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    The Frequency of Exfoliation Syndrome in the Central Anatolia Region of Turkey
    (Hindawi Ltd, 2014) Kilic, Rasit; Sezer, Hafize; Comcali, Sebile U.; Bayraktar, Serdar; Goktolga, Gokay; Cakmak, Yasin; Cetin, Abdi B.
    Aim. The aim of this study was to investigate the frequency of exfoliation syndrome in the Central Anatolia region of Turkey and to evaluate its relationship with cardiovascular and ocular diseases. Methods. Patients over the age of 45 years who presented to the clinic were included in the study. All cases underwent a comprehensive ophthalmology examination. Exfoliation syndrome was diagnosed with the presence of exfoliative material on the lens anterior capsule or iris on slit lamp examination. The patients were divided into two groups as the exfoliation syndrome group and nonexfoliation syndrome group according to the presence of exfoliative material. Results. Exfoliative material was found in one or both eyes of 212 of the 2103 patients (10.1%) evaluated within the scope of the study. A significant relationship was found between exfoliation syndrome and increasing age and male gender. A significant relationship was found between exfoliation syndrome and glaucoma, cataracts, age-related macular degeneration, and phacodonesis. While no relationship was found between exfoliation syndrome and hypertension or diabetes mellitus, a significant relationship was found with coronary artery disease. Conclusion. The unilateral or bilateral exfoliation syndrome frequency was 10.1% in this hospital-based study. A statistically significant relationship was found between exfoliation syndrome and advancing age, gender, and coronary artery disease.
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    The frequency of pseudoexfoliation syndrome in the middle Black Sea region of Turkey
    (Wichtig Editore, 2010) Cumurcu, Tongabay; Kilic, Rasit; Yologlu, Saim
    PURPOSE. To assess the frequency of pseudoexfoliation syndrome (PEX) and evaluate its association with specific ocular diseases in patients attending the Department of Ophthalmology at Gaziosmanpasa University Hospital. METHODS. A prospective study was conducted at the Gaziosmanpasa University Hospital between December 2007 and December 2008. A total of 831 subjects aged 45 or above attending the general ophthalmic clinics were recruited for this study. Each patient underwent complete ophthalmic assessment, including ocular history, visual acuity testing, slit-lamp examination, applanation tonometry, gonioscopy, and fundus examination. RESULTS. Of the 831 subjects, 12.2% had PEX. Pseudoexfoliation was bilateral in 74.2% of cases, significantly associated with cataract, glaucoma, age-related macular degeneration (AMD), and phacodenesis. Of the patients with PEX, 43.6% had cataract, 6.9% had glaucoma, 7.9% had AMD, and 0.9% had phacodenesis. In addition, 9.8% had cataract + glaucoma, 13.7% had cataract + phacodenesis, and 17.8% had all of them. The prevalence of PEX had a tendency to increase with age but had no sex predilection. CONCLUSIONS. The study findings enhance our knowledge of PEX in Anatolia, particularly in the Middle Black Sea region.
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    Proper Evaluation of Factors Affecting Oxidative Status
    (Taylor & Francis Inc, 2016) Kilic, Rasit; Cumurcu, Tongabay; Sancaktar, Enver; Evliyaoglu, Osman; Sezer, Hafize
    [Abstract Not Available]
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    Systemic Prolidase Activity and Oxidative Stress in Keratoconus
    (Taylor & Francis Inc, 2016) Kilic, Rasit; Cumurcu, Tongabay; Sancaktar, Enver; Evliyaoglu, Osman; Sezer, Hafize
    Aim: Our aim was to evaluate the serum prolidase activity, total antioxidant capacity (TAC) and total oxidant status (TOS) in patients with keratoconus.Material and method: A total 69 keratoconus patients and 72 control subjects with similar age and gender were evaluated within the scope of this study. The keratoconus group was divided into four stages with the modified Krumeich classification. Serum prolidase activity, TAC and TOS were measured and compared between the patient and control groups.Results: The median serum prolidase enzyme activity value was 528.3 (684.1-416.7) U/L in the keratoconus group and 606.2 (812.9-482.3) U/L in the control group. The difference between the groups was statistically significant (p=0.027). The median TAC value was 1.24 (1.37-1.05) mmol/L in the keratoconus group and 1.29 (1.38-1.18) mmol/L in the control group. The median TOS value was 2 (4-1)mol/L in the keratoconus group and 3 (4-2)mol/L in the control group. There was no statistically significant difference between the two groups in terms of TAC or TOS (p=0.113 and p=0.366, respectively). There was a positive correlation between TAC and TOS in keratoconus group but not in the control group (r=0.670, p=0.001 and r=0.141, p=0.241, respectively). No significant relationship was seen between the keratoconus group stages and serum prolidase activity, TAS or TOS (p=0.894, p=0.155 and p=0.381, respectively).Conclusion: In conclusion, a significant relationship was found between decreased serum prolidase activity and keratoconus but there was no significant relationship between keratoconus and serum TAC or TOS.