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    Comparison of the effects of variables in sperm preparation techniques on pregnancy rates in intrauterine insemination
    (2019) Kocaman, Nevin
    Aim: To investigate the effects of two sperm preparation techniques, density gradient centrifugation (DGC) and swim-up, on the pregnancy rates per cycle and per group in two intrauterine (IUI) cycles. Material and Methods: The retrospective study reviewed 634 patients who presented to Firat University Medical School Hospital and underwent a total of 1,032 IUI cycles. Group I consisted of 306 (48.3%) patients who underwent a total of 524 IUI cycles between January 2012 and January 2016 and Group II included 328 (51.7%) patients who underwent a total of 508 IUI cycles between April 2015 and January 2019. The study investigated the effects of technical changes applied to sperm preparation techniques on pregnancy rates in both groups. Results:A significant difference was found between the clinical pregnancy rates of the two groups with regard to the numbers of patients and IUI cycles (p0.001). The technique used in Group II increased the pregnancy rate by 3.195 times compared to the technique used in Group I. A logistic regression analysis revealed that the pregnancy rate in the first cycle was 3.530 times higher than that of the second cycle in both groups.Conclusion: The results indicated that the application of suitable alterations in sperm preparation techniques by taking into account the potential effect of all factors is likely to affect clinical pregnancy rates in IUI.
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    HSP70 immune reactivity and TUNEL positivity in the liver of toluene-inhaled and melatonin-treated rats
    (Sage Publications Inc, 2013) Tas, Ufuk; Ogeturk, Murat; Kuloglu, Tuncay; Sapmaz, Hilal Irmak; Kocaman, Nevin; Zararsiz, Ismail; Sarsilmaz, Mustafa
    Toluene is a clear, colorless and volatile hydrocarbon that is metabolized in liver, produced free oxygen radicals and can mediate cellular damage. Melatonin which is a pineal gland hormone is a very potent antioxidant. It can make the cellular membrane more durable against oxidative attacks and protect nuclear DNA from oxidative damage. This study aimed to investigate heat shock protein (HSP)70 immune reactivity and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) positivity (apoptotic activity) in the liver of toluene-inhaled and melatonin-treated rats. A total of 21 adult male Wistar albino rats were divided at random into 3 equal groups. Animals in group I were designated as control. The rats in group II were exposed to toluene (3000ppm/1h/day) for 30 days, while the rats in group III were treated with melatonin (10mg/kg/day, intraperitoneally) plus toluene inhalation. At the end of the 30-day experimental period, all rats were killed by decapitation. Then the liver tissues of rats were removed and tissue specimens were embedded in paraffin blocks. The specimens were stained with periodic acid-schiff (PAS) following routine histological procedures. Sections obtained from paraffin blocks were used for immune detection of TUNEL and HSP70. In light microscopic observations of tissues from toluene-inhaled rats, massive hepatocyte degeneration, ballooning degeneration and decreased PAS positivity were observed. Increased TUNEL positivity and HSP70 immune reactivity were determined in toluene-inhaled group and melatonin treatment decreased all these adverse effects.
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    The diagnostic potential of Asprosin and Meteorin-like proteins in basal and squamous cell carcinomas
    (Springer, 2025) Erdogan, Mehmet Mustafa; Erdogan, Esra; Kocaman, Nevin; Yasar, Seyma; Kavak, Songul Yerlikaya
    Non-melanoma skin cancer (NMSC) is the most prevalent malignancy worldwide, encompassing primarily BCC and SCC. Differentiating between these two carcinomas and distinguishing them from normal skin tissue can pose diagnostic challenges in certain cases. Adipokines, as regulators of various biological processes, have garnered attention for their potential roles in tumorigenesis. Asprosin (Asp) and Meteorin-like (Metrnl) are newly identified proteins implicated in several diseases, including cancer. Their potential contribution to the pathogenesis of skin cancers such as BCC and SCC remains underexplored. This study aimed to evaluate the expression profiles of Asp and Metrnl in BCC and SCC and to assess their potential utility as diagnostic biomarkers. The expression of Asp and Metrnl proteins was examined by immunohistochemical staining in biopsy samples from 60 control, 60 BCC, and 60 SCC cases obtained from the archive of the Pathology Laboratory of Malatya Turgut Ozal University Training and Research Hospital. Asp immunoreactivity was higher in BCC tissues compared to the other two groups, and it was statistically higher in SCC tissues compared to healthy control tissues. Metrnl immunoreactivity was also higher in BCC tissues compared to the other two groups, and statistically significant in SCC tissues when compared to healthy control tissues. The findings suggest that Asp and Metrnl proteins may serve as valuable biomarkers for distinguishing between BCC and SCC, the two most common non-melanoma skin cancers encountered in routine dermatopathology practice. These adipokines may also provide insights into the underlying pathophysiology of these malignancies, offering potential avenues for diagnostic and therapeutic advancements.