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    Enhanced catalytic performance of silica-supported Pd-NHC complexes in Suzuki-Miyaura coupling reactions
    (Elsevier, 2025) Akkoc, Mitat; Koc, Hatice Kubra; Ozdemir, Ismail
    Since silica-supported catalysts are effective due to their rigid but porous structure, which lacks thermal and chemical stability and swelling properties, the characteristic structure of this heterogeneous catalyst we synthesized was elucidated using methods such as NMR, XRD, FTIR, SEM, DTA, and TGA. In this study, benzimidazolium salt was first synthesized and then converted into a Pd-NHC complex. The synthesized Pd-NHC complex was bonded to the SiO2 structure, and heterogeneous SiO2@NHC@Pd was synthesized. The Suzuki-Miyaura C-C coupling reaction of this SiO2@NHC@Pd catalyst was successfully carried out under mild conditions in the presence of green solvents.
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    Synthesis, characterization and antimicrobial properties of silver complexes derived from 5,6-Dimethylbenzimidazol-2-ylidene
    (Pergamon-Elsevier Science Ltd, 2023) Cetinkaya, Erdem Atalay; Koc, Ahmet; Koc, Hatice Kubra; Karabiyik, Hande; Karabiyik, Hasan; Ustun, Elvan; Ozdemir, Ismail
    Benzimidazoles are considered as a class of bioactive heterocyclic compounds that exhibit many biological ac-tivities such as antimicrobial. Benzimidazole-silver complexes also have strong antimicrobial activity, sometimes even higher than that of conventionally used silver antimicrobials. In this study, six new 5,6-dimethylbenzimi-dazolium ligand precursors which were functionalized by using 2-naphthylmethyl and their silver complexes were synthesized. All molecules were characterized by elemental analysis, 1H NMR, 13C NMR, and IR spec-troscopy techniques. Additionally, mu-Dichloro-bis{[1-(2-naphthylmethyl)-3-(benzyl)-5,6-dimethylbenzimidazol-2-ylidene]silver(I)} was characterized structurally in the solid state by X-ray crystallography which was found to be dimeric with two bridging chlorides. In vitro antimicrobial activity of the synthesized compounds investigated in this work was tested against the reference strains: Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC MYA-2876) and Candida glabrata (ATCC 2001). Some of these new compounds have been found to display significant effectiveness. Also, the molecular docking analysis was performed for all optimized ligands and complexes against SarA