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Öğe Antioxidant Effect of Apelin on Renal Iischemia/Reperfusion Damage(Wiley-Blackwell, 2015) Bircan, Burak; Cakir, Murat; Kirbag, Sevda[Abstract Not Available]Öğe Cytotoxic effect of endemic Tchihatchewia isatidea Boiss. from Turkey(Brill, 2021) Kirbag, Sevda; Keser, Serhat; Tekin, Suat; Inci, Sule; Sandal, SuleymanTchihatchewia isatidea Boiss (Brassicaceae) is known among the public as Reddish Bride, Paint and Bridal Flower. Flower parts are used for painting and flowering branches for treatment of cough. In this study, anticancer properties of water, ethanol and methanol extracts of Tchihatch-ewia isatidea flower parts were investigated against human breast (MCF-7), human colon (HCT-116) and human prostate (LNCaP) cancer cell lines. Changes in the viability of cancer cells were de-tected by utilizing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Studies have shown that there is a statistically significant decrease in the cell viability of human breast cancer (MCF-7), colon (HCT-116) and prostate (LNCaP) cancer cells when extracts of T. isati-dea water, ethanol and methanol are used.Öğe Determination of Anticancer and Antimicrobial Properties of Alcea calvertii(Wiley-Blackwell, 2016) Keser, Serhat; Tekin, Suat; Kaygili, Omer; Keser, Fatma; Turkoglu, Ismail; Turkoglu, Semra; Kirbag, Sevda[Abstract Not Available]Öğe Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats(Taylor & Francis Ltd, 2016) Bircan, Burak; Cakir, Murat; Kirbag, Sevda; Gul, Huseyin FatihApelin is a peptide hormone defined as a ligand for G-protein clamped receptor (APJ) receptor. It is indicated in the literature both apelin and APJ are synthesized on the peripheral tissues including the renal tissues. Which roles does the apelin play on the renal tissue has not been completely illuminated yet. This study is designed to determine the possible protective effect of apelin-13 on the kidney I/R injury. Adult male Sprague-Dawley rats were used in this study. In the sham group, right kidneys of the animals were dissected. In the I/R group, right kidney was dissected and ischemia of 45min was performed, and then reperfusion was applied for 3h. In the treatment groups, three different doses of apelin were injected at the beginning of the ischemia unlike the I/R group. BUN, Cre, Na, K, Cl, total protein and albumin from serum samples were determined and TNF-, IL-1, IL-6, TAS and TOS parameters were read with ELISA reader. MDA, SOD, CAT and GSH-Px enzyme activations from renal tissues were measured. In comparison with the sham and I/R groups, while the serum BUN, CRE, CI and TNF- levels showed an increase in the groups on which the apelin-13 was applied, Na, total protein, albumin, TAS levels decreased. Serum TOS level of other groups showed an increase by comparison with the sham group. Our results showed that apelin-13 applied after I/R increased the antioxidant enzyme activity in a dose dependent manner, prevented the lipid oxidation and improved the renal functions.Öğe Effect of Apelin-13 on Liver Damage Following the Renal Ischemia/Reperfusion(Wiley-Blackwell, 2015) Bircan, Burak; Cakir, Murat; Kirbag, Sevda[Abstract Not Available]Öğe Effects of central irisin administration on the uncoupling proteins in rat brain(Elsevier Ireland Ltd, 2016) Erden, Yavuz; Tekin, Suat; Sandal, Suleyman; Onalan, Ebru Etem; Tektemur, Ahmet; Kirbag, SevdaIrisin is a thermogenic peptide that enables the development of brown adipose tissue from white adipose tissue by activating the UCP1. This study has been designed to determine the effects of the irisin on UCPs. Sprague Dawley female rats were used in the study. 1, 3 and 10 mu M concentrations of irisin were injected intracerebroventricularly to the rats, and the control group was received only vehicle. The animals were killed at the 16, 24, and 48 h time intervals and their brains were taken out. The hypothalamus, pituitary gland, hippocampus, cerebellum, striatum and cortex areas were separated and the UCP2, UCP3, UCP4 and UCP5 mRNA levels were determined. Just before the animals were killed, their body temperatures were recorded. It was observed that after application of the high dose irisin, UCP5 mRNA level in the all brain areas increased (p < 0.05); it was also observed that the three doses decreased the UCP4 expression in all brain areas (except the pituitary gland; p < 0.05). The UCP2 and UCP3 mRNA expressions showed significantly increase in cerebellum and striatum (p < 0.05). The UCP2 mRNA expression decreased in hypothalamus, pituitary gland, hippocampus and cortex areas (p < 0.05). It was also observed that the body temperatures of the rats increased depending on the irisin injection and this increase was the most considerable at the 24h (p < 0.05). The results of this study suggest that the UCP2-5 is expressed in different areas of the brain, and the irisin affects this expression, and may have effective roles in some brain functions. (C) 2016 Elsevier Ireland Ltd. All rights reserved.Öğe Radial Basis Function Artificial Neural Networks Can Predict UCP2 mRNA Levels According to Irisin Dose and Time of Application in the Cerebellum of Rats(Wiley-Blackwell, 2015) Erden, Yavuz; Tekin, Suat; Colak, Cemil; Sandal, Suleyman; Tektemur, Ahmet; Onalan, Ebru Etem; Kirbag, Sevda[Abstract Not Available]Öğe Structural and Dielectrical Properties of Ag- and Ba-Substituted Hydroxyapatites(Springer, 2014) Kaygili, Omer; Keser, Serhat; Dorozhkin, Sergey V.; Yakuphanoglu, Fahrettin; Al-Ghamdi, Ahmed A.; Kirbag, Sevda; Sertkaya, DuyguAg- and Ba-doped hydroxyapatite (HAp) samples were synthesized by sol-gel method. The crystallite sizes for all the samples were found to vary from 26 to 39 nm. Neither Ag nor Ba did result in dramatic changes in the morphology of all the samples, and the Ca/P molar ratio was varied. The dielectric parameters of the samples were changed with the dopant content. The maximum and minimum values of the dielectric constant were observed for 2.0 %Ba-HAp and 0.5 %Ba-HAp samples. The alternating current conductivity indicates that all the samples exhibit the insulator behavior. The results of the biological tests revealed that Ag-containing samples have an antimicrobial activity, while no antimicrobial activity was detected for both HAp and Ba-doped HAp samples.Öğe Synthesis, characterization, crystal structure, and antimicrobial studies of 2-morpholinoethyl-substituted benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes(Springer, 2017) Yildirim, Isil; Aktas, Aydin; Celepci, Duygu Barut; Kirbag, Sevda; Kutlu, Turkan; Gok, Yetkin; Aygun, MuhittinThis article describes synthesis of N-morpholinoethylbenzimidazole (1), 2-morpholinoethyl-substituted benzimidazolium salts (NHC precursors, 2a-c), and their Ag(I) N-heterocyclic carbene (NHC) complexes (3a-c). All compounds were characterized by H-1 and C-13 Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FTIR), and elemental analysis, and their antimicrobial effects examined. The molecular structure of the NHC precursor 2a (1) was established by single-crystal X-ray diffraction analysis. Minimum Inhibition Concentration (MIC) values were determined to evaluate their antimicrobial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacterial strains and Candida albicans fungal species. All tested samples were compared with silver nitrate. All the compounds exhibited strong antimicrobial activity.
