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Öğe Effects of glucagon as a neurohormone on the central nervous system and glucose homeostasis(Verduci Editore s.r.l, 2024) Tanbek K.; Yilmaz U.; Gul S.; Koç A.; Gul M.; Sandal S.OBJECTIVE: This study aimed to elucidate the possible effects of the acute/ long-term infusion of glucagon in the brain as the regulatory role on the endocrine secretions of the pancreas. MATERIALS AND METHODS: Ninety male Wistar albino rats were divided as Control, artificial Cerebrospinal Fluid (aCSF) (120 min), Glucagon (120 min), pancreatic denervation (PD)+aCSF (120 min), PD+Glucagon (120 min), aCSF (7 days), Glucagon (7 days), PD+aCSF (7 days) and PD+Glucagon (7 days). Glucagon and solvent (aCSF) were administered after pancreatic denervation (PD) by Hamilton syringe and osmotic mini pump (1 µg/10 µl/min) in the third ventricle of the brain. RESULTS: Acute intracerebroventricular (icv) administration of glucagon resulted in an elevation of glucagon levels and a concurrent reduction in blood glucose levels. Furthermore, in both the PD+aCSF (7 days) and PD+Glucagon (7 days) groups, there was a notable decrease in propiomelanocortin (POMC) and agouti-related protein (AgRP). Significant changes were observed in feed consumption and body weight, as well as pancreatic glucagon levels, with a simultaneous decrease in insulin levels in the PD (7 days), Glucagon (7 days), and PD+Glucagon (7 days) groups. These alterations were statistically significant when compared to the control group (p<0.05). CONCLUSIONS: The research outcomes established that pancreas-secreted glucagon functions as a neurohormone within the brain, activating central pathways linked to blood glucose regulation. The presence of glucagon led to a decrease in POMC levels. Surprisingly, this reduction in POMC resulted in the suppression of AgRP. Contrary to expectations, the suppression of AgRP led to an increase in food intake rather than a decrease. As already highlighted in the results section, it was emphasized that POMC may play a more significant role than AgRP in influencing feeding behavior. © 2024 Verduci Editore s.r.l. All rights reserved.Öğe Giant desmoid tumor in the neck(2014) Toplu Y.; Öztanır N.; Çetinkaya Z.; Koç A.; Kızılay A.Desmoid tumor is a benign tumor which originates from musculoaponeurotic system, can reach greater sizes with local invasion among facial plans, and cause severe deformities, morbidity and even mortality by compression of adjacent structures. These tumors are rarely seen in the head and neck region. The treatment of advanced desmoid tumors of head and neck region is surgery and radiotherapy. In this paper, we present -to the best of our knowledge- the greatest desmoid tumor case of the head and neck region in the literature.Öğe The roles of SFKs in the regulation of proinflammatory cytokines and NLRP3 in familial mediterranean fever patients(Academic Press, 2024) İçen Taşkın I.; Gürbüz S.; Koç A.; Kocabay S.; Yolbaş S.; Keser M.F.Familial Mediterranean Fever (FMF) is caused by mutations in pyrin, a protein produced in innate immune cells that regulates the development of interleukin (IL)-1? by interacting with caspase-1 and other components of inflammasomes. Although overexpression of proinflammatory cytokines have been observed in FMF patients, no studies have been conducted on the role of Src family kinases (SFKs). The purpose of this study was to examine the impact of SFKs on the modulation of IL-1?, IL-6, IL-8, TNF-?, and NLRP3 inflammasome in patients with FMF. The study included 20 FMF patients and 20 controls. Peripheral blood mononuclear cells (PBMCs) were isolated by density gradient centrifugation. Protein expression levels of SFKs members were measured by western blot. The effect of lipopolysaccharide-induced (LPS) activation and PP2- induced inhibition of SFKs on NLRP3 and IL-1?, IL 6, IL-8, TNF-? were examined by western blot and flow cytometry respectively. Patients with FMF have considerably greater levels of Lck expression. In addition, patients had a substantially greater basal level of NLRP3 than the control group (*p = 0.016). Most importantly, the levels of IL-1 ? were elevated with LPS stimulation and reduced with PP2 inhibition in FMF patients. These results suggest that SFKs are effective in regulation of IL-1 ? in FMF patients. © 2024 Elsevier LtdÖğe Synthesis, electrochemical, biological and catalytical studies of half-sandwich Ru(II)-NSHC complexes bearing benzothiazol-2-ylidene(Elsevier B.V., 2024) Tuncer H.; Kılınçarslan R.; Karci H.; Dündar M.; Özdemir İ.; Koç A.; Özdemir N.The half-sandwich ruthenium(II)-NSHC complexes (2a-l) bearing benzothiazol-2-ylidene were synthesized by in situ deprotonation of N-substituted benzothiazolium salts (1a-l) with Ag2O and of [(p-cymene)Cl2Ru]2, in dichloromethane under mild conditions. However, 1m and 1n under the same conditions gave N-coordinated Ru(II) complex (3). The structures of the compounds were elucidated by NMR, FT-IR, UV–Vis, HR-MS spectroscopic methods and elemental analysis. In addition, the structures of 2k and 3 were studied by X-ray crystallography. The electrochemical properties of the complexes were investigated. Ru(II)-NSHC complexes have been used as catalysts in the transfer hydrogenation of carbonyls to secondary alcohols in the presence i-PrOH/KOH. Additionally, the effects of structural differences arising from different alkyl groups on the nitrogen atom in the benzothiazole skeleton in Ru(II)-NSHC complexes on anticancer, antifungal and antimicrobial activity were also examined. © 2024 Elsevier B.V.
