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    Inflammation markers in patients with psychotic disorder who have committed offenses and their relationship with criminal behavior
    (Routledge Journals, Taylor & Francis Ltd, 2025) Yildiz, Sevler; Emir, Burcu Sirlier; Kilicaslan, Asli Kazgan; Kurt, Osman; Ugur, Kerim; Sehlikoglu, Seyma; Atmaca, Murad
    The role of inflammation in the etiology of psychotic disorders (PD) is well-established. This study aimed to identify inflammation parameters in patients diagnosed with PD, assess their potential as biomarkers, and examine their relationship with criminal behavior. This retrospective study comprised three groups: 530 patients diagnosed with PD who had committed crimes (offenders with PD), 530 patients with PD who had not committed crimes (non-offenders with PD), and 530 healthy controls, totaling 1,590 participants. Routine hematological tests were used to measure neutrophil, lymphocyte, monocyte, and platelet counts, high-density lipoprotein (HDL), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), and neutrophil/HDL (NHR), lymphocyte/HDL, platelet/HDL (PHR), and monocyte/HDL (MHR) ratios. Offenders with PD exhibited significantly higher levels of SII, SIRI, PHR, NHR, LHR, neutrophils, and monocytes compared to non-offenders with PD and healthy controls (p < 0.001). The criminal group had lower HDL and lymphocyte levels than the remaining two groups (p < 0.001). Among those treated in forensic psychiatry units, patients with two or more treatments showed significantly higher SIRI values compared to those with only one treatment (p = 0.045). Non-offenders with PD had higher platelet values than the remaining two groups (p < 0.001). This study underscores the role of systemic inflammation in the pathophysiology of psychotic disorders through a comparison of patients who have and have not committed crimes, highlighting the relationship between inflammation and lipid metabolism. Further research is required to clarify these findings.
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    Markers of inflammation in patients with generalized anxiety disorder
    (Cukurova Univ, Fac Medicine, 2024) Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Tabara, Muhammed Fatih; Kurt, Osman; Sehlikoglu, Seyma; Ugur, Kerim
    Purpose: The aim of this study was to analyze the systemic immune response index, systemic immune inflammation platelet/HDL, and monocyte/HDL ratio, used as inflammatory markers in patients with generalized anxiety Materials and Methods: A total of 864 participants, including 432 healthy controls and 432 patients diagnosed with GAD, were included in this study. High-density lymphocyte, and platelet counts; systemic inflammatory calculated. contributing to both diagnosis and management.
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    Serum HMGB1 and Beclin 1 Levels in Patients with a Diagnosis of Schizophrenia
    (Turkiye Sinir Ve Ruh Sagligi Dernegi, 2024) Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Ugur, Kerim; Kilic, Faruk
    Objective: It is known that inflammation plays a role in the etiopathogenesis of schizophrenia. In this study, we examined high mobility group box 1 protein (HMGB1) and Beclin 1 levels and their relationship with clinical variables in patients with schizophrenia. Method: Forty-three patients with schizophrenia and 43 healthy controls were included in this study. The patients were administered sociodemographic data form, the Positive Negative Symptoms Assessment Scale (PANSS) and the Clinical Global Impressions (CGI) scale. After the scales were filled, venous blood samples were taken from both the patient and control groups to measure serum HMGB1 and Beclin 1 levels. Serum samples obtained at the end of centrifugation were measured by Enzyme -Linked ImmunoSorbent Assay (ELISA) method. Results: The mean serum HMGB1 levels were significantly increased and the mean serum Beclin 1 levels were significantly decreased in the schizophrenia group compared to the control group. In addition, a negative correlation was found between HMGB1 and Beclin 1 levels. Conclusion: In conclusion, current research shows that HMGB1 is increased and Beclin 1 is decreased in patients with schizophrenia, and these findings may contribute to the role of autophagy in the pathogenesis of schizophrenia.
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    Technology Addiction and Social Connectedness in Psychiatric Illness: A Multicenter Study
    (Korean Neuropsychiatric Assoc, 2024) Kurt, Osman; Tabara, Muhammed Fatih; Yildiz, Sevler; Kilicaslan, Asli Kazgan; Emir, Burcu Sirlier; Oktay, Meltem; Cansel, Neslihan
    Objective: Technology addiction is an increasingly important public health problem all over the world that negatively affects people's mental and physical health. In this study, we examined technology addiction and social connectedness levels of psychiatric patients who admitted to clinics in different geographical regions of Turkey. Methods: A total of 642 people with a diagnosis of psychiatric illness who applied to psychiatry clinics in & Idot;stanbul, Elazig, Malatya, Yozgat, Ad & imath;yaman, and Bingol provinces were included. Sociodemographic data form, Technology Addiction Scale (TAS), and Social Connectedness Scale (SCS) were applied to all participants. Results: The total score of the TAS in patients diagnosed with anxiety disorder and somatoform disorder was significantly higher than the other patient groups (p<0.001). Patients diagnosed with anxiety disorder showed a significant difference from other patient groups in terms of SCS score (p<0.001). Anxiety disorder was found to be the highest in TAS total score and sub-dimensions and the lowest in SCS score, while major depressive disorder was found to be the lowest in TAS total score and sub-dimensions and the highest in SCS score. The multiple linear regression analysis showed that the total score of the TAS was predicted by the SCS score (beta=-1.857, p<0.001) and the SCS score was predicted by age (beta=0.046, p=0.049) and the total score of the TAS (beta=-0.316, p<0.001). Conclusion: As a result of this study, we can say that psychiatric patients have a moderate level of technology addiction, these people have high levels of social connectedness, and psychiatric patients with technology addiction have a high level of social belonging.