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Öğe Computed tomographic perfusion imaging for the prediction of response transarterial radioembolization with Yttrium-90 glass microspheres of hepatocellular carcinoma (vol 25, pg 366, 2021)(Verduci Publisher, 2021) Kaplan, E.; Kutlu, R.; Erbay, M. F.; Kahraman, A.; Kekilli, E.; Karadag, M. Otlu; Kaplan, S.[Abstract Not Available]Öğe Effects of different durations of treadmill training exercise on bone mineral density in growing rats(Inst Sport, 2008) Ertem, K.; Karakoc, Y.; Duzova, H.; Kekilli, E.; Emre, M. H.; Kilinc, E.; Yagmur, C.In this study, we aimed to investigate the effects of different durations of treadmill training exercise (daily for 30 min and 60 min) on bone mineral density (BMD) in young growing rats. Training consisted of treadmill running at 5 days per week during a period of 13 weeks. The rats in 30 min and 60 min exercise groups began to training on day 63 of life and had maintained for at least a week, with a minimal progression as a guide to the rats' training and adaptation to the treadmill. Running time was gradually increased from 15 min to 30 and 60 min per session for two exercise groups respectively. Control rats were kept in the cages at the same environmental conditions and daily inspected to control their health. At the end of 13 weeks, bone mineral densities of the bilateral tibia of all rats were measured with dual-energy X-ray absorptiometry (DEXA) (QDR 4500/W, Hologic Inc., Bedford, MA, USA) and results were evaluated. There were significantly increases in BMD of right and left tibia of rats in 30 min exercise group at post-exercise period (p<0.01 for both sides) when compared to the control group. BMD of right and left tibia of rats were also correlated with each other (r=0.556 and p=0.003). Otherwise, there is a positive correlation between pre- and post-exercise body weights of rats (r=0.588 and p=0.002). From our results, we concluded that subjects should perform moderate running exercise for development of bone mass and its protection during the lifelong. However, intensity and duration of performing exercise are required to put in order for every ages or actual physical conditions.Öğe Factors affecting the accuracy of 18F-FDG PET/CT in detecting additional tumor foci in breast cancer(Athens Medical Soc, 2021) Simsek, A.; Kutluturk, K.; Comak, A.; Akatli, A.; Kekilli, E.; Unal, B.OBJECTIVE To evaluate the effectiveness of F-18-FDG PET/CT for detecting additional tumor foci in breast cancer. MATERIAL-METHOD The data were reviewed retrospectively of 232 women who underwent F-18-FDG PET/CT examination prior to breast cancer surgery between January 2013 and December 2018. RESULTS Additional tumor foci were suspected in 95 cases on F-18-FDG PET/ CT, which were confirmed by histopathological analysis in 81 cases. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of F-18-FDG PET/CT in detection of additional tumor foci were 77.7%, 79.48%, 66.3%, 87.32%, and 79.23%, respectively. The false negative and false positive rates were 22.22% and 20.51%, respectively. In univariate analysis, only the patient's age was positively associated with accuracy of F-18-FDG PET/CT in detecting additional tumor foci. The accuracy was lower in women aged <= 50 years, with a substantial increase in false positive findings in women in that age group. CONCLUSIONS F-18-FDG PET/CT alone cannot replace conventional diagnostic procedures for evaluating additional tumor foci in breast cancer, as a substantial increase in false positive findings is recorded with this method in women aged <= 50 years old.Öğe Factors affecting the accuracy of 18F-FDG PET/CT in evaluating axillary metastases in invasive breast cancer(Wolters Kluwer Medknow Publications, 2019) Kutluturk, K.; Simsek, A.; Comak, A.; Gonultas, F.; Unal, B.; Kekilli, E.Background and Aim: There are conflicting results of studies on accuracy of positron emission tomography (PET)/computed tomography (CT) for axillary staging. The aim of this study is to determine the factors affecting the efficacy of 18F-fluorodeoxyglucose (F-18-FDG) PET/CT in detecting axillary metastases in invasive breast cancer. Materials and Methods: Data of 232 patients with invasive breast cancer who underwent F-18-FDG PET/CT examination before surgery between January 2013 and September 2017 were reviewed retrospectively. Histopathological examination of axillary lymph nodes (ALNs) was used as a reference to assess the efficacy of F-18-FDG PET/CT in detecting axillary metastases. Results: While 134 (57.8%) patients had axillary metastases as detected in F-18-FDG PET/CT scans, histopathologically axillary metastases were detected in 164 (70.7%) patients. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of F-18-FDG PET/CT in detection of axillary metastasis were 72.56%, 77.94%, 88.8%, 54%, and 74.1%, respectively. The false-negative and false-positive rates were 27.4% and 22%, respectively. In univariate analysis, patients' age, estrogen receptor positivity, higher ALN SUVmax, greater tumor size, and lymph node size determined by F-18-FDG PET/CT were all significantly associated with accuracy of F-18-FDG PET/CT for axillary metastasis. In multivariate analysis, tumor size determined by F-18-FDG PET/CT and ALN SUVmax were independent variables associated with axillary metastasis. The accuracy of F-18-FDG PET/CT for axillary metastasis was higher in patients with a larger tumor (>= 19.5 mm) and a higher ALN SUVmax (>= 3.2). Conclusion: F-18-FDG PET/CT should not be routinely used for axillary staging, especially in patients with small tumors. It cannot eliminiate the necessity of sentinel lymph node biopsy. When it is used, both visual information and optimal cut-off value of axillary node SUVmax should be taken into consideration.Öğe Transient Bone Loss of Distal Radius and Ulna Following Clean-Cut Tendon Injuries, Repair and Passive Mobilization(Springer, 2005) Kekilli, E.; Ertem, K.; Yagmur, C.; Atasever, A.; Elmali, N.; Harma, A.; Ceylan, F.[Abstract Not Available]
