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    Effects of thyroid hormone supplementation on oxidative stress after sleeve gastrectomy in rats
    (2018) Orman, Suleyman; Isbilen Basok, Banu; Kisa, Ucler; Isman, Ferruh Kemal; Genc Kahraman, Nevin
    Aim: Sleeve gastrectomy has been used for the surgical treatment of morbid obesity. The aim of the present study was to determine the effects of triiodothyronine supplementation on oxidative stress parameters in anastomotic tissue level. Material and Methods: Twenty-four male Wistar albino rats were divided into control (n:12), and experimental (n:12) groups and underwent sleeve gastrectomy. Experimental group rats received a single dose of triiodothyronine (400 mg/100 g) in the operation day. Rats were sacrificed on postoperative day 7. Serum thyroid hormones were analysed. The supernatants were used to measure total oxidant status, total antioxidant status, nitric oxide and malondialdehyde levels. All tissue parameters were analysed by spectrophotometric methods. Oxidative stress index values were calculated. Results: Thyroid stimulating hormone levels in both the control and triiodothyronine group did not significantly change on the 7th postoperative day (p=0.663). Free triiodothyronine levels were significantly higher in triiodothyronine group rats than in control group rats (triiodothyronine vs control: p=0.004). Although total oxidant status levels did not altered by thyroid hormone treatment (p>0.05), total antioxidant status levels significantly decreased (p<0.05). Oxidative stress index values were not statistically different in tissues (p>0.05). Tissue nitric oxide levels were also similar in both groups (p>0.05). Malondialdehyde levels increased in triiodothyronine given rats compared with the control group (p<0.01). Conclusion: This study showed that total oxidant status levels and oxidative stress index values were similar in both groups. However, triiodothyronine supplementation induced lipid peroxidation by increasing tissue malondialdehyde levels that might deplete tissue antioxidant level.
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    Is there any association between microalbuminuria and Parkinson’s disease?
    (2019) Alpua, Murat; Kisa, Ucler
    Aim: To investigate microalbuminuria in patients with Parkinson’s disease (PD) and to determine its relationship with the stages of the disease. Parkinson’s disease (PD) is a chronic neurodegeneration of dopaminergic neurons in the substantia nigra. The reason for the death of these neurons is still unclear; however, studies have demonstrated the potential involvement of mitochondria, endoplasmic reticulum in contributing to cellular oxidative stress.Material and Methods: Thirty-two PD patients who admitted to Neurology Clinic of Kirikkale University’s Medical Faculty and 30 healthy volunteers whose age and sex-matched were included in the study. Urine creatinine and urine albumin levels were determined in patient and healthy groups. The disease duration and Hoehn and Yahr stages were recorded.Results: There was no statistically significant difference between urine creatinine, microalbumin, and urine creatinine/albumin ratios when PD patient results compared with the healthy volunteers’. There was no significant correlation among urine creatinine, microalbumin, and urine creatinine/albumin ratio between the disease duration and Hoehn and Yahr staging in patients with PD.Conclusion: Microalbuminuria is an indirect finding of oxidative stress in urine. In the current study, microalbuminuria was not detected in PD patients at various stages of the disease. It is an important finding that microalbuminuria, a marker of oxidative stress in the urine in PD, a disease in which oxidative stress plays a significant role in etiopathogenesis, is not found.Keywords: Hoehn and Yahr Scale;microalbumin; oxidative stress; Parkinson’s disease; Urine creatinine.