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    Dust-mites: Effect on lipid peroxidation
    (All India Inst Medical Sciences, 2006) Atambay, Metin; Karabulut, Aysun Bay; Aycan, Ozlem Makbule; Kilic, Eser; Yazar, Suleyman; Saraymen, Recep; Karaman, Ulku
    Background. Dust-mites are present in our homes, feed on dead exfoliated skin and other organic material. It is also known that oxidative stress may lead to cellular damage that can be confirmed by markers of cellular disruption. Oxidative stress in various infective processes has been documented. We investigated whether house dust-mites cause oxidative stress in patients. Methods. Products of lipid peroxidation in erythrocytes and lymphocytes were assessed by measuring malondialdehyde concentration. Results, Our results showed that patients who had a positive skin test for dust-mite antigens and had dust-mites present in their houses (dust-mite positive) had increased erythrocyte malondialdehyde levels (62.39 [18.56]. nmol/g-Hb) compared with those who were skin test positive, dust-mite negative (45.45 [10.82]) or skin test negative, dust-mite negative (42.20 [5.68]). They also had significantly higher levels of lymphocyte malondialdehyde (4.22 [0.55] nmol/g-protein), compared with those who were skin test positive, dust-mite negative (3.46 [0.29]) or skin test negative, dust-mite negative (1.25 [0.31]; p < 0.05). However, there was no statistically significant difference between the malondialdehyde levels of dust-mite negative/skin test positive and dust-mite negative/skin test negative patients. Conclusion. Increased malondialdehyde activity in lymphocytes and erythrocytes in the dust-mite positive/skin test positive group shows the presence of the oxidative stress in patients with dust-mite infestation.
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    The Effect of Dust-Mites on Nitric Oxide Production
    (Tubitak Scientific & Technological Research Council Turkey, 2009) Yazar, Sueleyman; Kilic, Eser; Atambay, Metin; Karabulut, Aysun Bay; Aycan, Oezlem Makbule; Tamer, Guelden Soenmez; Daldal, Nilguen
    Aim: We aimed to investigate the effect of house dust mite on the level of nitric oxide in patients who had dust mite in their houses and suffering from rhinitis and/or asthma and/or eczema-like allergic symptoms and were positive for skin tests (Prick). Materials and Methods: The effect of dust-mites on nitric oxide concentration was investigated using Griess method in patients who had allergic symptoms and were positive for skin tests. Results: The plasma nitric oxide level was found to be statistically higher in patients who had dust mite in their houses and suffering from allergic symptoms and were positive for skin tests than in patients who did not have dust mite in their houses but were positive for skin tests or negative for skin tests. In addition. there was no statistical difference in the level of nitric oxide between the patients who did not have dust mite in their houses but were positive for skin tests and the patients who did not have dust mite in their houses and were negative for skin tests. Conclusions: There seems to be an effect of house dust mite on the level of nitric oxide. However, the molecular mechanism underneath of this effect is not yet clear. A plausible explanation for this might be the intrinsic radical properties of nitric oxide and its protective effect against the parasitic agents.