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    The Alterations of the Anterior Chamber Parameters Measured with Pentacam with Age in Healthy Subjects
    (Turkish Ophthalmological Soc, 2008) Emre, Sinan; Koc, Bekir; Doganay, Selim; Yologlu, Saim
    Purpose: To determine the mean values and standard deviations of anterior chamber parameters with pentacam and evaluate the alterations of these parameters with age. Material-Method: 224 eyes of 112 patients with just basic refractive errors were included in this study. After complete ophthalmologic examination of patients, under standard conditions anterior chamber parameters were measured with pentacam. Central corneal thickness (CCT), anterior chamber depth (ACD), corneal volume (CV), anterior chamber volume (ACV), anterior chamber angle (ACA), and also horizontal, vertical and mean keratometry values were recorded with pentacam. Results: 55 female and 57 male patients were included in this study. Mean age of patients was 28.57. Mean of the keratometric measurements was 43.1 D. Mean values for CCT, ACD, CV, ACV and ACA were 534 mu m, 3.14 mm, 59.77 mm(3), 190.26 mm(3), 36.88 degrees, respectively. Evaluation of parameters according to gender and eye distribution did not reveale any difference. Analysis the effect of age on CCT, ACD, CV, ACV and ACA parameters documented statistical significance (p< 0.005) and correlation coefficents were r=-0.185, -0.373, -0.263, -0.320, -0.264, respectively. Conclusion: This study documented the negative effect of age on the anterior chamber parameters with different correlation coefficients.
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    Comparison of the Protective Effects of Prostaglandin Analogues in the Ischemia and Reperfusion Model of Rabbit Eyes
    (Int Press Editing Centre Inc, 2009) Emre, Sinan; Gul, Mehmet; Ates, Burhan; Esrefoglu, Mukaddes; Koc, Bekir; Erdogan, Ali; Yesilada, Elif
    This study was planned to investigate the neuroprotective potentials of three commercially available prostaglandin analogues (PGA), in the ischemia and reperfusion model (I/R). Thirty New Zealand rabbits were divided into 5 groups and except for the control group (non-ischemic, non-treated), 0.9% NaCl, bimatoprost, latanoprost, or travoprost were applied to both eyes of animals of the respective groups for 1 week. At the end of treatment, ischemia was induced in both eyes of the 4 treatment groups by anterior chamber irrigation of the animals for 60 min. Following 24 h reperfusion, the animals were sacrified. Enucleated eyes and retinal tissues were investigated by light microscopy, electron microscopy, immunohistochemicstry for retinal histopathology, intracellular and apoptotic cells and by retinal morphometry. Vitreous samples were biochemically investigated for probable role of reactive oxygen species, by measuring xanthine oxidase (XO) activity. Analysis of morphometric measurements and vitreous XO activity revealed significant differences between the PGA-treated groups and the NaCl-treated group (P<0.05). Similarly, apoptotic cell counts in different retinal layers showed that PGA-treated groups had fewer apoptotic cells in all retinal layers than the NaCl-treated ischemic group (P<0.05). PGA may have high protective potential for different retinal layers and cells. Biochemical analysis of vitreous showed that all PGAs decreased vitreous XO activity significantly compared to the NaCl-treated group (P<0.05). However we could not find any statistically significant differences among the analogues. PGAs may reduce the injury induced by I/R, through the inhibition of XO activity, and it seems that their effects are elicited through numerous pathways.
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    Pupillary Block Glaucoma in a Patient Who Underwent Inverted Implantation of Intraocular Lens: Case Report
    (Ortadogu Ad Pres & Publ Co, 2012) Doganay, Selim; Firat, Penpegul; Cankaya, Cem; Koc, Bekir
    Current report presents an interesting case who had pupillary block glaucoma in postoperative period related to the inverted implantation of intraocular three piece-lens with optic haptic angulation of 5 degrees. A 23-year-old female admitted for severe pain and loss of vision in her left eye for 7-8 hours. Visual acuity was 0.9 in right eye and finger counting from two meters in left eye. Biomicroscopic examination showed that posterior chamber intraocular lens located in ciliary sulcus and open posterior capsule in central area in right eye. Ciliary congestion and severe corneal edema were observed in left eye. Anterior chamber structures were not clearly observed, anterior chamber was shallow and iris was dome shaped. The optic of intraocular lens which was placed in posterior chamber, entirely shifted to anterior chamber through pupilla and formed a pupillary block. Intraocular pressure was 12 mmHg in right eye, 63 mmHg in left eye. The patient whose intraocular pressure got under control by medical therapy was performed peripheral iridotomy using Nd:YAG laser. One week after iridotomy, the visual acuity was 0.5 and the intraocular pressure was measured as 15 mmHg. After corneal opacity completely improved, it was noticed that intraocular lens was placed inversely within the posterior chamber. The lens optic within the anterior chamber was placed into the posterior chamber with a surgical intervention. In the fourth month following surgery, inferior half of the intraocular lens optic was decentralized again into the anterior chamber (without pupil blockage because of the iridotomy open at 1 o'clock) and intraocular pressure was measured as 12 mmHg. With a second surgical intervention, the intraocular lens was set into correct position by inverting it and it was centralized at ciliary sulcus.