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    Serum salusin-? and -ß levels in patients with parkinson?s disease
    (Springer-Verlag Italia Srl, 2024) Algul, Fatma Ebru; Koc, Emine; Kaya, Hatice Tosun
    Background The etiology of Parkinson ' s disease (PD) is not well known and there is increasing evidence that oxidative stress also plays an important role in its pathogenesis. Salusins alpha (salusin-alpha) and beta (salusin-ss) affect the central nervous system, vasculature, and kidneys to increase the inflammatory response in endothelial cells, stimulate oxidative stress, and increase monocyte-endothelial adhesion. Neuroinflammation and oxidative stress play roles in the etiopathogenesis of PD. Purpose To investigate whether salusin-alpha and -ss are related to PD and whether they are correlated with the development of atherosclerosis, body mass index, disease duration, and the Parkinson ' s Hoehn and Yahr stage. Results The low-density lipoprotein cholesterol (LDL-C), total cholesterol, and salusin-ss levels were significantly lower and age was significantly higher in Parkinson patients compared to healthy controls (p < 0.005). We found a negative linear correlation between salusin-ss and the Hoehn and Yahr stage (p < 0.001, r = -0.515) in the patients. Conclusions There was a relationship between salusin-ss and PD and a correlation between the salusin-ss levels and Parkinson's stage. A possible underlying disease mechanism is an increase in oxidative stress and decrease in neuroprotective effects due to low salusin-ss levels. Therefore, the effects of salusin-ss in treating Parkinson disease should be evaluated. Further studies are needed to understand the effects of salusin-ss treatment on preventing or slowing the course of PD.