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Öğe Anti-tumor properties of microwave-assisted synthesized 6,7-dihydroxycoumarins: An in vitro study(Wiley-Blackwell, 2015) Tekin, Suat; Koran, Kenan; Ozen, Furkan; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Cytotoxic Properties of Amino Acid Substituted Novel Cinnamic Acid Compounds(Wiley, 2019) Caliskani, Eray; Ozturk, Dilara Altay; Tekin, Suat; Koran, Kenan; Gorgulu, Ahmet Orhan; Cetin, Ahmet[Abstract Not Available]Öğe Cytotoxic Properties of Peptide Substituted Novel Cyclotriphosphazene Compound(Wiley, 2019) Koran, Kenan; Tekin, Suat; Caliskan, Eray; Capan, Trfan; Sandal, Suleyman; Gorgulu, Ahmet Orhan[Abstract Not Available]Öğe Cytotoxicity Properties of Full Subsituted Organocyclophosphazene Derivatives Containing chalcone-groups against A2780 and MCF-7 Cancer Cell Lines(Wiley, 2017) Durmus, Merve; Beytur, Asiye; Celik, Mesut; Disli, Faruk; Koran, Kenan; Tekin, Suat; Gorgulu, Ahmet Orhan[Abstract Not Available]Öğe Determination of Anticancer Activities of Organophosphazene Compounds Bearing Ether Groups on Human Cancer Cell Lines(Wiley, 2017) Beytur, Asiye; Demir, Ilker; Koran, Kenan; Tekin, Suat; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Determination of antitumor properties of cyclophosphazene derivatives bearing chalcone-groups against PC-3 cell lines(Wiley-Blackwell, 2015) Tekin, Suat; Koran, Kenan; Ozen, Furkan; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Determination of Cytotoxicity Properties of Newly Synthesized Chalcone-Cyclophosphazene Compounds against Human Prostate Cancer Cell Lines(Wiley-Blackwell, 2015) Tekin, Suat; Koran, Kenan; Ozen, Furkan; Sandal, Suleyman; Gorgulu, Ahmet Orhan[Abstract Not Available]Öğe Determination of Cytotoxicity Properties of Oxime-Cyclotriphosphazene Derivatives Against PC-3 Cancer Cell Lines(Wiley, 2017) Calisgan, Seyma; Beytur, Asiye; Menengic, Kubra Nur; Tekin, Suat; Koran, Kenan; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Determination of in Vitro Cytotoxic Activity of new Chalcone-Phosphazene Compounds Bearing Indole and Imidazole Hetero Groups as Side Groups on A2780 and PC-3 Cancer Cell Lines(Wiley, 2018) Sandal, Suleyman; Tekin, Suat; Koran, Kenan; Gorgulu, A. Orhan[Abstract Not Available]Öğe (E)-1-(4-Hydroxyphenyl)-3-(substituted-phenyl) prop-2-en-1-ones: Synthesis, In Vitro Cytotoxic Activity and Molecular Docking Studies(Slovensko Kemijsko Drustvo, 2022) Sirka, Lutfiye; Dogan, Hacer; Bahar, Mehmet Refik; Caliskan, Eray; Tekin, Suat; Uslu, Harun; Koran, KenanA series of chalcone compounds (2-11) were designed and synthesized to determine their cytotoxic effects. The structures of 2-11 were fully characterized by their physical and spectral data. The in vitro cytotoxic effects of 2-11 were evaluated against human ovarian cancer (A2780), breast cancer (MCF-7) and prostate cancer (PC-3 and LNCaP) cell lines. The activity potentials of compounds were further evaluated through molecular docking studies with AutoDock4 and Vina softwares. All the compounds (except compound 5) showed significant cytotoxic effects at high doses in all cancer cell lines. Among all the compounds studied, one compound i.e. compound 2 demonstrated dose-dependent activity, particularly against A2780/LNCaP cancer cell lines. The most effective compounds 8, 9, 10 and 11 reduced the cell viability of A2780, MCF-7, PC-3 and LNCaP cells by 50-98%, while other compounds 2, 4 and 7 reduced the cell viability of A2780 cells by 70-90% at concentrations of 50 and 100 mu M.Öğe The first peptide derivatives of dioxybiphenyl-bridged spiro cyclotriphosphazenes: In vitro cytotoxicity activities and DNA damage studies(Academic Press Inc Elsevier Science, 2023) Koran, Kenan; Caliskan, Eray; Ozturk, Dilara Altay; Capan, Irfan; Tekin, Suat; Sandal, Suleyman; Gorgulu, Ahmet OrhanIn this study, we aimed to synthesize new peptide-substituted cyclotriphosphazenes from a series of tyrosine -based peptides and dioxyphenyl-substituted spirocyclotriphosphazenes, and to evaluate their in vitro cytotox-icity and genotoxicity activities. Genotoxicity studies were conducted to understand whether the cytotoxic compounds cause cell death through DNA damage. The structures of the novel series of phosphazenes were characterized by FT-IR, elemental analysis, MS, 1D (31P, 1H, and 13C-APT NMR), and 2D (HETCOR) NMR spectroscopic techniques. In vitro cytotoxic activities were carried out against human breast (MCF-7), ovarian (A2780), prostate (PC-3), colon (Caco-2) cancer cell lines and human normal epithelial cell line (MCF-10A) at different concentrations by using an MTT assay. The compounds showed considerable reductions in cell viability against all human cancer cell lines. Especially, the compounds exhibited notable effects in A2780 cell lines (p < 0.05). The IC50 values of the compounds in the A2780 cell line were calculated to be 1.914 mu M for TG, 20.21 mu M for TV, 20.45 mu M for TA, 4.643 mu M for TP, 5.615 mu M for BTG, 1.047 mu M for BTV, 27.02 mu M for BTA, 0.7734 mu M for BTP, 21.5 mu M for DTG, 1.65 mu M for DTV, 2.89 mu M for DTA and 4.599 mu M for DTP. DNA damage studies of the compounds were conducted by the comet assay method using tail length, tail density, olive tail moment, head length, and head density parameters, and the results showed that the cell death occurred through DNA damage mechanism. In a nutshell, these compounds show promising cytotoxic effects and can be considered powerful candidate molecules for pharmaceutical applications.Öğe Hexa-substituted cyclotriphosphazene derivatives containing hetero-ring chalcones: Synthesis, in vitro cytotoxic activity and their DNA damage determination(Academic Press Inc Elsevier Science, 2022) Beytur, Asiye; Tekin, Cigdem; Caliskan, Eray; Tekin, Suat; Koran, Kenan; Gorgulu, Ahmet Orhan; Sandal, SuleymanIn this study, hetero ring hexasubstituted cyclotriphosphazes were obtained in two steps and these compounds were investigated in terms of in vitro cytotoxicity and genotoxicity. The structural characterizations of the starting compounds 1-4 were defined by FT-IR, elemental analysis, and NMR (1H and 13C) spectroscopy techniques. In addition to these techniques, the 31P NMR spectroscopy technique was also used in the characterization of cyclotriphosphazenes (FSC 1-4). The changes in cell viability at 1, 5, 25, 50, and 100 mu M concentrations against human ovarian (A2780) and human prostate (PC-3 and LNCaP) cell lines for 24 h were determined by the MTT assay method. According to MTT assay results, the inhibitory concentration 50 (IC50/ LogIC50) value was calculated in Graphpad Prism 6 program. The comet assay was performed to determine whether the effects of compounds on cell viability were through DNA damage. In the comet assay experiments, the highest concentration of compounds (100 mu M) was applied to the cells for 24 h and tail length (TL), tail intensity (TI), olive tail moment (OTM) parameters were examined. The results showed that the compound 1-4 and FSC 1-4 compounds reduced the cell viability against all cancer cell lines (p < 0.05). At the same time, different concentrations of these compounds caused DNA damage in all three cell types (p < 0.05). The possible interactions and chemical mechanisms of the synthesized compounds were explained by computational methods with molecular docking. In addition, pharmacological properties of drug candidate molecules have been defined. Experimental and calculated data comply with each other. The study results showed that these compounds have cytotoxic effects against cancer cells and suggested that these effects have occurred through genotoxicity.Öğe In Vitro Cytotoxic and Genotoxic Properties of Hexa Substituted New Organophosphazene Compounds(Wiley, 2019) Dogan, Hacer; Bahar, Mehmet Refik; Caliskan, Eray; Koran, Kenan; Tekin, Suat; Sandal, Suleyman; Gorgulu, Ahmet Orhan[Abstract Not Available]Öğe Investigation of Anti-cancer Properties of 2,2,4,4-Tetra (4?-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene Derivatives Against Human Ovarian (A2780) and Prostate (PC-3) Cancer Cell Lines(Wiley-Blackwell, 2016) Tekin, Cigdem; Koran, Kenan; Tekin, Suat; Sandal, Suleyman; Gorgulu, Ahmet Orhan[Abstract Not Available]Öğe Investigation of Anti-Carcinogenic Properties of 2-(2,3,4-trimethoxyphenyl)-1-(substituephenyl) Acrylonitrile and 7,8-dihydroxy-1-(substituephenyl) Coumarine Compounds against Human Breast Cancer Cell Lines(Wiley-Blackwell, 2015) Tekin, Suat; Koran, Kenan; Ozen, Furkan; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Investigation of Cytotoxic and Genotoxic Properties of Hybrid Compounds Containing New Generation Amino Acid Structures(Wiley, 2023) Sekerci, Guldeniz; Yuksel, Furkan; Tekin, Suat; Caliskan, Eray; Biryan, Fatih; Koran, Kenan; Sandal, Suleyman[Abstract Not Available]Öğe Investigation of Cytotoxicity Properties of Novel Phthalocyanine Complexes Containing Chalcones Groups on Different Cancer Cell Lines(Wiley, 2017) Tekin, Suat; Koran, Kenan; Gorgulu, Ahmet Orhan; Sandal, Suleyman[Abstract Not Available]Öğe Synthesis and spectroscopic characterizations of hexakis[(1-(4 '-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes: their in vitro cytotoxic activity, theoretical analysis and molecular docking studies(Taylor & Francis Inc, 2022) Dogan, Hacer; Bahar, Mehmet Refik; Caliskan, Eray; Tekin, Suat; Uslu, Harun; Akman, Feride; Koran, KenanThe hexachlorocyclotriphosphaze compound (N3P3Cl6, HCCP) was reacted with excess (E)-(1-(4 '-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-ones (2-11) to produce hexakis[(1-(4-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes (CP 2-11). The structures of products (CP 2-11) were confirmed using elemental analysis, FT-IR, MS spectral analysis as well as P-31, H-1 and C-13-APT NMR techniques and their thermal properties determined by TGA and DSC techniques. The HOMO-LUMO energy gap and chemical reactivity identifiers were calculated and HOMO and LUMO images were viewed. According to the calculations, all the chemical potential values of CP 2-11 are negative and it shown that the molecules are stable. The in vitro cytotoxic of CP 2-11 investigated and their activity potentials were evaluated by molecular docking studies with Autodock Vina softwares. CP 2-11 compounds were found to demonstrate cytotoxic activity against human cancer cell lines (A2780, LNCaP and PC-3). The CP 2-11 compounds reduced the cell viability against all cancer cell lines in the range 36%-90% especially. The results showed that these compounds are powerful candidate molecules for pharmaceutical applications.Öğe Synthesis of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitriles: in vitro anticancer activity against MCF-7, PC-3 and A2780 cancer cell lines(Springer, 2016) Ozen, Furkan; Tekin, Suat; Koran, Kenan; Sandal, Suleyman; Gorgulu, Ahmet OrhanA series of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitrile (2-9) were designed and synthesized to develop new cancer drugs. The structures of synthesized compounds 2-9 were described by using melting point, mass (MALDI-TOF-MS), FT-IR, elemental analysis, H-1, C-13, C-13-APT and 2D NMR spectroscopy. The in vitro anticancer activities of 2-9 against human breast cancer (MCF-7), human prostate cancer (PC-3) and human ovarian cancer cells (A2780) were investigated by [3-(4,5-dimethylthiazol)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide] (MTT) assay method. Additionally, the LogIC(50) values of these compounds on A2780, MCF-7 and PC-3 cell lines were calculated by using inhibition % values by the GraphPad Prism 6 program on a computer. The results indicated that these compounds have high anticancer activity against MCF-7, PC-3 and A2780 cell lines (especially A2780 cell lines, p < 0.05).Öğe Synthesis of New Amino Acid Conjugates Containing Cinnamic Acid Derivatives and Investigation of Their Cytotoxic and Genotoxic Properties(Wiley, 2023) Sandal, Suleyman; Tekin, Suat; Caliskan, Eray; Koran, Kenan; Gorgulu, Ahmet Orhan; Cetin, Ahmet[Abstract Not Available]
