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Öğe A bioactive product lipoxin A4 attenuates liver fibrosis in an experimental model by regulating immune response and modulating the expression of regeneration genes(2019) Kurtoğlu, Elçin Latife; Kayhan, Başak; Gül, Mehmet; Kayhan, Burçak; Akdoğan Kayhan, Meral; Karaca, Zeynal Mete; Yeşilada, ElifAbstract: Background/Aims: Lipoxin A4 (LXA4), an anti-inflammatory lipid mediator, regulates leukocyte cellular activity and activates gene transcription. The therapeutic effect of LXA4 on liver fibrosis and its mechanism on the immune system are largely unknown. Because the regenerative capacity of hepatocytes in acute and chronic liver failure models of mouse increases by silencing MKK4, we aimed to investigate the effect of parenteral administration of LXA4 on the genes responsible for regeneration of liver, namely MKK4, MKK7, and ATF2, and visualize the therapeutic effects in an experimental model. Materials and Methods: Fibrosis was induced in mice by administration of thioacetamide (TAA). LXA4 was administered during the last two weeks of fibrosis induction. The fibrosis level was measured by Knodell scoring. The liver function was measured by analyzing serum ALT, AST, and AP levels. Expression levels of genes responsible for liver fibrosis (TGF-?) and cell regeneration (MKK4, MKK7, and ATF2) have been measured by RT-PCR analysis. Inflammatory and anti-inflammatory cytokine levels were measured in serum samples and liver homogenates by Enzyme Linked Immunosorbent Assay (ELISA). Ultrathin sections were examined using a transmission electron microscope and analyzed. Results: We observed significant healing in liver of the LXA4-treated group, histologically. This finding was in parallel with reduction of serum ALT, AST, but not AP levels. TGF-? and MKK4 expressions were significantly reduced in the LXA4-treated group. Administration of LXA4 caused significant elevation of IL-10 in systemic circulation; however, that elevation was not detected in liver homogenates. Nevertheless, significant reductions in TNF-? and IL-17 have been observed. Conclusion: The anti-inflammatory effect of LXA4 maintains the regenerative capacity of liver during fibrosis in an experimental liver fibrosis model. LXA4 may be therapeutically beneficial in liver fibrosis.Öğe Can IL 2R alpha be a valuable marker along with CA 19 9 in the diagnosis of chronic pancreatitis and pancreatic cancer(International journal of biological markers, 2004) Kayhan, Başak; Kayhan, Burçak; Akdoğan, MeralPancreatic cancer is characterized initially by non-specific abdominal symptoms followed by rapid tumor progression. Although chronic pancreatitis is a benign disorder, it can be one of the causative factors of pancreatic cancer. The level of the tumor marker carbohydrate antigen 19-9 (CA 19-9) in pancreatic cancer does not correlate with the stage of the neoplasm. Soluble interleukin 2 receptor (sIL-2R) is a cytokine that shows increased levels during some inflammatory processes and malignant disorders. AIM: Our aim in this study was to investigate whether sIL-2Ralpha levels can be used in association with CA 19-9 in the early diagnosis of pancreatic cancer and chronic pancreatitis. PATIENTS: Serum samples were obtained from the blood of 21 pancreatic cancer patients without distant metastasis who were deemed inoperable, 16 chronic pancreatitis patients and 20 normal volunteers. RESULTS: We did not find any significant differences in CA 19-9 levels between normal controls and patients with chronic pancreatitis. There was a significant difference in the levels between the control group and the pancreatic cancer group (p = 0.003) and between patients with chronic pancreatitis and those with pancreatic cancer (p = 0.004). Although there was no significant difference in sIL-2Ralpha levels between the control group and the patient groups, we found a slight correlation between sIL-2Ralpha and CA 19-9 levels in the pancreatic cancer group (p = 0.003, r = 0.623) and a more marked correlation in the chronic pancreatitis group (p < 0.01, r = 0.751). CONCLUSION: According to our results, sIL-2Ralpha alone is not a good candidate marker in the diagnosis of pancreatic cancer; it can, however, be used in association with CA 19-9 for this purpose.Öğe The comparison of the effect of somatostatin and SMS 201 995 on enzyme change following endoscopic retrograde cholangiopancreotography(Gazi MEdical Journal, 1998) Görgül, Ahmet; Kayhan, Burçak; Menteş, Bülent; Kayhan, Başak; Akı, ZeynepÖğe Prophylactic effect of somatostain on ERCP induced pancreatitis(Gazi Medical Journal, 1996) Görgül, Ahmet; Kayhan, Burçak; Kayhan, Başak; Menteş, Bülent; Aybay, Cemalettin; Cindoruk, Mehmet; Akçalı, Zafer; Dumlu, Şükrü; İmir, TurgutÖğe Serum pankreatik elastaz 1 acil servislerde akut ankreatit tanısı için güvenilir bir yöntem olabilir mi?(Akademik Gastroenteroloji Dergisi, 2006) Kayhan, Başak; Kayhan, Burçak; Özaslan, Ersan; Özer, DiğdemAcil servise karın ağrısı ile başvuran hastaların bir kısmında, rutin radyolojik ve laboratuvar testleri ile akut pankreatit teşhis edilememektedir. Bu çalışmada, akut pankreatit tanısında serum elastazın duyarlılığı araştırılmıştır. Gereç ve yöntem: Acil servise karın ağrı- sı ile başvuran, tanı almadan önce karın ağrısı kendiliğinden iyileşen, aynı zamanda radyolojik ve laboratuvar bulguları normal olan 80 hastanın serum elastaz düzeyine bakılmıştır. Bulgular: Laboratuvar sonuçları ve USG bulguları normal olan 2 olguda, elastaz düzeyi yüksek bulunmuş- tur. Bu olgular daha sonra pankreatit bulguları göstermiş ve hastaneye yatırılmıştır. Sonuç: Serum pankreatik elastaz, acil serviste akut pankreatit tanısında diğer laboratuvar testlerinden daha özgül ve duyarlı olabilir.
