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Öğe Acquired Capillary Hemangioma With Features of Tufted Angioma in the External Auditory Canal(Lippincott Williams & Wilkins, 2013) Cetinkaya, Zekeriya; Toplu, Yuksel; Kizilay, Ahmet; Aydin, Nasuhi EnginTufted angiomas may occur in the head and neck region, but the external auditory canal is a previously undefined localization. There are only 19 cases of hemangiomas reported in this unique localization. However, this case is the first capillary hemangioma of the tufted variant being reported with a recurrence after 7 years after surgical excision in a 47-year-old male patient.Öğe Congenital Muscular Torticollis in Older Children: Treatment With Z-Plasty Technique(Lippincott Williams & Wilkins, 2014) Ekici, Nur Yucel; Kizilay, Ahmet; Akarcay, Mustafa; Firat, YezdanCongenital muscular torticollis (CMT) is a common congenital disorder of the musculoskeletal system in neonates and infants. The aim of this study was to evaluate the results of inferior Z-plasty in older children with CMT. They had mean age of 10 years (range, 5-14 years) and were followed up for 1 to 6 years. Postoperative protocol included a neck exercise program composed of active and passive movements in all cases and immobilization with a cervical collar in only 4 patients. This study concluded that surgical management of older children with CMT using Z-lengthening gives excellent clinical and functional results. The procedure is much more effective than other techniques and relatively complication-free and safe. Postoperative cervical collar and a well-planed physiotherapy protocol go a long way toward ensuring good to excellent results. Early diagnosis and treatment are necessary for good results.Öğe Cutaneous Myiasis in a Malignant Wound of the Head and Neck Region(Lippincott Williams & Wilkins, 2012) Bayindir, Tuba; Cicek, Mehmet T.; Atambay, Metin; Kizilay, AhmetMyiasis is a parasitic infestation of vital tissue of humans or other mammals by dipterous larvae. Human myiasis is a rare clinic condition but more frequently seen in tropical and subtropical areas, in patients who have poor hygiene, have bad housing conditions, are with mental retardation, or have advanced age. We report a case of myiasis in a malignant wound (squamous cell carcinoma) in the head and neck region because a few literature reports were seen in this localization. The patient's treatment was antisepsis, larval removal, and general care preventions, whereas standard treatment options or guidelines are not available.Öğe Deep learning model developed by multiparametric MRI in differential diagnosis of parotid gland tumors(Springer, 2022) Gunduz, Emrah; Alcin, Omer Faruk; Kizilay, Ahmet; Yildirim, Ismail OkanPurpose To create a new artificial intelligence approach based on deep learning (DL) from multiparametric MRI in the differential diagnosis of common parotid tumors. Methods Parotid tumors were classified using the InceptionResNetV2 DL model and majority voting approach with MRI images of 123 patients. The study was conducted in three stages. At stage I, the classification of the control, pleomorphic adenoma, Warthin tumor and malignant tumor (MT) groups was examined, and two approaches in which MRI sequences were given in combined and non-combined forms were established. At stage II, the classification of the benign tumor, MT and control groups was made. At stage III, patients with a tumor in the parotid gland and those with a healthy parotid gland were classified. Results A stage I, the accuracy value for classification in the non-combined and combined approaches was 86.43% and 92.86%, respectively. This value at stage II and stage III was found respectively as 92.14% and 99.29%. Conclusions The approach presented in this study classifies parotid tumors automatically and with high accuracy using DL models.Öğe The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin(Korean Soc Otorhinolaryngol, 2016) Toplu, Yuksel; Sapmaz, Emrah; Parlakpinar, Hakan; Kelles, Mehmet; Kalcioglu, M. Tayyar; Tanbek, Kevser; Kizilay, AhmetObjectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P <0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group's measurements. Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.Öğe Effect of Intranasal Estrogen on Vocal Quality(Mosby-Elsevier, 2009) Firat, Yezdan; Engin-Ustun, Yaprak; Kizilay, Ahmet; Ustun, Yusuf; Akarcay, Mustafa; Selimoglu, Erol; Kafkasli, AyseThe objective of this study was to evaluate the effect of intranasal estrogen therapy on female vocal quality. Thirty-two women who had surgically induced menopause were included into the study group and examined through hall year for this study. Estrogen treatment was proposed to all of the patients. Twenty-three of them accepted the treatment protocols including oral (n = 12) (2 mg estradiol; Estrofem; Novo Nordisk, Denmark) and intranasal (n = 11) (300 mcg 17beta-estradiol; Aerodiol; Servier, Chambray-les-Tours, France) form of estrogen. The rest of patients refused estrogen treatment and those patients constituted the control group (n = 9). Vocal changes were evaluated with Voice Handicap Index (VHI) and acoustic analysis of voice variations (fundamental frequency [F0], SD F0, jitter, shimmer, normalized voice energy, and harmonics-to-noise ratio) at baseline and after 1-year follow-up. According to VHI, while voice improvement was not clear in oral estrogen group, it was significant at intranasal estrogen group. Voice quality in patients treated with hormone replacement therapy (HRT) was significantly higher than patients without HRT. But between two treatment groups, there were no any statistical discrepancy. According to acoustic analysis, vocal stability among the women who use HRT was significantly better than those who did not use. Intranasal estrogen exerted the most significant effects on vocal stability. The data of our study support that voice undergoes changes in lack of estrogen in surgically induced menopausal women. Taken together with the relevant studies, while oral estrogen replacement therapy shows a favorable influence on voice quality, it seems to be more pronounced with intranasal estrogen than oral form.Öğe The effects of residual parotid volume on symptom-specific quality of life and complications in patients undergoing parotid surgery(Springer, 2021) Aydin, Sukru; Erbay, Mehmet Fatih; Kizilay, AhmetPurpose To measure postoperative residual parotid volumes in parotidectomy patients and to measure the effect of residual parotid volumes on the symptom-specific quality of life (SSQOL) and complications. Methods Between January 2010 and December 2016, 148 parotid gland surgeries were performed, and 74 patients were included in the study. Bilateral parotid gland volumes were measured by Magnetic Resonance Imaging (MRI). Parotidectomy Outcome Inventory-8 and aesthetic scale questionnaire were applied to the patients. The volumetric averages obtained were compared with the questions in the SSQOL scale, the aesthetic scale data, and complications. Results In the volumetric examination performed with MRI, the mean residual volumes of the operated parotid glands were 9.5 cm(3), while the non-operated side was 28.8 cm(3). The width of the surgery and the residual parotid tissue volume was inversely correlated. There was a statistically significant difference between the residual parotid gland volume and the pain related to the surgical area, depression in the surgical site, Frey's syndrome, incision scar, and numbness. As the residual parotid gland volumes decreased, the patients' cosmetic problems related to the surgical field increased significantly, and their SSQOL decreased. Conclusion Postoperative residual parotid tissue volume could be an objective parameter to measure patients' SSQOL and complications. After parotidectomy, the maximum amount of disease-free tissue of the parotid gland should be left in place to increase patients' quality of life and minimize complications.Öğe Effects of Topical Phenytoin on Nasal Wound Healing After Mechanical Trauma: An Experimental Study(Wiley, 2014) Simsek, Gokce; Ciftci, Osman; Karadag, Nese; Karatas, Erkan; Kizilay, AhmetObjectives/HypothesisImpaired postoperative wound healing is the second most common morbidity after synechia formation in endoscopic sinus surgery. The aim of this experimental study was to investigate the potential effects of topical phenytoin on wound healing after nasal mucosal trauma in rats. Study DesignAn experimental study at the Inonu University Faculty of Medicine. MethodsTwenty-four rats were randomized into three groups: 1) phenytoin group (n=8), 2) control group (n=8), and 3) vehicle group (n=8). After damaging the right nasal cavity, in the phenytoin group, 1% topical phenytoin cream was applied for 7 days. The rats in the control group did not receive any treatment. The vehicle group was treated with daily topical cold cream for 1 week. The rats were sacrificed at the end, and the nasal cavities were excised. Tissue edema and inflammatory cell infiltration were compared among the groups. Additionally, proliferating cell nuclear antigen (PCNA) and cluster of differentiation 31 (CD31) immunoexpression levels were evaluated. Furthermore, in biochemical analysis, the tissue levels of vascular endothelial growth factor and (EGF) of the groups were investigated. ResultsIn the phenytoin group, tissue edema and inflammatory cell infiltration were significantly decreased, and PCNA and CD31 immunoexpression levels were more prominent (P<.001) and the tissue EGF levels were significantly higher (P<.01). ConclusionsTopical phenytoin treatment may alter the nasal wound healing after mechanical trauma. The potential beneficial effects of topical phenytoin on nasal mucosa should be investigated by further experimental and human trials. Level of EvidenceNA Laryngoscope, 124:E449-E454, 2014Öğe Endoscopic Transoral Resection of Parapharyngeal Osteoma: A Case Report(W B Saunders Co-Elsevier Inc, 2016) Yaslikaya, Serhat; Koca, Cigdem Firat; Toplu, Yuksel; Kizilay, Ahmet; Akpolat, NusretOsteoma is a benign, mesenchymal, slow-growing, osteogenic tumor commonly occurring in the craniofacial bones and is characterized by the proliferation of compact or cancellous bone. Solitary osteomas can be classified as peripheral (parosteal, periosteal, or exophytic) when arising from the periosteum or central (endosteal) when arising from soft tissue. Peripheral osteoma occurs most frequently in the paranasal sinuses. Other locations include the orbital wall, temporal bone, pterygoid processes, external ear canal, and, rarely, the mandible. Osteomas in the oromandibular region often appear in the jaw in the canine fossa, hard palate, and maxillary sinus and in the lower jaw in the inner mandible and outer circumference and lingual side of the molar region. At radiologic imaging, a peripheral osteoma of the mandible appears as a well-circumscribed, round to oval, mushroom-like radiopaque mass with distinct borders. Computed tomography is the best imaging modality for determining the location and actual extension of the lesion. Parapharyngeal space tumors are rare tumors of the head and neck region. Benign tumors of the parapharyngeal space are more common than malignant tumors. A foreign body sensation in the pharynx, difficulty with deglutition, and hoarseness are symptoms generally related to the position of the tumor. Upper airway obstruction, painful throat, unilateral tinnitus, trismus, dysarthria, glossopharyngeal neuralgia, and cranial nerve palsies are other reported symptoms. This report presents the case of a huge osteoma of the left mandibular condyle extending to the parapharyngeal space. (C) 2016 American Association of Oral and Maxillofacial SurgeonsÖğe Endoscopic Transoral Resection of Tongue Base Ancient Schwannoma(Lippincott Williams & Wilkins, 2020) Yaslikaya, Serhat; Kizilay, Ahmet; Samdanci, EmineSchwannoma is a benign slow growing nerve sheath tumor that is typically encapsulated and composed of well-differentiated schwann cells. Schwannomas may take origin from different nerves such as cranial, spinal nerves, and the sympathetic chain. Approximately 25% to 45% of all occur in the head and neck only 1% of them are located in the oral cavity. However, it is quite rare to for schwannomas to form on the tongue base. Ancient schwannoma is the rarest, and also extremely rare in oropharynx. A 32-year-old female patient was admitted to our clinic with complaints of hoarseness, difficulty in swallowing, throat pain, snoring, and dyspnea. In examination, a smooth surfaced circumscribed mass, which originated from the tongue base was observed. In the magnetic resonance imaging, a 4.5 x 3 cm sized tongue base mass which narrowed the upper airway was detected. An endoscopic transoral excisional biopsy was performed. The histopathological diagnosis was determined as ancient schwannoma. The use of the endoscopic transoral approach can be suitable to protect the important anatomical structures, functions, and reduce the complications and esthetic concerns for the resection of tongue base schwannomas.Öğe Experimental otoacoustic emission and auditory brainstem response changes by stellate ganglion blockage in rat(W B Saunders Co-Elsevier Inc, 2008) Firat, Yezdan; Kizilay, Ahmet; Ozturan, Orhan; Ekici, NurIntroduction: To investigate the effect of stellate ganglion (SG) block on hearing in rats. Materials and methods: Sixteen male adult rats were randomly divided into 2 equal groups. Both groups underwent preblock auditory brainstem responses (ABRs) in response to tone bursts at 4, 6, and 8 kHz and otoacoustic emissions in response to distortion products as a function of f2 frequency at 1, 2, 4, and 6 kHz. Local anesthetic (0.2 mL of 2% prilokain) was administered to the left SG of the study group by posterior cervical percutaneous approach for cervical sympathetic blockage. In the control group, 0.2 mL of physiological saline was injected to the left SG. Postblock hearing evaluations were made after 15 minutes of injections. Results: Both Dp-gram and I/O function records suggested that whereas hearing thresholds were not affected in lower frequencies after SG blockage, it tended to increase at higher frequencies. In ABR records, waves I and II showed marked latency shift across all frequencies. The interpeak latency of waves I and II was shortened after blockage. Saline injection did not show any significant ABR or distortion-product otoacoustic emission threshold shift across frequencies at 60, 70, 80, and 90 dB sound pressure level. Conclusion: Our data demonstrate that SG block improved the hearing parameters in rats with normal cochlear blood flow. To recommend SG blockage as a treatment option in the vascular pathologies of cochlea, further investigation should assess the efficiency of ganglion blockage in hearing parameters of rats with impaired cochlear blood flow. (C) 2008 Elsevier Inc. All rights reserved.Öğe Follicular dendritic cell sarcoma associated with hyaline-vascular castleman's disease(Pakistan Medical Assoc, 2013) Cakir, Ebru; Aydin, N. Engin; Samdanci, Emine; Karadag, Nese; Sayin, Sadegul; Kizilay, AhmetFollicular dendritic cell sarcoma (FDCS) of the head and neck region, associated with Castleman's disease (CD), is an extremely rare entity. To the best of our knowledge, we report the first case demonstrating the transformation of the former into the latter as documented in the same lymph node disection material. A 45-year-old female presented to our hospital with right sided neck swelling. Radio logic imaging showed a well defined 3.5x3.5cm mass of soft tissue at the right side of the neck with multiple bilateral cervical lymph nodes. Excision of the right neck mass with lymph node disection was performed. Microscopic examination and immunohistochemical findings showed features of follicular dendritic cell sarcoma. The associated lymph nodes exhibited changes consistent with hyaline-vascular type CD, follicular dendritic cell hyperplasia and foci of overgrowth in which FDCS possibly evolved. This report confirms the evolving of FDCS in the setting of follicular dendritic cell hyperplasia occurring in Castleman's disease.Öğe A Forgotten reason of dysphagia “Forestier syndrome”(2017) Yaslikaya, Serhat; Kizilay, AhmetForestier syndrome or diffuse idiopathic skeletal hyperostosis is a chronic disease characterized by diffuse formation of osteophytes on the spine that increase with age and occur as a result of enchondral ossification of paravertebral ligaments and muscles. The exact etiology of disease is not known. It is more common in males and usually it occurs over sixty-five years of age. Stiffness, limitation of movement, and spinal pain is seen frequently in patients. Foreign body sensation in the throat, odynophagia, disphagia, hoarseness, stridor, obstructive sleep apnea, and otalgia can be found according to location and size of the pathology. Exact diagnosis can be reached with radiological imaging methods. In early stage and symptomatic cases, physiotherapy, training, and medical treatment may be sufficient. In patients with advanced disease who do not benefit from these treatments, surgery can be performed.Öğe Inflammatory Myofibroblastic Tumor: A Rare Tumor in the Tongue(Hindawi Ltd, 2013) Ekici, Nur Yucel; Bayindir, Tuba; Kizilay, Ahmet; Aydin, Nasuhi EnginInflammatory myofibroblastic tumor is composed of myofibroblast and inflammatory cell infiltration of the tissue. Malign transformation and recurrence rate of this tumor is rare and accepted as benign fibroinflammatory disease. The main etiology is unclear, but infection, trauma, and immunologic event are accused. In this study, we presented a 75-year-old man with a mass on his tongue, which was diagnosed as inflammatory myofibroblastic tumor. This type of tumor is rarely seen in the tongue and might be difficult to diagnose. Complete mass excision was provided for an adaquete treatment.Öğe Isolated preauricular pits and tags: is it necessary to investigate renal abnormalities and hearing impairment?(Springer, 2008) Firat, Yezdan; Sireci, Sule; Yakinci, Cengiz; Akarcay, Mustafa; Karakas, Hakki Muammer; Firat, Ahmet Kemal; Kizilay, AhmetWe investigated the incidence and co-existence of hearing impairment and renal abnormalities in healthy children with preauricular tags and pits. Study population consists of 13,740 primary school children from routine health check. Thirty-five children with preauricular tags and pits were noted. Control group consisted of 91 patients without pits and tags, who underwent renal ultrasound and were scheduled to pediatric outpatient clinic. Urinanalysis, renal ultrasound, otoacoustic emission were performed in both the groups. The prevalence of renal abnormality (1/36; 2.7%) and hearing impairment (1/36; 2.7%) in patients with preauricular tags and pits was similar to that of control group (3/91; 3.2% and 4/91; 4.3%) (P = 0.87, P = 0.64, respectively). According to our results, it is not necessary to investigate hearing or urinary abnormality in patients with preauricular tag or pit, unless there is an association of a syndrome or family history of hearing or renal impairment.Öğe Metastatic Renal Cell Carcinoma to the Condyle of the Mandible(Lippincott Williams & Wilkins, 2012) Kelles, Mehmet; Akarcay, Mustafa; Kizilay, Ahmet; Samdanci, EmineA 59-year-old woman who had left nephrectomy because of renal cell carcinoma (RCC) 3 years ago referred with trismus and a mass on her left temporomandibular joint. Computed tomography scan revealed an expanding lytic lesion on the left condyle of the mandible. Incisional biopsy was carried out. Histopathologic diagnosis was metastatic clear cell variant of RCC. Metastasis of RCC to the condyle of the mandible has not been reported yet. In this study, we presented a case of RCC metastasis to the condyle of the mandible.Öğe Middle turbinate angiofibroma: an unusual location for juvenile angiofibroma(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2018) Toplu, Yuksel; Can, Sermin; Sanli, Mukadder; Sahin, Nurhan; Kizilay, Ahmet[Abstract Not Available]Öğe Olfactory function, olfactory bulb volume, and quality of life after radiotherapy for nasopharyngeal cancer(Aves, 2021) Kaplan, Bilge Kurnaz; Kizilay, Ahmet; Kaplan, Fatih; Toplu, YukselObjective: Radiotherapy (RT) is the standard treatment for nasopharyngeal cancer (NPC). Various advers effects may occur after RT. In this study, we aimed to evaluate the advers effects of RT on the olfactory bulb and olfactory function in patients with NPC and describe the impact of these effects on the patients' quality of life. Methods: We investigated 21 patients with NPC who received RT at least 12 months earlier, in addition to 21 age- and sex-matched healthy controls. The participants underwent a detailed nasoendoscopic ear, nose, and throat examination. All participants received orthonasal olfaction tests and a nasopharyngeal magnetic resonance imaging scan to measure olfactory bulb volume; in addition, they filled out a quality of life questionnaire. Results: There was a significant difference between the orthonasal olfactory test results of the patients and controls (p<0.05). The left and right side olfactory bulb volume values of the patients and controls were statistically similar (p=0.07). There was a significant difference between the quality of life questionnaire results of the patients and controls (p<0.05). Conclusion: Olfactory dysfunction was present in the majority of patients with NPC who received RT.Öğe Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience(Medicine Science, 2016) Ekici, Kemal; Temelli, Oztun; Eraslan, Ayse Fatma; Gurocak, Simay; Kaplan Bozdag, Nihal; Elkiran, Emin Tamer; Kekilli, Ersoy; Kizilay, Ahmet[Abstract Not Acailable]Öğe Pediatric Sudden Sensorineural Hearing Loss(Lippincott Williams & Wilkins, 2016) Kizilay, Ahmet; Koca, Cigdem FiratSudden sensorineural hearing loss is defined as sudden unilateral or bilateral sensorineural hearing loss with at least 30 dB decrease in threshold in 3 contiguous test frequencies occurring over 72 hours or less. It is rare among children. The mechanism of the process and prognosis of the disorder remains unclear. The current incidence of sudden sensorineural hearing loss among pediatric population is unknown. The authors carried out a retrospective chart analysis of patients under 15 years of age from 2004 to 2015, who consulted to the Otolaryngology Head and Neck Surgery Department of Inonu University Medical Faculty. Age, sex, number of affected ear and side, audiometric evaluations, medical follow-up, treatment method, duration of treatment recovery, associated complaints; tinnitus and/or vertigo, presence of mumps disease were recorded for each patient. A 4-frequency pure-tone average (500, 1000, 2000, and 4000 Hz) was calculated for each ear. Complete recovery, defined as some hearing level compared with the nonaffected ear, was observed in 3 patients (21.4 %) and there was no partial hearing recovery. The hearing loss of 11 patient remained unchanged after prednisolone treatment. Two of the 11 patients had bilaterally total sensorineural hearing loss and evaluated as appropriate for cochlear implantation. Sex of patient and laterality of hearing loss were not correlated with hearing recovery. Sensorineural hearing loss among pediatrics has been the issue of otolaryngologists. The incidence, etiology, and treatment methods should be more studied.
