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    Central pontine myelinolysis in Wilson's disease: MR spectroscopy findings
    (Elsevier Science Inc, 2004) Kizkin, S; Sarac, K; Ozisik, HI; Ozcan, C
    Although a pontine lesion on cranial MRI is frequently associated with an extrapontine lesion, few cases report solitary pontine involvement in Wilson disease, and it is usually recognized as central pontine lesions related to hepatic dysfunction. A patient with Wilson's disease having a solitary pontine lesion without basal ganglia involvement in cranial MRI with cerebellar symptoms is presented. Based on MR spectroscopy findings, this solitary pontine lesion could be regarded as central pontine myelinolysis rather than the neurologic involvement in Wilson's disease. (C) 2004 Elsevier Inc. All rights reserved.
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    Cerebral artery hemodynamics in polycystic ovary syndrome
    (Taylor & Francis Ltd, 2005) Kizkin, S; Engin-Ustun, Y; Ustun, Y; Ozcan, C; Serbest, S; Ozisik, HI
    Objective. The aim of the present study was to investigate hemodynamic changes in the medial cerebral artery and also the internal carotid artery in young women with polycystic ovary syndrome (PCOS) and polycystic ovaries (PCO). Methods. Twenty-eight patients with PCOS, 16 patients with PCO and 24 healthy control subjects were included in the study. Blood flow rate, pulsatility index and back pressure of both the medial cerebral artery and the internal carotid artery were determined by transcranial Doppler ultrasonography and the results compared between groups. Results. There were no significant differences between the groups in bilateral medial cerebral artery and internal carotid artery blood flow rate, pulsatility index and back pressure. Conclusion. Our results do not indicate whether the risk of cerebrovascular events will increase for PCOS patients in middle and advanced age, but do show that changes in cerebral hemodynamics are not likely in PCOS at an early stage.
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    Cognitive event-related potential and neuropsychological findings in Behcet's disease without neurological manifestations
    (Tohoku Univ Medical Press, 2005) Ozisik, HI; Karlidag, R; Hazneci, E; Kizkin, S; Ozcan, C
    Behcet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers and uveitis. BD patients without neurological involvement frequently have mild neurological symptoms. The aim of this study was to evaluate whether BD patients without neurological involvement have any changes in cognitive functions. Twenty BD patients without neurological involvement and 13 control subjects were included in the study and were analyzed by neurophysiological and neuropsychological examinations. The cognitive event- related potentials (P300) were recorded from the frontal, central and parietal areas of the right and left hemispheres of the patients and control subjects. Likewise, all individuals were evaluated with neuropsychological tests. In contrast to a study with similar design, C, we did not find any difference between the cognitive event-related potentials values of BD patients without neurological involvement and the control subjects. All BD patients without neurological involvement exhibit normal results of the neuropsychological test. In conclusion. the results of neuropsychological tests and cognitive event-related potentials values in BD patients without neurological involvement are indistinguishable from those in control subjects and no alteration of cognitive functions is present. (c) 2005 Tohoku University Medical Press.
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    Crocodile tears syndrome: botulinum toxin treatment under EMG guidance
    (C I C-Edizioni Internazionali Srl, 2005) Kizkin, S; Doganay, S; Ozisik, HI; Ozcan, C
    In conclusion, we recommend EMG guidance in the treatment of crocodile tears syndrome with botulinum toxin.Crocodile tears syndrome is one of the rare complications of facial paralysis. There have been several reports of cases in which botulinum toxin was found to be useful in the treatment of crocodile tears syndrome. The adverse effects, due to the paralytic action of botulinum toxin, have been reported to involve the palpebral muscle, lateral rectus and superior rectus. Therefore, we considered that it might be more appropriate to carry out the injection procedure under electromyographic guidance in order to inject botulinum toxin selectively into the lacrimal gland and protect the above-mentioned muscles.
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    Isolated intracranial hypertension
    (Elsevier Science Bv, 2004) Özisik, HI; Ersoy, Y; Tevfik, MR; Kizkin, S; Özcan, C
    Brucella melitensis infection is endemic in the eastern and south-eastern Anatolia regions of Turkey. We report an unusual case of brucella meningitis presenting with bilateral papilla stasis, diplopia and absence of other neurological involvement. Diagnosis was made by positive culture of Brucella spp. with a BACTEC 9120 system with inoculation of the patient's cerebrospinal fluid (CSF). This is the first report of isolation of Brucella spp. from CSF on a BACTEC 9120 system for diagnosis of meningitis. This case demonstrated that brucella meningitis may present with very slight symptoms, and inoculation of CSF into BACTEC bottle besides conventional cultures improves the detection of Brucella in endemic areas such as Turkey. (C) 2004 Elsevier SAS. All rights reserved.
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    Sympathetic skin response in premenstrual syndrome
    (Springer Heidelberg, 2005) Ozisik, HI; Kamisli, O; Karlidag, R; Kizkin, S; Ozcan, C
    Premenstrual syndrome is a term which includes a broad group of emotional, behavioral and physical symptoms that occur for several days before menses and subside following the menstrual period. Many women experience premenstrual syndrome symptoms, particularly physical ones such as breast tenderness and swelling. Approximately 5-10% women suffer from severe premenstrual syndrome and another 30-40% have moderate symptoms. Premenstrual syndrome continues to be an unsolved problem. In this study, we evaluated 24 premenstrual syndrome patients and 20 healthy women in the control group. The ages of the women were 22-34 years (mean +/- SD: 25 +/- 3) for the premenstrual syndrome group and 23-34 (25 +/- 3) for the control group. The sympathetic skin response was recorded from the palms, soles and genital regions by using electrical stimuli to the median nerve at the wrist. The sympathetic skin response was recorded twice, in the follicular and late luteal phases of menstruation. The follicular and late luteal phase sympathetic skin response of the two groups were compared. The amplitudes and latency values of the late luteal and follicular phase sympathetic skin response from the premenstrual syndrome group and control group women were statistically similar. We also did not find any latency or amplitude difference in the sympathetic skin response obtained from the three regions of the premenstrual syndrome patients and the control group. We checked sympathetic skin response in the symptomatic (late luteal phase) and asymptomatic (follicular phase) periods of patients with premenstrual syndrome, a disorder known to have many autonomic symptoms, to determine whether there was sudomotor sympathetic involvement. The results of our PMS patients indicate at the very least that there is no difference with the control subjects as regards peripheral sudomotor functions.
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    Topographic abnormalities in event-related potentials in children with monosyptomatic nocturnal enuresis
    (Wiley, 2004) Karlidag, R; Ozisik, HI; Soylu, A; Kizkin, S; Sipahi, B; Unal, S; Ozcan, C
    Aims: A functional maturational delay in the central nervous system is dwelled upon in the pathogenesis of monosymptomatic nocturnal enuresis (NINE). In this study we studied whether according to controls N200 and P300, components of the event-related potential (ERP), which is related to aspects of cognitive processing, showed any difference in its topographic distribution in children within the age group 10-13 with monosymptomatic nocturnal enuresis and discussed its relation to the pathogenesis of MNE. Methods: We performed P300 in 18 patients with MNE and in 16 age-matched healthy subjects. P300 were evoked by an auditory oddball paradigm consisting of 150 tone bursts (80% 1 kHz; 20% 2 kHz). The latencies of the N200 and the P300 waves and the amplitude of the P300 wave were measured. Results: There was no statistical difference between the enuretic group and the controls in N200 and P300 latency and amplitude in the midline frontal (Fz), central (Cz), and parietal (Pz) recording site of the 10-20 International System. In the enuretic group while P300 amplitude in the Fz site was significantly less than the P300 amplitude in the Cz site, there was no statistical difference between the Fz and Pz P300 amplitude values. Conclusions: When different levels of maturational delay are considered in NINE, it may be claimed that maturational delay in children whose enuresis lasts until older ages will be different from those whose enuresis ends at an early age. The determination of P300 amplitude in parietal records being less in enuretics when compared to the controls may show that there are regional differences in stimuli processing rate/quality. (C) 2004 Wiley-Liss, Inc.