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  • Küçük Resim
    Öğe
    Ratlarda safra kanalı bağlanması ile oluşan kolestatik karaciğer hasarına karşı cape'nin koruyucu etkisi
    (İnönü Üniversitesi, 2005) Koçak, Özcan
    Bilier obstrüksiyon yapılan ratlarda CAPE'nin karaciğer üzerine koruyucu etkisini araştırdık. Bilier obstrüksiyon 14 gün devam etti. Ratlar 3 gruba ayırıldı. Grup A; BO Grup B; BO+CAPE Grupo C; Kontrol. GGT, AST, ALT seviyeleri CAPE verilen grupta azaldı. MDA, GSH, MPO seviyeleri anti-oksidan düzeyleri için çalışıldı. Sonuçta CAPE'nin BO sonrası oluşan karaciğer hasarına karşı koruyucu etkisi olduğu görüldü.
  • Küçük Resim Yok
    Öğe
    Spontaneous small bowel perforations due to intestinal tuberculosis should not be repaired by simple closure
    (J Gastrointest Surg. , 0–0., 2005) Ara, Cengiz; Söğütlü, Gökhan; Yıldız, Ramazan; Koçak, Özcan; Işık, Burak; Kırımlıoğlu, Vedat
    Intestinal tuberculosis is a major problem in many regions of the world. The incidence of it is rising in Western countries due to immigration from Third World countries and human immunodeficiency virus infection. The difference between the simple closure and resection and anastomosis was evaluated in this study. Retrospectively, 12 patients with intestinal tuberculosis diagnosed histopathologically among 50 patients with free intestinal perforations operated on between 1995 and 2003 at Turgut Ozal Medical Center were evaluated. Each patient underwent routine laboratory tests and radiologic studies. The most common symptoms of patients were abdominal pain, night sweats, and weight loss. Sites of perforation were ileum in 10 patients (multiple perforation in 4) and jejunum in 2 patients (both had multiple perforations). The perforation was closed by primary closure in 7 patients. Resection-anastomosis was performed in 5 patients. Leaks occurred in overall 3 of 7 patients with primary closure. Three of the 7 patients with leaks due to septicemia died. The mortality rate among all patients was 25%. Intestinal tuberculosis should be kept in mind as a cause in free intestinal perforations. Because of high mortality rate, the resection of the affected area and anastomosis may be the treatment of choice rather than primary closure.
  • Küçük Resim
    Öğe
    Spontaneous small bowel perforations due to intestinal tuberculosis should not be repaired by simple closure
    (Journal of Gastrointestinal Surgery, 2005) Ara, Cengiz; Söğütlü, Gökhan; Yıldız, Ramazan; Koçak, Özcan; Işık, Burak; Yılmaz, Sezai; Kırımlıoğlu, Vedat
    Intestinal tuberculosis is a major problem in many regions of the world. The incidence of it is rising in Western countries due to immigration from Third World countries and human immunodeficiency virus infection. The difference between the simple closure and resection and anastomosis was evaluated in this study. Retrospectively, 12 patients with intestinal tuberculosis diagnosed histopathologically among 50 patients with free intestinal perforations operated on between 1995 and 2003 at Turgut Ozal Medical Center were evaluated. Each patient underwent routine laboratory tests and radiologic studies. The most common symptoms of patients were abdominal pain, night sweats, and weight loss. Sites of perforation were ileum in 10 patients (multiple perforation in 4) and jejunum in 2 patients (both had multiple perforations). The perforation was closed by primary closure in 7 patients. Resection-anastomosis was performed in 5 patients. Leaks occurred in overall 3 of 7 patients with primary closure. Three of the 7 patients with leaks due to septicemia died. The mortality rate among all patients was 25%. Intestinal tuberculosis should be kept in mind as a cause in free intestinal perforations. Because of high mortality rate, the resection of the affected area and anastomosis may be the treatment of choice rather than primary closure.