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  • Küçük Resim
    Öğe
    Investigation of in vitro amoebicidal activities of Ornithogalum sigmoideum on Acanthamoeba castellanii cysts and trophozoites
    (2018) Kaynak, Bulent; Koloren, Zeynep; Karaman, Ülkü
    Aim: In this study, amoebicidal activity of methanol and ringer extracts obtained from Ornithogalum sigmoideum against Acanthamoeba castellanii cyst and trophozoite forms was investigated by determining cell viability percentage and IC50 values. Material and Methods: The in vitro amoebicidal activities methanolic (1%) and Ringer extracts of O. sigmoideum prepared at varying concentrations (in the range of 40 mg/ml -1.25 mg/ml) on A. castellanii trophozoites and cysts were investigated. Results: IC50 results observed at 1st, 3rd, 6th, 8th, 24th, 48th and 72nd hours in A. castellanii trophozite form were 23.2, 15.6, 12.1, 10.1, 8.3, 6.6 and 2.9 mg/ml by using the methanolic extract of O. sigmoideum, and 24.2, 16.7. 13.3, 11.9, 8.9, 8.4 and 7.3, mg/ml by using the Ringer extract ofsigmoideum respectively. The 40 mg/ml methanolic extract of O. sigmoideum killed all trophozoites at 48th and 72nd hours. The % viability rate at 72nd hour when using the Ringer extract of O. sigmoideum was 2.0±0.0. Conclusion: The methanolic extract was found to be more effective than the Ringer extract on Acanthamoebatrophozoites. The sensitivity of A. castellanii cysts to both extracts was not very different from each other, and the sensitivity of trophozoites to both extracts was higher than that of cysts. The methanolic extracts of O. sigmoideum can be used as an alternative treatment option or in combination with other therapies for treating Acanthamoeba infections. In addition, Ringer extract of O. sigmoideum can also be used as an alternative to the methanolic extract.
  • Küçük Resim Yok
    Öğe
    PREVALENCE OF DEMODEX ECTOPARASITES AMONG HUMANS IN ORDU PROVINCE IN TURKEY
    (Southeast Asian Ministers Educ Organization, 2016) Karaman, Ulku; Koloren, Zeynep; Enginyurt, Ozgur; Colak, Cemil
    Demodex folliculorum and Demodex brevis are common ectoparasites in humans. Demodex parasite infestations have not been determined in the province of Ordu. We determined the prevalence of Demodex species among humans in Ordu Provience, Turkey. Seven hundred ninety-nine subjects (438 males and 361 females) aged >= 18 years living in the central districts of Ordu Province, Turkey, were selected using the World Health Organization cluster sampling method. A superficial skin biopsy of the face was obtained from each subject. Six hundred sixty-nine subjects (83.7%) had a Demodex parasite. Factors significantly associated with the presence of Demodex infestation were: female gender, employment in the private sector, people who only occasionally wash their face and district of residence. Since Demodex ectoparasites were common in Ordu Province, it is suggested that the diagnosis and treatment of this ectoparasite should be carried out in the hospitals of this region.
  • Küçük Resim
    Öğe
    The Protozoa and helminths in the water of Terme and Kocaman Boroughs of Samsun Province
    (2017) Karaman, Ülkü; Koloren, Zeynep; Ayaz, Emine; Demirel, Elif; Seferoglu, Onuralp
    Aim: It was aimed to determine the presence of parasites and helminths in the environmental waters of the Terme and Kocaman districts of Samsun.Meterial and Methods: In this study, 6 stations in Terme and 6 stations in Kocaman Miliç River areas were included.The research was conducted between August 2012 - July 2013 and every month water samples were collected. The pellet part of the supernatant samples was examined on the same day by native-lugol methods. The samples were also examined by kinyoun acid fast, Weber’s modified trichrome and trichrome methods. The samples were painted and evaluated according to parasitologic terms.Results: As a result of water sample examination, 144 Cryptosporidium spp., oocysts 96 Cyclospora spp., oocysts 60 Strongyloides spp., larvae 36 Microsporidia spores, 48 Blastocystis spp. granular forms, 24 Chilomastix spp. trophozoits, 24 Balantidium spp. trophozoits, 60 hookworm eggs and 132 Giardia spp. cysts have been observed.Conclusion: The animal husbandry made in those regions, direct discharge of the waste water pipes into the river, the usage of this water for irrigation and animal drinking and water cooling explain the presence of parasites in the water. As water is an agricultural, industrial and domestic requirement, it should be free of pathogenic microorganisms in accordance with the criteria related to its potential use. Water, which is a domestic requirement for agriculture and industry, needs to be purified from pathogenic microorganisms in accordance with the criteria for its potential use.Keywords: Terme; Kocaman; Environmental Waters; Parasites.