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Öğe The association of ABO blood group and rh factor with recurrent aphthous ulceration(2018) Sagiroglu, Saime; Oztarakci, Huseyin; Ozturk, Perihan; Doganer, Adem; Koca, Tuba Tulay; Bilal, Nagihan; Sarica, Selman; Orhan, IsrafilAim: In this study we aimed to investigate effects of blood group and Rh factor on recurrent aphthous ulceration (RAS). Material and Methods: A total of 350 persons were included in the study, 175 with RAS and 175 as the healthy control group. Medical histories and laboratory findings of the patients presenting to the outpatient clinic were evaluated. Patients that had aphthae lesions more than three times a year were studied. Haemoglobin (Hb), vitamin B12, ferritin, folic acid, and iron levels were measured and the blood groups were recorded. Results: Of RAS patients, 16.8% had a deficiency in Hb, 16.3% in vitamin B12, 18.5% in ferritin, 6.4% in folic acid and 28.2% in iron. The patient blood groups were distributed as follows 33.7% Group A, 20% Group B, 8.6% Group AB and 33.1% Group O. Of RAS patients were 92% Rh(+) and 8% Rh(-). No statistically significant difference was found between the distribution of blood groups and RAS. However, the risk of RAS was found to be six times higher in B Rh(+) patients compared to B Rh(-) patients and three times higher in AB Rh(+) patients com-pared to AB Rh(-) patients. Conclusions: Rh factor may have an effect on the etiology of RAS disease. Anemia and vitamin B12 deficiency are common in RAS patients, making a hematological evaluation a necessity for RAS patientsÖğe Comparison of sagittal lumbosacral parameters in patients with ankylosing spondylitis and chronic mechanical back pain(2019) Kocyigit, Burhan Fatih; Nacitarhan, Vedat; Koca, Tuba Tulay; Berk, EjderAim: Lumbosacral parameters can be affected in ankylosing spondylitis (AS) and chronic mechanical back pain.We compared lumbosacral parameters between patients with AS and chronic mechanical back pain to identify specific changes in AS. Material and Methods:This study has a retrospective design. A total of 42 patients with AS (16 females, 26 males) and 66 patients with chronic mechanical back pain (31 females, 35 males) were enrolled in the study. Lumbar lordosis angle (LLA), lumbosacral angle (LSA), sacral tilt (ST), and lumbosacral disc angle (LSDA) were measured using digitalized standing lateral lumbar radiographs. CRP and ESR concentrations of AS patients were obtained from the hospital database. Results: LLA, LSA, ST and LSDA were significantly smaller in the patients with AS (p < 0.05).CRP and ESR were significantly and negatively correlated with LLA and LSA (r = -0.516, p < 0.001; r = -0.401, p = 0.009 for CRP and r = -0.623, p < 0.001; r = -0.474, p = 0.002 for ESR). In AS patients, LLA was significantly and positively correlated with LSA and ST (r = 0.490, p = 0.001; r = 0.399, p = 0.009). Additionally, LSA was significantly and positively correlated with LSDA (r = 0.613, p < 0.001). Conclusion: The sagittal lumbosacral parameters of patients with AS were found to be significantly different from those of patients with chronic mechanical back pain. İnflammation negatively affects lumbosacral alignment in AS. The identification of specific changes in sagittal spinal alignment in patients with AS will contribute to the establishment of appropriate rehabilitation strategies and surgical plansÖğe The effect of fibromyalgia syndrome to nasal mucociliary function in females(2019) Karaer Cakmak , Isil; Koca, Tuba TulayAim: Fibromyalgia syndrome (FM) is soft tissue rheumatism characterized by chronic widespread musculoskeletal pain. Central sensitization–related neuroaudiological symptoms are frequently seen in patients with FM. The aim of this study was to investigate the duration of nasal mucociliary clearance in FM patients and its relation with pain. Material and Methods: A prospective case–control study was carried out in Otorhinolaryngology Clinic. Forty four (N=44) females were enrolled in the study. Twenty two (22) FM patients with age (p=0.5) and body mass index (BMI) (p=0.072) matched healthy controls were included in the study. The FM diagnosis has been determined by clinical examination according to the American College of Rheumatology (ACR) 2010 criteria. All study participants underwent measurements of nasal mucociliary clearance duration by the same individual. Results: The mean age was 38.7 ± 1.8 years in FM group, while it was 37.05 ± 1.8 years in control. The mean duration of nasal mucociliary clearance were 8.06 ± 0.5 minutes in FM group, and 5.86 ± 0.4 minutes in control. The duration of nasal mucociliary clearance was longer in FM patients than controls (p=0.0005). The duration of mucociliary clearance was found positively correlated with visual analog scale (VAS) score (r=0.423; p=0.005). Conclusion: There was a significant prolonged nasal mucociliary clearance duration inpatients with FMand positively correlated with pain score. Clinically, women with FM should be followed up for possible adverse effects of prolonged mucociliary clearance duration such as sinonasal and middle ear infections.Öğe Evaluation of sleep disorder and its effect on sexual dysfunction in patients with Fibromyalgia syndrome(Galenos Yayincilik, 2016) Koca, Tuba Tulay; Acet, Gunseli Karaca; Tanrikut, Emrullah; Talu, BurcuObjective: Sexual problems are commonly seen in women with fibromyalgia syndrome (FMS). The objective of this study was to reveal the relationship between the severity of symptoms, sleep disorder, and sexual dysfunction in women with FMS. Materials and Methods: A total of 140 sexually active women with FMS aged 17-67 years who presented to our physical medicine and rehabilitation outpatient clinic between January 2016 and June 2016 were enrolled in the study. The patients' age, height, body weight, body mass index (BMI), and general pain score [visual analogue scale, (VAS)] for the last 1 week were recorded. The patients were given three different sets of questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Fibromyalgia Impact Questionnaire (FIQ), and Female Sexual Function Index (FSFI). Results: The mean age of the patients was 40.3 +/- 8.5 years; the mean BMI was 27.1 +/- 4.4 kg/m(2), VAS (last 1 week) was 6.9 +/- 2 cm, the mean PSQI was 24.8 +/- 10.8 (one patient with PSQI <= 5), FIQ was 65.9 +/- 19.2, and FSFI was 19.0 +/- 6.9. No significant relationship was observed between the mean PSQI and BMI values (p=0.401), whereas a significant relationship was found between the mean values of VAS, FIQ, and FSFI (p=0.03; p=0.034; p<0.001, respectively). In Pearson's correlation analysis, a positive correlation was noted between PSQI and VAS (r=0.324; p<0.001) and FIQ values (r=0.271; p=0.001). A significant relationship was found between the FIQ and VAS values (p<0.001). P less than 0.005 was considered statistically significant. Conclusion: Sleep disorder is regarded as the underlying cause for many signs and symptoms in FMS. Sexual dysfunction may develop in women with FMS, based on the severity of the disease and poor sleep quality. We found that sleep dysfunction was significantly related with the severity of disease, pain, and sexual disfunction. We also found a positive correlation between VAS and PSQI.Öğe Is migraine an inflammatory event? Which inflammatory markers can we use for migraine?(2019) Tugan Yildiz, Buket; Koca, Tuba TulayAim: It is considered that a relationship exist between migraine and neurogenic inflammation. High levels of tumor necrosis factor, interleukin-6 and C-reactive protein were determined in the studies. The cytoprotective and antioxidant effect of bilirubin has been shown. Lower serum bilirubin levels have been shown some diseases. For all that, there is no consensus in the results. Our purpose in this study is to determine the relationship between migraine and inflammation markers like erythrocyte sedimentation rate, C-reactive protein , bilirubin. Material and Methods: The study included 50 migraine patients and 40 healthy individuals as a control group. Erythrocyte sedimentation rate and C-reactive protein, bilirubin parameters, aspartate aminotransferase, alanine aminotransferase were recorded. Results: Erythrocyte sedimentation rate and C-reactive protein were significantly higher in migraine group. Bilirubin parameters and aspartate aminotransferase , alanine aminotransferase values were similar. Conclusion: Higher serum inflammatory markers support the role of inflammation in migraine pathogenesis. For bilirubin levels larger cross- sectional studies are needed.Öğe Isokinetic strength of the trunk flexors and extensors in ankylosing spondylitis(Ios Press, 2013) Durmus, Bekir; Sahin, Nilay; Baysal, Ozlem; Ersoy, Yuksel; Baysal, Tamer; Koca, Tuba Tulay; Altay, ZuhalBACKGROUND: Objective measurement of trunk muscles strength in ankylosing spondylitis (AS) may provide clinical information that can be used to evaluate functional disability. OBJECTIVE: To compare the isokinetic strength of trunk muscles in AS patients with healthy subjects. METHODS: Thirty-four patients with AS and thirty-one healthy subjects were enrolled. Patients with spinal ankylosis and bridged syndesmophytes in the lumbar and dorsal vertebrae were excluded. Trunk flexor and extensor strength was measured at: 60 and 90 degrees/sec. RESULTS: When compared with the control group, AS patients demonstrated 38% and 24% decrease in the extensor and flexor strength, respectively (p < 0.05). In addition, the flexor/extensor strength ratio was 1.0 and 0.8 in the patients and control subjects, respectively. CONCLUSIONS: In view of the relatively selective extensor weakness we recommend assessment of trunk muscle strength in these patients for guiding clinicians regarding possible reconditioning exercises in the early period of AS.Öğe Lumbosacral alignment in lumbar disc herniation(2019) Nacitarhan, Vedat; Kocyigit, Burhan Fatih; Berk, Ejder; Koca, Tuba TulayAim: Lumbosacral alignment has a potential role in providing proper spinal function, balanced and appropriate posture. The aim of our study was to compare lumbosacral angles between lumbar disc herniation and lumbar disc herniation-free patients. It was aimed to identify specific changes in lumbar disc herniation.Material and Methods: A total of 118 (69 female, 49 male) patients with the complaint of chronic low back pain were enrolled. Lumbar magnetic resonance images and standing lateral lumbar radiographs were obtained from the electronic hospital database. The presence or absence of disc herniation was diagnosed with lumbar magnetic resonance images. Measurement of lumbosacral angles were performed on the standing lateral lumbar radiographs.Results: Lumber lordosis angle and lumbosacral disc angle were significantly smaller in the lumbar disc herniation group (p = 0.033 and p = 0.038). No significant difference was detected in sacral tilt and lumbosacral angle (p = 0.705 and p = 0.413).Conclusion: The variations in lumbosacral angles cause changes in the spinal kinematics that may affect the occurrence of disc herniation. Loss of lumbar lordosis increases the compressive forces on the spine and may associate with the presence of disc herniation. Lumbosacral alignment must be taken into account when evaluate the pathophysiology of lumbar disc herniation.Öğe The relation of body image perception with body mass index, gender and disease activity in ankylosing spondylitis and rheumatoid arthritis(2018) Koca, Tuba Tulay; Gogebakan, Hasan; Yildirim Cetin, GozdeAim: Ankylosing spondylitis (AS) and Rheumatoid arthritis (RA) diseases causes physical deformities and chronic pain which lead to impairment in the body image perception (BIP) of the body. Material and Methods: Sixty (N=60) AS patients and 55 RA patients were included into the study. Age, gender, body mass index (BMI), duration of diagnosis, education and disease activity of the patients were recorded. Results: At the mean age of 38.5 ± 9.8 years, 46 male (M) and 14 female (F) patients with AS were included in the study. In patients with AS, BIP score was positively correlated only with peripheral joint involvement (r = 0.32 / p = 0.005). At mean age of 52.1 ± 13 years, 12 male and 43 female patients with RA were included. The BIP score in RA patients did not correlatewith any parameter. The BIP score was not significantly different between the two groups. In the AS group, BIP score was significantly higher in female gender (F = 110.2 ± 29 / M = 95.8 ± 20.5; p = 0.041). In the whole group only in male gender BIP score was negatively correlated with duration of diagnosis (r = -0.264, p = 0.047); it was positively correlated with BASFI (r = 0.306; p = 0.041). Conclusion: In the early active periods of the rheumatologic diseases and in the later stages of them with the progress of physical disability, BIP may get worse. A better understanding of factors affecting BIP will increase the success of treatment regimens.Öğe The relationship between vitamin D level and disease activity and focal erosion in rheumatoid arthritis(2019) Kocyigit, Burhan Fatih; Akyol, Ahmet; Koca, Tuba TulayAim: Bone loss,fragility,and fractures are well-described complications that affect quality of life, morbidity, and health care costs during the course of rheumatoid arthritis (RA). Besides its well-known role in bone metabolism, vitamin D is also an important immune modulator, meant to affect the disease activity of rheumatic disorders. However, conflicting results have been demonstrated about the relationship between levels of vitamin D and disease activity in RA. Primary aim of was to compare vitamin D levels and Bone Mineral Density (BMD) values between RA and control groups.The secondary aim was to assess the correlations between vitamin D and disease activity and radiologic damage in RA.Material and Methods: A total of 41 RA patients and 40 healthy controls were included in this study. The patient and control groups were between the ages of 18 and 65. Disease activity score 28 (DAS-28) was used to determine the severity of disease.Sharp/van der Heijde method was performed to evaluate the radiologic changes.Dual energy X-ray absorptiometry (DEXA) was performed to measure Bone Mineral Density (BMD).Enzyme-Linked Immunosorbent Assay (ELISA) method was used to measure serum D vitamin concentrations.Results: Vitamin D levels, the BMD-lumbar spine, BMD-femur total and BMD-femur neck values were significantly lower in the patient group (p = 0.012, p 0.001, p 0.001 and p 0.05). DAS-28 was significantly and negatively correlated with BMD values (p 0.05).Conclusion: Our study suggests that RA patients have lower vitamin D levels, BMD-lumbar spine, BMD-femur total and BMD-femur neck values. Higher disease activity increases bone loss in RA. Vitamin D levels and BMD values should be monitored for the risk of osteoporosis and fracture in RA.Keywords: Rheumatoid Arthritis; Vitamin D; Bone Mineral Density; Disease Activity; Radiologic Damage.Öğe Treatment of Chronic Plantar Heel Pain With Radiofrequency Neural Ablation of the First Branch of the Lateral Plantar Nerve and Medial Calcaneal Nerve Branches(Elsevier Science Inc, 2016) Arslan, Aydin; Koca, Tuba Tulay; Utkan, Ali; Sevimli, Resit; Akel, IbrahimFrom March 2012 to February 2013, 37 patients experiencing plantar heel pain for >= 6 months despite treatment with physical therapy and other conservative treatment modalities were followed up. If neurogenic heel pain originating from the first branch of the lateral plantar nerve was present, with or without the medial calcaneal nerve, diagnostic nerve blocks to these nerves were performed for confirmation. If the pain was determined to be of neurogenic origin, radiofrequency neural ablation (RFNA) was applied to the corresponding sensory nerve endings. Pain was evaluated using the visual analog scale, and patients were followed for at least one year. A total of 41 feet from 37 patients (30 [81.1%] females, 7 [18.9%] males; mean age, 50.7 +/- 1.6 years; mean bodymass index, 30.6 +/- 0.7 kg/m(2)) were included. The mean visual analog scale scores improved significantly from 1 to 6 to 12 months after the procedure relative to before the procedure, with 88% of all patients rating the treatment as either very successful or successful at 12 months postoperatively. RFNA applied to both the first branch of the lateral plantar nerve and the medial calcaneal nerve sensory branches (16 [39%] feet) and only the first branch of the lateral plantar nerve sensory branches (25 [61%] feet) showed similarly high levels of success. Of the 41 feet, 28 [68.3%] had received extracorporeal shockwave therapy, 35 [85.4%] had received steroid injections, and 22 [53.7%] had received both extracorporeal shockwave therapy and steroid injections before RFNA as an index procedure. All were unresponsive to these previous treatments. In contrast, almost all (88%) were treated successfully with RFNA. Despite a high incidence of neurologic variations, with a precise diagnosis and good application of the technique using the painful points, chronic plantar heel pain can be treated successfully with RFNA. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
