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Öğe Analysis of the effects of hypothalamic-pituitary-adrenal axis activity in menstrual cycle on ankle proprioception, dynamic balance scores and visual-auditory reaction times in healthy young women(Jmni, 2021) Senol, Deniz; Ucar, Cihat; Toy, Seyma; Kisaoglu, Aysegul; Ozbag, Davut; Ersoy, Yuksel; Yildiz, SedatObjectives: Menstrual cycle (MC) can affect not only the female reproductive system, but also functions such as neuromuscular performance. For this reason. the aim of this study is to investigate the effect of hypothalamic-pituitary-adrenal axis (HPA) activity in MC on proprioception, balance and reaction times. Methods: For cortisol analysis, saliva samples were taken from the same women (n=43) in the four phases of MC. While State Trait Anxiety Inventory-I (STAI-I) was applied in each phase to support cortisol analysis, pain was measured with visual analogue scale (VAS). Proprioception, dynamic balance, visual and auditory reaction times (VRT-ART) measurements were made in the four phases of MC. Results: Cortisol, STAI-I and VAS scores, angular deviations in proprioception measurements, dynamic balance scores, VRT and ART measurements were found to show statistically significant difference between MC phases (p<0.05). As a result of the post hoc test conducted to find out which MC phase the statistical difference resulted from, it was found that statistically significant difference was caused by the mensturation (M) phase (p<0.05). Conclusions: It was found that neuromuscular performance and postural control was negatively affected by HPA axis activity in M phase of MC and by pain, which is a significant menstrual symptom.Öğe Are visual and auditory reaction times influenced by ramadan fasting? Neuro performance study on healthy individuals(2019) Senol, Deniz; Kisaoglu, Aysegul; Canbolat, Mustafa; Calisgan, Elisa; Acak, Mahmut; Duz, Serkan; Ozbag, DavutAim: The purpose of this study is to find out whether visual and auditory reaction time (VRT and ART) is influenced by Ramadan fasting in healthy individuals in terms of neuro performance. Materials and Methods: 60 healthy individuals (30 male, 30 female) with the mean age of 20.22±1.45 years participated in the study. First reaction measurement was collected on the second week of the date Ramadan fasting started and this period was called fasting period. Second reaction measurement was collected five days after Ramadan fasting ended and this period was called post-fasting period. VRT and ART of the samples who participated in the study were made with reaction timer device. 10 trials for sound and light stimuli were taken from each sample. The first five trials were considered as exercise and the average of the last five trials was determined as reaction time. The analysis of VRT and ART in fasting and post-fasting periods was conducted with Wilcoxon matched pairs test. In addition, Mann Whitney U test was used to analyze whether there were differences between fasting and post-fasting periods of males and females in terms of VRT and ART. Results: No statistical difference was found between the VRT and ART of males and females in fasting and post-fasting period (p>0.05). Conclusion: In this study which examined the effect of fasting on VRT and ART, it was found that males and females who participated in this study were not negatively influenced by Ramadan fasting in terms of neuro performance.Öğe Investigation of the Effect of Astaxanthin on Oxidative Stress in Renal Ischemia-Reperfusion Modeled Rats(Wiley, 2022) Kisaoglu, Aysegul; Kose, Evren; Yilmaz, Nesibe; Tanbek, Kevser; Yilmaz, Umit; Ozbag, Davut[Abstract Not Available]Öğe Protective effect of astaxanthin on testis torsion/detorsion injury through modulation of autophagy(Mre Press, 2024) Yilmaz, Nesibe; Yildiz, Azibe; Tanbek, Kevser; Kisaoglu, Aysegul; Yilmaz, Umit; Kose, EvrenA significant clinical condition known as testicular torsion leads to permanent ischemic damage to the testicular tissue and consequent loss of function in the testicles. In this study, it was aimed to evaluate the protective effects of Astaxanthin (ASTX) on testicular damage in rats with testicular torsion/detorsion in the light of biochemical and histopathological data. Spraque Dawley rats of 21 were randomly divided into three groups; sham, testicular torsion/detorsion (TTD) and astaxanthin + testicular torsion/detorsion (ASTX + TTD). TTD and ASTX + TTD groups underwent testicular torsion for 2 hours and then detorsion for 4 hours. Rats in the ASTX + TTD group were given 1 mg/kg/day astaxanthin by oral gavage for 7 days before torsion. Following the detorsion process, oxidative stress parameters and histopathological changes in testicular tissue were evaluated. Malondialdehyde (MDA) and total oxidant status (TOS) levels were significantly decreased in the ASTX group compared to the TTD group, while superoxide dismutase (SOD), glutathione (GSH) and total antioxidant status (TAS) levels were increased ( p < 0.05). Moreover, histopathological changes were significantly reduced in the group given ASTX ( p < 0.0001). It was determined that ASTX administration increased Beclin-1 immunoreactivity in ischemic testicular tissue, while decreasing caspase-3 immunoreactivity ( p < 0.0001). Our study is the first to investigate the antiautophagic and antiapoptotic properties of astaxanthin after testicular torsion/detorsion based on the close relationship of Beclin-1 and caspase-3 in ischemic tissues. Our results clearly demonstrate the protective effects of ASTX against ischemic damage in testicular tissue. In ischemic testicular tissue, ASTX contributes to the survival of cells by inducing autophagy and inhibiting the apoptosis.
