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Öğe Appendiceal Enterobius vermicularis infestation in adults(Int College Of Surgeons, 2007) Isik, Burak; Yilmaz, Mehmet; Karadag, Nese; Kahraman, Latif; Sogutlu, Gokhan; Yilmaz, Sezai; Kirimlioglu, VedatThe objective of this study is to evaluate the incidence of Enterobius vermicularis in the appendices of the adult population and a possible relationship between E. vermicularis and acute appendicitis. E. vermicularis was identified in 18 (2%) of 890 patients. Six hundred sixty-five operations were performed for presumptive diagnosis of acute appendicitis, and E. vermicularis was found in 12 (2%) patients. The histopathological examination revealed acute inflammatory cells in four cases (33%). Three of these four specimens included luminal ova and one E. vermicularis. Histopathological examination of six cases revealed E. vermicularis in 225 incidental appendectomies with no evidence of either acute or chronic inflammatory cells. This study suggests a relationship between the presence of E. vermicularis ova and acute inflammation, but the presence of the pinworm in the lumen of the appendix is coincidental. On the other hand E. vermicularis in the appendix lumen can cause symptoms of acute appendicitis.Öğe The Assessment of Hepatosteatosis in Living-Donor Liver Transplant: Comparison of Liver Attenuation Index and Histopathologic Results(Baskent Univ, 2017) Kahraman, Aysegul Sagir; Karakas, Hakki Muammer; Kirimlioglu, Hale; Kahraman, Bayram; Yilmaz, Sezai; Kirimlioglu, VedatObjectives: The purpose of the study was to determine the diagnostic value of computed tomography densitometry in the quantification of hepatosteatosis. Materials and Methods: Fifty-one potential liver donors, ranging in age from 19 to 52 years (mean age: 32.4 years +/- 10.2), participated in the study. The mean hepatic attenuation and mean splenic attenuation were determined using regions of interest measurements. The difference between the mean hepatic attenuation and mean splenic attenuation (or liver attenuation index), with liver attenuation index = mean hepatic attenuation - mean splenic attenuation were calcu lated. Computed tomography densitometric para meters were correlated with histopathologic results. Results: From the histopathologic analysis, the degree of macrovesicular hepatosteatosis was 0% to 8% (mean: 1.1% +/- 2%). Seven donors (13.7%) had a degree of macrovesicular steatosis of > 5%, and 12 donors (23.5%) had >= 2%. Of the 29 normal donors with histopathologic verification, computed tomography densitometry predicted <= 5% of the hepa to steatosis in 27 donors, and >= 2% hepato-steatosis in 2 subjects. The liver attenuation index was sig nificantly correlated to the histopathologic results. The mathematical relation between liver attenuation index and the degree of histopathologic hepatosteatosis was calculated using the least-squares methods, which provided quadratic polynomials. Conclusions: Computed tomography densitometry is a rapid, robust, noninvasive technique for the assessment of hepatosteatosis. When used in conjunction with clinically stable reference measurements of spleen, the density measurements of liver correctly predicted the presence of fatty infiltration with significant sensitivity (77%) and specificity (75%). This technique, which was refined during the course of our liver transplant program, minimizes the need for highly invasive percutaneous liver biopsies.Öğe Duodeno-sigmoid fistula due to ingested metallic wire(Elsevier Science Inc, 2008) Yilmaz, Mehmet; Isik, Burak; Sogutlu, Gokhan; Ara, Cengiz; Yilmaz, Sezai; Kirimlioglu, Vedat[Abstract Not Available]Öğe EARLY BILIARY COMPLICATIONS IN 128 CONSECUTIVE LIVING DONOR LIVER TRANSPLANT RECIPIENTS PERFORMED IN ONE YEAR: A NEW SURGICAL TECHNIQUE.(John Wiley & Sons Inc, 2009) Kirimlioglu, Vedat; Yilmaz, Sezai; Yilmaz, Mehmet; Kayaalp, Cuneyt; Isik, Burak; Unal, Bulent; Kirimlioglu, Hale[Abstract Not Available]Öğe The effect of calcineurin inhibitor and alemtuzumab treatment to the rat liver regeneration.(Wiley, 2006) Kirimlioglu, Vedat; Kirimlioglu, Hale; Yilmaz, Sezai; Kayaalp, Cuneyt; Yologlu, Saim[Abstract Not Available]Öğe THE EFFECTS OF ANTIVIRAL DRUGS ON REGENERATION IN CIRRHOTIC LIVERS: A STUDY OF STATS, INTERLEUKINS AND KI-67(John Wiley & Sons Inc, 2009) Kirimlioglu, Hale; Dirican, Abuzer; Tatli, Faik; Aydin, Burcu; Yilmaz, Sezai; Kirimlioglu, Vedat[Abstract Not Available]Öğe Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis(Lippincott Williams & Wilkins, 2008) Karadag, Nese; Kirimlioglu, Hale; Isik, Burak; Yilmaz, Sezai; Kirimlioglu, VedatThe correlation between matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14 expression on the prognostic parameters of gallbladder carcinoma (GBC) and their role in carcinogenesis were evaluated. Carcinomas of the gallbladder (n = 20) and chronic cholecystitis (n = 10) were studied for the expression of MMP-2, MMP-9, and MMP-14 by immunohistochemistry. In all of the cases, metaplastic and dysplastic epithelial alterations, and (in GBC histologic type, grade of differentiation, level of infiltration, perineural and angiolymphatic invasion, liver invasion, and lymph node involvement were noted. MMP-2, MMP-9, MMP-14 were expressed in tumor epithelium in 9 (45%), 20 (100%), and 20 (100%) of the cases, respectively. MMP stromal expression including muscle layer, vascular endothelium, fibroblasts, and lymphoid cells were detected in all cases. MMP-2 was not expressed in normal, metaplastic, and dysplastic epithelia. In contrast, MMP-9 and MMP-14 immunoreactivities were present in antral-type metaplastic areas as moderate (grade 2) and strong in dysplastic epithelia (grade 3). Only in mucinous-type GBC was the expression of the MMPs lower than in the other types. No significant correlation was detected with the grade of differentiation, level of infiltration, perineural and angiolymphatic invasion, liver invasion, or lymph node involvement. These data suggest that MMP-9 and MMP-14 overexpression may have an important role in tumorigenesis. MMP-2, MMP-9, and MMP-14 were expressed in GBC epithelium but also the expression in the stromal component may be essential for the malignant potential of GBC.Öğe The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gall bladder cancer, ampullary carcinoma; Role of matrixmetalloproteinases in tumor progression(Springer, 2007) Kirimlioglu, Hale; Karadag, Nese; Turkmen, Ilknur; Yilmaz, Sezai; Kirimlioglu, Vedat[Abstract Not Available]Öğe The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: Role of matrix metalloproteinases in tumor progression and prognosis(Aves, 2009) Kirimlioglu, Hale; Turkmen, Ilknur; Bassullu, Nuray; Dirican, Abuzer; Karadag, Nese; Kirimlioglu, VedatBackground/aims: Carcinomas of the biliary tree are rare tumors of the gastrointestinal tract, with an increasing incidence in recent years. Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma. We aimed to determine the expression profile of matrix metalloproteinase (MMP)-2, MMP-9 and MMP-14 in the biliary neoplasms classified according to their localization and the relation with the prognosis. Methods: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study. The immunohistochemical expression of MMP-2, MMP-9 and MMP-14 was detected in the nontumoral, metaplastic, dysplastic and tumoral epithelia. The tumor differentiation, angiolymphatic and perineural invasion of the tumor, and presence of lymph node and distant metastasis were determined. Survey of the patients was noted from the patient follow-up data. Results: The nontumoral epithelia of the gallbladder, intrahepatic ducts, and Klatskin tumor did not express MMP-2. MMP-2 expression was detected in the distal part of the biliary ducts, in 7.5% (6118) of cases and in. the nontumoral epithelia of the ampullary region in 50% (5110) of cases. The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors. In the intrahepatic cholangiocarcinoma, the hepatocytes were positively stained but the infiltrative tumors were spared. Klatskin tumors were also not stained with MMP-2. The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively. MMP-9 and MMP-14 were expressed in normal, inetaplastic, and dysplastic epithelium and tumoral cells in all of the cases of the groups. Expressions of MMAs were higher in subjects with neural invasion, but there was no correlation between MMP expression and tumor differentiation or angiolymphatic invasion. Conclusions: When tumors of the biliary system are divided as intrahepatic and extrahepatic cholongiocarcinomas, MMP-2 expression was present in the extrahepatic cholangiocarcinomas including gallbladder carcinomas. Like the intrahepatic cholangiocarcinoma, Klatskin. tumors also did not express MMP-2. This can be related with its characteristic growth pattern. MMP-9 and MMP-4 were present in metaplasia, dysplasia carcinoma sequence in all of the bile tract tumors, suggesting that MMPs play art important role in carcinogenesis. The higher expression of the MMPs with neural invasion suggests the significant role of those tumors in the invasion activity.Öğe A giant retroperitoneal lipoma case with recurrent course(Int Scientific Literature, Inc, 2008) Dirican, Abuzer; Unal, Bulent; Aydin, Cemalettin; Unal, Demet; Kirimlioglu, VedatBackground: Retroperitoneal lipomas are very rare cases and most of them are reported as liposarcoma. We want to present a giant retroperitoneal lipoma case with recurrent course that reported as lipoma in two histopathological examinations after primary and recurrent resection. Case Report: The blood laboratory tests of a 67 year old woman who applied to hospital with constipation and abdominal swelling complaints were assessed to be normal. Retroperitoneal located mass of 43x30X14 cm in fat density was detected in abdominal computerized tomography (CT). After fine needle aspiration biopsy, the mass was found to be compatible with lipoma. Mass excision was performed on the patient (5450 gr). Histopathological examination was reported to be lipoma. The patient applied to the clinic with recurrent retroperitoneal lipoma in the postoperative first year. Second histopathological examination was reported to be compatible with lipoma. Mass was not detected in the first year check of the patient in follow-up. Conclusions: Indeed retroperitoneal lipomas are benign character, this lesions require close follow up due to their possibility of recurrence.Öğe HEPATIC ARTERY THROMBOSIS IN 153 CONSECUTIVE LIVER TRANSPLANT RECIPIENTS PERFORMED IN YEAR 2008: A NEW SURGICAL TECHNIQUE.(John Wiley & Sons Inc, 2009) Kirimlioglu, Vedat; Yilmaz, Sezai; Nisanoglu, Vedat; Ara, Cengiz; Aydin, Cemalettin; Ozgor, Dincer; Kirimlioglu, Hale[Abstract Not Available]Öğe IMPACT OF VENOUS DRAINAGE ON HISTOPATHOLOGY OF THE ANTERIOR SEGMENT OF RIGHT LIVING-RELATED LIVER GRAFTS(John Wiley & Sons Inc, 2008) Kirimlioglu, Vedat; Yilmaz, Sezau; Kirimlioglu, Hale; Yilmaz, Mehmet[Abstract Not Available]Öğe Kaposi's sarcoma after liver transplantation from a donor with a history of ventriculoperitoneal shunt and craniotomy for primary central nervous system lymphoma: Report of a case(Springer, 2008) Isik, Burak; Yilmaz, Sezai; Kirimlioglu, Vedat; Kirimlioglu, Hale; Yilmaz, Mehmet; Sogutlu, Gokhan; Ara, CengizThe transplantation of organs from donors who have undergone shunt surgery or craniotomy for a malignant central nervous system (CNS) tumor is controversial. We report a case of Kaposi's sarcoma (KS) developing as a result of immunosuppression in the recipient of a liver transplant from a donor who underwent craniotomy and ventriculoperitoneal shunt surgery for primary CNS lymphoma. Polymerase chain reaction assay did not isolate human herpes virus-8 in the Kaposi lesions. To our knowledge, this is the only case ever reported of KS developing after liver transplantation from a donor with lymphoma. Thus, with appropriate screening to exclude possible dissemination, patients with a history of high-grade primary CNS lymphoma treated by ventriculoperitoneal shunt and craniotomy may be accepted as donors.Öğe Laparoscopic splenectomy with a vessel sealing device(Taylor & Francis As, 2008) Aydin, Cemalettin; Kayaalp, Cuneyt; Olmez, Aydemir; Tatli, Faik; Kirimlioglu, VedatWhen compared with open splenectomy, laparoscopic splenectomy was associated with fewer complications, however, with more hemorrhagic complications. Furthermore, the mean operative time for laparoscopy was significantly longer than for the open procedure. Vessel sealing systems are represented as decreasing operative time and blood loss in Several surgical procedures. The aim of this study is to evaluate the blood loss and operating time of laparoscopic splenectomy with a vessel sealing system. We evaluated 19 laparoscopic splenectomies with a vessel sealing device, particularly focusing on operative blood loss and operating time. Patients were operated in the right lateral decubitus position usually with three ports. In all cases, dissection of the spleen and sealing of hilar vessels and short gastric vessels were performed with a vessel sealing system. No clips, sutures, or monopolar bipolar diathermy were used. Mean operative blood loss was 88ml (range 20400 ml) and mean operative time was 107 minutes (range 45-230 minutes). Both results were better than those of most series of laparoscopic splenectomy performed with endostaplers or endoclips. Laparoscopic splenectomy with a vessel sealing system is safe for all vascular controls in laparoscopic splenectomy and can lead to less blood loss. This technique removes the disadvantage of longer operating times for laparoscopic as compared to open splenectomy.Öğe LIVING DONOR LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA: TWO-CENTER PRELIMINARY RESULTS(John Wiley & Sons Inc, 2009) Tokat, Yaman; Yilmaz, Sezai; Kirimlioglu, Vedat; Kirimlioglu, Hale; Kayaalp, Cuneyt; Yuzer, Yildiray[Abstract Not Available]Öğe Matrix metalloprotein expression in gastrointestinal stromal tumors(Springer, 2007) Kirimlioglu, Hale; Isik, Burak; Kirimlioglu, Vedat[Abstract Not Available]Öğe Matrix metalloproteinase expression in nontumoral pancreas, pancreatic intraepithelial neoplasia and ductal pancreas carcinoma: Role in carcinogenesis and prognosis(Springer, 2007) Kirimlioglu, Hale; Kirimlioglu, Vedat; Yilmaz, Sezai[Abstract Not Available]Öğe Proximal jejunojejunal intussusception secondary to submucosal lipoma in an adult(Int Scientific Literature, Inc, 2008) Dirican, Abuzer; Unal, Bulent; Ozgor, D.; Piskin, T.; Kirimlioglu, VedatBackground: Jejunojejunal intussusception in adult is a rare condition. Jejunal lipoma induced intussusception in adult cases in literature are limited in number. Case Report: The present report describes a case of proximal jejunojejunal intussusception secondary to submucosal lipoma in a adult with history of severe nausea and vomiting. The diagnosis was suspected in computed tomography preoperatively. An intraluminal mass with a diameter of 2.5 cm was palpated at laparatomy after reduction of intussusception. Partial resection and jejunojejunostomy was performed. Pathological evaluation revealed jejunal submucosal lipoma. Conclusions: In conclusion intussusception and/or masses located in proximal part of small intestine must be kept in mind in cases with severe nausea and vomiting without a known origin and resulting in renal failure.Öğe Tuberculosis of the Thyroid Gland: An Uncommon Cause of Thyroid Nodules(Galenos Yayincilik, 2006) Sogutlu, Gokhan; Isik, Burak; Yilmaz, Mehmet; Karadag, Nese; Olmez, Aydemir; Kebebew, Electron; Kirimlioglu, VedatWe present the case of a 33-year-old woman with tuberculosis of the thyroid. She presented with a thyroid mass, weakness and palpitation for two years. The diagnosis was established on histological examination after thyroid lobectomy. She had an uneventful recovery and received antituberculous medications.
