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Öğe Assessment of palliative care in lung cancer in turkey(Assessment of palliative care in lung cancer in turkey, 2017) Kilic, T.; Kirkil, G.Objective: To investigate the symptoms of lung cancer in Turkey and to evaluate approaches to alleviate these symptoms. Subjects and Methods: This study included 1,245 lung cancer patients from 26 centers in Turkey. Demographic characteristics as well as information regarding the disease and treatments were obtained from medical records and patient interviews. Symptoms were evaluated using the Edmonton Symptom Assessment Scale (ESAS) and were graded on a scale between 0 and 10 points. Data were compared using the. 2, Student t, and Mann-Whitney U tests. Potential predictors of symptoms were analyzed using logistic regression analysis. Results: The most common symptom was tiredness (n = 1,002; 82.1%), followed by dyspnea (n = 845; 69.3%), appetite loss (n = 801; 65.7%), pain (n = 798; 65.4%), drowsiness (n = 742; 60.8%), anxiety (n = 704; 57.7%), depression (n = 623; 51.1%), and nausea (n = 557; 45.5%). Of the 1,245 patients, 590 (48.4%) had difficulty in initiating or maintaining sleep. The symptoms were more severe in stages III and IV. Logistic regression analysis indicated a clear association between demographic characteristics and symptom distress, as well as between symptom distress (except nausea) and well-being. Overall, 804 (65.4%) patients used analgesics, 630 (51.5%) received treatment for dyspnea, 242 (19.8%) used enteral/parenteral nutrition, 132 (10.8%) used appetite stimulants, and 129 (10.6%) used anxiolytics/antidepressants. Of the 799 patients who received analgesics, 173 (21.7%) reported that their symptoms were under control, and also those on other various treatment modalities (dyspnea: 78/627 [12.4%], appetite stimulant: 25/132 [18.9%], and anxiolytics/antidepressants: 25/129 [19.4%]) reported that their symptoms were controlled. Conclusion: In this study, the symptoms progressed and became more severe in the advanced stages of lung cancer, and palliative treatment was insufficient in most of the patients in Turkey. (C) 2016 S. Karger AG, BaselÖğe Essential oil compositions of some species of Cyclotrichium and antimicrobial activities(Springer, 2007) Kilic, T.; Karahan, A.; Dirmenci, T.; Arabaci, T.; Kocabas, E.; Goren, A. C.[Abstract Not Available]Öğe Evaluation of auditory functions in patients with asthma(Verduci Publisher, 2014) Kilic, T.; Karatas, E.; Toplu, Y.; Koc, A.; Bulam, N.; Kaya, O.OBJECTIVE: The objective of this study is to evaluate the auditory functions in chronic asthma patients with the use of pure tone high frequency audiometry. PATIENTS AND METHODS: Twenty-two healthy controls and 42 adult patients were included as a prospective, randomized, and controlled study. Pulmonary function tests and blood gas studies were completed on all subjects. Asthma patients have divided into two groups [Group A: Arterial oxygen tension (PaO2) > 75 mmHg, Group B: PaO2 <= 75 mmHg, Group C: Control group). Acoustic assessments of patients were performed in 250-20000 Hz by using pure-tone audiometry (PTA) and tympanometry. RESULTS: The mean value of air and bone conduction hearing threshold levels were in normal range for all groups. All patients had normal peripheral hearing all threshold levels across 250 Hz to 3000 Hz in the both ears. Significant differences were observed between the chronic asthma patients and control group for the extended high frequencies (10000-20000 Hz). Group B had statistically more significant increased hearing threshold levels than Group A in frequencies higher than 10000 Hz. There were no statistical differences between the hearing threshold levels and FEV1, FVC, FEV1/FVC and tympanogram results in the groups. CONCLUSIONS: This is the first study of evaluating the auditory functions in asthma patients. Sensorineural hearing loss in high frequencies (10000 Hz-20000 Hz) is common in chronic asthma and is probably present more often than were formerly thought.Öğe Long-term follow-up of chronic obstructive pulmonary disease patients on long-term oxygen treatment(Wiley, 2012) Gulbas, G.; Gunen, H.; In, E.; Kilic, T.Aims: Few studies exist on influence of long-term oxygen treatment (LTOT) on survival of chronic obstructive pulmonary disease (COPD) patients. This study was designed to determine whether LTOT improves survival or not in severely hypoxaemic COPD patients. Materials: COPD patients prescribed oxygen concentrator were consecutively included. Patients' baseline characteristics were noted. During follow-up, patients were divided into three groups according to LTOT utilisation: (i) non-utilisers, (ii) intermittent utilisers (< 15 h/day) and (iii) true utilisers (15 h/day). Patients' status (live or death) and, if died, the date of death were checked throughout the study. The factors which might influence mortality during 5-year period were analysed. Results: Two-hundred and twenty-eight patients completed the study. Of these patients, 55 were in Group 1, 112 were in Group 2 and 61 were in Group 3. Regarding the initial characteristics, there was not any significant difference between groups. Mean follow-up for whole group was 27.8 +/- 18.5 months. Median survivals were similar between groups (19.5 +/- 5.6, 32.5 +/- 4.1 and 30.0 +/- 5.7 months respectively) (p > 0.05). Compared with Group 1, survival was improved in Group 2 (p < 0.05) and there was a positive trend for Group 3 during first 2-year period. However, this improvement disappeared during further follow-up. Analysis of multiple factors which might influence mortality during 5-year period did not yield statistically significant parameter. Discussion and conclusion: We found that, regarding survival, any kind of LTOT proved to be beneficial over no LTOT only in the first 2 years of follow-up, and that there was not any difference between intermittent and true LTOT utilisation.
