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    Effects of acute moderate and strenuous exercise bouts on IL-17 production and inflammatory response in trained rats
    (Journal Sports Science & Medicine, 2009) Duzova, Halil; Karakoc, Yunus; Emre, Memet Hanifi; Dogan, Zumrut Yilmaz; Kilinc, Evren
    In this study, we aimed to compare the effects of a single bout of acute moderate and strenuous running exercise on the production of interleukin-17 (IL-17), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and inflammatory response of skeletal muscles in regularly trained rats. Eight week old rats were trained by treadmill running 5 days per week for 13 weeks at the durations of 30 min (moderate) and 60 min (strenuous). Two days after the last training session, the animals were subjected to a single bout of moderate or strenuous exercise and serum samples were analyzed for IL-17, IL-6, IL-1ra levels and myeloperoxidase (MPO) activity of gastrocnemius muscle were determined. IL-17 level significantly increased in strenuous exercise group when compared to that of sedentary controls (p < 0.01), On the other hand, only in the moderate exercise group, there was a negative correlation between IL-6 and IL-17 levels (r = 0.857 and p = 0.014). In conclusion, acute single bout of strenuous exercise increased IL-17 production in trained rats and, this cytokine may be involved in inflammatory process of skeletal muscles.
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    Evaluation of organ weights and ventricular thicknesses in electrocution related deaths based on autopsy reports: A biophysical approach
    (Pakistan Medical Assoc, 2023) Kilinc, Evren; Ozturk, Onur; Oruc, Mucahit; Celbis, Osman
    Objective: To evaluate autopsy reports of the deaths due to electrocution in terms of body mass index, body surface area, and organ weights with a biophysical perspective. Method: The retrospective study was conducted in Malatya, Turkiye, and comprised autopsy reports of electrocution cases that were obtained from the local branch of the Council of Forensic Medicine related to the period from 2012 to 2019. Organ weights and ventricular thicknesses were compared in terms of body mass index and body surface area. Electrical marks were also evaluated in detail. Data was analysed using SPSS 18. Results: Of the 45 cases, 36(%) were male and 9(%) were female. The overall mean age was 39 +/- 13 years (range: 20-71 years). There were no significant differences in organ weights and ventricular thicknesses in different body mass index groups (p>0.05). The weights of head and heart were significantly different in relation to body surface area (p<0.05), but no significant difference were found for other organs and ventricular thickness (p>0.05). Conclusion: Comparing the organ weights in electrocution autopsies to normal organ weights may help decide the cause of death. During autopsy, electrical marks should be evaluated by considering the characteristics of the electrical current.
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    Plasma viscosity and mean platelet volume in patients undergoing coronary angiography
    (Ios Press, 2010) Senen, Kubilay; Topal, Ergun; Kilinc, Evren; ten Cate, Hugo; Tek, Ibrahim; Karakoc, Yunus; Yetkin, Ertan
    Background: Markers of platelet activation and haemorrheological indices have been demonstrated to play a role in the pathophysiology of atherosclerosis and cardiovascular events. In this study, we aimed at investigate the association between plasma viscosity and platelet indices in patients undergoing coronary angiography. Materials and methods: Three hundred and eighty four consecutive patients scheduled to undergo coronary angiography were included in the study. Prior to coronary angiography, blood samples were withdrawn to determine routine biochemical markers, blood cell analyses and viscosity measurements. According to the results of coronary angiography, patients were classified either in a subgroup with coronary artery disease (CAD; 1 or more stenoses > 50%) or normal coronary arteries (NCA; no stenoses or < 50%). Results: There was a statistically significant correlation between plasma viscosity and mean platelet volume levels in all patients undergoing coronary angiography (r = 0.199, p < 0.001). Additionally, when correlation analysis was performed within each group, plasma viscosity significantly correlated with MPV both in patients with CAD (r = 0.18, p = 0.004) and in patients with NCAs (r = 0.272, p = 0.002). Linear regression analysis revealed that plasma viscosity was positively associated with MPV while platelet number was inversely but significantly associated with MPV. Conclusion: We have shown for the first time that MPV correlates with plasma viscosity in patients undergoing coronary angiography, suggesting a relation with plasma proteins and activation of circulating platelets or peripheral consumption of platelets. To evaluate this relation further controlled studies also in patients with acute coronary syndromes are warranted.
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    The relationship between serum leptin and VO2max levels in pre-puberty swimmer girls: effect of acute exercise
    (Mattioli 1885, 2020) Gullu, Esin; Gullu, Abdullah; Duzova, Halil; Ozgor, Bilge; Kilinc, Evren; Akcinar, Faruk
    Objective: The aim of this study was to determine the relationship between serum leptin (SL) level, which is the sensor of changes in energy intake and consumption, and maximal oxygen consumption (VO2max) level in pre-puberty swimmer girls. Methods: Voluntary participants were divided into swimmer group (n:16) and the control group (n:15). Bruce protocol was used for acute exercise effect. Body composition, VO2max and SL concentrations of the study group were measured before and after acute exercise. The paired-samples t-test and independent samples t-test were used for intra- and inter-group comparisons. The linear relations between the VO2max and SL levels were determined by Pearson correlation coefficient. The level of significance was used at 0.05. Results: There was a significant difference between the SL level and test stage, test duration, HR of test-end, and VO2max variables in both groups (p<0.05). There was a high level of negative correlation between VO2max and SL levels in both groups after exercise (SG, r=-0.63; p<0.01, and CG, r=-0.60; p<0.05, respectively). Conclusion: Acute exercise resulted in decreased SL levels of both groups. It was concluded that regular swimming sports has a positive effect on body composition, VO2max, and SL values of pre-pubertal girls.