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    Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma
    (Gustav Fischer Verlag, 2000) Vural, H; Uzun, K; Uz, E; Koçyigit, A; Çigli, A; Akyol, Ö
    In this study, serum copper, zinc, magnesium, iron and calcium concentrations were investigated in 40 patients with bronchial asthma (BA) and in 43 healthy subjects. Copper and calcium levels were found to be increased in patients with BA compared to the control group (p<0.001 and p<0.001 respectively). On the other hand, the serum zinc level was significantly lower in healthy subjects (p<0.01). No changes were found in serum magnesium and iron levels in patients with BA compared to controls. In addition to various elements, certain serum proteins such as albumin, transferrin and ferritin were also assessed to determine whether there was a relationship between the elements and proteins in patients with BA. There was only a significant decrease in albumin concentration in patients with BA (p<0.05).
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    The role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorder
    (Springer Heidelberg, 2004) Yanik, M; Vural, H; Tutkun, H; Zoroglu, SS; Sava, HA; Herken, H; Koçyigit, A
    There is a reciprocal regulation of arginase and nitric oxide synthase (NOS) in L-arginine-metabolizing pathways. Nitric oxide (NO) may be involved in some psychiatric disorders like schizophrenia, depression and bipolar affective disorder (BPAD). To our knowledge, there is no study in the literature in which the role of arginase, an important part of the arginine regulatory system affecting NOS activity, was investigated in BPAD. This study aims to investigate arginase, manganese (Mn) and total nitrite levels (a metabolite of NO) and their relationship to the arginine-NO pathway in patients with BPAD. Arginase activities, Mn and total nitrite levels were measured in plasma from forty-three patients with BPAD (Type one) and thirty-one healthy control subjects. Plasma arginase activities and Mn were found to be significantly lower and total nitrite level higher in patients with BPAD compared with controls. Our results suggest that the arginine-NO pathway is involved in the pathogenesis of BPAD.