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Öğe Neuroprotective effect of transient receptor potential Vanilloid 1 agonist capsaicin in Alzheimer?s disease model induced with okadaic acid(Elsevier, 2023) Cakir, Murat; Yuksel, Furkan; Ozkut, Mahmud Mustafa; Durhan, Merve; Kaymak, Emin; Tekin, Suat; Cigremis, YilmazBackground: The presence of Transient Receptor Potential Vanilloid 1 (TRPV1) channels was detected in many regions of the human and rat brain, including the cortex and hippocampus. TRPV1 channels have functions such as the modulation of synaptic transmission and plasticity and the regulation of cognitive functions. Previous studies conducted with TRPV1 agonists and antagonists show that this channel is associated with the neuro-degenerative process. In the present study, the purpose was to investigate the effects of capsaicin, which is a TRPV1 agonist, and capsazepine, a TRPV1 antagonist, in the Alzheimer's Disease (AD) model that was induced by intracerebroventricular (ICV) administration of okadaic acid (OKA). Methods: The AD-like experimental model was created with bilateral ICV OKA injection. Intraperitoneal capsaicin and capsazepine injections were administered to the treatment groups for 13 days and histological and immu-nohistochemical examinations were performed from the cortex and hippocampal CA3 regions of the brain. The Morris Water Maze Test was used for spatial memory measurement.Results: ICV OKA administration increased the levels of caspase-3, phosphorylated-tau-(ser396), A beta, TNF-alpha, and IL1-beta, from the cortex and hippocampal CA3 regions of the brain and decreased the phosphorylated-Glycogen synthase kinase-3 beta-(ser9) levels. In addition, the OKA administration corrupted the spatial memory. The TRPV1 agonist capsaicin reversed the pathological changes induced by ICV OKA administration, but not the TRPV1 antagonist capsazepine.Conclusions: It was found in the study that the administration of the TRPV1 agonist capsaicin reduced neuro-degeneration, neuroinflammation, and deterioration in spatial memory in the AD model induced by OKA.Öğe The protective effect of cannabinoid type 2 receptor activation on renal ischemia-reperfusion injury(Springer, 2019) Cakir, Murat; Tekin, Suat; Doganyigit, Zuleyha; Cakan, Pinar; Kaymak, EminKidney ischemia reperfusion (IR) injury is an important health problem resulting in acute renal failure. After IR, the inflammatory and apoptotic process is triggered. The relation of Cannabinoid type 2 (CB2) receptor with inflammatory and apoptotic process has been determined. The CB2 receptor has been shown to be localized in glomeruli and tubules in human and rat kidney. Activation of CB2 receptor with JWH-133 has been shown to reduce apoptosis and inflammation. In this study, it was investigated whether CB2 activation with selective CB2 receptor agonist JWH-133 was protective against renal IR injury. Male Sprague-Dawley rats were divided into 5 groups (n=45). Bilateral ischemia was treated to the IR group rat's kidneys for 45 min and then reperfusion was performed for 24 h. Three different doses of JWH-133 (0.2, 1 and 5 mg/kg) were administered to the treatment groups at the onset of ischemia. The JWH-133 application at three different doses decreased the glomerular and tubular damage. Additionally, in the renal tissue, nuclear factor-kappa B, tumour necrosis factor alpha, interleukin-1beta, and caspase-3 levels decreased immunohistochemically. Similarly, JWH-133 application decreased the serum tumour necrosis factor alpha, blood urea nitrogen, creatinine, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, Cystatin C, interleukin-18, interleukin-1beta, interleukin-6, and interleukin-10 levels. We found that JWH-133 and CB2 receptor activation had a curative effect against kidney IR damage. JWH-133 may be a new therapeutic agent in preventing kidney IR damage.Öğe TRPV1 Agonist Capsaicin Reduces Neurodegeneration in Alzheimer's Disease Model Induced with Okadaic Acid(Wiley, 2023) Cakir, Murat; Yuksel, Furkan; Ozkut, Mahmud Mustafa; Tekin, Suat; Kaymak, Emin[Abstract Not Available]
