groups were compared with each other and age-sex matched sedentary controls. Amplitude and area of sEMG recorded from gastrocnemius muscle of handball -basketball-volleyball players were significantly higher than those of soccer players (p < 0.01 and p < 0.05), whereas not significantly different based on the abductor pollicis brevis (p > 0.05 in both). F-response of both muscles and H-reflex of handball-basketball-volleyball players were also significantly higher from those of soccer players and control group (p < 0.05 for all), whereas only F-response of gastrocnemius muscle of soccer player was significantly lower than that of control group (p < 0.05). We conclude that EMG amplitude of gastrocnemius muscle, F-response and H-reflex times of lower limbs increase in handball-basketball-volleyball players due to the nature of training skills. Volleyball, handball or basketball training contributes to neuromuscular differences in both upper and lower extremities more than football training because both extremities are extensively used in these sport categories.
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    s-domain analysis of lightning surges in three-phase systems using nonuniform single-phase line model
    (Springer, 2005) Kaygusuz, A; Mamis, MS; Akin, E
    Surge response of the transmission tower in a three-phase transmission system is computed using s-domain nonuniform single-phase transmission line modelling. First, tower top voltage is obtained considering the tower and the ground wire by excluding the effect of the phase conductors, and then the induced voltages on the phase conductors as a result of the current flowing through the ground wire are computed using the magnetic coupling between the ground wire and the phase conductors. The first step of the analysis is the formulation of the system response in the s-domain, and the second step is the frequency to time domain conversion, which is carried out using fast inverse Laplace transform (FILT). The voltages on the phase conductors and the voltages across the tower insulators are computed, and some of the results obtained using s-domain analysis are compared with those obtaining using electromagnetic transients program (EMTP). The effect of frequency dependence of the line parameters is investigated.