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Öğe Bioactive contents, In vitro antiradical, antimicrobial and cytotoxic properties of rhubarb (Rheum ribes L.) extracts(Taylor & Francis Ltd, 2020) Keser, Serhat; Keser, Fatma; Karatepe, Mustafa; Kaygili, Omer; Tekin, Suat; Turkoglu, Ismail; Demir, ErsinRheum ribes L. (rhubarb) is belonging to Polygonaceae, and its roots and fresh shoots are consumed as vegetable in Turkey. This plant is considered to be one of the most important pharmaceutical raw materials in Middle East. In this study, the antiradical, antimicrobial, cytotoxic and bioactive properties of water, ethanol, and methanol extracts of R. ribes stems were determined. R. ribes stems water, ethanol and methanol extracts are better scavenged ABTS(center dot+) (99.27, 99.91, and 99.88%), DPPH center dot (83.11, 81.42, and 83.26%), and OH center dot radicals (93.49, 94.21, 95.86%) than standard antioxidant BHA (95.32, 80.49, and 93.78%). Stems of R. ribes abundantly include bioactive compounds, dominated by rutin, catechin, caffeic acid, ferulic acid, alpha-tocopherol and vitamin D. These extracts show effective cytotoxic properties against PC-3, A2780, HCT-116 and MCF-7 cancer cell lines at 24h. It is found that R. ribes contain high amount important bioactive contents, and has effective antiradical and cytotoxic properties.Öğe Determination of Anticancer and Antimicrobial Properties of Alcea calvertii(Wiley-Blackwell, 2016) Keser, Serhat; Tekin, Suat; Kaygili, Omer; Keser, Fatma; Turkoglu, Ismail; Turkoglu, Semra; Kirbag, Sevda[Abstract Not Available]Öğe The Effect of Hypericum scabrum on the Human Prostate, Colon and Breast Cancer(Wiley-Blackwell, 2016) Keser, Serhat; Tekin, Suat; Kaygili, Omer; Keser, Fatma; Sandal, Suleyman[Abstract Not Available]Öğe In vitro Antiradical, Antimicrobial and Antiproliferative Activities and Phytochemical Compositions of Endemic Alcea calvertii (Boiss) Boiss. Flowers(2020) Keser, Serhat; Keser, Fatma; Tekin, Suat; Kaygılı, Ömer; Turkoglu, Ismail; Demır, Ersin; Karatepe, Mustafa; Kırbağ, Sevda; Yılmaz, Okkes; Sandal, Suleyman; Turkoglu, SemraAbstract: Alcea calvertii (Boiss) Boiss. is belonged to Malvaceae family, and it is a perennial herbaceous endemic plant. Alcea genus plants are grown as ornamental plants in the gardens. In the present study, the antiproliferative, antimicrobial, antiradical activities and phytochemical compositions of ethanol, water, methanol and acet one extracts of A. calvertii flowers were examined. A. calvertii flowers water, ethanol, methanol and acetone extracts are lower scavenged DPPH, ABTS and OH radicals than standard antioxidant trolox. A. calvertii flowers contain vitamins, sterols, flavonoids and phenolic acids, dominated by vanillic acid, gallic acid, catechin, ?-tocopherol, ergosterol and vitamin D. A. calvertii flowers water extract showed better antiproliferative activities than other extracts against to MCF-7 and HCT-116 cell lines. A. calvertii flowers methanol extract showed higher antiproliferative effect against to LNCaP cell lines.Öğe In Vitro Biological Evaluation and Phytochemical Contents of Three Centaurea L. Species Growing from Eastern Anatolia in Turkey(2020) Keser, Serhat; Keser, Fatma; Turkoglu, Ismail; Kaygılı, Ömer; Tekin, Suat; Demır, Ersin; Karatepe, Mustafa; Yılmaz, Ökkeş; Kırbağ, Sevda; Sandal, Suleyman; Turkoglu, SemraAbstract: Centaurea L. species were used as medicinal plants among the people for treatment of the common cold, abscesses, peptic ulcers, hemorrhoid and diabetes etc.. In the present study, antiradical properties, phytochemical contents, antimicrobial and antiproliferative activities of three Centaurea species were investigated. Centaurea saligna (K.Koch) Wagenitz methanol (99.94%), Centaurea virgata Lam. methanol (98.23%) and water (98.10%) extracts were showed higher ABTS scavenging than trolox (96.79%). Centaurea kurdica Reichardt extracts showed lower activity than trolox for all the antiradical assays. Centaurea extracts exhibited antimicrobial activity against to some microorganisms. It was determined that these Centaurea species contain high amount of total flavonoid, phenolic and proanthocyanidin, phenolic acids, phytosterols and unsaturated fatty acids. Also, three Centaurea extracts showed very high antiproliferative property on LNCaP, HCT-116, MCF-7 cancer cell lines.Öğe Investigation of Antiproliferative Properties of Malva neglecta Extracts(Wiley, 2017) Tekin, Suat; Keser, Serhat; Keser, Fatma; Sandal, Suleyman; Turkoglu, Ismail; Karatepe, Mustafa; Turkoglu, Semra[Abstract Not Available]Öğe Investigation of The Anticarcinogenic Effects of Portulaca oleracea Extracts on Different Human Cancer Cell Lines(Wiley, 2017) Sandal, Suleyman; Keser, Serhat; Tekin, Suat; Keser, Fatma; Turkoglu, Ismail; Karatepe, Mustafa[Abstract Not Available]Öğe Phytochemical compounds and antiradical, antimicrobial, and cytotoxic activities of the extracts from Hypericum scabrum L. Flowers(Taylor & Francis Ltd, 2020) Keser, Serhat; Keser, Fatma; Kaygili, Omer; Tekin, Suat; Demir, Ersin; Turkoglu, Ismail; Turkoglu, SemraHypericum scabrum L. has been widely used in traditional medicine for the treatment of many diseases just as the other Hypericum species. In the present study, the antiradical, antimicrobial and cytotoxic activities of water and ethanol extracts of H. scabrum flowers were investigated. Their phytochemical contents and composition were also determined. The water and ethanol extracts are better scavenged ABTS (97.89 and 98.99%) and OH radicals (96.36 and 97.33%); the water extract is better scavenged DPPH radicals (91.66%) than the standard antioxidant BHA (94.33, 85.19, 90.16%, respectively). Flowers of H. scabrum contain flavonoids, phenolic acids, vitamins and phytosterols, dominated by catechin, vanillic acid, vitamin K and ergosterol. The extracts exhibit a strong cytotoxic activity against MCF-7, HCT-116, and LNCaP cancer cell lines. It is found that their antimicrobial activities are higher than the standard antibiotics. These results indicate that H. scabrum flowers have potent antiradical, antimicrobial and cytotoxic activities.Öğe Rumex acetosella L. (Kuzukulağı)’nın In vitro Antiradikal, Antimikrobiyal, Antikanser ve Fitokimyasal Özellikleri(2022) Keser, Fatma; Karatepe, Mustafa; Keser, Serhat; Tekin, Suat; Turkoglu, Ismail; Kaygılı, Ömer; Demır, ErsinPolygonaceae familyasında yer alan R. acetosella, çok yıllık otsu bir bitkidir ve Türkiye’de halk arasında sebze olarak tüketilmektedir. Bu çalışmada R. acetosella toprak üst kısımlarının etanol, su ve metanol ekstraktlarının antimikrobiyal (Escherichia coli, Bacillus megaterium, Bacillus subtilis, Proteus vulgaris, Pseudomonas aeruginosa, Listeria monocytogenes, Klebsiella pneumoniae, Staphylococcus aureus bakterileri ve Candida albicansmaya-mantarına karşı), antiradikal (DPPH, ABTS ve OH radikallerine karşı), antikanser (insan prostat kanseri (PC-3), insan kolon kanseri (HCT-116), insan yumurtalık kanseri (A2780) ve insan göğüs kanseri (MCF 7) hücre serilerine karşı) ve fitokimyasal özellikleri (yağda çözünen vitaminler, yağ asitleri, flavonoitler,fitosteroller, fenolik asitler, toplam fenolik bileşik, toplam flavonoit ve toplam proantosiyanidinler) incelenmiştir. Sonuçlarımıza göre R. acetosella ekstraktlarının ABTS, DPPH ve OH radikali yok etme testlerinde BHT’den daha yüksek aktiviteye sahip oldukları belirlenmiştir. Ayrıca bu bitkinin yüksek antimikrobiyal aktiviteye ve fitokimyasal içeriğe sahip olduğu, PC-3 insan prostat kanseri hücrelerine karşı etkili antikanser aktivite gösterdiği anlaşılmıştır. Aynı zamanda sunulan çalışma, R. acetosella ekstraktlarının in vitro antikanser aktivitesi ile ilgili ilk çalışma olma özelliği taşımaktadır.
