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    Apricot attenuates oxidative stress and modulates of Bax, Bcl-2, caspases, NF?-B, AP-1, CREB expression of rats bearing DMBA-induced liver damage and treated with a combination of radiotherapy
    (Pergamon-Elsevier Science Ltd, 2014) Karabulut, Aysun Bay; Karadag, Nese; Gurocak, Simay; Kiran, Tugba; Tuzcu, Mehmet; Sahin, Kazim
    We evaluated the ability of apricot to attenuate apoptosis and oxidative stress developed during the process of 7,12-dimethylbenz[a]anthracene (DMBA) and radiotherapy in the liver of rats bearing liver damage. Fifty female Wistar rats were divided into 7 groups; (i) normal control rats; (ii) rats fed with standard diet with apricot (20%), (ii) rats fed with standard diet and administrated 6 gray radiotherapy with Co 60 device applied to a single fraction, (iv) rats fed with standard diet and administered intraperitoneally DMBA (20 mg/kg), (v) rats fed with standard diet and administered DMBA and 6 gray radiotherapy, (vi) rats fed with standard rat diet and administered DMBA and supplemented apricot, (vii) rats fed with standard diet supplemented apricot administered DMBA and radiotherapy (RT) for 6 weeks. Expression of Bax, caspase 3, and glutathione activity decreased in the liver but liver expression of NF-kappa B, AP-1, CREB, Bcl-2 and ALT, AST, 5'NT, MDA, NO levels increased in DMBA-induced liver damage rats. In conclusion, the results suggest that apricot supplementation and irradiation given in combination, offer maximum protection against DMBA-induced hepatic carcinogenesis. (C) 2014 Elsevier Ltd. All rights reserved.
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    The Levels of Adenosine Deaminase (ADA) in the Serum of Enterobius Vermicularis Positive Patients
    (2014) Karaman, Ülkü; Kiran, Tugba; Çolak, Cemil
    It has been reported that the parasites can make the free oxygen radicals such as superoxide and hydrogen peroxide and they contain enzymes which produce them. The cytokines play role in the regulation of immune response in living beings. The synthesizing of IL-10 is increased in Enterobius vermicularis, too. The adenosine deaminase (ADA) is also an aminohydrolase which plays role in the catabolism of purine nucleotides, inosines and deoxyinosine deamidates the adenosine and deoxyadenosine irreversibly. In the study, the comparison of ADA levels between the serums of the control group and the group of patients with E. vermicularis was aimed. In the study, the experimental group included 40 E. vermicularis positive patients. The average age of the patients is 35.2±5.4, 20 of them are men and 10 of them are women. The average age of 40 healthy Enterobius vermicularis negative people is 40.23±7.01, 31 of them are male and 9 of them are female. A significant decrease between the Enterobius vermicularis positive patients and the control group was detected in the level of ADA (p=0.0001). It can be considered that the ADA level of E. vermicularis positive patients in the study may be decreased because of increasing oxidative stress due to the parasitic infection.