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Öğe Aim: Besides primary ovarian tumor, a part of adnexal masses are metastatic colorectal cancers (CRC). Additionally, the risk of CRC is increased if the genitourinary cancers are present. In this study, we want to examine the separation of primer ovarian tumor and colorectal tumor metastasis and we investigated whether the routine colonoscopy is necessary in patients with adnexal mass. Material and Methods: This study included 58 women who underwent colonoscopy due to adnexal mass (Group 1) and 438 women who underwent colonoscopy for other reasons (Group 2). The colonoscopy results compared retrospectively in both groups between March 2014 and June 2016 at Harran University, Faculty of Medicine. Results: DThe mean age were 46.18 ± 16.89 (range 20-84) and 48.72± 17.95 (range 20-94) years in group 1 and 2, respectively. CRC was seen in two women (3.4%) and polyp in five (8.6%) in group 1. However, CRC was detected in 22 women (5%) and polyp in 71 (16.3) in group 2. The incidences of CRC and polyp were found to be lower in women with adnexal mass than group 2. Conclusions: The incidences of CRC and polyp were found to be lower in women with adnexal mass than those of without adnexal mass. Nevertheless, routine colonoscopy screening should be considered for women with adnexal mass due to the difficulties in the discrimination of primary and metastatic ovarian cancer in preoperative period.(2018) Koc, MustafaAim: The aim of this study was to evaluate the role of dynamic and diffusion-weighted (DW) magnetic resonance imaging (MRI) in the differentiation of benign from malignant thrombus in patients diagnosed with portal vein thrombosis. Material and Methods: A total of 56 patients were analyzed, 27 with benign and 29 with malignant thrombus on abdomen dynamic and DW MRI. The b-value of DW MRI was 400 and 1,000 mm2/sec. ADC of portal vein thrombosis was measured. Characteristics of the DW MRI signal were recorded. Contrast imaging of the thrombus was performed. The diameter of the portal vein was measured. A comparison of the ADC values between the malignant and benign groups was made using the Mann-Whitney U test. Results: The mean ADC values of benign thrombus were calculated as 1.03±0.27 x 10-3 mm2/sec for b400, and 1.01±0.23 x 10-3 mm2/sec for b1000. The mean ADC values were calculated as 0.93±0.13 x 10-3 mm2/sec for b400 and 0.88±0.26 x 10-3 mm2/ sec for b1000 for malignant thrombus. No statistically significant difference was found between the groups (p=0.778). Malignant thrombus was reported to have higher signal intensity compared to the benign cases in DW MRI. Arterial mild contrasting was found with malignant thrombus with dynamic MRI on subtraction images. Statistically, a significant difference was found between the groups for portal vein diameter (p<0.05). Conclusion: Our results show that the DW MRI signal characteristics and dynamic MRI contrast media enhancement, with measurements of thrombosed portal vein diameters, are helpful in the differential diagnosisÖğe The association between intima media thickness, central obesity and diastolic blood pressure in obese and owerweight children: A cross-sectional school-based study(Elsevier Ireland Ltd, 2013) Elkiran, Ozlem; Yilmaz, Erdal; Koc, Mustafa; Kamanli, Ayhan; Ustundag, Bilal; Ilhan, NecipObjective: To examine relationship between carotid intima-media thickness (IMT) and central obesity, cardiovasculary risk factors, and chronic inflammation markers in overweight and obese schoolchildren in Eastern Turkey. Methods: A cross-sectional school-based survey on 2765 schoolchildren was performed. We collected the clinical data (age, sex, percentage of body fat, and measured systolic blood pressure [BP] and diastolic BP, triglycerides, high-and low-density lipoprotein cholesterol, glucose, insulin, homocysteine and high-sensitivity C-reactive protein) in 67 obese and 24 overweight children. The control group was composed of nonobese children of similar age and sex. Results: Mean systolic and diastolic BP values in the cases of overweight and obese groups were higher than those in the control group cases (p = 0.001). Obese and overweight children demonstrated a significantly thicker intima media as compared with the control group (p = 0.001). Carotid IMT was significantly correlated to the body mass index (r = 0.396, p = 0.001), fat mass percentage (r = 0.257, p = 0.036), waist circumference (r = 0.390, p = 0.001), diastolic BP (r = 0.266, p = 0.030), glucose (r = 0.250, p = 0.042), and high-sensitivity C-reactive protein levels (r = 0.269, p = 0.001) in the obese group. In multiple linear regression analysis, carotid IMT correlated significantly to waist circumference (p = 0.045), and diastolic BP (p = 0.031) in obese group. Conclusions: Obesity is related to cardiovascular risk factors leading to early atherosclerosis in schoolchildren. There is a relationship between atherosclerosis, and central obesity, diastolic BP, and chronic inflammation. Waist circumference measurement is more sensitive than other anthropometric measurements in predicting obesity and associated complications. (c) 2011 Elsevier Ireland Ltd. All rights reserved.Öğe Endobronchial lipoma; A rare case report(2020) Koc, MustafaThe endobronchial lipoma is a rare benign tumor that can cause lung injury. It constitutes 0.1% of all lung tumors. Endobronchial lipoma can be confused clinically with malignant tumors. A 45-year-old female with a history of previous limb malignant neoplasm applied to the emergency room with complaints of shortness of breath, chest pain. Upon detecting atelectasis in the left lung lower lobe, thorax computed tomography (CT) was performed for further examination and evaluation, and then PET CT examination was performed in thorax CT, it was observed that there was a non-contrasted, smooth solid mass that contained the fatty values, occluding the left lung lower lobe bronchus and atelectasis in the lower lobe of the lung. It was removed totally with bronchoscopy. The histopathological examination of the mass was reported as an endobronchial lipoma. We decided to present this rare case with radiological imaging findings.Öğe The investigation of clinical and radiological findings of hepatic alveolar cyst hydatid disease(2018) Koc, MustafaAim: The aim of this study is to investigate the clinical and radiological findings of hepatic alveolar hydatid cyst diagnosed in our clinic. Material and Methods: Records of patient files with histological diagnosis of hepatic alveolar hydatid cyst between March 2013 and February 2018 were retrospectively reviewed. Fifteen cases were included in the study. Nine of the cases were males (60 %) and 6 were females (40 %). Their ages ranged from 27 to 62 with a mean age of 41 ± 7.3 years. Clinical and laboratory findings and radiological imaging findings of the cases were investigated and recorded. Results: The most common symptoms were right upper quadrant pain (75 %), jaundice (24 %), fever (13 %) and weight loss (12 %). The most common finding in physical examinations was hepatomegaly (96 %). AST, ALT, and ALP values increased 3-4 times. Bilirubin values were generally increased (0.8-21.2 mg/dL). Abdominal ultrasonography (US) was described as a mass lesion with irregularly border, heterogeneous echogenicity, which consisted of the most solid component. It was located in the right liver lobe (82 %). Multislice Computed Tomography (MSCT) and Magnetic Resonance Imaging (MRI) findings supported the US findings. There was no contrast material involvement in the lesion. Diffusion MRI showed mild diffusion restriction somewhere. Conclusions: Alveolar echinococcosis frequently confused with other malignant liver lesions. Early diagnosis of the disease is very important in terms of treatment. Immunologic tests and biopsy are helpful in diagnosis. Radiological findings have an important role and contribution in the diagnosis of the disease.Öğe The Investigation of Incidence and Radiological Findings of Gastrointestinal Stromal Tumor As a Rare Cause of Abdominal Mass(2017) Koc, Mustafa; Serhatlioglu, SelamiAim: The aim of the present study was to evaluate the investigation of incidence and radiological findings of gastrointestinal stromal tumors (GIST) as a rare cause of abdominal mass, with current literature review.Öğe The knockdown of stathmin with si-RNA inhibits invasion of mesothelioma(Churchill Livingstone, 2024) Aksoy, Asude; Varoglu, Asuman; Onalan, Ebru Etem; Tektemur, Ahmet; Artas, Gokhan; Koc, Mustafa; Cakmak, MuharremBackground To investigate the mechanism of action of stathmin1 (STMN1) in mesothelioma (MSM) and whether it has any role in its treatment. Methods STMN1 expression was examined using immunohistochemistry in biopsy tissues taken from MSM patients. The relationships between the levels of STMN1 expression in the pathology preparations of MSM patients, and the clinicopathological characteristics of these patients, and their survival times were investigated. Transfection of STMN1-specific siRNA into SPC212 cells was compared to negative control siRNAs. The mRNA levels of genes that may play a role in invasion, apoptosis, and autophagy were evaluated by RT-PCR. Results The expression of STMN1 was shown to be high in MSM tissues (p < 0.05). It was found that the only independent predictor factor affecting the survival time of MSM patients was the disease stage (p < 0.05). STMN1 was significantly reduced after siRNA intervention (81.5%). STMN1 with specific siRNA has been shown to suppress invasion by reducing the mRNA levels of cadherin-6 (CDH6), fibroblast growth factor-8 (FGF8), hypoxia-inducible factor 1 (HIF1A), matrix metallopeptidase 1-2 (gelatinase A) (MMP1-2), and TIMP metallopeptidase inhibitor 2 (TIMP2), which are important markers for invasion. Although the expression of apoptosis and autophagy-related genes, caspase-2 (Casp2) and LC-3, was reduced by silencing STMN1 with specific siRNA in western blot analysis, this effect was not observed in PCR results. Conclusions Immunohistochemical analysis of STMN1 may contribute to the differential diagnosis of MSM, and STMN1 may also be considered as a potential therapeutic target in the early invasive stage of MSM therapy.Öğe Paratesticular liposarcoma: ultrasonography findings(2017) Koc, Mustafa; Ozercan, ResatGenitourinary system sarcomas constitute 1-2% of all urological tumors. Paratesticular liposarcoma a very rare tumor accounts for 3-7% of paratesticular sarcomas. In this article, we presented a 67 year-old patient with a painless mass-swelling in the left testicular region for about 1 year. Imaging findings revealed a large heterogeneous mass in the left scrotal sac observed with a lobulated contour and hyperechogenic areas, approximately 74x34 mm in size, no test planes with testis, epididymis and spermatic cord. The mass was treated with orchiectomy. Histopathological evaluation of the tumor was reported as pleomorphic liposarcoma with paratesticular placement. We decided to present a rare case with ultrasonography (US) and Doppler US findings.Öğe Primary hand rhabdomyosarcoma: A rare case report(2017) Koc, Mustafa; Ozercan, ResatRhabdomyosarcomas are malignant, soft tissue tumors with striated muscle origin. Malignant round cell tumors are the common malignancy of childhood. The primary localizations are head and neck and genitourinary system. Only 7 % of lesion is seen in the upper extremity. Primer hand involvement is rare. In this article, we presented a 16-year-old girl who admitted to our clinic with a complaint of a painful mass that grew rapidly in the left hand thenar area. Imaging findings revealed a heterogeneous solid mass lesion between the 1st and 2nd fingers, which showed dense contrast enhancement, approximately 6x5x7 cm in size, leading to destruction in the bony structures. A histopathological examination of the mass indicated alveolar rhabdomyosarcoma. We decided to present this rare entity with the radiological imaging findings.Öğe A Rare Congenital Vascular Anomaly: A Case of Left-sided Inferior Vena Cava - Computed Tomography Findings(Aves, 2012) Koc, Mustafa; Kose, Evren; Sarsilmaz, Mustafa[Abstract Not Available]Öğe Tubeless percutaneous nephrolithotomy versus standart nephrolithotomy in geriatric patients: Single surgeon experience(2020) Koc, MustafaAim: Percutaneous nephrolithotomy(PCNL) is the most effective and reliable surgical procedure in the world fob large renal stones.Tubeless PCNL(T-PCNL) has recently been used effectively.The aim of our study is to compare two methods in elderly patients who underwent T-PCNL and Standart PCNL(S-PCNL).Material and Methods: Our study included 60 patients over 60 years of age who underwent operation for renal stones in Beylikduzu State Hospital.T-PCNL was performed on 30 of these patients,whereas S-PCNL was performed on the remaining 30 patients.The mean age, presence of hypertension and diabetes,body-mass index(BMI) and stone size information was recorded within the framework of demographic data of the patients.Length of intraoperative and postoperative hospital stays, operation times,stone free rates,requirement of preoperative blood transfusion,decrease in postoperative hemoglobin,decrease in postoperative parenchymal thickness and Clavien scores were reviewed.Chi-square test and Student T Test was used for statistical analysis.Results: In the light of the intraoperative and postoperative data,a statistically significant difference was found in favor of T-PCNL group compared to the S-PCNL group,in terms of length of hospital stays,operation times and postoperative narcotic analgesic use (p 0.05).On the other hand,no statistically significant difference was found between the two groups on the basis of the stone free ratio,Clavien scoring, preoperative blood transfusion and postoperative renal parenchymal thickness.Conclusion: T-PCNL is a safe and effective surgical procedure in geriatric patients with large renal stones,as is S-PCNL.T-PCNL was found to be superior in terms of length of hospital stay, operation times and postoperative narcotic analgesic use.Öğe Ultrasonography and Doppler ultrasonography findings of children with iron deficiency anemia(2018) Koc, Mustafa; Girgin, Feyza; Serhatlioglu, SelamiAim: Iron deficiency anemia (IDA) is an important health problem in children in the worldwide. It affects both growth and mental motor development. Iron decrease then irons deficiency (ID) occurs during the developing of IDA. In the literature, there is no information about ultrasonography (US) and Doppler US findings in the development of IDA. The aim of this study is to search the US and Doppler US findings of liver, spleen and main vascular structures of children with the iron decrease, ID, and IDA. Material and Methods: This study including 160 patients who have the iron decrease (n=43), ID (n=52), and IDA (n=65) in laboratory findings. The control group was 50 children. The liver and spleen sizes with parenchymal echogenicity, CCA Vmax -Vmin, ICA Vmax -Vmin, their pulsatility (PI) and resistive index (RI) were measured. Results: 23 patients (35%) were diagnosed with hepatomegaly and 8 patients (12%) were diagnosed with splenomegaly having IDA. There was a statistically significant difference between the groups in terms of CCA Vmax -Vmin, ICA Vmax -Vmin, and also RI - PI index of CCA with ICA (p<0.05). Conclusion: Hepatomegaly and splenomegaly can be seen in IDA. Increasing of anemia cause changes in the vascular flow velocities, and also increase the blood volume of the brain. If anemia is detected at an early stage and treatment is regulated, cognitive disturbances will not occur in children. In the diagnosis, an US and a Doppler US examination are useful.
